BRPI0609667A2 - composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto - Google Patents

composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto Download PDF

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Publication number
BRPI0609667A2
BRPI0609667A2 BRPI0609667-0A BRPI0609667A BRPI0609667A2 BR PI0609667 A2 BRPI0609667 A2 BR PI0609667A2 BR PI0609667 A BRPI0609667 A BR PI0609667A BR PI0609667 A2 BRPI0609667 A2 BR PI0609667A2
Authority
BR
Brazil
Prior art keywords
formula
original document
document page
see original
compound
Prior art date
Application number
BRPI0609667-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Frank Diaz
Ryan C Holcomb
Edward A Kesicki
Hua Chee Ooi
Alexander Rudolph
Frank Stappenbeck
Eugene D Thorsett
Kimba L Fischer
Francine S Farouz
John Joseph Gaudino
Adam Wade Cook
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of BRPI0609667A2 publication Critical patent/BRPI0609667A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
BRPI0609667-0A 2005-03-29 2006-03-29 composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto BRPI0609667A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
US60/666,026 2005-03-29
PCT/US2006/011584 WO2006105262A1 (en) 2005-03-29 2006-03-29 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

Publications (1)

Publication Number Publication Date
BRPI0609667A2 true BRPI0609667A2 (pt) 2010-04-20

Family

ID=36677174

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609667-0A BRPI0609667A2 (pt) 2005-03-29 2006-03-29 composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto

Country Status (31)

Country Link
US (1) US8093244B2 (cg-RX-API-DMAC7.html)
EP (2) EP1869020B1 (cg-RX-API-DMAC7.html)
JP (2) JP5117374B2 (cg-RX-API-DMAC7.html)
KR (2) KR100912998B1 (cg-RX-API-DMAC7.html)
CN (2) CN102219784A (cg-RX-API-DMAC7.html)
AR (1) AR056645A1 (cg-RX-API-DMAC7.html)
AT (1) ATE490248T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006230337B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0609667A2 (cg-RX-API-DMAC7.html)
CA (1) CA2602199C (cg-RX-API-DMAC7.html)
CR (1) CR9395A (cg-RX-API-DMAC7.html)
CY (1) CY1111240T1 (cg-RX-API-DMAC7.html)
DE (1) DE602006018590D1 (cg-RX-API-DMAC7.html)
DK (1) DK1869020T3 (cg-RX-API-DMAC7.html)
EA (1) EA011287B1 (cg-RX-API-DMAC7.html)
ES (1) ES2356068T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20100678T1 (cg-RX-API-DMAC7.html)
IL (1) IL185481A0 (cg-RX-API-DMAC7.html)
MA (1) MA29439B1 (cg-RX-API-DMAC7.html)
MX (1) MX2007012116A (cg-RX-API-DMAC7.html)
NO (1) NO20074944L (cg-RX-API-DMAC7.html)
NZ (1) NZ561458A (cg-RX-API-DMAC7.html)
PL (1) PL1869020T3 (cg-RX-API-DMAC7.html)
PT (1) PT1869020E (cg-RX-API-DMAC7.html)
RS (1) RS51616B (cg-RX-API-DMAC7.html)
SI (1) SI1869020T1 (cg-RX-API-DMAC7.html)
TN (1) TNSN07369A1 (cg-RX-API-DMAC7.html)
TW (1) TWI375559B (cg-RX-API-DMAC7.html)
UA (1) UA92164C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006105262A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200707715B (cg-RX-API-DMAC7.html)

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US11179394B2 (en) 2014-06-17 2021-11-23 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of Chk1 and ATR inhibitors
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
US11464774B2 (en) 2015-09-30 2022-10-11 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
CA3013514C (en) 2016-02-04 2021-11-23 Pharmaengine, Inc. 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (chk1) inhibitors, and their preparations and applications
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
KR20190130621A (ko) * 2017-03-31 2019-11-22 시애틀 지네틱스, 인크. Chk1 저해제와 wee1 저해제의 조합물
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
CN112457306A (zh) 2019-09-06 2021-03-09 上海瑛派药业有限公司 3,5-二取代吡唑化合物作为激酶抑制剂及其应用
US12404332B2 (en) * 2020-03-13 2025-09-02 Research Development Foundation Methods for diagnosing and treating cancers
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Also Published As

Publication number Publication date
PT1869020E (pt) 2010-12-23
ES2356068T3 (es) 2011-04-04
ZA200707715B (en) 2009-09-30
JP2009227682A (ja) 2009-10-08
WO2006105262A1 (en) 2006-10-05
MX2007012116A (es) 2008-04-08
CY1111240T1 (el) 2015-06-11
TWI375559B (en) 2012-11-01
US8093244B2 (en) 2012-01-10
DK1869020T3 (da) 2011-01-24
UA92164C2 (ru) 2010-10-11
TW200722090A (en) 2007-06-16
CN101151259B (zh) 2011-06-15
NZ561458A (en) 2011-03-31
AU2006230337B2 (en) 2011-10-27
HK1119670A1 (en) 2009-03-13
JP2008535830A (ja) 2008-09-04
TNSN07369A1 (en) 2008-12-31
CR9395A (es) 2008-03-31
EA200702094A1 (ru) 2008-02-28
EA011287B1 (ru) 2009-02-27
KR20090031459A (ko) 2009-03-25
RS51616B (sr) 2011-08-31
CN102219784A (zh) 2011-10-19
KR20070107178A (ko) 2007-11-06
CA2602199A1 (en) 2006-10-05
US20090143357A1 (en) 2009-06-04
DE602006018590D1 (de) 2011-01-13
EP1869020B1 (en) 2010-12-01
CN101151259A (zh) 2008-03-26
EP1869020A1 (en) 2007-12-26
NO20074944L (no) 2007-10-24
HRP20100678T1 (hr) 2011-02-28
KR100912998B1 (ko) 2009-08-20
IL185481A0 (en) 2008-01-06
ATE490248T1 (de) 2010-12-15
JP5117374B2 (ja) 2013-01-16
AU2006230337A1 (en) 2006-10-05
AR056645A1 (es) 2007-10-17
PL1869020T3 (pl) 2011-05-31
MA29439B1 (fr) 2008-05-02
EP2330105A1 (en) 2011-06-08
CA2602199C (en) 2013-09-10
SI1869020T1 (sl) 2011-02-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]