NZ516317A - Stainless steel canister for propellant operated metering aerosols - Google Patents
Stainless steel canister for propellant operated metering aerosolsInfo
- Publication number
- NZ516317A NZ516317A NZ516317A NZ51631700A NZ516317A NZ 516317 A NZ516317 A NZ 516317A NZ 516317 A NZ516317 A NZ 516317A NZ 51631700 A NZ51631700 A NZ 51631700A NZ 516317 A NZ516317 A NZ 516317A
- Authority
- NZ
- New Zealand
- Prior art keywords
- container
- canister
- valve
- canister according
- propellant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C38/00—Ferrous alloys, e.g. steel alloys
- C22C38/18—Ferrous alloys, e.g. steel alloys containing chromium
- C22C38/40—Ferrous alloys, e.g. steel alloys containing chromium with nickel
- C22C38/44—Ferrous alloys, e.g. steel alloys containing chromium with nickel with molybdenum or tungsten
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/38—Details of the container body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C38/00—Ferrous alloys, e.g. steel alloys
- C22C38/18—Ferrous alloys, e.g. steel alloys containing chromium
- C22C38/40—Ferrous alloys, e.g. steel alloys containing chromium with nickel
- C22C38/42—Ferrous alloys, e.g. steel alloys containing chromium with nickel with copper
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Safety Valves (AREA)
- Nozzles (AREA)
Abstract
The invention relates to a corrosion-resistant special steel canister for propellant-containing aerosol formulations and used in propellant-driven inhalators.
Description
<div class="application article clearfix" id="description">
<p class="printTableText" lang="en">- 1 - <br><br>
Stainless steel canister for propellant operated metering aerosols <br><br>
The present invention relates to corrosion-resistant 5 stainless steel canisters for propellant gas-containing aerosol formulations for use in propellant gas-operated inhalers. <br><br>
Background of the Invention <br><br>
10 In propellant-driven inhalers, the active substances are stored together with the propellant in cartridge-like canisters. These canisters generally consist of an aluminium container sealed with an aluminium valve cup in which a valve is embedded. A canister of this kind can then 15 be placed in the inhaler in the manner of a cartridge and is either left there permanently or replaced with a new cartridge after use. Since chlorofluorocarbons (CFCs) were proscribed on the grounds of their ozone-destroying properties at the Rio de Janeiro Conference at the beginning 20 of the 90s, the use of fluorohydrocarbons (FHC) is promoted as an alternative for use in propellant-driven inhalers. The most promising example to date are TG 134a (1,1,2,2-tetrafluoroethane) and TG 227 (1,1,1,2,3,3,3-heptafluoropropane). Accordingly, existing systems of 25 delivery for treatments by"inhalation have had to be converted to CFC-free propellants and new delivery systems and active substance formulations have had to be developed. <br><br>
Surprisingly, it has been found that aluminium canisters are 30 not always resistant to drug formulations containing fluorohydrocarbons as propellants but have a high risk of corrosion depending on the composition of the formulations. This is particularly true of formulations <br><br>
- 3: <br><br>
RECEIVED <br><br>
516317 <br><br>
- 2 - <br><br>
which contain electrolytes and/or free ions, particularly free halides. In these cases, the aluminium is attacked, which means that aluminium cannot be used as a casing material for the canisters. Similar instabilities in the aluminium canisters have been observed when fluorohydrocarbons are used as propellants if the formulations contain acid or basic components, e.g. in the form of the active substances, the additives, in the form of stabilisers, surfactants, flavour enhancers, antioxidants, etc. <br><br>
Description of the Invention <br><br>
One of the tasks of the present invention is to provide a canister for propellant-driven inhalers which is corrosion-resistant in the presence of active substance formulations for inhalation therapy containing a fluorohydrocarbon as propellant, which has sufficient compressive and breaking strength to withstand processing and use, which ensures the quality of the formulations stored therein and overcomes the other disadvantages known from the prior art. <br><br>
A further objective of the invention is to provide a canister for propellant-driven inhalers, the container of which consists of a single inherently homogeneous material. <br><br>
The abovementioned objects should be read disjunctively with the object to at least provide the public with a useful alternative. <br><br>
Surprisingly, it has been found that a canister for propellant operated metering aerosols comprising a container and a valve,cup with valve embedded therein, and <br><br>
INTELLECTUAL PROPERTY OFRCF OF N.Z <br><br>
19 MAR 2003 received <br><br>
(Followed by page 2a) <br><br>
516317 <br><br>
- 2a - <br><br>
which includes a fluorohydrocarbon as propellant and an active substance selected from ipatropium bromide, oxitropium bromide, tiotropium bromide, albuterol or fenoterol, the container consisting of certain stainless 5 steel alloys solve the problem according to the invention. These alloys contain as components chromium (Cr), nickel (Ni), molybdenum (Mo), iron (Fe) and carbon (C). Such alloys may additionally contain copper (Cu), manganese (Mn) and silicon (Si). The container preferably consists of one 10 of the alloys described below. <br><br>
(Followed by page 3) <br><br>
- 3 - <br><br>
The invention further relates to the use of a container or canister of this kind consisting of a container (2) and a valve cup (8) with valve (9) in propellant-operated metering aerosols (inhalers) and a process for producing 5 them. <br><br>
The invention is hereinafter explained more fully with reference to Figures 1 and 2. <br><br>
10 Fig. 1 shows the canister consisting of container (2), valve cup (8) and the valve (9) in cross-section. Fig. 2 shows another embodiment of the valve cup (8) and the valve (9) in cross-section. <br><br>
15 Figure 1 shows the canister (1) according to the invention in cross-section. The canister (1) consists of a container (2) for holding the pharmaceutical formulation and a valve cup (8) with valve (9). The shape and dimensions of the canister correspond to those of the 20 aluminium canisters known from the prior art. <br><br>
The container (2) according to the invention is made of an alloy having a chromium content of 19.0 - 21.0%, a nickel content of 24.0 - 26.0%, a molybdenum content of 25 4.0 - 5.0%, a copper content of 1.0 - 2.0%, a manganese content of up to 2.0%, a silicon content of up to 0.5% and a carbon content of 0.02%. The remainder consists essentially of iron. The alloy is preferably an alloy according to DIN 4539. <br><br>
30 <br><br>
In an alternative embodiment the container (2) according to the invention consists of an alloy containing 16.5 - 18.5% of chromium, 11.0 - 14.0% of nickel, 2.0 - 2.5% of molybdenum, a maximum of 0.03% of carbon and 35 iron as the remaining component. The alloy is preferably an alloy according to DIN 4404. <br><br>
- 4 - <br><br>
The alloys mentioned above are such that they are corrosion-resistant to various liquefied fluorohydrocarbons such as TG 134a (1,1,1,3-tetrafluorohydrocarbon) 5 and TG 227 (1,1,1,2,3,3,3-heptafluoropropane). These include propellant gas formulations having active substances suitable for inhalation therapy, surfactants, cosolvents, stabilisers, complexing agents, flavour correctors, antioxidants, salts, acids, bases or 10 electrolytes, such as hydroxide ions, cyanide ions and/or halide anions such as fluoride, chloride, bromide or iodide. <br><br>
The container (2) is formed from a casing made of one of 15 the alloys described above. The container (2) has four different zones: the flat or concave, inwardly domed base (3), a cylindrical portion (4) which merges into the tapering neck (5) in its upper third and finally ends in the bead (6) which encircles the opening (7) of the 2 0 container. <br><br>
The wall thickness of the container (2) is between 0.1 and 0.5 mm in a preferred embodiment, preferably between 0.15 and 0.35 mm, most preferably about 0.19 to 3.0 mm. <br><br>
25 <br><br>
In a preferred embodiment the container (2) will withstand a bursting pressure of more than 3 0000 hPa, preferably more than 100000 hPa, most preferably more than 200000 hPa. The weight of the container (2) is 5-15 g in <br><br>
30 a preferred embodiment, 7-10 g in another and 7.9 - 8.7g in yet another. In an equally preferred embodiment the container (2) has a volume of 5 to 5 0 ml. Other containers have a volume of 10 to 2 0 ml whilst still others have volumes of about 15 - 18 ml. <br><br>
35 <br><br>
- 5 - <br><br>
In the sealed state the container (2) is tightly sealed by means of the valve cup (8) after being filled with the pharmaceutical formulation and the propellant. <br><br>
5 In another embodiment the valve cup (8) also consists of corrosion-resistant material. Preferably this is one of the alloys described above for the containers and/or a plastics material of suitable pharmaceutical quality. <br><br>
10 In another embodiment the valve cup (8) consists of aluminium. In this case the seal (10) and/or the valve (9) are constructed so that the valve cup (8) itself cannot come into contact with the liquid inside the container. <br><br>
15 <br><br>
A preferred embodiment of the valve cup (8) is as described in GB 2324121, to which reference is hereby made. <br><br>
20 In the closed state of the canister, the valve cup (8) is crimped around the container (2) at its bead (6). In preferred embodiments a seal or gasket (10) seals the valve cup (8) relative to the bead (6). The seal may be annular or disc shaped. It is preferably disc shaped. It 25 may consist of materials known from the prior art which are suitable for using pharmaceutical formulations with fluorohydrocarbons as the propellants. Examples of suitable materials include thermoplasts, elastomers, materials such as neoprene, isobutylene, isoprene, butyl 3 0 rubber, buna rubber, nitrile rubber, copolymers of ethylene and propylene, terpolymers of ethylene, propylene and a diene, e.g. butadiene, or fluorinated polymers. The preferred materials are ethylene/propylene/diene terpolymers (EPDM). <br><br>
35 <br><br>
- 6 - <br><br>
On the side of the valve cup (8) facing the inside of the container, a valve (9) is formed so that the valve stem (12) passes through the valve cup (8) to the other side. The valve (9) sits in the central opening of the gasket 5 (10) to form a seal. The gasket (10) and valve (9) <br><br>
together seal the valve cup (8) from the inside of the container, so that it cannot come into contact with the liquid in the container (2). <br><br>
10 The valve (9) is constructed so that every element which is capable of coming into contact with the liquid inside the container (2) consists of a material which is corrosion-resistant with respect to this liquid. Such elements include for example the spring or springs (11), 15 the valve stem (12), which projects from the inside to the outside through the opening (17) in the valve cup (8), the metering chamber (13) and the valve body (14). The spring (11) consists of steel, preferably a stainless steel. The other elements of the valve (9) may consist, for example, 20 of steel, the alloy described above and/or a plastic. The elements (12), (13) and (14) preferably consist of a plastic, particularly a polyester, most preferably polybutylene terephthalate. <br><br>
25 As shown in Figure (1), one or more other gaskets or seals, e.g. the gaskets (15) and/or (16), may be provided to prevent liquid or gas from escaping outwards from the inside of the container. The gasket or gaskets may be arranged so that the liquid inside the container comes 3 0 into contact only with the container jacket and the valve, apart from the actual gasket or gaskets. <br><br>
The gasket (15) seals off the valve stem, which is optionally vertically movable, at the point where it 35 penetrates the valve cup (8). The gasket (16) seals the valve stem (12) inside the valve relative to the valve <br><br>
- 7 - <br><br>
body (14) and/or the metering chamber (13). In this way, the gaskets (15) and (16) prevent any liquid or gas from escaping from the interior of the container along the outer casing of the valve stem and out of the canister or 5 from coming into contact with the valve cup by this route. The gaskets (15) and (16) may be made of the same material as the gasket (10), preferably an ethylene/propylene/diene terpolymer. <br><br>
10 In one embodiment in which the valve cup (8) is not made of aluminium but of one of the corrosion-resistant materials described above, it is not necessary for the gasket (10) together with the valve (9) to isolate the valve cup completely from the inside of the container. 15 Therefore, it is not necessary in this case for the gasket (10) and valve (9) to be in sealing contact with one another. There may be a gap between the gasket (10) and the valve (9). In such a case the gasket (10) sits directly on the underside of the valve cup (8), for 2 0 example, and seals the edge of the valve cup (8) relative to the bead (6) on the container. The gasket (15) then seals the opening (17) in the valve cup (8) from the interior of the container. <br><br>
25 Figure 2 shows another embodiment of the valve cup (8) <br><br>
with embedded valve (9). This embodiment is largely identical to that in Figure 1. The major difference is that the gasket (10) and the gasket (16) in the embodiment in Figure 2 are combined to form one gasket (18). The 30 gasket (18) encloses the underside of the valve plate (18). It is arranged so that the valve body (14) is embedded in the gasket. The valve stem (12) passes through the gasket via the opening (19) which is located directly below the opening (17) in the valve cup (8). The 35 opening (19) is of such dimensions as to seal the valve stem (12) relative to the valve cup (8). The sealing <br><br>
- 8 - <br><br>
material for the gasket (18) is identical to that described for the gasket (10). <br><br>
The container (2) according to the invention is produced 5 analogously to the processes known from the prior art for producing aluminium canisters and the like, in which the container is stamped out of a sheet of the material in question, or the corresponding alloy. In the present invention, the container (2) is stamped out of a sheet of 10 the above-mentioned alloys of chromium (Cr), nickel (Ni), molybdenum (Mo), iron (Fe) and carbon (C) or from an alloy which additionally contains copper (Cu), manganese (Mn) and silicon (Si). <br><br>
15 The container (2) or canister consisting of container (2) and valve cup (8) with valve (9) according to the invention is particularly suitable for use with propellant gas formulations containing fluorohydrocarbons. <br><br>
Propellant gas formulations which can preferably be used <br><br>
2 0 in conjunction with the invention are disclosed in <br><br>
WO 94/13262, to which reference is hereby made. Particularly preferred formulations disclosed therein are acid-stabilised and/or ethanol propellant gas formulations containing 1,1,2,2-tetrafluoroethane (TG 134a) and/or 25 1,1,1,2,3,3,3-heptafluoropropane (TG 227) as the propellant gas, particularly those which contain ipatropium bromide, oxitropium bromide, albuterol, tiotropium bromide or fenoterol as active substance. <br><br>
3 0 Depending on the active substance, inorganic or organic acids may be used as stabilisers. Examples of inorganic acids include, in addition to halic acids and other mineral acids: sulphuric acid, hydrochloric acid, nitric acid or phosphoric acid, whilst examples of organic acids 35 include ascorbic acid or citric acid. In the case of the salts of the active substances, the preferred acids are <br><br>
- 9 - <br><br>
those wherein the anion is identical to that of the salt of the active substance. Citric acid is generally suitable for all active substances and their salts and is also most preferred. <br><br>
5 <br><br>
The acid content is such that the pH of the formulation is between 1.0 and 7.0, preferably between 2.0 and 5.0 and most preferably at about 3.5. In the case of inorganic acids the preferred acid content is in the range from 10 about 0.00002 to 0.01 N. In the case of ascorbic acid the preferred content is roughly in the range from 0.0045 to 5.0 mg/ml and in the case of citric acid it is within the range from 0.003 9 to 27.7 mg/ml. <br><br>
15 The formulations may additionally contain ethanol as cosolvent. The preferred amount is 1.0 to 50.0% by weight of the formulation. <br><br>
The following are some preferred formulations by way of 2 0 example which can be stored in a canister or a container of the type described above: <br><br>
Example 1 <br><br>
Ipatropium bromide monohydrate 25 Absolute ethanol TG 134a Inorganic acid Water <br><br>
30 flxample 2 <br><br>
Ipatropium bromide monohydrate Absolute ethanol TG 134a Ascorbic acid 35 Purified water <br><br>
0.001 - 2.5% by weight 0.001 - 50% by weight 50.0 - 99.0% by weight 0.01 - 0.00002 normal 0.0 - 5.0% by weight <br><br>
0.001 - 2.5% by weight 0.001 - 50% by weight 50.0 - 99.0% by weight 0.00015 - 5.0 mg/ml 0.0 - 5.0% by weight <br><br>
- 10 - <br><br>
Example 3 <br><br>
Ipatropium bromide monohydrate <br><br>
Absolute ethanol <br><br>
TG 134a <br><br>
Citric acid <br><br>
Purified water <br><br>
Total <br><br>
0.0187% by weight 15.0000% by weight 84.47730% by weight 0.0040% by weight 0.5000% by weight 100.0000% by weight <br><br>
Example 4 10 Ipatropium bromide monohydrate Absolute ethanol TG 134a Citric acid Purified water 15 Total <br><br>
0.0374% by weight 15.0000% by weight 84.4586% by weight 0.0040% by weight 0.5 0 00% by weight 100.0000% by weight <br><br>
Example 5 <br><br>
Ipatropium bromide monohydrate Absolute ethanol 20 TG 134a <br><br>
Citric acid Purified water Total <br><br>
0.0748% by weight 15.0000% by weight 84.4212% by weight 0.0040% by weight 0.5000% by weight 100.0000% by weight <br><br>
25 Example 6 <br><br>
Fenoterol hydrobromide Absolute ethanol TG 134a Citric acid 30 Purified water Total <br><br>
0.192% by weight 3 0.000% by weight 67.8 06% by weight 0.002% by weight 2.000% by weight 100.0000% by weight <br><br>
35 <br><br>
A method of filling the canisters with the corresponding formulation might be, for example, the dual stage pressure fill method, the single stage cold fill method or the single stage pressure fill method. <br><br></p>
</div>
Claims (32)
1. Canister for propellant operated metering aerosols comprising a container and a valve cup with valve embedded therein, and which includes a fluorohydrocarbon as propellant and an active substance selected from ipatropium bromide, oxitropium bromide, tiotropium bromide, albuterol or fenoterol, the container consisting of an alloy containing 40.0 - 53.0% iron, 23.0 - 28.0% nickel,<br><br> 19.0 - 23.0% chromium, 4.0 - 5.0% molybdenum, 0.0 - 2.0% manganese, 1.0 - 2.0% copper, 0.0 - 1.0% silicon, 0.0 -0.045% of phosphorus, 0.0 - 0.035% sulphur and 0.0 - 0.020% carbon.<br><br>
2. Canister according to claim 1, wherein the container consists of an alloy having the following composition: chromium 19.0 - 21.0%, nickel 24.0 - 26.0%, molybdenum 4.0 - 5.0%, copper 1.0 - 2.0%, manganese up to 2.0%,<br><br> silicon up to 0.5% and carbon up to 0.02%, with iron substantially as the remaining ingredient.<br><br>
3. Canister according to claim 1 or 2, wherein the valve cup consists of aluminium and is sealed with a gasket and/or relative to the interior of the container.<br><br>
4. Canister according to one of claims 1 to 3, wherein the valve contains one or more stainless steel springs, a valve stem, the metering chamber and a valve body, the valve stem, the metering chamber and/or the valve body being made of steel, the alloy according to claim 1 or 2 and/or a plastic.<br><br> "INTE^^7UALTR0PiRTY<br><br> OFFICE OF |\j.z<br><br> 19 MAR 2003<br><br> received<br><br> 12-- -<br><br>
5. Canister according to claim 4, wherein the spring(s) consist(s) of a stainless steel and the valve stem, the metering chamber and the body of the valve consist of polybutylene terephthalate.<br><br>
6. Canister according to claim 4 or 5, wherein the valve stem is sealed off from the valve cup by a gasket.<br><br>
7. Canister according to one of claims 3 to 6, wherein the gasket(s) consist(s) of an ethylene/propylene/diene terpolymer.<br><br>
8. Canister according to one of claims 1 to 7, wherein the valve cup consists of the same alloy as the container.<br><br>
9. Canister according to one of claims 1 to 8, wherein the container withstands a bursting pressure of more than 30,000 hPa.<br><br>
10. Canister according to one of claims 1 to 8, wherein the container withstands a bursting pressure of more than 100,000 hPa.<br><br>
11. Canister according to one of claims 1 to 8, wherein the container withstands a bursting pressure of more than 200,000 hPa.<br><br>
12. Canister according to one of claims 1 to 11, wherein the container has a wall thickness of 0.1 to 0.5 mm.<br><br>
13. Canister according to one of claims 1 to 11, wherein the container has a wall thickness of 0.15 to 0.35 mm.<br><br> INTELLECTUAL PROPERTY OFRCE OF M.Z<br><br> 19 MAR 2C03 Received<br><br> i3<br><br> - 14 -<br><br>
14. Canister according to one of claims 1 to 13, wherein the propellant is 1,1,2,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane.<br><br> 5
15. Canister according to one of claims 1 to 14 wherein the canister further includes an acid.<br><br>
16. Canister according to claim 15, wherein the acid is citric acid or a mineral acid.<br><br> 10<br><br>
17. Container for use in propellant-operated metering aerosols, which exhibits corrosion resistance in the presence of active substances for inhalation therapy containing fluorohydrocarbon propellants the container<br><br> 15 consisting of an alloy defined in claim 1 or 2.<br><br>
18. Container according to claim 17, wherein the container withstands a bursting pressure of more than 30,000 hPa.<br><br> 20
19. Container according to claim 17, wherein the container withstands a bursting pressure of more than 100,000 hPa.<br><br>
20. Container according to claim 17, wherein the container withstands a bursting pressure of more than 200,000 hPa.<br><br> 25<br><br>
21. Container according to one of claims 17 to 20, wherein the container has a wall thickness of 0.1 to 0.5 mm.<br><br>
22. Container according to claim 21, wherein the container 30 has a wall thickness of 0.15 to 0.35 mm.<br><br> 5<br><br> 1<br><br> 7<br><br> I*<br><br> - W ~<br><br> 10<br><br>
23. Use of a canister according to claims 1 to 16 in an inhaler and/or for storing active substance formulations.<br><br>
24. Use of a container according to one of claims 17 to 22 in an inhaler and/or for storing active substance formulations.<br><br>
25. A canister according to any one of claims 1 to 16 substantially as herein described.<br><br>
26. A canister according to any one of claims 1 to 16 substantially as herein described with reference to any one of Examples 1 to 6 or Figures 1 and 2.<br><br>
27. A canister substantially as herein described with reference to any one of Examples 1 to 6 or Figures 1 and 2.<br><br>
28. A container according to any one of claims 17 to 22 substantially as herein described.<br><br>
29. A container according to any one of claims 17 to 22 substantially as herein described with reference to any one of Examples 1 to 6 or Figures.1 and 2.<br><br>
30. A container substantially as herein described with reference to any one of Examples 1 to 6 or Figures 1 and 2.<br><br>
31. Use according to claim 23 or claim 24 substantially as herein described.<br><br> 1 9 MAR 2003<br><br> received<br><br> 51631':<br><br> - >6 -<br><br>
32. Use according to claim 23 or claim 24 substantially as herein described with reference to any one of Examples 1 to 6 or Figures 1 and 2.<br><br> BOEHRINGER INGELHEIM PHARMA KG<br><br> By its Attorneys BALDWIN SHELSTON WATERS<br><br> - 16 -<br><br> Abstract<br><br> The present invention relates to corrosion resistant stainless steel canisters for propellant-containing aerosol formulations for use in propellant gas-operated inhalers.<br><br> </p> </div>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924098A DE19924098A1 (en) | 1999-05-26 | 1999-05-26 | Stainless steel canister for propellant-powered MDIs |
PCT/EP2000/004662 WO2000073170A1 (en) | 1999-05-26 | 2000-05-24 | Special steel canister for propellant-operated dosing aerosols |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ516317A true NZ516317A (en) | 2003-07-25 |
Family
ID=7909229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ516317A NZ516317A (en) | 1999-05-26 | 2000-05-24 | Stainless steel canister for propellant operated metering aerosols |
Country Status (37)
Country | Link |
---|---|
EP (2) | EP1413528A3 (en) |
JP (1) | JP4048027B2 (en) |
KR (1) | KR100715138B1 (en) |
CN (1) | CN1106999C (en) |
AR (1) | AR024113A1 (en) |
AT (1) | ATE289276T1 (en) |
AU (1) | AU772768B2 (en) |
BG (1) | BG64861B1 (en) |
BR (1) | BR0011546A (en) |
CA (1) | CA2373094C (en) |
CO (1) | CO5271757A1 (en) |
CZ (1) | CZ305422B6 (en) |
DE (2) | DE19924098A1 (en) |
EA (1) | EA003690B1 (en) |
EE (1) | EE04394B1 (en) |
EG (1) | EG22571A (en) |
ES (1) | ES2238292T3 (en) |
HK (1) | HK1045973B (en) |
HR (1) | HRP20010874B1 (en) |
HU (1) | HU224648B1 (en) |
IL (2) | IL146713A0 (en) |
ME (1) | ME01657B (en) |
MX (1) | MXPA01011839A (en) |
MY (1) | MY128067A (en) |
NO (1) | NO325134B1 (en) |
NZ (1) | NZ516317A (en) |
PE (1) | PE20010107A1 (en) |
PL (1) | PL205866B1 (en) |
PT (1) | PT1198395E (en) |
RS (1) | RS49749B (en) |
SK (1) | SK286477B6 (en) |
TR (1) | TR200103410T2 (en) |
TW (1) | TW522124B (en) |
UA (1) | UA74338C2 (en) |
UY (1) | UY26165A1 (en) |
WO (1) | WO2000073170A1 (en) |
ZA (1) | ZA200109597B (en) |
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GB9616237D0 (en) | 1996-08-01 | 1996-09-11 | Norton Healthcare Ltd | Aerosol formulations |
US6739333B1 (en) | 1999-05-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Stainless steel canister for propellant-driven metering aerosols |
GB0106046D0 (en) | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Canister |
DE20218974U1 (en) * | 2002-12-07 | 2003-07-10 | Boehringer Ingelheim Pharma | Atomizers for liquids |
DE102005002444A1 (en) * | 2005-01-19 | 2006-07-27 | Wella Ag | Container with a valve |
CA2618048C (en) | 2005-08-12 | 2010-12-07 | Jfe Steel Corporation | Two-piece can, method for manufacturing same, and steel sheet therefor |
CN100447283C (en) * | 2006-01-13 | 2008-12-31 | 宝山钢铁股份有限公司 | Stainless teel casting material for anti-high temp, sulfide, ammonium salt corrosion and mfg. process thereof |
WO2007107174A1 (en) * | 2006-03-21 | 2007-09-27 | Coster Tecnologie Speciali S.P.A. | Structural unit for a dispensing valve for dispensing pressurized fluids, and container having a structural unit of this type |
JP4972771B2 (en) | 2006-12-05 | 2012-07-11 | Jfeスチール株式会社 | Method for producing aerosol drawn can and aerosol drawn can |
EP2201934A1 (en) | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Tiotropium aerosol formulation products with improved chemical stability |
GB201205243D0 (en) | 2012-03-26 | 2012-05-09 | Kraft Foods R & D Inc | Packaging and method of opening |
CA2896275A1 (en) * | 2012-12-24 | 2014-07-03 | Petapak Ip Limited | Mounting cup and collar assembly for plastics aerosol container |
GB2511560B (en) | 2013-03-07 | 2018-11-14 | Mondelez Uk R&D Ltd | Improved Packaging and Method of Forming Packaging |
GB2511559B (en) | 2013-03-07 | 2018-11-14 | Mondelez Uk R&D Ltd | Improved Packaging and Method of Forming Packaging |
FR3065176B1 (en) * | 2017-04-13 | 2019-06-07 | Aptar France Sas | DOSING VALVE FOR FLUID PRODUCT DISPENSER |
CN113768906B (en) * | 2021-10-25 | 2023-05-09 | 上海方予健康医药科技有限公司 | Novel glucocorticoid inhalation aerosol and pharmaceutical assembly |
CN114293103B (en) * | 2021-12-31 | 2022-07-29 | 台州绿创包装容器股份有限公司 | Metal aerosol can |
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JPH0539545A (en) * | 1991-08-03 | 1993-02-19 | Nippon Steel Corp | Stainless steel for ultrahigh vacuum equipment excellent in corrosion resistance and production of ultrahigh vacuum vessel |
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1999
- 1999-05-26 DE DE19924098A patent/DE19924098A1/en not_active Ceased
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2000
- 2000-05-24 CZ CZ2001-4225A patent/CZ305422B6/en not_active IP Right Cessation
- 2000-05-24 HU HU0201330A patent/HU224648B1/en active IP Right Grant
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- 2000-05-24 CO CO00038310A patent/CO5271757A1/en active IP Right Grant
- 2000-05-24 SK SK1709-2001A patent/SK286477B6/en not_active IP Right Cessation
- 2000-05-24 JP JP2000621251A patent/JP4048027B2/en not_active Expired - Lifetime
- 2000-05-24 AT AT00943730T patent/ATE289276T1/en active
- 2000-05-24 UA UA2001129044A patent/UA74338C2/en unknown
- 2000-05-24 KR KR1020017014997A patent/KR100715138B1/en active IP Right Grant
- 2000-05-24 CN CN00808003A patent/CN1106999C/en not_active Expired - Lifetime
- 2000-05-24 EG EG20000668A patent/EG22571A/en active
- 2000-05-24 ME MEP-2001-833A patent/ME01657B/en unknown
- 2000-05-24 EP EP03027354A patent/EP1413528A3/en not_active Withdrawn
- 2000-05-24 PL PL352052A patent/PL205866B1/en unknown
- 2000-05-24 EP EP00943730A patent/EP1198395B1/en not_active Expired - Lifetime
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- 2000-05-24 CA CA2373094A patent/CA2373094C/en not_active Expired - Lifetime
- 2000-05-24 PT PT00943730T patent/PT1198395E/en unknown
- 2000-05-24 AU AU58092/00A patent/AU772768B2/en not_active Expired
- 2000-05-24 WO PCT/EP2000/004662 patent/WO2000073170A1/en active IP Right Grant
- 2000-05-24 TR TR2001/03410T patent/TR200103410T2/en unknown
- 2000-05-24 DE DE50009558T patent/DE50009558D1/en not_active Expired - Lifetime
- 2000-05-24 EA EA200101158A patent/EA003690B1/en not_active IP Right Cessation
- 2000-05-24 MX MXPA01011839A patent/MXPA01011839A/en active IP Right Grant
- 2000-05-24 PE PE2000000495A patent/PE20010107A1/en active IP Right Grant
- 2000-05-24 BR BR0011546-0A patent/BR0011546A/en active Pending
- 2000-05-24 NZ NZ516317A patent/NZ516317A/en not_active IP Right Cessation
- 2000-05-24 IL IL14671300A patent/IL146713A0/en active IP Right Grant
- 2000-05-25 UY UY26165A patent/UY26165A1/en not_active IP Right Cessation
- 2000-05-26 AR ARP000102576A patent/AR024113A1/en active Pending
- 2000-05-26 TW TW089110269A patent/TW522124B/en not_active IP Right Cessation
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2001
- 2001-11-13 BG BG106108A patent/BG64861B1/en active Active
- 2001-11-21 ZA ZA200109597A patent/ZA200109597B/en unknown
- 2001-11-23 IL IL146713A patent/IL146713A/en not_active IP Right Cessation
- 2001-11-23 NO NO20015718A patent/NO325134B1/en not_active IP Right Cessation
- 2001-11-23 HR HR20010874A patent/HRP20010874B1/en not_active IP Right Cessation
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2002
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