NZ553149A - Use of inositol hexaphosphate or inositol hexasulphate to complex biologically active compounds for the preparation of controlled release pharmaceutical compositions - Google Patents
Use of inositol hexaphosphate or inositol hexasulphate to complex biologically active compounds for the preparation of controlled release pharmaceutical compositionsInfo
- Publication number
- NZ553149A NZ553149A NZ553149A NZ55314905A NZ553149A NZ 553149 A NZ553149 A NZ 553149A NZ 553149 A NZ553149 A NZ 553149A NZ 55314905 A NZ55314905 A NZ 55314905A NZ 553149 A NZ553149 A NZ 553149A
- Authority
- NZ
- New Zealand
- Prior art keywords
- biologically active
- inositol
- active compound
- pharmaceutical composition
- complex
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 143
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 title claims abstract description 66
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 34
- 238000013270 controlled release Methods 0.000 title claims abstract description 29
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 229960000367 inositol Drugs 0.000 title claims abstract description 27
- 229940068041 phytic acid Drugs 0.000 title claims abstract description 27
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 title claims abstract description 26
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 85
- 229920000447 polyanionic polymer Polymers 0.000 claims abstract description 69
- 238000000034 method Methods 0.000 claims abstract description 33
- 239000003814 drug Substances 0.000 claims abstract description 30
- 125000000524 functional group Chemical group 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 17
- 229920003176 water-insoluble polymer Polymers 0.000 claims abstract description 17
- 239000003937 drug carrier Substances 0.000 claims abstract description 15
- 230000002459 sustained effect Effects 0.000 claims abstract description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 229920000642 polymer Polymers 0.000 claims description 102
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 84
- 239000000243 solution Substances 0.000 claims description 82
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 69
- 108010016076 Octreotide Proteins 0.000 claims description 69
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 239000007943 implant Substances 0.000 claims description 29
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- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 22
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- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 19
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 11
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- 108010088847 Peptide YY Proteins 0.000 claims description 11
- 102100029909 Peptide YY Human genes 0.000 claims description 11
- 229960004679 doxorubicin Drugs 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 10
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- 102000004169 proteins and genes Human genes 0.000 claims description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000010408 film Substances 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 8
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 8
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- 108090000790 Enzymes Proteins 0.000 claims description 6
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- 102000016943 Muramidase Human genes 0.000 claims description 6
- 108010014251 Muramidase Proteins 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 6
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 6
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- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 6
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- 150000001412 amines Chemical class 0.000 claims description 6
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- 239000004325 lysozyme Substances 0.000 claims description 6
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- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 6
- 229960003022 amoxicillin Drugs 0.000 claims description 5
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 5
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 5
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2005
- 2005-08-11 AU AU2005271242A patent/AU2005271242B9/en not_active Ceased
- 2005-08-11 PT PT05807464T patent/PT1786400E/pt unknown
- 2005-08-11 PL PL05807464T patent/PL1786400T3/pl unknown
- 2005-08-11 SI SI200530705T patent/SI1786400T1/sl unknown
- 2005-08-11 JP JP2007525814A patent/JP5053846B2/ja not_active Expired - Fee Related
- 2005-08-11 CA CA2576689A patent/CA2576689C/en not_active Expired - Fee Related
- 2005-08-11 NZ NZ553149A patent/NZ553149A/en not_active IP Right Cessation
- 2005-08-11 MX MX2007001760A patent/MX2007001760A/es active IP Right Grant
- 2005-08-11 RU RU2007105872/15A patent/RU2390355C2/ru not_active IP Right Cessation
- 2005-08-11 DK DK05807464T patent/DK1786400T3/da active
- 2005-08-11 WO PCT/US2005/028676 patent/WO2006017852A2/en not_active Ceased
- 2005-08-11 US US11/201,932 patent/US7964219B2/en not_active Expired - Fee Related
- 2005-08-11 KR KR1020077005752A patent/KR101231856B1/ko not_active Expired - Fee Related
- 2005-08-11 CN CN2005800337160A patent/CN101035512B/zh not_active Expired - Fee Related
- 2005-08-11 AT AT05807464T patent/ATE424848T1/de active
- 2005-08-11 BR BRPI0514297-0A patent/BRPI0514297A/pt not_active IP Right Cessation
- 2005-08-11 DE DE602005013244T patent/DE602005013244D1/de not_active Expired - Lifetime
- 2005-08-11 EP EP05807464A patent/EP1786400B1/en not_active Expired - Lifetime
- 2005-08-11 ES ES05807464T patent/ES2323141T3/es not_active Expired - Lifetime
-
2009
- 2009-06-11 CY CY20091100618T patent/CY1109425T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005013244D1 (de) | 2009-04-23 |
| JP5053846B2 (ja) | 2012-10-24 |
| CN101035512B (zh) | 2012-01-18 |
| ATE424848T1 (de) | 2009-03-15 |
| AU2005271242B2 (en) | 2011-09-15 |
| MX2007001760A (es) | 2007-07-24 |
| US20060034923A1 (en) | 2006-02-16 |
| ES2323141T3 (es) | 2009-07-07 |
| KR20070043881A (ko) | 2007-04-25 |
| DK1786400T3 (da) | 2009-06-29 |
| CA2576689C (en) | 2012-10-09 |
| EP1786400A2 (en) | 2007-05-23 |
| CN101035512A (zh) | 2007-09-12 |
| US7964219B2 (en) | 2011-06-21 |
| RU2007105872A (ru) | 2008-09-20 |
| EP1786400B1 (en) | 2009-03-11 |
| AU2005271242A2 (en) | 2006-02-16 |
| RU2390355C2 (ru) | 2010-05-27 |
| KR101231856B1 (ko) | 2013-02-08 |
| SI1786400T1 (sl) | 2009-08-31 |
| AU2005271242B9 (en) | 2012-04-12 |
| HK1108638A1 (en) | 2008-05-16 |
| CY1109425T1 (el) | 2014-08-13 |
| AU2005271242A1 (en) | 2006-02-16 |
| JP2008511544A (ja) | 2008-04-17 |
| CA2576689A1 (en) | 2006-02-16 |
| PT1786400E (pt) | 2009-06-19 |
| WO2006017852A3 (en) | 2006-08-31 |
| BRPI0514297A (pt) | 2008-06-10 |
| PL1786400T3 (pl) | 2009-08-31 |
| WO2006017852A2 (en) | 2006-02-16 |
| EP1786400A4 (en) | 2008-07-09 |
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