NZ533568A - Condensed hexacyclic camptothecin compounds as antitumor agents - Google Patents

Condensed hexacyclic camptothecin compounds as antitumor agents

Info

Publication number
NZ533568A
NZ533568A NZ533568A NZ53356802A NZ533568A NZ 533568 A NZ533568 A NZ 533568A NZ 533568 A NZ533568 A NZ 533568A NZ 53356802 A NZ53356802 A NZ 53356802A NZ 533568 A NZ533568 A NZ 533568A
Authority
NZ
New Zealand
Prior art keywords
ethyl
pyrano
pyrido
hydroxy
quinazoline
Prior art date
Application number
NZ533568A
Other languages
English (en)
Inventor
Takeshi Murata
Satoshi Niizuma
Nobuo Shimma
Hitomi Suda
Masao Tsukazaki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of NZ533568A publication Critical patent/NZ533568A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ533568A 2001-11-30 2002-11-25 Condensed hexacyclic camptothecin compounds as antitumor agents NZ533568A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01128361 2001-11-30
PCT/EP2002/013216 WO2003045952A2 (en) 2001-11-30 2002-11-25 Condensed camptothecins as antitumor agents

Publications (1)

Publication Number Publication Date
NZ533568A true NZ533568A (en) 2006-01-27

Family

ID=8179394

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ533568A NZ533568A (en) 2001-11-30 2002-11-25 Condensed hexacyclic camptothecin compounds as antitumor agents

Country Status (28)

Country Link
US (2) US6825194B2 (enExample)
EP (1) EP1480984B9 (enExample)
JP (1) JP4305909B2 (enExample)
KR (1) KR100895746B1 (enExample)
CN (1) CN100338066C (enExample)
AT (1) ATE398131T1 (enExample)
AU (1) AU2002356720B2 (enExample)
BR (1) BR0214615A (enExample)
CA (1) CA2468824C (enExample)
DE (1) DE60227113D1 (enExample)
ES (1) ES2307830T3 (enExample)
GT (1) GT200200250A (enExample)
HU (1) HUP0500062A3 (enExample)
IL (1) IL162058A0 (enExample)
MX (1) MXPA04005185A (enExample)
MY (1) MY136138A (enExample)
NO (1) NO329005B1 (enExample)
NZ (1) NZ533568A (enExample)
PA (1) PA8558901A1 (enExample)
PE (1) PE20030725A1 (enExample)
PL (1) PL207510B1 (enExample)
RS (1) RS51051B (enExample)
RU (1) RU2299212C2 (enExample)
TW (1) TWI258481B (enExample)
UA (1) UA80409C2 (enExample)
UY (1) UY27560A1 (enExample)
WO (1) WO2003045952A2 (enExample)
ZA (1) ZA200404522B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004073601A2 (en) * 2003-02-21 2004-09-02 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
US7910593B2 (en) 2004-04-09 2011-03-22 Chugai Seiyaku Kabushiki Kaisha Water-soluble prodrugs
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
US20090118271A1 (en) * 2005-10-19 2009-05-07 Chugai Seiyaku Kabushiki Kaisha Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug
RU2439073C1 (ru) * 2010-07-13 2012-01-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ИНДОЛИЗИНО[7,6-b]ИНДОЛА
KR20240104214A (ko) 2019-03-29 2024-07-04 메디뮨 리미티드 화합물 및 이의 접합체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
DE69834923T2 (de) 1997-02-14 2006-10-19 Bionumerik Pharmaceuticals, Inc., San Antonio Hochgradig lipophile camptothecin-derivate
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives

Also Published As

Publication number Publication date
KR100895746B1 (ko) 2009-04-30
MXPA04005185A (es) 2004-08-11
PL370479A1 (en) 2005-05-30
AU2002356720A1 (en) 2003-06-10
RU2004119841A (ru) 2005-03-27
ATE398131T1 (de) 2008-07-15
HUP0500062A3 (en) 2012-12-28
IL162058A0 (en) 2005-11-20
PA8558901A1 (es) 2003-06-30
NO20042729L (no) 2004-08-27
US6825194B2 (en) 2004-11-30
EP1480984B9 (en) 2009-03-11
RU2299212C2 (ru) 2007-05-20
JP2005511643A (ja) 2005-04-28
HK1077303A1 (en) 2006-02-10
TWI258481B (en) 2006-07-21
UY27560A1 (es) 2003-05-30
US20030144304A1 (en) 2003-07-31
ZA200404522B (en) 2005-01-04
MY136138A (en) 2008-08-29
CN100338066C (zh) 2007-09-19
PE20030725A1 (es) 2003-08-28
NO329005B1 (no) 2010-07-19
UA80409C2 (en) 2007-09-25
WO2003045952A3 (en) 2003-10-16
GT200200250A (es) 2004-01-15
PL207510B1 (pl) 2010-12-31
AU2002356720B2 (en) 2009-01-29
US20050059679A1 (en) 2005-03-17
ES2307830T3 (es) 2008-12-01
RS47004A (sr) 2007-02-05
TW200408642A (en) 2004-06-01
DE60227113D1 (de) 2008-07-24
CA2468824C (en) 2011-01-11
JP4305909B2 (ja) 2009-07-29
WO2003045952A2 (en) 2003-06-05
RS51051B (sr) 2010-10-31
KR20040062976A (ko) 2004-07-09
US7109195B2 (en) 2006-09-19
HUP0500062A2 (hu) 2005-04-28
EP1480984B1 (en) 2008-06-11
BR0214615A (pt) 2004-09-14
CN1617874A (zh) 2005-05-18
CA2468824A1 (en) 2003-06-05
HK1072935A1 (en) 2005-09-16
EP1480984A2 (en) 2004-12-01

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
S38A Application for proceedings under section 38 (amendment of specification with leave of commissioner)

Free format text: BY WAY OF CORRECTION

S38C Proceedings under section 38 (amendment of specification with leave of commissioner): specification amended
RENW Renewal (renewal fees accepted)
LAPS Patent lapsed