NZ561458A - Heteroaryl urea derivatives useful for inhibiting CHK1 - Google Patents

Info

Publication number

NZ561458A

NZ561458A NZ561458A NZ56145806A NZ561458A NZ 561458 A NZ561458 A NZ 561458A NZ 561458 A NZ561458 A NZ 561458A NZ 56145806 A NZ56145806 A NZ 56145806A NZ 561458 A NZ561458 A NZ 561458A

Authority

NZ

New Zealand

Prior art keywords

compound

methyl

chkl

cancer

cells

Prior art date

2005-03-29

Links

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• -1 Heteroaryl urea derivatives Chemical class 0.000 title abstract description 51
• 230000002401 inhibitory effect Effects 0.000 title description 14
• 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 title description 2
• 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 173
• 238000011282 treatment Methods 0.000 claims abstract description 45
• 239000003814 drug Substances 0.000 claims abstract description 15
• 150000003839 salts Chemical class 0.000 claims description 27
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• 206010009944 Colon cancer Diseases 0.000 claims description 13
• 208000006265 Renal cell carcinoma Diseases 0.000 claims description 8
• 208000003174 Brain Neoplasms Diseases 0.000 claims description 7
• 206010006187 Breast cancer Diseases 0.000 claims description 7
• 206010025323 Lymphomas Diseases 0.000 claims description 7
• 208000032839 leukemia Diseases 0.000 claims description 7
• 201000001441 melanoma Diseases 0.000 claims description 7
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 6
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
• 238000002560 therapeutic procedure Methods 0.000 claims description 6
• 206010005003 Bladder cancer Diseases 0.000 claims description 5
• 208000026310 Breast neoplasm Diseases 0.000 claims description 5
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 5
• 208000004354 Vulvar Neoplasms Diseases 0.000 claims description 5
• 208000020816 lung neoplasm Diseases 0.000 claims description 5
• 201000008968 osteosarcoma Diseases 0.000 claims description 5
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
• 206010033128 Ovarian cancer Diseases 0.000 claims description 4
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
• 239000003085 diluting agent Substances 0.000 claims description 4
• 206010017758 gastric cancer Diseases 0.000 claims description 4
• 201000010536 head and neck cancer Diseases 0.000 claims description 4
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
• 201000005202 lung cancer Diseases 0.000 claims description 4
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
• 201000002528 pancreatic cancer Diseases 0.000 claims description 4
• 201000011549 stomach cancer Diseases 0.000 claims description 4
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• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 37
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