HK1113680A1 - Inhibitors of cytosolic phospholipase a2 - Google Patents

Inhibitors of cytosolic phospholipase a2

Info

Publication number
HK1113680A1
HK1113680A1 HK08109102.8A HK08109102A HK1113680A1 HK 1113680 A1 HK1113680 A1 HK 1113680A1 HK 08109102 A HK08109102 A HK 08109102A HK 1113680 A1 HK1113680 A1 HK 1113680A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
cytosolic phospholipase
cytosolic
phospholipase
Prior art date
Application number
HK08109102.8A
Other languages
English (en)
Inventor
John C Mckew
Katherine L Lee
Lihren Chen
Richard Vargas
James D Clark
Cara Williams
Valerie Clerin
Suzana Marusic
Kevin Pong
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of HK1113680A1 publication Critical patent/HK1113680A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HK08109102.8A 2005-05-27 2008-08-15 Inhibitors of cytosolic phospholipase a2 HK1113680A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68556405P 2005-05-27 2005-05-27
PCT/US2006/020847 WO2006128142A2 (en) 2005-05-27 2006-05-26 Inhibitors of cytosolic phospholipase a2

Publications (1)

Publication Number Publication Date
HK1113680A1 true HK1113680A1 (en) 2008-10-10

Family

ID=37188759

Family Applications (2)

Application Number Title Priority Date Filing Date
HK08109102.8A HK1113680A1 (en) 2005-05-27 2008-08-15 Inhibitors of cytosolic phospholipase a2
HK11106893.2A HK1152710A1 (en) 2005-05-27 2011-07-05 Inhibitors of cytosolic phospholipase a2

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK11106893.2A HK1152710A1 (en) 2005-05-27 2011-07-05 Inhibitors of cytosolic phospholipase a2

Country Status (33)

Country Link
US (3) US7557135B2 (pl)
EP (2) EP1891006B1 (pl)
JP (1) JP5116666B2 (pl)
KR (1) KR101353982B1 (pl)
CN (2) CN102040550B (pl)
AR (1) AR054195A1 (pl)
AT (1) ATE489364T1 (pl)
AU (1) AU2006251946B2 (pl)
BR (1) BRPI0610049A2 (pl)
CA (1) CA2607857C (pl)
CR (1) CR9520A (pl)
CY (1) CY1111151T1 (pl)
DE (1) DE602006018451D1 (pl)
DK (1) DK1891006T3 (pl)
ES (1) ES2354908T3 (pl)
GT (1) GT200600228A (pl)
HK (2) HK1113680A1 (pl)
HN (1) HN2006019513A (pl)
IL (1) IL186912A (pl)
MX (1) MX2007014589A (pl)
MY (1) MY144672A (pl)
NI (1) NI200700287A (pl)
NO (1) NO20075627L (pl)
NZ (1) NZ563736A (pl)
PE (1) PE20061426A1 (pl)
PL (1) PL1891006T3 (pl)
PT (1) PT1891006E (pl)
RU (1) RU2433997C2 (pl)
SI (1) SI1891006T1 (pl)
SV (1) SV2008002551A (pl)
TW (1) TW200718687A (pl)
UA (1) UA91053C2 (pl)
WO (1) WO2006128142A2 (pl)

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Also Published As

Publication number Publication date
US20100022536A1 (en) 2010-01-28
EP1891006B1 (en) 2010-11-24
TW200718687A (en) 2007-05-16
US7557135B2 (en) 2009-07-07
CA2607857A1 (en) 2006-11-30
EP1891006A2 (en) 2008-02-27
US8283373B2 (en) 2012-10-09
HK1152710A1 (en) 2012-03-09
JP2008542303A (ja) 2008-11-27
CN102040550A (zh) 2011-05-04
RU2007140910A (ru) 2009-07-10
MX2007014589A (es) 2008-01-21
PL1891006T3 (pl) 2011-05-31
ATE489364T1 (de) 2010-12-15
CY1111151T1 (el) 2015-06-11
CN101184729B (zh) 2011-02-16
HN2006019513A (es) 2011-03-02
US20070004719A1 (en) 2007-01-04
AU2006251946A1 (en) 2006-11-30
RU2433997C2 (ru) 2011-11-20
ES2354908T3 (es) 2011-03-21
MY144672A (en) 2011-10-31
KR101353982B1 (ko) 2014-02-18
CN101184729A (zh) 2008-05-21
BRPI0610049A2 (pt) 2010-05-25
IL186912A0 (en) 2008-02-09
WO2006128142A8 (en) 2007-12-27
DK1891006T3 (da) 2011-01-24
WO2006128142A3 (en) 2007-03-29
CN102040550B (zh) 2012-10-03
PT1891006E (pt) 2011-01-26
PE20061426A1 (es) 2007-01-24
SI1891006T1 (sl) 2011-02-28
NO20075627L (no) 2008-01-03
SV2008002551A (es) 2008-07-23
CA2607857C (en) 2014-02-11
DE602006018451D1 (de) 2011-01-05
CR9520A (es) 2008-02-20
KR20080021618A (ko) 2008-03-07
AU2006251946B2 (en) 2011-05-12
WO2006128142A2 (en) 2006-11-30
IL186912A (en) 2012-05-31
AR054195A1 (es) 2007-06-06
JP5116666B2 (ja) 2013-01-09
EP2248801A1 (en) 2010-11-10
NZ563736A (en) 2010-11-26
US20100029645A1 (en) 2010-02-04
UA91053C2 (en) 2010-06-25
NI200700287A (es) 2008-05-27
GT200600228A (es) 2006-12-26

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