AU2003274735B2 - Prostaglandin compounds for the treatment of obesity - Google Patents

Prostaglandin compounds for the treatment of obesity Download PDF

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Publication number
AU2003274735B2
AU2003274735B2 AU2003274735A AU2003274735A AU2003274735B2 AU 2003274735 B2 AU2003274735 B2 AU 2003274735B2 AU 2003274735 A AU2003274735 A AU 2003274735A AU 2003274735 A AU2003274735 A AU 2003274735A AU 2003274735 B2 AU2003274735 B2 AU 2003274735B2
Authority
AU
Australia
Prior art keywords
alkyl
hydroxy
compound
prostaglandin
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003274735A
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English (en)
Other versions
AU2003274735A1 (en
Inventor
Ryuji Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Sucampo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo GmbH filed Critical Sucampo GmbH
Publication of AU2003274735A1 publication Critical patent/AU2003274735A1/en
Application granted granted Critical
Publication of AU2003274735B2 publication Critical patent/AU2003274735B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Child & Adolescent Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003274735A 2002-10-23 2003-10-22 Prostaglandin compounds for the treatment of obesity Ceased AU2003274735B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42033602P 2002-10-23 2002-10-23
US60/420,336 2002-10-23
PCT/JP2003/013453 WO2004037268A1 (en) 2002-10-23 2003-10-22 Prostaglandin compounds for the treatment of obesity

Publications (2)

Publication Number Publication Date
AU2003274735A1 AU2003274735A1 (en) 2004-05-13
AU2003274735B2 true AU2003274735B2 (en) 2008-12-04

Family

ID=32176556

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003274735A Ceased AU2003274735B2 (en) 2002-10-23 2003-10-22 Prostaglandin compounds for the treatment of obesity

Country Status (11)

Country Link
US (1) US8114911B2 (enExample)
EP (1) EP1562604B1 (enExample)
JP (1) JP4705782B2 (enExample)
AT (1) ATE539756T1 (enExample)
AU (1) AU2003274735B2 (enExample)
CA (1) CA2502439C (enExample)
DK (1) DK1562604T3 (enExample)
ES (1) ES2379652T3 (enExample)
NZ (1) NZ539582A (enExample)
PT (1) PT1562604E (enExample)
WO (1) WO2004037268A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
WO2007111806A2 (en) * 2006-03-23 2007-10-04 Massachusetts Eye And Ear Infirmary Cyclopentane heptanoic acid compounds for reducing body fat
CA2824317C (en) * 2011-01-19 2014-12-16 Terakine Therapeutics, Inc. Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
SG11201600237YA (en) 2012-11-21 2016-02-26 Topokine Therapeutics Inc Methods and compositions for locally increasing body fat
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
AU2014250937A1 (en) 2013-04-12 2015-10-22 Allergan, Inc. Sustained release of bimatoprost, bimatoprost analogs, prostamides and prostaglandins for fat reduction
NO2753788T3 (enExample) 2013-05-10 2018-06-16
US9820993B2 (en) 2013-05-15 2017-11-21 Topokine Therapeutics, Inc. Methods and compositions for topical delivery of prostaglandins to subcutaneous fat
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
US11452703B2 (en) 2020-05-21 2022-09-27 Peregrine Ophthalmic PTE LTD. Methods and compositions for reducing adipocyte numbers

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US388919A (en) * 1888-09-04 Benjamin scables
EP0410646A2 (en) * 1989-07-27 1991-01-30 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Treatment of hyperlipidemia with 15-keto-prostaglandin compounds
NZ228111A (en) * 1988-02-26 1991-02-26 Ueno Seiyaku Oyo Kenkyujo Kk Stabilisation of 13,14-dihydro-15-keto prostaglandin compositions using etherised cyclodextrins
NZ226198A (en) * 1988-09-15 1991-05-28 Ueno Seiyaku Oyo Kenkyujo Kk Fervescence (temperature raising) composition comprising 15-keto-pge
NZ226199A (en) * 1988-09-15 1991-05-28 Ueno Seiyaku Oyo Kenkyujo Kk 13,14-dihydro-15-keto-pgf derivatives and pharmaceutical compositions
WO1996033724A2 (en) * 1995-04-25 1996-10-31 The Salk Institute For Biological Studies Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
WO1999053927A1 (en) * 1998-04-17 1999-10-28 Trustees Of Tufts College Methods for treating and preventing insulin resistance and related disorders
JP2000157260A (ja) * 1998-11-26 2000-06-13 Toyobo Co Ltd 初代前駆脂肪細胞の分化誘導方法及びその分化用培地

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888919A (en) * 1971-03-11 1975-06-10 Upjohn Co 11,15 dimethyl pge' 1 'and pgf' 1'
US5166174A (en) 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
CA1322749C (en) 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5221763A (en) 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5317032A (en) 1987-10-02 1994-05-31 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Prostaglandin cathartic
JPH085794B2 (ja) * 1989-07-27 1996-01-24 株式会社上野製薬応用研究所 高脂質血症処置・血中脂質成分低下剤
US5234954A (en) * 1989-07-27 1993-08-10 K.K. Ueno Seiyaku Oyo Kenkyujo Treatment of hyperlipidemia with 15-keto-prostaglandin compounds
TW249226B (enExample) 1990-04-04 1995-06-11 Aderk Ueno Kk
CA2150287C (en) 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
KR19990036322A (ko) 1996-06-10 1999-05-25 류지 우에노 엔도텔린길항제
ATE402925T2 (de) 1999-10-15 2008-08-15 Sucampo Ag Neue zusammensetzung enthaltend eine bicyclische verbindung und ein glycerid
US6414016B1 (en) 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
BR0209863A (pt) 2001-05-18 2004-06-08 Sucampo Ag Composição catártica
JP4786866B2 (ja) 2001-08-31 2011-10-05 スキャンポ・アーゲー クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
AR037524A1 (es) 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
US7732487B2 (en) 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
JP4889219B2 (ja) 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
DE602004030245D1 (de) 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI387454B (zh) 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
KR101466980B1 (ko) 2005-04-12 2014-12-01 수캄포 아게 위장 장애 치료를 위한 프로스타글란딘 화합물과 양성자펌프 억제제의 병용

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US388919A (en) * 1888-09-04 Benjamin scables
NZ228111A (en) * 1988-02-26 1991-02-26 Ueno Seiyaku Oyo Kenkyujo Kk Stabilisation of 13,14-dihydro-15-keto prostaglandin compositions using etherised cyclodextrins
NZ226198A (en) * 1988-09-15 1991-05-28 Ueno Seiyaku Oyo Kenkyujo Kk Fervescence (temperature raising) composition comprising 15-keto-pge
NZ226199A (en) * 1988-09-15 1991-05-28 Ueno Seiyaku Oyo Kenkyujo Kk 13,14-dihydro-15-keto-pgf derivatives and pharmaceutical compositions
EP0410646A2 (en) * 1989-07-27 1991-01-30 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Treatment of hyperlipidemia with 15-keto-prostaglandin compounds
WO1996033724A2 (en) * 1995-04-25 1996-10-31 The Salk Institute For Biological Studies Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
WO1999053927A1 (en) * 1998-04-17 1999-10-28 Trustees Of Tufts College Methods for treating and preventing insulin resistance and related disorders
JP2000157260A (ja) * 1998-11-26 2000-06-13 Toyobo Co Ltd 初代前駆脂肪細胞の分化誘導方法及びその分化用培地

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Physiol Chem & Phys, 1980, 12(6): 564-8 *

Also Published As

Publication number Publication date
EP1562604B1 (en) 2012-01-04
ES2379652T3 (es) 2012-04-30
DK1562604T3 (da) 2012-04-02
CA2502439A1 (en) 2004-05-06
CA2502439C (en) 2011-11-22
JP2006506381A (ja) 2006-02-23
US8114911B2 (en) 2012-02-14
US20050261373A1 (en) 2005-11-24
WO2004037268A1 (en) 2004-05-06
NZ539582A (en) 2007-07-27
EP1562604A1 (en) 2005-08-17
JP4705782B2 (ja) 2011-06-22
PT1562604E (pt) 2012-04-09
ATE539756T1 (de) 2012-01-15
AU2003274735A1 (en) 2004-05-13

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired