NZ563736A - Inhibitors of cytosolic phospholipase A2 - Google Patents
Inhibitors of cytosolic phospholipase A2Info
- Publication number
- NZ563736A NZ563736A NZ563736A NZ56373606A NZ563736A NZ 563736 A NZ563736 A NZ 563736A NZ 563736 A NZ563736 A NZ 563736A NZ 56373606 A NZ56373606 A NZ 56373606A NZ 563736 A NZ563736 A NZ 563736A
- Authority
- NZ
- New Zealand
- Prior art keywords
- mmol
- compound
- disease
- ethyl
- afford
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68556405P | 2005-05-27 | 2005-05-27 | |
PCT/US2006/020847 WO2006128142A2 (en) | 2005-05-27 | 2006-05-26 | Inhibitors of cytosolic phospholipase a2 |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ563736A true NZ563736A (en) | 2010-11-26 |
Family
ID=37188759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ563736A NZ563736A (en) | 2005-05-27 | 2006-05-26 | Inhibitors of cytosolic phospholipase A2 |
Country Status (33)
Country | Link |
---|---|
US (3) | US7557135B2 (pl) |
EP (2) | EP2248801A1 (pl) |
JP (1) | JP5116666B2 (pl) |
KR (1) | KR101353982B1 (pl) |
CN (2) | CN102040550B (pl) |
AR (1) | AR054195A1 (pl) |
AT (1) | ATE489364T1 (pl) |
AU (1) | AU2006251946B2 (pl) |
BR (1) | BRPI0610049A2 (pl) |
CA (1) | CA2607857C (pl) |
CR (1) | CR9520A (pl) |
CY (1) | CY1111151T1 (pl) |
DE (1) | DE602006018451D1 (pl) |
DK (1) | DK1891006T3 (pl) |
ES (1) | ES2354908T3 (pl) |
GT (1) | GT200600228A (pl) |
HK (2) | HK1113680A1 (pl) |
HN (1) | HN2006019513A (pl) |
IL (1) | IL186912A (pl) |
MX (1) | MX2007014589A (pl) |
MY (1) | MY144672A (pl) |
NI (1) | NI200700287A (pl) |
NO (1) | NO20075627L (pl) |
NZ (1) | NZ563736A (pl) |
PE (1) | PE20061426A1 (pl) |
PL (1) | PL1891006T3 (pl) |
PT (1) | PT1891006E (pl) |
RU (1) | RU2433997C2 (pl) |
SI (1) | SI1891006T1 (pl) |
SV (1) | SV2008002551A (pl) |
TW (1) | TW200718687A (pl) |
UA (1) | UA91053C2 (pl) |
WO (1) | WO2006128142A2 (pl) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US7605156B2 (en) * | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
HN2004000536A (es) | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
IL161579A0 (en) | 2004-04-22 | 2004-09-27 | Mor Research Applic Ltd | ANTISENSE OLIGONUCLEOTIDES AGAINST cPLA2, COMPOSITIONS AND USES THEREOF |
US8029815B2 (en) | 2004-04-28 | 2011-10-04 | Elford Howard L | Methods for treating or preventing restenosis and other vascular proliferative disorders |
GT200600228A (es) * | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
US20080009485A1 (en) * | 2006-05-26 | 2008-01-10 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis |
IL178401A (en) * | 2006-09-28 | 2012-04-30 | Univ Ben Gurion | Use of antisense oligonucleotides against 2 cPLA in the treatment of cancer |
CL2007003146A1 (es) * | 2006-10-31 | 2008-01-25 | Wyeth Corp | Composición farmacéutica que comprende un compuesto derivado de indol y un sistema portador que comprende 15-25% de un mejorador de la viscosidad, 5-15% de un solubilizante, 10-50% de un diluyente y 1-10% de un estabilizante; proceso de preparación; y forma de dosificación. |
BRPI0717943A2 (pt) * | 2006-10-31 | 2013-10-29 | Wyeth Corp | Composição farmacêutica; forma de dosagem farmacêutica; processo para a preparação de uma composição farmacêutica; e produto preparado pelo processo |
KR20090125799A (ko) | 2007-03-29 | 2009-12-07 | 아스비오파마 가부시키가이샤 | Cpla2 저해 활성을 가지는 인돌 유도체 및 그 용도 및 제조 방법 |
EP2030615A3 (en) * | 2007-08-13 | 2009-12-02 | ELFORD, Howard L. | Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases |
US20130211209A1 (en) * | 2010-06-18 | 2013-08-15 | Majid Sarrafzadeh | Energy aware sensor management for wearable medical systems optimization |
EP2614144B1 (en) | 2010-09-08 | 2015-07-22 | Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH | Use of inhibitors of phospholipase a2 for the treatment or prevention of flavivirus infection |
GB201401904D0 (en) * | 2014-02-04 | 2014-03-19 | Ziarco Pharma Ltd | Pharmaceutical composition for topical administration |
WO2015129592A1 (ja) * | 2014-02-28 | 2015-09-03 | 住友化学株式会社 | 2-(ハロゲノメチル)-3-メチルニトロベンゼンの製造方法 |
CN103804150A (zh) * | 2014-03-01 | 2014-05-21 | 江苏斯威森生物医药工程研究中心有限公司 | 一种3,4-二甲氧基苄基溴的制备方法 |
CN108017522B (zh) * | 2017-11-16 | 2021-01-05 | 贵州大学 | 一种2,6-二溴苯甲磺酰氯的制备工艺 |
PL424613A1 (pl) | 2018-02-16 | 2019-08-26 | Paweł Wawrzyński | Rower dwukołowy o zmiennej konfiguracji |
WO2020236777A1 (en) * | 2019-05-20 | 2020-11-26 | Saint Louis University | Reprogramming of lipid metabolism to inhibit t cell senescence and enhance tumor immunotherapy |
CA3176061A1 (en) * | 2020-04-02 | 2021-10-07 | Gilead Sciences, Inc. | Process for preparing a cot inhibitor compound |
US20230338529A1 (en) * | 2020-08-06 | 2023-10-26 | The Children's Medical Center Corporation | Compositions for altering a microglial cell, and methods of use therefore |
Family Cites Families (64)
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CH48411A (fr) | 1909-07-19 | 1910-10-17 | Stephen Alley | Outillage pour mettre en place et enlever les bandages élastiques des roues de véhicules |
GB1148909A (en) | 1965-04-19 | 1969-04-16 | Sumitomo Chemical Co | Process for production of novel phenylhydrazone and phenylhydrazine derivatives |
FR1492929A (fr) | 1966-05-11 | 1967-08-25 | Roussel Uclaf | Nouveaux 1-(omega-carboxyalcoyl) indoles substitués et procédé de préparation |
US3505354A (en) | 1967-05-18 | 1970-04-07 | Geigy Chem Corp | 2-methyl-3-p-halobenzoylindole-n-aliphatic acids |
DE1816335A1 (de) | 1968-12-21 | 1970-07-09 | Thiemann Gmbh Chem Pharm Fabri | Verfahren zur Herstellung von [2-Methyl-5-alkoxy-3-acyl-indol-1]-essigsaeuren und deren Estern |
US3931229A (en) | 1973-08-23 | 1976-01-06 | Warner-Lambert Company | 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4271263A (en) | 1980-05-15 | 1981-06-02 | Minnesota Mining And Manufacturing Company | Thermally developable photosensitive compositions containing acutance agents |
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ATE84532T1 (de) | 1988-04-13 | 1993-01-15 | Ici America Inc | Cyclische amide. |
GB8906032D0 (en) | 1988-04-14 | 1989-04-26 | Ici America Inc | Hetera-aliphatic carboxamides |
US5166170A (en) | 1989-07-03 | 1992-11-24 | Hoechst-Roussel Pharmaceuticals Incorporated | 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders |
GB8916774D0 (en) | 1989-07-21 | 1989-09-06 | Bayer Ag | New indole derivatives,a process for their preparation and their use in medicaments |
US5420289A (en) | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
PT95692A (pt) | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
US5229516A (en) | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5081145A (en) | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
US5622832A (en) | 1990-02-28 | 1997-04-22 | Genetics Institute, Inc. | Arachidonic acid releasing phospholipase A2 enzyme and methods of use |
US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5190968A (en) | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
US5206377A (en) | 1991-12-05 | 1993-04-27 | Whitby Research, Inc. | Compounds useful as antiproliferative agents |
MX9301088A (es) | 1992-05-13 | 1993-11-01 | Syntex Inc | Derivados de indol, azaindol, y tetrahidro-1h-pirrol 2,3-c piridin-7-ona substituidos. |
US5212195A (en) | 1992-05-13 | 1993-05-18 | Syntex (U.S.A.) Inc. | Substituted indole antagonists derivatives which are angiotensin II |
US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
IL109311A0 (en) | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
US5424329A (en) | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
US5686481A (en) | 1993-12-21 | 1997-11-11 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
US5641800A (en) | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
US5482960A (en) | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
DE59711058D1 (de) | 1996-08-01 | 2004-01-08 | Merckle Gmbh | Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a2 |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
WO1998008818A1 (en) | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
US5994398A (en) | 1996-12-11 | 1999-11-30 | Elan Pharmaceuticals, Inc. | Arylsulfonamides as phospholipase A2 inhibitors |
EA200000873A1 (ru) | 1998-02-25 | 2001-04-23 | Дженетикс Инститьют, Инк. | Ингибиторы фосфолипазы a |
BR9908280A (pt) * | 1998-02-25 | 2000-10-31 | Genetics Inst | Inibidores de enzimas de fosfolipase |
NZ506329A (en) * | 1998-02-25 | 2004-01-30 | Inst Genetics Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6358980B1 (en) | 1999-01-27 | 2002-03-19 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
US6424105B1 (en) | 1999-06-08 | 2002-07-23 | Camco International, Inc. | Real-time control of feedback signals to a motor for optimum performance |
CN1455783A (zh) | 2001-01-22 | 2003-11-12 | 索尼公司 | 溶剂吸收性树脂及其制备方法 |
US7101875B2 (en) * | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
EP1451154B1 (en) * | 2001-12-03 | 2008-01-16 | Wyeth | Inhibitors of cytosolic phospholipase a2 |
US7713964B2 (en) * | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
US7439249B2 (en) | 2002-12-31 | 2008-10-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of phosphatases |
JP4619795B2 (ja) | 2002-12-31 | 2011-01-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ホスファターゼのインヒビター |
TW200510305A (en) | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
US7582771B2 (en) | 2003-09-03 | 2009-09-01 | Wyeth | Process for the synthesis of cPLA2 inhibitors |
WO2005023201A2 (en) | 2003-09-09 | 2005-03-17 | Medarex, Inc. | Methods for treating rheumatoid arthritis |
US7342119B2 (en) | 2003-09-30 | 2008-03-11 | Wyeth Holdings Corporation | Process for the synthesis of a CPLA2 inhibitor |
HN2004000536A (es) | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
AR053410A1 (es) | 2004-08-19 | 2007-05-09 | Wyeth Corp | Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios |
GT200600228A (es) | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
US20080009485A1 (en) * | 2006-05-26 | 2008-01-10 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis |
-
2006
- 2006-05-25 GT GT200600228A patent/GT200600228A/es unknown
- 2006-05-25 TW TW095118534A patent/TW200718687A/zh unknown
- 2006-05-26 CN CN2010105355308A patent/CN102040550B/zh not_active Expired - Fee Related
- 2006-05-26 HN HN2006019513A patent/HN2006019513A/es unknown
- 2006-05-26 UA UAA200713220A patent/UA91053C2/ru unknown
- 2006-05-26 AU AU2006251946A patent/AU2006251946B2/en not_active Ceased
- 2006-05-26 MY MYPI20062443A patent/MY144672A/en unknown
- 2006-05-26 MX MX2007014589A patent/MX2007014589A/es active IP Right Grant
- 2006-05-26 PL PL06771540T patent/PL1891006T3/pl unknown
- 2006-05-26 EP EP10172388A patent/EP2248801A1/en not_active Withdrawn
- 2006-05-26 DK DK06771540.9T patent/DK1891006T3/da active
- 2006-05-26 KR KR1020077027672A patent/KR101353982B1/ko active IP Right Grant
- 2006-05-26 PT PT06771540T patent/PT1891006E/pt unknown
- 2006-05-26 EP EP06771540A patent/EP1891006B1/en not_active Not-in-force
- 2006-05-26 NZ NZ563736A patent/NZ563736A/en not_active IP Right Cessation
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