KR100912998B1 - Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체 - Google Patents

Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체 Download PDF

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Publication number
KR100912998B1
KR100912998B1 KR1020077022281A KR20077022281A KR100912998B1 KR 100912998 B1 KR100912998 B1 KR 100912998B1 KR 1020077022281 A KR1020077022281 A KR 1020077022281A KR 20077022281 A KR20077022281 A KR 20077022281A KR 100912998 B1 KR100912998 B1 KR 100912998B1
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South Korea
Prior art keywords
methyl
compound
chk1
cell
cells
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20070107178A (ko
Inventor
프랭크 디아즈
프랑씬 에스. 파루
라이언 홀콤
에드워드 에이. 케시키
후아 치 오이
알렉산더 루돌프
프랭크 스타펜벡
유진 쏘셋
존 조셉 가우디노
킴바 엘. 피셔
아담 웨이드 쿡
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이코스 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
KR1020077022281A 2005-03-29 2006-03-29 Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체 Expired - Fee Related KR100912998B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
US60/666,026 2005-03-29

Related Child Applications (1)

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KR1020097002925A Division KR20090031459A (ko) 2005-03-29 2006-03-29 Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체

Publications (2)

Publication Number Publication Date
KR20070107178A KR20070107178A (ko) 2007-11-06
KR100912998B1 true KR100912998B1 (ko) 2009-08-20

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ID=36677174

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KR1020077022281A Expired - Fee Related KR100912998B1 (ko) 2005-03-29 2006-03-29 Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체
KR1020097002925A Ceased KR20090031459A (ko) 2005-03-29 2006-03-29 Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체

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KR1020097002925A Ceased KR20090031459A (ko) 2005-03-29 2006-03-29 Ｃｈｋ1 억제에 유용한 헤테로아릴 우레아 유도체

Country Status (31)

Country Link
US (1) US8093244B2 (cg-RX-API-DMAC7.html)
EP (2) EP1869020B1 (cg-RX-API-DMAC7.html)
JP (2) JP5117374B2 (cg-RX-API-DMAC7.html)
KR (2) KR100912998B1 (cg-RX-API-DMAC7.html)
CN (2) CN102219784A (cg-RX-API-DMAC7.html)
AR (1) AR056645A1 (cg-RX-API-DMAC7.html)
AT (1) ATE490248T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006230337B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0609667A2 (cg-RX-API-DMAC7.html)
CA (1) CA2602199C (cg-RX-API-DMAC7.html)
CR (1) CR9395A (cg-RX-API-DMAC7.html)
CY (1) CY1111240T1 (cg-RX-API-DMAC7.html)
DE (1) DE602006018590D1 (cg-RX-API-DMAC7.html)
DK (1) DK1869020T3 (cg-RX-API-DMAC7.html)
EA (1) EA011287B1 (cg-RX-API-DMAC7.html)
ES (1) ES2356068T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20100678T1 (cg-RX-API-DMAC7.html)
IL (1) IL185481A0 (cg-RX-API-DMAC7.html)
MA (1) MA29439B1 (cg-RX-API-DMAC7.html)
MX (1) MX2007012116A (cg-RX-API-DMAC7.html)
NO (1) NO20074944L (cg-RX-API-DMAC7.html)
NZ (1) NZ561458A (cg-RX-API-DMAC7.html)
PL (1) PL1869020T3 (cg-RX-API-DMAC7.html)
PT (1) PT1869020E (cg-RX-API-DMAC7.html)
RS (1) RS51616B (cg-RX-API-DMAC7.html)
SI (1) SI1869020T1 (cg-RX-API-DMAC7.html)
TN (1) TNSN07369A1 (cg-RX-API-DMAC7.html)
TW (1) TWI375559B (cg-RX-API-DMAC7.html)
UA (1) UA92164C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006105262A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200707715B (cg-RX-API-DMAC7.html)

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US11179394B2 (en) 2014-06-17 2021-11-23 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of Chk1 and ATR inhibitors
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
US11464774B2 (en) 2015-09-30 2022-10-11 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
CA3013514C (en) 2016-02-04 2021-11-23 Pharmaengine, Inc. 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (chk1) inhibitors, and their preparations and applications
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
KR20190130621A (ko) * 2017-03-31 2019-11-22 시애틀 지네틱스, 인크. Chk1 저해제와 wee1 저해제의 조합물
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
CN112457306A (zh) 2019-09-06 2021-03-09 上海瑛派药业有限公司 3,5-二取代吡唑化合物作为激酶抑制剂及其应用
US12404332B2 (en) * 2020-03-13 2025-09-02 Research Development Foundation Methods for diagnosing and treating cancers
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US20040014765A1 (en) * 2002-05-29 2004-01-22 Millennium Pharmaceuticals, Inc. Chk-1 inhibitors
US20040259885A1 (en) * 2002-08-13 2004-12-23 Gaoquan Li Urea kinase inhibitors

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Publication number Publication date
PT1869020E (pt) 2010-12-23
ES2356068T3 (es) 2011-04-04
ZA200707715B (en) 2009-09-30
JP2009227682A (ja) 2009-10-08
WO2006105262A1 (en) 2006-10-05
MX2007012116A (es) 2008-04-08
CY1111240T1 (el) 2015-06-11
TWI375559B (en) 2012-11-01
US8093244B2 (en) 2012-01-10
DK1869020T3 (da) 2011-01-24
UA92164C2 (ru) 2010-10-11
TW200722090A (en) 2007-06-16
CN101151259B (zh) 2011-06-15
NZ561458A (en) 2011-03-31
AU2006230337B2 (en) 2011-10-27
HK1119670A1 (en) 2009-03-13
JP2008535830A (ja) 2008-09-04
BRPI0609667A2 (pt) 2010-04-20
TNSN07369A1 (en) 2008-12-31
CR9395A (es) 2008-03-31
EA200702094A1 (ru) 2008-02-28
EA011287B1 (ru) 2009-02-27
KR20090031459A (ko) 2009-03-25
RS51616B (sr) 2011-08-31
CN102219784A (zh) 2011-10-19
KR20070107178A (ko) 2007-11-06
CA2602199A1 (en) 2006-10-05
US20090143357A1 (en) 2009-06-04
DE602006018590D1 (de) 2011-01-13
EP1869020B1 (en) 2010-12-01
CN101151259A (zh) 2008-03-26
EP1869020A1 (en) 2007-12-26
NO20074944L (no) 2007-10-24
HRP20100678T1 (hr) 2011-02-28
IL185481A0 (en) 2008-01-06
ATE490248T1 (de) 2010-12-15
JP5117374B2 (ja) 2013-01-16
AU2006230337A1 (en) 2006-10-05
AR056645A1 (es) 2007-10-17
PL1869020T3 (pl) 2011-05-31
MA29439B1 (fr) 2008-05-02
EP2330105A1 (en) 2011-06-08
CA2602199C (en) 2013-09-10
SI1869020T1 (sl) 2011-02-28

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