NZ565333A - Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents - Google Patents

Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

Info

Publication number
NZ565333A
NZ565333A NZ565333A NZ56533306A NZ565333A NZ 565333 A NZ565333 A NZ 565333A NZ 565333 A NZ565333 A NZ 565333A NZ 56533306 A NZ56533306 A NZ 56533306A NZ 565333 A NZ565333 A NZ 565333A
Authority
NZ
New Zealand
Prior art keywords
formula
compound
process according
nitro
6alkyl
Prior art date
Application number
NZ565333A
Other languages
English (en)
Inventor
Anthony Eamon Storey
Clare Louise Jones
Denis Raymond Christophe Bouvet
Nicolas Lasbistes
Steven Michael Fairway
Lorenzo Williams
Alexander Mark Gibson
Robert James Nairne
Farhad Karimi
Bengt Langstrom
Original Assignee
Ge Healthcare Ltd
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Ge Healthcare As filed Critical Ge Healthcare Ltd
Publication of NZ565333A publication Critical patent/NZ565333A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24Stationary reactors without moving elements inside
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45Monoamines
    • C07C211/46Aniline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24Stationary reactors without moving elements inside
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NZ565333A 2005-08-12 2006-08-11 Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents NZ565333A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0516564.2A GB0516564D0 (en) 2005-08-12 2005-08-12 Fluorination process
PCT/GB2006/003009 WO2007020400A1 (en) 2005-08-12 2006-08-11 Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

Publications (1)

Publication Number Publication Date
NZ565333A true NZ565333A (en) 2011-07-29

Family

ID=35098197

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ565333A NZ565333A (en) 2005-08-12 2006-08-11 Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

Country Status (20)

Country Link
US (3) US8410312B2 (deDer)
EP (1) EP1915330B1 (deDer)
JP (2) JP5566605B2 (deDer)
KR (2) KR101409608B1 (deDer)
CN (2) CN101282920B (deDer)
AU (1) AU2006281216B2 (deDer)
BR (1) BRPI0614752B1 (deDer)
CA (1) CA2618448C (deDer)
DK (1) DK1915330T3 (deDer)
ES (1) ES2527864T3 (deDer)
GB (1) GB0516564D0 (deDer)
IL (1) IL188933A0 (deDer)
MX (2) MX341173B (deDer)
NO (1) NO341560B1 (deDer)
NZ (1) NZ565333A (deDer)
PL (1) PL1915330T3 (deDer)
PT (1) PT1915330E (deDer)
RU (1) RU2419601C2 (deDer)
WO (1) WO2007020400A1 (deDer)
ZA (1) ZA200801860B (deDer)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
US20100150835A1 (en) * 2007-02-27 2010-06-17 Bengt Langstrom Synthesis of [18F] Fluoromethyl Benzene Using Benzyl Pentafluorobenzenesulfonate
WO2009027452A2 (en) * 2007-08-30 2009-03-05 Ge Healthcare Limited Radiopharmaceutical composition
US8980221B2 (en) 2008-01-03 2015-03-17 Ge Healthcare Limited Fluoride processing method
PT2338059E (pt) 2008-09-23 2015-08-03 Wista Lab Ltd Ligandos para moléculas de tau agregada
GB0921967D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
GB201019303D0 (en) 2010-11-15 2010-12-29 Strom Hans E P Agents and methods for visualising analytes
CN103613589B (zh) * 2013-11-29 2016-03-30 江苏华益科技有限公司 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法
WO2016087653A1 (en) 2014-12-04 2016-06-09 Ge Healthcare Limited Method of removing acetaldehyde from radioactive pharmaceuticals
JP6485914B2 (ja) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 フルテメタモルの製造方法
JP6955347B2 (ja) * 2017-02-28 2021-10-27 日本メジフィジックス株式会社 フルテメタモルの製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878206A (en) * 1973-06-06 1975-04-15 Morton Norwich Products Inc 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines
FR2449677B1 (fr) 1979-02-26 1986-03-28 Fabre Sa Pierre Nouveaux derives de benzoyl-2 glycylanilides substitues, leur preparation et leur application en tant que medicaments anxiolytiques
FR2693781B1 (fr) * 1992-07-15 1994-10-28 Otis Elevator Co Dispositif de réglage de la tension d'un câble faisant boucle.
DE4402056A1 (de) 1994-01-25 1995-07-27 Basf Ag p-Phenylendiamin-Derivate und sie enthaltende fungizide Mittel
US7270800B2 (en) * 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
RU2440995C2 (ru) * 2003-03-14 2012-01-27 Юнивесити Оф Питсбэг Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего
CA2438032C (en) 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
AU2005270026A1 (en) * 2004-07-02 2006-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of thioflavin radiolabeled derivatives in amyloid imaging for assessing anti-amyloid therapies
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process

Also Published As

Publication number Publication date
CA2618448A1 (en) 2007-02-22
ES2527864T3 (es) 2015-01-30
HK1177463A1 (zh) 2013-08-23
AU2006281216B2 (en) 2012-01-19
US8410312B2 (en) 2013-04-02
IL188933A0 (en) 2008-04-13
US20150328344A1 (en) 2015-11-19
CN101282920B (zh) 2014-06-04
MX2008002068A (es) 2008-04-16
AU2006281216A1 (en) 2007-02-22
PT1915330E (pt) 2015-01-16
ZA200801860B (en) 2008-12-31
KR101392538B1 (ko) 2014-05-07
RU2419601C2 (ru) 2011-05-27
US9468694B2 (en) 2016-10-18
CN102731432A (zh) 2012-10-17
KR20130114279A (ko) 2013-10-16
GB0516564D0 (en) 2005-09-21
KR101409608B1 (ko) 2014-06-18
NO341560B1 (no) 2017-12-04
EP1915330B1 (en) 2014-12-10
EP1915330A1 (en) 2008-04-30
US20130225829A1 (en) 2013-08-29
WO2007020400A1 (en) 2007-02-22
BRPI0614752B1 (pt) 2024-01-09
JP2009507775A (ja) 2009-02-26
DK1915330T3 (en) 2015-01-19
NO20081167L (no) 2008-03-05
PL1915330T3 (pl) 2015-03-31
RU2008103989A (ru) 2009-09-20
MX341173B (es) 2016-08-10
US20100234611A1 (en) 2010-09-16
BRPI0614752A2 (pt) 2012-12-04
CA2618448C (en) 2014-05-06
JP2014028837A (ja) 2014-02-13
KR20080035618A (ko) 2008-04-23
CN102731432B (zh) 2015-10-21
US9126961B2 (en) 2015-09-08
CN101282920A (zh) 2008-10-08
JP5566605B2 (ja) 2014-08-06

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