NZ570997A - Buprenorphine derivatives and uses thereof - Google Patents
Buprenorphine derivatives and uses thereofInfo
- Publication number
- NZ570997A NZ570997A NZ570997A NZ57099707A NZ570997A NZ 570997 A NZ570997 A NZ 570997A NZ 570997 A NZ570997 A NZ 570997A NZ 57099707 A NZ57099707 A NZ 57099707A NZ 570997 A NZ570997 A NZ 570997A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compounds
- buprenorphine
- july
- medicament
- compound
- Prior art date
Links
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical class C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 208000026251 Opioid-Related disease Diseases 0.000 claims abstract description 17
- 208000002193 Pain Diseases 0.000 claims abstract description 14
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 11
- 201000005040 opiate dependence Diseases 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims description 75
- 239000003814 drug Substances 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 229910052717 sulfur Inorganic materials 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 238000006467 substitution reaction Methods 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims description 3
- 150000005690 diesters Chemical class 0.000 abstract 1
- RMRJXGBAOAMLHD-CTAPUXPBSA-N buprenorphine Chemical class C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-CTAPUXPBSA-N 0.000 description 107
- 229960001736 buprenorphine Drugs 0.000 description 100
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 74
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- 239000000651 prodrug Substances 0.000 description 5
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- 229910000104 sodium hydride Inorganic materials 0.000 description 5
- 239000007909 solid dosage form Substances 0.000 description 5
- 241000894007 species Species 0.000 description 5
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 5
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 4
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- 239000000600 sorbitol Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229940053209 suboxone Drugs 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- YCGAZNXXGKTASZ-UHFFFAOYSA-N thiophene-2,5-dicarboxylic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)S1 YCGAZNXXGKTASZ-UHFFFAOYSA-N 0.000 description 1
- 150000003577 thiophenes Chemical class 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0606124.6A GB0606124D0 (en) | 2006-03-28 | 2006-03-28 | Buprenorphine derivatives and uses thereof |
| PCT/GB2007/001120 WO2007110636A1 (en) | 2006-03-28 | 2007-03-27 | Buprenorphine derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ570997A true NZ570997A (en) | 2011-08-26 |
Family
ID=36384277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ570997A NZ570997A (en) | 2006-03-28 | 2007-03-27 | Buprenorphine derivatives and uses thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7964610B2 (enExample) |
| EP (1) | EP2001891B1 (enExample) |
| JP (1) | JP5167446B2 (enExample) |
| KR (1) | KR101430626B1 (enExample) |
| CN (2) | CN104151320A (enExample) |
| AU (1) | AU2007231133B2 (enExample) |
| BR (1) | BRPI0709157A8 (enExample) |
| CA (1) | CA2647417C (enExample) |
| DK (1) | DK2001891T3 (enExample) |
| ES (1) | ES2432169T3 (enExample) |
| GB (1) | GB0606124D0 (enExample) |
| IL (1) | IL193917A (enExample) |
| MX (1) | MX2008011984A (enExample) |
| MY (1) | MY151025A (enExample) |
| NZ (1) | NZ570997A (enExample) |
| PL (1) | PL2001891T3 (enExample) |
| PT (1) | PT2001891E (enExample) |
| RU (1) | RU2435773C2 (enExample) |
| TW (1) | TWI501969B (enExample) |
| WO (1) | WO2007110636A1 (enExample) |
| ZA (1) | ZA200807614B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7511054B2 (en) | 2006-09-22 | 2009-03-31 | Alltranz Inc. | Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs |
| PT2307420E (pt) * | 2008-04-24 | 2012-02-14 | Janssen Pharmaceutica Nv | Pró-fármacos de di-éster de nalmefeno |
| FR2975912B1 (fr) | 2011-05-30 | 2013-06-14 | Flamel Tech Sa | Composition a liberation controlee de buprenorphine |
| MX2018004835A (es) * | 2015-10-26 | 2018-08-01 | Orphomed Inc | Etilenglicol eter de buprenorfina. |
| CA3016510A1 (en) | 2016-03-09 | 2017-09-14 | Indivior Uk Limited | Abuse-resistant pharmaceutical formulations |
| CN109789137B (zh) | 2016-09-13 | 2023-01-13 | 昱展新药生技股份有限公司 | 丁丙诺啡缓释制剂 |
| WO2019064026A1 (en) | 2017-09-29 | 2019-04-04 | Orexo Ab | NEW PHARMACEUTICAL COMPOSITIONS |
| KR102839314B1 (ko) * | 2018-05-11 | 2025-07-29 | 에일러 파마슈티컬스 아이엔씨. | 오래 지속되는 주사용 제제와 부프레노핀 유도체 |
| GB201904767D0 (en) | 2019-04-04 | 2019-05-22 | Orexo Ab | New pharmaceutical compositions |
| WO2023102489A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents Of The University Of Nebraska | Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction |
| CN116283893B (zh) * | 2023-03-22 | 2024-04-26 | 阜阳欣奕华制药科技有限公司 | 硫代羟基乙酸酐的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| GB8728294D0 (en) | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5512593A (en) | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| US5750534A (en) | 1994-03-16 | 1998-05-12 | National Science Council | Nalbuphine esters having long acting analgesic action and method of use |
| US6004969A (en) | 1996-04-15 | 1999-12-21 | National Science Council | Transdermal delivery of buprenorphine preparations |
| KR100204659B1 (ko) | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| US6225321B1 (en) | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
| ES2298323T3 (es) | 1998-11-13 | 2008-05-16 | Jagotec Ag | Inhalador de polvo seco multidosis con reserva de polvo. |
| US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| EP2517710B1 (en) | 2000-02-08 | 2015-03-25 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
| JP2005523876A (ja) | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | 乱用の可能性が低減したオピオイド製剤 |
| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| US7666876B2 (en) | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE10250084A1 (de) | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| AU2003285934A1 (en) * | 2002-10-25 | 2004-05-25 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| DE10250087A1 (de) | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US20050186139A1 (en) | 2002-10-25 | 2005-08-25 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| US20050191244A1 (en) | 2002-10-25 | 2005-09-01 | Gruenenthal Gmbh | Abuse-resistant pharmaceutical dosage form |
| RU2215741C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения |
| CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| ATE382050T1 (de) * | 2002-11-25 | 2008-01-15 | Chi Mei Foundation Medical Ct | Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel |
| JP2004175706A (ja) * | 2002-11-26 | 2004-06-24 | Chi Mei Foundation Medical Center | 新規なブプレノルフィンのエステル誘導体及びそれらの調製方法、及び長時間効力持続性鎮痛薬剤組成物 |
| TW200500067A (en) * | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
| US7501113B2 (en) | 2003-02-04 | 2009-03-10 | Philip Morris Usa Inc. | Aerosol formulations and aerosol delivery of buprenorphine |
| US7195882B2 (en) | 2003-06-03 | 2007-03-27 | Roche Diagnostics Operations, Inc. | Monoclonal antibodies specific for buprenorphine and metabolites thereof |
| US7759358B2 (en) | 2003-07-23 | 2010-07-20 | Crooks Peter A | Oral bioavailable prodrugs |
| US7589233B2 (en) | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
| US7220842B2 (en) | 2004-04-05 | 2007-05-22 | Dade Behring Inc. | Immunoassays for buprenorphine and norbuprenorphine |
-
2006
- 2006-03-28 GB GBGB0606124.6A patent/GB0606124D0/en not_active Ceased
-
2007
- 2007-03-27 NZ NZ570997A patent/NZ570997A/en not_active IP Right Cessation
- 2007-03-27 ES ES07732177T patent/ES2432169T3/es active Active
- 2007-03-27 AU AU2007231133A patent/AU2007231133B2/en not_active Ceased
- 2007-03-27 US US12/294,462 patent/US7964610B2/en not_active Expired - Fee Related
- 2007-03-27 MY MYPI20083500 patent/MY151025A/en unknown
- 2007-03-27 EP EP07732177.6A patent/EP2001891B1/en active Active
- 2007-03-27 JP JP2009502210A patent/JP5167446B2/ja not_active Expired - Fee Related
- 2007-03-27 RU RU2008142527/04A patent/RU2435773C2/ru not_active IP Right Cessation
- 2007-03-27 TW TW096110534A patent/TWI501969B/zh not_active IP Right Cessation
- 2007-03-27 BR BRPI0709157A patent/BRPI0709157A8/pt not_active IP Right Cessation
- 2007-03-27 KR KR1020087023692A patent/KR101430626B1/ko not_active Expired - Fee Related
- 2007-03-27 CN CN201410318622.9A patent/CN104151320A/zh active Pending
- 2007-03-27 WO PCT/GB2007/001120 patent/WO2007110636A1/en not_active Ceased
- 2007-03-27 MX MX2008011984A patent/MX2008011984A/es active IP Right Grant
- 2007-03-27 CN CNA2007800108118A patent/CN101410402A/zh active Pending
- 2007-03-27 PL PL07732177T patent/PL2001891T3/pl unknown
- 2007-03-27 PT PT77321776T patent/PT2001891E/pt unknown
- 2007-03-27 CA CA2647417A patent/CA2647417C/en not_active Expired - Fee Related
- 2007-03-27 DK DK07732177.6T patent/DK2001891T3/da active
-
2008
- 2008-09-04 IL IL193917A patent/IL193917A/en not_active IP Right Cessation
- 2008-09-04 ZA ZA200807614A patent/ZA200807614B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5167446B2 (ja) | 2013-03-21 |
| RU2435773C2 (ru) | 2011-12-10 |
| CA2647417C (en) | 2014-09-23 |
| RU2008142527A (ru) | 2010-05-10 |
| MX2008011984A (es) | 2008-10-03 |
| EP2001891A1 (en) | 2008-12-17 |
| TWI501969B (zh) | 2015-10-01 |
| CA2647417A1 (en) | 2007-10-04 |
| US20100234412A1 (en) | 2010-09-16 |
| PT2001891E (pt) | 2013-10-30 |
| WO2007110636A1 (en) | 2007-10-04 |
| BRPI0709157A2 (pt) | 2011-06-28 |
| EP2001891B1 (en) | 2013-07-24 |
| AU2007231133A8 (en) | 2011-08-25 |
| AU2007231133A1 (en) | 2007-10-04 |
| CN104151320A (zh) | 2014-11-19 |
| AU2007231133B2 (en) | 2011-09-01 |
| JP2009531406A (ja) | 2009-09-03 |
| AU2007231133A2 (en) | 2008-10-16 |
| PL2001891T3 (pl) | 2014-03-31 |
| GB0606124D0 (en) | 2006-05-03 |
| KR101430626B1 (ko) | 2014-08-18 |
| IL193917A (en) | 2014-12-31 |
| BRPI0709157A8 (pt) | 2018-04-24 |
| DK2001891T3 (da) | 2013-11-04 |
| CN101410402A (zh) | 2009-04-15 |
| ES2432169T3 (es) | 2013-12-02 |
| TW200806672A (en) | 2008-02-01 |
| KR20080105124A (ko) | 2008-12-03 |
| US7964610B2 (en) | 2011-06-21 |
| MY151025A (en) | 2014-03-31 |
| ZA200807614B (en) | 2009-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| ASS | Change of ownership |
Owner name: RB PHARMACEUTICALS LIMITED, GB Free format text: OLD OWNER(S): RECKITT BENCKISER HEALTHCARE (UK) LIMITED |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 27 MAR 2017 BY COMPUTER PACKAGES INC Effective date: 20140328 |
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| LAPS | Patent lapsed |