NZ539582A - Prostaglandin compounds for the treatment of obesity - Google Patents
Prostaglandin compounds for the treatment of obesityInfo
- Publication number
- NZ539582A NZ539582A NZ539582A NZ53958203A NZ539582A NZ 539582 A NZ539582 A NZ 539582A NZ 539582 A NZ539582 A NZ 539582A NZ 53958203 A NZ53958203 A NZ 53958203A NZ 539582 A NZ539582 A NZ 539582A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkyl
- hydroxy
- prostaglandin
- compound
- halogen
- Prior art date
Links
- -1 Prostaglandin compounds Chemical class 0.000 title claims abstract description 70
- 208000008589 Obesity Diseases 0.000 title claims abstract description 32
- 235000020824 obesity Nutrition 0.000 title claims abstract description 32
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 73
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 58
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 47
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 31
- 125000003118 aryl group Chemical group 0.000 claims abstract description 26
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract description 26
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 24
- 150000002367 halogens Chemical class 0.000 claims abstract description 22
- 125000005843 halogen group Chemical group 0.000 claims abstract description 21
- 125000004423 acyloxy group Chemical group 0.000 claims abstract description 20
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims abstract description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 125000004104 aryloxy group Chemical group 0.000 claims abstract description 16
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 9
- 229910052717 sulfur Chemical group 0.000 claims abstract description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 8
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- 125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract description 7
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- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 44
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- 238000007910 systemic administration Methods 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US42033602P | 2002-10-23 | 2002-10-23 | |
| PCT/JP2003/013453 WO2004037268A1 (en) | 2002-10-23 | 2003-10-22 | Prostaglandin compounds for the treatment of obesity |
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| NZ539582A true NZ539582A (en) | 2007-07-27 |
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| EP (1) | EP1562604B1 (enExample) |
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| DK (1) | DK1562604T3 (enExample) |
| ES (1) | ES2379652T3 (enExample) |
| NZ (1) | NZ539582A (enExample) |
| PT (1) | PT1562604E (enExample) |
| WO (1) | WO2004037268A1 (enExample) |
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| DE602004030245D1 (de) * | 2003-07-03 | 2011-01-05 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
| WO2007111806A2 (en) | 2006-03-23 | 2007-10-04 | Massachusetts Eye And Ear Infirmary | Cyclopentane heptanoic acid compounds for reducing body fat |
| ES2687494T3 (es) * | 2011-01-19 | 2018-10-25 | Topokine Therapeutics, Inc. | Métodos y composiciones para reducir la grasa corporal |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| CA2869676C (en) | 2012-11-21 | 2015-06-23 | Topokine Therapeutics, Inc. | Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| CN110840899A (zh) | 2013-04-12 | 2020-02-28 | 阿勒根公司 | 用于减脂的比马前列素、比马前列素类似物、前列腺酰胺和前列腺素的持续释放 |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| US11452703B2 (en) | 2020-05-21 | 2022-09-27 | Peregrine Ophthalmic PTE LTD. | Methods and compositions for reducing adipocyte numbers |
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| US388919A (en) * | 1888-09-04 | Benjamin scables | ||
| US3888919A (en) * | 1971-03-11 | 1975-06-10 | Upjohn Co | 11,15 dimethyl pge' 1 'and pgf' 1' |
| CA1322749C (en) * | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5166174A (en) * | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5221763A (en) * | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| US5317032A (en) * | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| JP2597629B2 (ja) | 1988-02-26 | 1997-04-09 | 株式会社 上野製薬応用研究所 | １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化 |
| NZ226199A (en) | 1988-09-15 | 1991-05-28 | Ueno Seiyaku Oyo Kenkyujo Kk | 13,14-dihydro-15-keto-pgf derivatives and pharmaceutical compositions |
| NZ226198A (en) | 1988-09-15 | 1991-05-28 | Ueno Seiyaku Oyo Kenkyujo Kk | Fervescence (temperature raising) composition comprising 15-keto-pge |
| JPH085794B2 (ja) * | 1989-07-27 | 1996-01-24 | 株式会社上野製薬応用研究所 | 高脂質血症処置・血中脂質成分低下剤 |
| DE69006964T2 (de) * | 1989-07-27 | 1994-06-09 | Ueno Seiyaku Oyo Kenkyujo Kk | Behandlung von Hyperlipidemia mit 15-keto-Prostaglandin-Verbindungen. |
| US5234954A (en) * | 1989-07-27 | 1993-08-10 | K.K. Ueno Seiyaku Oyo Kenkyujo | Treatment of hyperlipidemia with 15-keto-prostaglandin compounds |
| CA2039420C (en) * | 1990-04-04 | 1996-12-10 | Ryuji Ueno | Treatment of cataract with 15-keto-prostaglandin compounds |
| CA2150287C (en) * | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| US6022897A (en) * | 1995-04-25 | 2000-02-08 | The Salk Institute For Biological Studies | Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof |
| EP0857718B1 (en) * | 1996-06-10 | 2002-08-14 | Sucampo AG | Endothelin antagonist |
| EP1071429B1 (en) * | 1998-04-17 | 2002-01-30 | Trustees Of Tufts College | Map kinase inhibitors in the treatment of disorders caused by tnf-alpha induced lipolysis |
| JP2000157260A (ja) | 1998-11-26 | 2000-06-13 | Toyobo Co Ltd | 初代前駆脂肪細胞の分化誘導方法及びその分化用培地 |
| KR100830061B1 (ko) * | 1999-10-15 | 2008-05-16 | 수캄포 아게 | 이환식 화합물 조성물 및 이의 안정화 방법 |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| TWI302100B (en) * | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| MXPA03010510A (es) * | 2001-05-18 | 2004-03-02 | Sucampo Ag | Composicion catartica. |
| MXPA04002006A (es) * | 2001-08-31 | 2004-06-07 | Sucampo Ag | Analogos de prostagladina como abridor del canal de cloruro. |
| AR037524A1 (es) * | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| MXPA05006981A (es) * | 2002-12-27 | 2005-12-14 | Sucampo Ag | Derivados de prostaglandinas para el tratamiento de la molestia abdominal. |
| DE602004030245D1 (de) * | 2003-07-03 | 2011-01-05 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| JP5711442B2 (ja) * | 2005-04-12 | 2015-04-30 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 胃腸障害の処置のためのプロスタグランジン化合物およびプロトンポンプ阻害剤の併用 |
-
2003
- 2003-10-22 WO PCT/JP2003/013453 patent/WO2004037268A1/en not_active Ceased
- 2003-10-22 NZ NZ539582A patent/NZ539582A/en not_active IP Right Cessation
- 2003-10-22 US US10/531,874 patent/US8114911B2/en not_active Expired - Fee Related
- 2003-10-22 EP EP03758747A patent/EP1562604B1/en not_active Expired - Lifetime
- 2003-10-22 DK DK03758747.4T patent/DK1562604T3/da active
- 2003-10-22 AT AT03758747T patent/ATE539756T1/de active
- 2003-10-22 JP JP2004546433A patent/JP4705782B2/ja not_active Expired - Fee Related
- 2003-10-22 CA CA2502439A patent/CA2502439C/en not_active Expired - Fee Related
- 2003-10-22 AU AU2003274735A patent/AU2003274735B2/en not_active Ceased
- 2003-10-22 PT PT03758747T patent/PT1562604E/pt unknown
- 2003-10-22 ES ES03758747T patent/ES2379652T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004037268A1 (en) | 2004-05-06 |
| EP1562604A1 (en) | 2005-08-17 |
| JP4705782B2 (ja) | 2011-06-22 |
| AU2003274735A1 (en) | 2004-05-13 |
| DK1562604T3 (da) | 2012-04-02 |
| US20050261373A1 (en) | 2005-11-24 |
| CA2502439A1 (en) | 2004-05-06 |
| AU2003274735B2 (en) | 2008-12-04 |
| CA2502439C (en) | 2011-11-22 |
| PT1562604E (pt) | 2012-04-09 |
| US8114911B2 (en) | 2012-02-14 |
| ATE539756T1 (de) | 2012-01-15 |
| JP2006506381A (ja) | 2006-02-23 |
| EP1562604B1 (en) | 2012-01-04 |
| ES2379652T3 (es) | 2012-04-30 |
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