NZ521228A - Metabotropic glutamate receptor antagonists for treating tolerance and dependency - Google Patents
Metabotropic glutamate receptor antagonists for treating tolerance and dependencyInfo
- Publication number
- NZ521228A NZ521228A NZ521228A NZ52122801A NZ521228A NZ 521228 A NZ521228 A NZ 521228A NZ 521228 A NZ521228 A NZ 521228A NZ 52122801 A NZ52122801 A NZ 52122801A NZ 521228 A NZ521228 A NZ 521228A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dependence
- antagonist
- substance
- tolerance
- mglur5
- Prior art date
Links
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- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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| CN1694701A (zh) * | 2002-09-10 | 2005-11-09 | 诺瓦提斯公司 | 治疗包括成瘾与抑郁症在内的与mGLU受体相关疾病的mGLU受体拮抗剂 |
| ES2564187T3 (es) | 2005-04-05 | 2016-03-18 | Yale University | Agentes de modulación de glutamato en el tratamiento de trastornos mentales |
| WO2006121919A2 (en) * | 2005-05-05 | 2006-11-16 | Massachusetts Institute Of Technology | Methods of treating obsessive compulsive disorder |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| WO2007035823A2 (en) * | 2005-09-20 | 2007-03-29 | Molecular Neuroimaging, Llc | Partial mglur5 antagonists and methods of use thereof |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| PL2083811T3 (pl) | 2006-11-22 | 2017-05-31 | Clinical Research Associates, Llc | Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| US20110294879A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012009646A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012054724A1 (en) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Methods of treating seizure disorders |
| US20130123254A1 (en) * | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| EP3661500B1 (en) * | 2017-07-31 | 2026-01-07 | Novartis AG | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| CA3067688A1 (en) | 2017-07-31 | 2019-02-07 | Novartis Ag | Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use |
| JP7620694B2 (ja) * | 2020-07-17 | 2025-01-23 | ノバルティス アーゲー | オピオイド使用の低減用医薬品及びオピオイド禁断の促進用医薬品 |
| AU2021404023A1 (en) * | 2020-12-14 | 2023-06-29 | Novartis Ag | Use of mglur5 antagonists for treating gambling disorder |
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| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| US5543698A (en) * | 1994-09-27 | 1996-08-06 | Allen-Bradley Company, Inc. | Method and apparatus used with AC motor for detecting unbalance |
| GB9609976D0 (en) * | 1996-05-13 | 1996-07-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| DE69832156T2 (de) * | 1997-03-14 | 2006-08-03 | The Johns Hopkins University | Zusammensetzungen des synaptischen Aktivierungsproteins und Verfahren |
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| EP1183238A1 (en) * | 1999-05-17 | 2002-03-06 | Eli Lilly And Company | Metabotropic glutamate receptor antagonists |
| US6666209B2 (en) * | 2001-02-20 | 2003-12-23 | 3M Innovative Properties Company | Method and system of calibrating air flow in a respirator system |
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Also Published As
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| SE1267869T3 (https=) | 2004-08-31 |
| US20030195139A1 (en) | 2003-10-16 |
| TR200401862T4 (tr) | 2004-10-21 |
| JP2003525902A (ja) | 2003-09-02 |
| DK1267869T3 (da) | 2004-09-20 |
| DE60103384D1 (de) | 2004-06-24 |
| EP1267869A1 (en) | 2003-01-02 |
| ES2220727T3 (es) | 2004-12-16 |
| CA2402341A1 (en) | 2001-09-13 |
| DE60103384T2 (de) | 2005-06-16 |
| EP1267869B1 (en) | 2004-05-19 |
| WO2001066113A1 (en) | 2001-09-13 |
| SE1267869T5 (https=) | 2004-09-07 |
| PT1267869E (pt) | 2004-10-29 |
| HK1053262A1 (en) | 2003-10-17 |
| CN1427720A (zh) | 2003-07-02 |
| GB0005700D0 (en) | 2000-05-03 |
| AU3763401A (en) | 2001-09-17 |
| ATE267013T1 (de) | 2004-06-15 |
| AU783869B2 (en) | 2005-12-15 |
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