NZ533430A - Tetrahydrocarbozole derivatives as ligands for G-protein coupled receptors (GPCR) - Google Patents
Tetrahydrocarbozole derivatives as ligands for G-protein coupled receptors (GPCR)Info
- Publication number
- NZ533430A NZ533430A NZ533430A NZ53343002A NZ533430A NZ 533430 A NZ533430 A NZ 533430A NZ 533430 A NZ533430 A NZ 533430A NZ 53343002 A NZ53343002 A NZ 53343002A NZ 533430 A NZ533430 A NZ 533430A
- Authority
- NZ
- New Zealand
- Prior art keywords
- amino
- carbonyl
- radical
- tetrahydro
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10164564A DE10164564B4 (de) | 2001-12-14 | 2001-12-14 | Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR) |
US34187801P | 2001-12-21 | 2001-12-21 | |
PCT/EP2002/014344 WO2003051837A2 (de) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbazolderivate als liganden für g-protein gekoppelte rezeptoren (gpcr) |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ533430A true NZ533430A (en) | 2005-12-23 |
Family
ID=26010882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ533430A NZ533430A (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for G-protein coupled receptors (GPCR) |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1453803A2 (es) |
JP (1) | JP2005518375A (es) |
CN (1) | CN100500654C (es) |
AR (1) | AR037863A1 (es) |
AU (1) | AU2002361430B2 (es) |
BR (1) | BR0214958A (es) |
CA (1) | CA2468880A1 (es) |
HR (1) | HRP20040609A2 (es) |
HU (1) | HUP0500014A3 (es) |
IL (2) | IL161626A0 (es) |
MX (1) | MXPA04005768A (es) |
NO (1) | NO326692B1 (es) |
NZ (1) | NZ533430A (es) |
PL (1) | PL373400A1 (es) |
RU (1) | RU2319692C2 (es) |
TW (1) | TWI246423B (es) |
WO (1) | WO2003051837A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1638551T1 (sl) * | 2003-05-19 | 2012-04-30 | Irm Llc | Imunosupresivne spojine in sestavki |
ES2314446T3 (es) * | 2003-06-10 | 2009-03-16 | Smithkline Beecham Corporation | Derivados de tetrahidrocarbazol y su uso farmaceutico. |
US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
US20050209300A1 (en) * | 2003-09-12 | 2005-09-22 | Andrew Napper | Methods of treating a disorder |
DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
PT1833791E (pt) * | 2004-12-27 | 2011-10-19 | Actelion Pharmaceuticals Ltd | Derivados de 2,3,4,9-tetra-hidro-1h-carbazol como antgonistas do receptor crth2 |
BRPI0611705A2 (pt) * | 2005-06-24 | 2016-11-16 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto |
KR101411820B1 (ko) * | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-아미노-1,2,3,4-테트라하이드로-9h-카르바졸-9-일)-아세트산 유도체 |
EP1967202A1 (en) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
EP1988098A1 (en) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
EP2095818A1 (en) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
BR112012024114B1 (pt) | 2010-03-22 | 2021-02-09 | Idorsia Pharmaceuticals Ltd | Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica |
CN103459389B (zh) | 2011-04-14 | 2016-03-30 | 埃科特莱茵药品有限公司 | 7-(杂芳基-氨基)-6,7,8,9-四氢吡啶并[1,2-a]吲哚乙酸衍生物和其作为前列腺素D2受体调节剂的用途 |
PE20161177A1 (es) | 2014-03-17 | 2016-11-18 | Actelion Pharmaceuticals Ltd | Derivados del acido acetico azaindol y su uso como moduladores del receptor de prostaglandina d2 |
US9850241B2 (en) | 2014-03-18 | 2017-12-26 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
TWI711616B (zh) | 2015-09-15 | 2020-12-01 | 瑞士商愛杜西亞製藥有限公司 | 結晶型式 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1418703A (en) * | 1973-06-02 | 1975-12-24 | Pfizer Ltd | 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles |
EP0239306B1 (en) * | 1986-03-27 | 1993-06-02 | Merck Frosst Canada Inc. | Tetrahydrocarbazole esters |
US5607939A (en) * | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
EP0986385A4 (en) * | 1997-06-05 | 2001-05-16 | Merck & Co Inc | GONADOLIBERINE ANTAGONISTS |
-
2002
- 2002-12-16 CN CNB028241487A patent/CN100500654C/zh not_active Expired - Fee Related
- 2002-12-16 HU HU0500014A patent/HUP0500014A3/hu unknown
- 2002-12-16 NZ NZ533430A patent/NZ533430A/en unknown
- 2002-12-16 RU RU2004121776/04A patent/RU2319692C2/ru not_active IP Right Cessation
- 2002-12-16 AU AU2002361430A patent/AU2002361430B2/en not_active Ceased
- 2002-12-16 TW TW091136440A patent/TWI246423B/zh not_active IP Right Cessation
- 2002-12-16 MX MXPA04005768A patent/MXPA04005768A/es active IP Right Grant
- 2002-12-16 EP EP02796648A patent/EP1453803A2/de not_active Withdrawn
- 2002-12-16 CA CA002468880A patent/CA2468880A1/en not_active Abandoned
- 2002-12-16 WO PCT/EP2002/014344 patent/WO2003051837A2/de active Application Filing
- 2002-12-16 JP JP2003552724A patent/JP2005518375A/ja active Pending
- 2002-12-16 IL IL16162602A patent/IL161626A0/xx unknown
- 2002-12-16 BR BR0214958-3A patent/BR0214958A/pt not_active IP Right Cessation
- 2002-12-16 PL PL02373400A patent/PL373400A1/xx not_active Application Discontinuation
- 2002-12-17 AR ARP020104893A patent/AR037863A1/es unknown
-
2004
- 2004-05-26 NO NO20042198A patent/NO326692B1/no not_active IP Right Cessation
- 2004-07-05 HR HR20040609A patent/HRP20040609A2/hr not_active Application Discontinuation
-
2008
- 2008-07-23 IL IL192991A patent/IL192991A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005518375A (ja) | 2005-06-23 |
CA2468880A1 (en) | 2003-06-26 |
RU2004121776A (ru) | 2005-05-10 |
WO2003051837A2 (de) | 2003-06-26 |
AU2002361430B2 (en) | 2007-09-13 |
IL161626A0 (en) | 2004-09-27 |
CN1599720A (zh) | 2005-03-23 |
MXPA04005768A (es) | 2004-09-10 |
HUP0500014A2 (hu) | 2005-04-28 |
RU2319692C2 (ru) | 2008-03-20 |
AR037863A1 (es) | 2004-12-09 |
TW200305405A (en) | 2003-11-01 |
WO2003051837A8 (de) | 2004-05-06 |
NO20042198L (no) | 2004-07-09 |
WO2003051837A3 (de) | 2004-02-26 |
AU2002361430A1 (en) | 2003-06-30 |
BR0214958A (pt) | 2004-12-28 |
HRP20040609A2 (en) | 2005-06-30 |
CN100500654C (zh) | 2009-06-17 |
EP1453803A2 (de) | 2004-09-08 |
NO326692B1 (no) | 2009-02-02 |
TWI246423B (en) | 2006-01-01 |
PL373400A1 (en) | 2005-08-22 |
HUP0500014A3 (en) | 2010-06-28 |
IL192991A0 (en) | 2011-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |