NZ531639A - Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection - Google Patents
Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infectionInfo
- Publication number
- NZ531639A NZ531639A NZ531639A NZ53163902A NZ531639A NZ 531639 A NZ531639 A NZ 531639A NZ 531639 A NZ531639 A NZ 531639A NZ 53163902 A NZ53163902 A NZ 53163902A NZ 531639 A NZ531639 A NZ 531639A
- Authority
- NZ
- New Zealand
- Prior art keywords
- delivery system
- milk
- mixture
- apoprotein
- medicament
- Prior art date
Links
- 235000013336 milk Nutrition 0.000 title claims abstract description 105
- 239000008267 milk Substances 0.000 title claims abstract description 105
- 210000004080 milk Anatomy 0.000 title claims abstract description 105
- 102000006410 Apoproteins Human genes 0.000 title claims abstract description 70
- 108010083590 Apoproteins Proteins 0.000 title claims abstract description 70
- 210000002966 serum Anatomy 0.000 title claims description 48
- 238000011282 treatment Methods 0.000 title claims description 15
- 230000000813 microbial effect Effects 0.000 title description 12
- 208000036142 Viral infection Diseases 0.000 title description 11
- 230000009385 viral infection Effects 0.000 title description 10
- 238000011321 prophylaxis Methods 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 100
- 235000021588 free fatty acids Nutrition 0.000 claims abstract description 43
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 29
- 244000052769 pathogen Species 0.000 claims abstract description 19
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 238000009472 formulation Methods 0.000 claims description 54
- 102000007544 Whey Proteins Human genes 0.000 claims description 24
- 108010046377 Whey Proteins Proteins 0.000 claims description 24
- 239000005862 Whey Substances 0.000 claims description 23
- 150000007524 organic acids Chemical class 0.000 claims description 22
- 208000015181 infectious disease Diseases 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 18
- 150000002148 esters Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- 150000002430 hydrocarbons Chemical group 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 11
- 102000004190 Enzymes Human genes 0.000 claims description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 11
- 150000004665 fatty acids Chemical class 0.000 claims description 11
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 9
- 230000003115 biocidal effect Effects 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 102000008192 Lactoglobulins Human genes 0.000 claims description 8
- 108010060630 Lactoglobulins Proteins 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 8
- 102000004895 Lipoproteins Human genes 0.000 claims description 7
- 108090001030 Lipoproteins Proteins 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 7
- 230000001419 dependent effect Effects 0.000 claims description 7
- 108090001060 Lipase Proteins 0.000 claims description 5
- 239000004367 Lipase Substances 0.000 claims description 5
- 102000004882 Lipase Human genes 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 235000015165 citric acid Nutrition 0.000 claims description 5
- 235000019421 lipase Nutrition 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 230000009885 systemic effect Effects 0.000 claims description 5
- 230000000699 topical effect Effects 0.000 claims description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 5
- 206010007134 Candida infections Diseases 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229940087168 alpha tocopherol Drugs 0.000 claims description 4
- 230000003301 hydrolyzing effect Effects 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 210000000214 mouth Anatomy 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 230000000069 prophylactic effect Effects 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 229960000984 tocofersolan Drugs 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- 239000002076 α-tocopherol Substances 0.000 claims description 4
- 235000004835 α-tocopherol Nutrition 0.000 claims description 4
- 102000004407 Lactalbumin Human genes 0.000 claims description 3
- 108090000942 Lactalbumin Proteins 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 235000006708 antioxidants Nutrition 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 3
- 235000021241 α-lactalbumin Nutrition 0.000 claims description 3
- 206010022678 Intestinal infections Diseases 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 235000020247 cow milk Nutrition 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 239000003889 eye drop Substances 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 claims description 2
- 239000002324 mouth wash Substances 0.000 claims description 2
- 229940051866 mouthwash Drugs 0.000 claims description 2
- 239000007922 nasal spray Substances 0.000 claims description 2
- 229940097496 nasal spray Drugs 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000000606 toothpaste Substances 0.000 claims description 2
- 229940034610 toothpaste Drugs 0.000 claims description 2
- 102000007592 Apolipoproteins Human genes 0.000 claims 2
- 108010071619 Apolipoproteins Proteins 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- 208000025157 Oral disease Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 229940112822 chewing gum Drugs 0.000 claims 1
- 239000000551 dentifrice Substances 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 235000020251 goat milk Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000030194 mouth disease Diseases 0.000 claims 1
- 210000001331 nose Anatomy 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 description 42
- 238000010586 diagram Methods 0.000 description 37
- 108090000623 proteins and genes Proteins 0.000 description 35
- 235000018102 proteins Nutrition 0.000 description 34
- 102000004169 proteins and genes Human genes 0.000 description 34
- 238000012360 testing method Methods 0.000 description 32
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 30
- 150000002632 lipids Chemical class 0.000 description 27
- 241000894006 Bacteria Species 0.000 description 24
- 238000000034 method Methods 0.000 description 24
- 241000222122 Candida albicans Species 0.000 description 21
- 229940095731 candida albicans Drugs 0.000 description 21
- 239000001509 sodium citrate Substances 0.000 description 20
- 239000000463 material Substances 0.000 description 17
- 239000000126 substance Substances 0.000 description 17
- 238000003556 assay Methods 0.000 description 15
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 210000002919 epithelial cell Anatomy 0.000 description 14
- 230000007062 hydrolysis Effects 0.000 description 14
- 238000006460 hydrolysis reaction Methods 0.000 description 14
- 239000002953 phosphate buffered saline Substances 0.000 description 14
- 241000194019 Streptococcus mutans Species 0.000 description 13
- 230000017066 negative regulation of growth Effects 0.000 description 13
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 12
- 230000000840 anti-viral effect Effects 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 9
- 208000002925 dental caries Diseases 0.000 description 9
- 241000894007 species Species 0.000 description 9
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 8
- 241000191967 Staphylococcus aureus Species 0.000 description 8
- 150000001720 carbohydrates Chemical class 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 239000003925 fat Substances 0.000 description 8
- 239000008101 lactose Substances 0.000 description 8
- 235000005985 organic acids Nutrition 0.000 description 8
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 8
- 229940038773 trisodium citrate Drugs 0.000 description 8
- 230000003612 virological effect Effects 0.000 description 8
- 241000700605 Viruses Species 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- 239000011550 stock solution Substances 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 6
- 229960003085 meticillin Drugs 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 241000233866 Fungi Species 0.000 description 5
- 208000007514 Herpes zoster Diseases 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 210000003298 dental enamel Anatomy 0.000 description 5
- 108010074605 gamma-Globulins Proteins 0.000 description 5
- 210000003097 mucus Anatomy 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- 102000004506 Blood Proteins Human genes 0.000 description 4
- 108010017384 Blood Proteins Proteins 0.000 description 4
- 206010011409 Cross infection Diseases 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 4
- 108010000912 Egg Proteins Proteins 0.000 description 4
- 241000282849 Ruminantia Species 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 201000005884 exanthem Diseases 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- -1 monoglyceride esters Chemical class 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 206010037844 rash Diseases 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 102000011632 Caseins Human genes 0.000 description 3
- 108010076119 Caseins Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000010201 Exanthema Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 208000007027 Oral Candidiasis Diseases 0.000 description 3
- 108010071390 Serum Albumin Proteins 0.000 description 3
- 102000007562 Serum Albumin Human genes 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241000295644 Staphylococcaceae Species 0.000 description 3
- 241000287411 Turdidae Species 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 201000003984 candidiasis Diseases 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
- 235000021240 caseins Nutrition 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 235000013365 dairy product Nutrition 0.000 description 3
- 230000007071 enzymatic hydrolysis Effects 0.000 description 3
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000012678 infectious agent Substances 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 238000002203 pretreatment Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000003248 secreting effect Effects 0.000 description 3
- 231100000046 skin rash Toxicity 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- 210000005253 yeast cell Anatomy 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 2
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 208000009889 Herpes Simplex Diseases 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102000010445 Lactoferrin Human genes 0.000 description 2
- 108010063045 Lactoferrin Proteins 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 description 2
- 206010037128 Pseudomembranous colitis Diseases 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 108010059993 Vancomycin Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 229960004150 aciclovir Drugs 0.000 description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000014103 egg white Nutrition 0.000 description 2
- 210000000969 egg white Anatomy 0.000 description 2
- 210000002969 egg yolk Anatomy 0.000 description 2
- 235000013345 egg yolk Nutrition 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 238000001215 fluorescent labelling Methods 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000021242 lactoferrin Nutrition 0.000 description 2
- 229940078795 lactoferrin Drugs 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000006151 minimal media Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000004252 protein component Nutrition 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 235000003441 saturated fatty acids Nutrition 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229960003165 vancomycin Drugs 0.000 description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 241000710929 Alphavirus Species 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000700663 Avipoxvirus Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 241001112696 Clostridia Species 0.000 description 1
- 241000193163 Clostridioides difficile Species 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000223935 Cryptosporidium Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000224432 Entamoeba histolytica Species 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000710831 Flavivirus Species 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- 241000224467 Giardia intestinalis Species 0.000 description 1
- 241000282818 Giraffidae Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229920002306 Glycocalyx Polymers 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- 241000700586 Herpesviridae Species 0.000 description 1
- 102100024023 Histone PARylation factor 1 Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001047783 Homo sapiens Histone PARylation factor 1 Proteins 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241000712902 Lassa mammarenavirus Species 0.000 description 1
- 241000711828 Lyssavirus Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241000712045 Morbillivirus Species 0.000 description 1
- 102000015728 Mucins Human genes 0.000 description 1
- 108010063954 Mucins Proteins 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 241000700629 Orthopoxvirus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000710778 Pestivirus Species 0.000 description 1
- 241000711902 Pneumovirus Species 0.000 description 1
- 241000700625 Poxviridae Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000712907 Retroviridae Species 0.000 description 1
- 241000710801 Rubivirus Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 239000012506 Sephacryl® Substances 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 241000710924 Togaviridae Species 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 229940025131 amylases Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940021722 caseins Drugs 0.000 description 1
- MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 description 1
- 239000002036 chloroform fraction Substances 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000459 effect on growth Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 229940007078 entamoeba histolytica Drugs 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 229960004396 famciclovir Drugs 0.000 description 1
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 description 1
- 150000002194 fatty esters Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000020243 first infant milk formula Nutrition 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229940085435 giardia lamblia Drugs 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000004517 glycocalyx Anatomy 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 230000008376 long-term health Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002032 methanolic fraction Substances 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 229940051875 mucins Drugs 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20010780 | 2001-08-23 | ||
| PCT/IE2002/000121 WO2003018049A2 (en) | 2001-08-23 | 2002-08-20 | Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ531639A true NZ531639A (en) | 2006-02-24 |
Family
ID=11042830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ531639A NZ531639A (en) | 2001-08-23 | 2002-08-20 | Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7687074B2 (https=) |
| EP (1) | EP1427436B1 (https=) |
| JP (1) | JP4532900B2 (https=) |
| KR (1) | KR100907959B1 (https=) |
| CN (1) | CN1578670B (https=) |
| AT (1) | ATE399562T1 (https=) |
| AU (1) | AU2002356112B2 (https=) |
| CA (1) | CA2458146C (https=) |
| DE (1) | DE60227389D1 (https=) |
| DK (1) | DK1427436T3 (https=) |
| ES (1) | ES2309228T3 (https=) |
| NZ (1) | NZ531639A (https=) |
| PT (1) | PT1427436E (https=) |
| RU (1) | RU2305547C2 (https=) |
| WO (1) | WO2003018049A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2863168A1 (fr) * | 2003-12-04 | 2005-06-10 | Centre Nat Rech Scient | Utilisation d'inducteurs de la voie de degradation de la gamma-butyrolactone pour inactiver le signal n-acy homoserine lactone. |
| BRPI0512864B8 (pt) * | 2004-07-01 | 2021-05-25 | Johnson & Johnson Vision Care | composição oftálmica, uso de pelo menos um ácido graxo ômega-6 e pelo menos um ácido graxo ômega-3 e método para preparar a referida composição |
| WO2007035870A2 (en) * | 2005-09-20 | 2007-03-29 | Prolacta Bioscience, Inc. | A method for testing milk |
| WO2007061942A2 (en) | 2005-11-18 | 2007-05-31 | Glanbia Nutritionals (Ireland) Ltd. | Compositions for disrupting and inhibiting reconstitution of wound biofilm |
| JP5017531B2 (ja) * | 2006-09-11 | 2012-09-05 | 株式会社アップウェル | 口内清浄剤 |
| KR20100108526A (ko) * | 2007-12-04 | 2010-10-07 | 웨스트게이트 바이올로지컬 리미티드 | 지방산 및 우유 단백질을 포함하는 항균성 조성물 |
| JP2009190994A (ja) * | 2008-02-13 | 2009-08-27 | Kitasato Institute | 抗インフルエンザウイルス剤、及びその有効成分の製造方法 |
| US20090311236A1 (en) * | 2008-06-11 | 2009-12-17 | Immune @Work, Inc. | Therapeutic Peptide Compositions And Methods Of Making And Using Same |
| EP2316445A4 (en) * | 2008-06-11 | 2011-12-21 | Ricom Corp | HUMAN BETA3 ADRENERGER RECEPTOR LIGAND AND THEREOF FOOD OR PHARMACEUTICAL PREPARATION |
| US8808345B2 (en) * | 2008-12-31 | 2014-08-19 | Medtronic Ardian Luxembourg S.A.R.L. | Handle assemblies for intravascular treatment devices and associated systems and methods |
| WO2010082587A1 (ja) * | 2009-01-13 | 2010-07-22 | 株式会社大気倶楽部 | 空中懸濁物吸着剤 |
| KR101119538B1 (ko) * | 2009-06-10 | 2012-02-22 | 장선호 | 시알릭산-함유 유청 단백질을 유효성분으로 함유하는 인플루엔자 바이러스 감염증의 예방 및 치료용 조성물 |
| ES2643862T3 (es) * | 2009-11-17 | 2017-11-24 | Michael Anthony Folan | Composiciones antimicrobianas que contienen ácidos grasos libres |
| AR082943A1 (es) * | 2010-08-06 | 2013-01-23 | Aptalis Pharma Ltd | Formula nutricional predigerida |
| KR101355018B1 (ko) * | 2010-12-13 | 2014-01-24 | 노부오 구보 | 시알릭산-함유 유청 단백질을 유효성분으로 함유하는 인플루엔자 바이러스 감염증의 예방용 동물사료 첨가제 및 이를 포함하는 동물사료용 조성물 |
| RU2494726C2 (ru) * | 2011-04-11 | 2013-10-10 | Общество с Ограниченной Ответственностью "Производственная Торговая Компания "Лактив" | Способ профилактики и лечения грибковой инфекции у больных с голосовыми протезами |
| EP3150257A1 (en) * | 2015-09-30 | 2017-04-05 | Buga, Doris | A method for producing a composition for strengthening the immune system |
| CA3026402A1 (en) | 2017-12-05 | 2019-06-05 | James F. Kane | Water-soluble cannabinoids and methods of making same |
| US11298379B2 (en) * | 2020-04-16 | 2022-04-12 | James F. Kane | Compositions comprising milk fat globules and methods of making same |
| CN113855787A (zh) * | 2020-06-30 | 2021-12-31 | 北京大学 | 乳清蛋白作为冠状病毒广谱抑制剂的用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2796378A (en) * | 1954-04-09 | 1957-06-18 | Jr Edgar A Ferguson | Methionine free reaction product of a water-soluble copper salt and lactalbumin hydrolysate as fungicide |
| GB1050756A (https=) * | 1964-09-10 | 1900-01-01 | ||
| US4397927A (en) * | 1982-03-25 | 1983-08-09 | Brog Roy A | Imitation milk compositions and aqueous dispersions prepared therefrom |
| EP0210204B1 (de) | 1985-01-18 | 1988-12-07 | Kailash Kumar Dr. Prof. Gauri | Proteinhydrolysate, verfahren zu ihrer herstellung und arzneimittel, die diese hydrolysate enthalten |
| JPS62249931A (ja) | 1986-04-21 | 1987-10-30 | Morinaga Milk Ind Co Ltd | 抗菌性組成物 |
| JPH085798B2 (ja) * | 1987-02-02 | 1996-01-24 | 紀夫 多田 | 抗菌剤 |
| DE69003014T2 (de) * | 1989-06-07 | 1993-12-16 | Kao Corp | Essbare Öl-in-Wasser-Emulsion. |
| JP2673320B2 (ja) * | 1990-01-25 | 1997-11-05 | 雪印乳業株式会社 | う蝕原菌付着阻止剤 |
| JPH04159232A (ja) * | 1990-08-21 | 1992-06-02 | Yakult Honsha Co Ltd | 日和見感染症予防・治療用経口組成物 |
| CA2094570A1 (en) | 1992-05-27 | 1993-11-28 | Jerome F. Trumbetas | Enzymatic protein process and product |
| CA2148261A1 (en) | 1992-10-30 | 1994-05-11 | Jerry A. Peterson | Anti-diarrheic product and method of treating rotavirus-associated infection |
| US5785984A (en) * | 1993-02-05 | 1998-07-28 | Kao Corporation | Taste-modifying method and bitterness-decreasing method |
| US6197356B1 (en) * | 1993-08-03 | 2001-03-06 | Immunopath Profile, Inc. | Process for preparing hypoallergenic foods |
| AU7792294A (en) * | 1994-08-16 | 1996-03-07 | Hemant Sabharwal | Antibacterial composition containing multimeric alpha-lactalbumin |
| JP4233615B2 (ja) * | 1996-08-22 | 2009-03-04 | 森永乳業株式会社 | 経口抗ヒト爪白癬及び／又は爪白癬以外のヒト足部白癬用医薬品 |
| DE69824150T2 (de) | 1997-01-09 | 2005-05-25 | Morinaga Milk Industry Co. Ltd. | Lactoferrin-tabletten |
| IE970541A1 (en) | 1997-07-25 | 1999-01-27 | Michael Anthony Folan | Maternal immune secretions and their use in the treatment and/or prophylaxis of the buccal cavity |
| JP4129566B2 (ja) * | 1997-09-05 | 2008-08-06 | 大塚製薬株式会社 | 肝臓脂肪蓄積抑制組成物及び肝臓脂肪蓄積抑制用食品添加剤 |
| US6287590B1 (en) | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
| AUPP051497A0 (en) | 1997-11-24 | 1997-12-18 | University Of Melbourne, The | Antimicrobial peptides |
| US6126955A (en) * | 1998-04-16 | 2000-10-03 | University Of Utah Research Foundation | Apo-transferrin as a potent inhibitor of bacterial adhesion to biomaterials |
| ATE259654T1 (de) | 1998-06-26 | 2004-03-15 | Nutricia Nv | Pharmazeutische präparate zur bekämpfung oder prophylaxe von mikroorganismen infizierten oberflächen |
| JP2000119257A (ja) * | 1998-08-14 | 2000-04-25 | Nippon Nohyaku Co Ltd | ピリダジノン誘導体 |
| GB9903584D0 (en) | 1999-02-18 | 1999-04-07 | Univ Leeds | Modified calycins |
| JP3662445B2 (ja) * | 1999-06-30 | 2005-06-22 | 花王株式会社 | 油中水型乳化油脂組成物 |
| WO2002094035A1 (en) * | 2001-05-23 | 2002-11-28 | Nutricopia, Inc. | Nutritional frozen dessert and methods of manufacture |
| US20030165606A1 (en) | 2001-07-18 | 2003-09-04 | Lasekan John B. | Anti-regurgitation formula and uses thereof |
| EP1319407A1 (en) * | 2001-12-14 | 2003-06-18 | Montoie Import-Export S.A. | Pharmaceutical composition for topical treatment of skin disorders and skin wounds |
-
2002
- 2002-08-20 WO PCT/IE2002/000121 patent/WO2003018049A2/en not_active Ceased
- 2002-08-20 CA CA2458146A patent/CA2458146C/en not_active Expired - Fee Related
- 2002-08-20 JP JP2003522566A patent/JP4532900B2/ja not_active Expired - Fee Related
- 2002-08-20 PT PT02796345T patent/PT1427436E/pt unknown
- 2002-08-20 CN CN028210786A patent/CN1578670B/zh not_active Expired - Fee Related
- 2002-08-20 DE DE60227389T patent/DE60227389D1/de not_active Expired - Lifetime
- 2002-08-20 AU AU2002356112A patent/AU2002356112B2/en not_active Ceased
- 2002-08-20 ES ES02796345T patent/ES2309228T3/es not_active Expired - Lifetime
- 2002-08-20 KR KR1020047002518A patent/KR100907959B1/ko not_active Expired - Fee Related
- 2002-08-20 US US10/487,616 patent/US7687074B2/en not_active Expired - Lifetime
- 2002-08-20 DK DK02796345T patent/DK1427436T3/da active
- 2002-08-20 NZ NZ531639A patent/NZ531639A/en not_active IP Right Cessation
- 2002-08-20 RU RU2004108040/13A patent/RU2305547C2/ru not_active IP Right Cessation
- 2002-08-20 AT AT02796345T patent/ATE399562T1/de active
- 2002-08-20 EP EP02796345A patent/EP1427436B1/en not_active Expired - Lifetime
-
2010
- 2010-01-30 US US12/657,884 patent/US7972629B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040041579A (ko) | 2004-05-17 |
| DE60227389D1 (de) | 2008-08-14 |
| WO2003018049A2 (en) | 2003-03-06 |
| CN1578670B (zh) | 2013-09-04 |
| JP2005501863A (ja) | 2005-01-20 |
| CA2458146A1 (en) | 2003-03-06 |
| EP1427436A2 (en) | 2004-06-16 |
| ES2309228T3 (es) | 2008-12-16 |
| KR100907959B1 (ko) | 2009-07-16 |
| EP1427436B1 (en) | 2008-07-02 |
| US7687074B2 (en) | 2010-03-30 |
| CA2458146C (en) | 2012-07-24 |
| US7972629B2 (en) | 2011-07-05 |
| RU2305547C2 (ru) | 2007-09-10 |
| AU2002356112B2 (en) | 2007-11-08 |
| US20050042299A1 (en) | 2005-02-24 |
| RU2004108040A (ru) | 2005-09-27 |
| CN1578670A (zh) | 2005-02-09 |
| WO2003018049A3 (en) | 2003-11-06 |
| JP4532900B2 (ja) | 2010-08-25 |
| PT1427436E (pt) | 2008-09-08 |
| US20100209526A1 (en) | 2010-08-19 |
| DK1427436T3 (da) | 2008-10-13 |
| ATE399562T1 (de) | 2008-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7972629B2 (en) | Product comprising a combination of milk serum apoproteins and free fatty acids | |
| AU2002356112A1 (en) | Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection | |
| US12208075B2 (en) | Antimicrobial compositions containing free fatty acids | |
| US20100317734A1 (en) | Free fatty acid blends and use thereof | |
| US8338363B2 (en) | Pharmaceutical compositions comprising casein derived peptides and methods of use thereof | |
| US9283269B2 (en) | Method for reducing the allergenicity of animal dander | |
| CA2687123A1 (en) | Method for the treatment of atopic eczema | |
| JP3962538B2 (ja) | コラーゲンを主成分とする創傷の皮膚繊維芽細胞遊走・増殖促進剤及びメチシリン耐性黄色ブドウ球菌に作用する抗菌剤 | |
| JP3805975B2 (ja) | 創傷治癒剤 | |
| JP4313767B2 (ja) | ヘリコバクター・ピロリ剥離作用を有するポリペプチド | |
| AU3554099A (en) | Methods and compositions for inactivating infectious agents using lactoferrin and related molecules | |
| WO2005037248A1 (en) | Glycoprotein and/or glycomacropeptide containing preparations for medical uses | |
| AU2012200889A1 (en) | Pharmaceutical compositions comprising casein derived peptides and methods of use thereof | |
| Godinez | Amoebicidal Activity of Milk, Apo-lactoferrin, sIgA and Lysozyme | |
| JP2000136148A (ja) | 細胞への付着阻害組成物 | |
| IL222487A (en) | Casein-derived peptides and methods for using them to increase milk yield | |
| IL222486A (en) | Casein-derived peptides and methods for using them to enhance milk cleanliness |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 AUG 2016 BY CAROL KELLY Effective date: 20150812 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 AUG 2017 BY CAROL KELLY Effective date: 20160816 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 AUG 2018 BY CAROL Effective date: 20170817 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 AUG 2019 BY FRKELLY Effective date: 20180815 |
|
| LAPS | Patent lapsed |