NZ582349A - Heterocyclic compounds useful as raf kinase inhibitors - Google Patents
Heterocyclic compounds useful as raf kinase inhibitorsInfo
- Publication number
- NZ582349A NZ582349A NZ582349A NZ58234908A NZ582349A NZ 582349 A NZ582349 A NZ 582349A NZ 582349 A NZ582349 A NZ 582349A NZ 58234908 A NZ58234908 A NZ 58234908A NZ 582349 A NZ582349 A NZ 582349A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- optionally substituted
- nitrogen
- ring
- mmol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94731907P | 2007-06-29 | 2007-06-29 | |
PCT/US2008/068789 WO2009006404A2 (en) | 2007-06-29 | 2008-06-30 | Heterocyclic compounds useful as raf kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ582349A true NZ582349A (en) | 2012-06-29 |
Family
ID=40015666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ582349A NZ582349A (en) | 2007-06-29 | 2008-06-30 | Heterocyclic compounds useful as raf kinase inhibitors |
Country Status (8)
Country | Link |
---|---|
US (1) | US7968536B2 (ja) |
EP (1) | EP2167497A2 (ja) |
JP (1) | JP2010532381A (ja) |
CN (1) | CN101743242A (ja) |
AU (1) | AU2008273017C1 (ja) |
CA (1) | CA2694284A1 (ja) |
NZ (1) | NZ582349A (ja) |
WO (1) | WO2009006404A2 (ja) |
Families Citing this family (33)
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CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
CN102227425A (zh) * | 2008-09-26 | 2011-10-26 | 贝林格尔·英格海姆国际有限公司 | 作为ccr1受体拮抗剂的氮杂吲唑化合物 |
EP2379513A1 (en) * | 2008-12-30 | 2011-10-26 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as raf kinase inhibitors |
GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
WO2011062437A2 (ko) | 2009-11-20 | 2011-05-26 | 에스케이케미칼주식회사 | 고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
WO2012142029A2 (en) | 2011-04-10 | 2012-10-18 | Florida A&M University | Serms for the treatment of estrogen receptor-mediated disorders |
US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
BR112014018812A8 (pt) | 2012-02-03 | 2017-07-11 | Basf Se | Compostos, processo para preparar os compostos i, composição agroquímica, método para combater fungos nocivos fitopagênicos, uso dos compostos de fórmula i e semente |
US9462809B2 (en) | 2012-03-13 | 2016-10-11 | Basf Se | Fungicidal pyrimidine compounds |
CN102936251A (zh) * | 2012-11-05 | 2013-02-20 | 上海毕得医药科技有限公司 | 一种吡咯并[2,3-d]嘧啶衍生物的制备方法 |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
US9045477B2 (en) | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
US9776996B2 (en) | 2013-03-15 | 2017-10-03 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
WO2015036059A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
WO2015036058A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
CN104761502A (zh) * | 2014-01-03 | 2015-07-08 | 中国药科大学 | 苯并咪唑衍生物、其制法及医药用途 |
US9914698B2 (en) | 2014-01-08 | 2018-03-13 | Shanghai Jiaotong University School Of Medicine | Stearoyl amino acid salt and preparation method and application thereof |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
JP6246901B2 (ja) * | 2015-01-14 | 2017-12-13 | 株式会社東芝 | 非水電解質電池及び電池パック |
EP3185341B1 (fr) * | 2015-12-21 | 2019-09-11 | The Swatch Group Research and Development Ltd | Cathode de pile métal/air et procédés de fabrication d'une telle cathode |
JP2019196307A (ja) | 2016-09-15 | 2019-11-14 | 武田薬品工業株式会社 | 複素環アミド化合物 |
AU2017329090B9 (en) | 2016-09-19 | 2019-09-05 | Novartis Ag | Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor |
JP7341060B2 (ja) | 2017-02-10 | 2023-09-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Mapk経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物 |
CN106928152A (zh) * | 2017-03-03 | 2017-07-07 | 符爱清 | 一种尿嘧啶的制备方法 |
JP7309614B2 (ja) | 2017-05-02 | 2023-07-18 | ノバルティス アーゲー | 組み合わせ療法 |
WO2018220533A2 (ja) * | 2017-05-30 | 2018-12-06 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | 光学活性化合物の製造法 |
WO2019067623A1 (en) * | 2017-09-27 | 2019-04-04 | The Regents Of The University Of California | POWERFUL ANTIVIRAL COMPOUNDS CONTAINING PYRIDINE |
EP3732285A1 (en) | 2017-12-28 | 2020-11-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
CN111741944A (zh) | 2018-02-01 | 2020-10-02 | 悉尼大学 | 抗癌化合物 |
US20230119479A1 (en) | 2019-12-10 | 2023-04-20 | Shionogi & Co., Ltd. | A histone deacetylase inhibitor having a nitrogen-containing aromatic heterocyclyl group |
US20230159492A1 (en) * | 2020-03-02 | 2023-05-25 | Sironax Ltd. | Ferroptosis inhibitors - diarylamine para-acetamides |
CN117567388B (zh) * | 2023-11-14 | 2024-04-16 | 济南悟通生物科技有限公司 | 一种2-乙酰基-5-噻唑甲酸的合成方法 |
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CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
EP2379513A1 (en) | 2008-12-30 | 2011-10-26 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as raf kinase inhibitors |
-
2008
- 2008-06-30 JP JP2010515223A patent/JP2010532381A/ja active Pending
- 2008-06-30 CA CA2694284A patent/CA2694284A1/en not_active Abandoned
- 2008-06-30 NZ NZ582349A patent/NZ582349A/en not_active IP Right Cessation
- 2008-06-30 EP EP08781174A patent/EP2167497A2/en not_active Withdrawn
- 2008-06-30 US US12/164,905 patent/US7968536B2/en not_active Expired - Fee Related
- 2008-06-30 AU AU2008273017A patent/AU2008273017C1/en not_active Expired - Fee Related
- 2008-06-30 WO PCT/US2008/068789 patent/WO2009006404A2/en active Application Filing
- 2008-06-30 CN CN200880022610A patent/CN101743242A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2167497A2 (en) | 2010-03-31 |
JP2010532381A (ja) | 2010-10-07 |
CN101743242A (zh) | 2010-06-16 |
AU2008273017C1 (en) | 2014-02-13 |
AU2008273017A1 (en) | 2009-01-08 |
US7968536B2 (en) | 2011-06-28 |
WO2009006404A2 (en) | 2009-01-08 |
CA2694284A1 (en) | 2009-01-08 |
AU2008273017B2 (en) | 2013-10-10 |
US20090005359A1 (en) | 2009-01-01 |
WO2009006404A3 (en) | 2009-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ASS | Change of ownership |
Owner name: MILLENNIUM PHARMACEUTICALS, US Free format text: OLD OWNER(S): BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC. Owner name: SUNESIS PHARMACEUTICALS, US Free format text: OLD OWNER(S): BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC. |
|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) | ||
LAPS | Patent lapsed |