CA2373094A1 - Stainless steel canister for propellant-driven metering aerosols - Google Patents
Stainless steel canister for propellant-driven metering aerosols Download PDFInfo
- Publication number
- CA2373094A1 CA2373094A1 CA002373094A CA2373094A CA2373094A1 CA 2373094 A1 CA2373094 A1 CA 2373094A1 CA 002373094 A CA002373094 A CA 002373094A CA 2373094 A CA2373094 A CA 2373094A CA 2373094 A1 CA2373094 A1 CA 2373094A1
- Authority
- CA
- Canada
- Prior art keywords
- container
- canister
- valve
- alloy
- canister according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C38/00—Ferrous alloys, e.g. steel alloys
- C22C38/18—Ferrous alloys, e.g. steel alloys containing chromium
- C22C38/40—Ferrous alloys, e.g. steel alloys containing chromium with nickel
- C22C38/44—Ferrous alloys, e.g. steel alloys containing chromium with nickel with molybdenum or tungsten
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/38—Details of the container body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C38/00—Ferrous alloys, e.g. steel alloys
- C22C38/18—Ferrous alloys, e.g. steel alloys containing chromium
- C22C38/40—Ferrous alloys, e.g. steel alloys containing chromium with nickel
- C22C38/42—Ferrous alloys, e.g. steel alloys containing chromium with nickel with copper
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Nozzles (AREA)
- Safety Valves (AREA)
Abstract
The present invention relates to corrosion resistant stainless steel canisters for propellant-containing aerosol formulations for use in propellant gas-operated inhalers.
Claims (26)
1. Canister (1) for propellant operated metering aerosols consisting of a container (2) and a valve cup (8) with valve (9) embedded therein, characterised in that the container consists of an alloy containing 40.0 - 53.0%
iron, 23.0 - 28.0% nickel, 19.0 - 23.0% chromium, 4.0 - 5.0% molybdenum, 0.0 - 2.0% manganese, 1.0 - 2.0%
copper, 0.0 - 1.0% silicon, 0.0 - 0.045% of phosphorus, 0.0 - 0.035% sulphur and 0.0 - 0.020% carbon.
iron, 23.0 - 28.0% nickel, 19.0 - 23.0% chromium, 4.0 - 5.0% molybdenum, 0.0 - 2.0% manganese, 1.0 - 2.0%
copper, 0.0 - 1.0% silicon, 0.0 - 0.045% of phosphorus, 0.0 - 0.035% sulphur and 0.0 - 0.020% carbon.
2. Canister according to claim 1, characterised in that the container consists of an alloy having the following composition: chromium 19.0 - 21.0%, nickel 24.0 - 26.0%, molybdenum 4.0 - 5.0%, copper 1.0 - 2.0%, manganese up to 2.0%, silicon up to 0.5% and carbon up to 0.02%, with iron substantially as the remaining ingredient.
3. Canister (1) for propellant-operated metering aerosols consisting of a container (2) and a. valve cup (8) with valve (9) embedded therein, characterised in that the container consists of an alloy having the following composition: iron 60.0 - 72.0%, nickel 9.0 - 13.0%, chromium 17.0 - 21.0%, molybdenum 2.0 - 3.0%, manganese 0.0 - 1.5%, silicon 0.0 - 1.5%, phosphorus 0.0 - 0.04%, sulphur 0.0 - 0.04% and carbon 0.0 - 0.03%.
4. Canister (1) for propellant-operated metering aerosols consisting of a container (2) and a valve cup (8) with valve (9) embedded therein, characterized in that the container consists of an alloy of 16.5 - 18.5% chromium, 11.0 - 14.0% nickel, 2.0 - 2.5% molybdenum, a maximum of 0.03% carbon and iron making up the remainder.
5. Canister according to one of claims 1 to 4, characterised in that the valve cup (8) consists of aluminium and is sealed with a gasket (10) and/or (18) relative to the interior of the container.
6. Canister according to one of claims 1 to 5, characterised in that the valve (9) contains one or more stainless steel springs (11), a valve stem (12), the metering chamber (13) and a valve body (14), the valve stem (12), the metering chamber (13) and/or the valve body (14) being made of steel, the alloy according to one of claims 1 to 3 and/or a plastic.
7. Canister according to one of claims 1 to 6, characterised in that the spring(s) (11) consist(s) of a stainless steel and the valve stem (12), the metering chamber (13) and the body of the valve (14) consist of polybutylene terephthalate.
8. Canister according to one of claims 1 to 7, characterised in that the valve stem (12) is sealed off from the valve cup (18) by a gasket (15) or (18).
9. Canister according to one of claims 1 to 8, characterised in that the gasket (10) and/or gasket (15) and/or gasket (18) consist or consists of an ethylene/propylene/diene terpolymer.
10. Canister according to one of claims 1 to 9, characterised in that the valve cup (8) consists of the same alloy as the container (2).
11. Canister according to one of claims 1 to 10, characterised in that the container withstands a bursting pressure of more than 30,, 000 hPa, preferably more than 100,000 hPa.
12. Canister according to one of claims 1 to 11, characterised in that the container withstands a bursting pressure of more than 200,000 hPa.
13. Canister according to one of claims 1 to 12, characterised in that the container has a wall thickness of 0.1 to 0.5 mm, preferably 0.15 to 0.35 mm.
14. Canister according to one of claims 1 to 13, characterised in that the container has a wall thickness of 0.19 to 3.0 mm.
15. Container for a canister (1) for propellant-operated metering aerosols, characterised in that the container consists of an alloy according to one of claims 1 to 4.
16. Container according to claim 15, characterised in that the container withstands a bursting pressure of more than 30,000 hPa, preferably more than 100,000 hPa.
17. Container according to claim 15, characterised in that the container withstands a bursting pressure of more than 200,000 hPa.
18. Container according to one of claims 15 to 17, characterised in that the container has a wall thickness of 0.1 to 0.5 mm, preferably 0.15 to 0.35 mm.
19. Container according to one of claims 15 to 18, characterised in that the container has a wall thickness of 0.19 to 3.0 mm.
20. Use of a canister according to claims 1 to 14 or a container according to one of claims 15 to 19 in an inhaler and/or for storing active substance formulations which contain 1,1,2,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane as propellants.
21. Use of a Canister according to claims 1 to 14 or a container according to one of claims 15 to 19 as in claim 20, characterised in that the formulation contains acid for stabilisation, ethanol as a cosolvent and ipatropium bromide, oxitropium bromide, tiotropium bromide, albuterol or fenoterol as active substance.
22. Use of a canister according to claims 1 to 14 or a container according to one of claims 15 to 19 as in claim 20 of 21, characterised in that the formulation contains acid for stabilisation, ethanol and ipatropium bromide, oxitropium bromide or tiotropium bromide as active substance.
23. Use of a canister according to Claims 1 to 14 or a container according to one of claims 15 to 19 as in claim 20, 21 or 22, characterised in that the formulation contains citric acid.
24. Use of a canister according to claims 1 to 14 or a container according to one of claims 15 to 19 as in claim 20, 21 or 22, characterised in that the formulation contains a mineral acid.
25. Use of a canister according to claims 1 to 14 or a container according to one of claims 15 to 19 as in claim 20, 21 or 22, characterised in that the formulation contains hydrochloric acid.
26. Process for producing a container (2) or a canister (1) consisting of a container (2) and a valve cup (8) with valve (9) embedded therein for propellant-operated metering aerosols, characterised in that the container (2) is stamped out from a sheet consisting of an alloy according to one of claims 1 to 4.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19924098A DE19924098A1 (en) | 1999-05-26 | 1999-05-26 | Stainless steel canister for propellant-powered MDIs |
| DE19924098.1 | 1999-05-26 | ||
| PCT/EP2000/004662 WO2000073170A1 (en) | 1999-05-26 | 2000-05-24 | Special steel canister for propellant-operated dosing aerosols |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2373094A1 true CA2373094A1 (en) | 2000-12-07 |
| CA2373094C CA2373094C (en) | 2012-07-17 |
Family
ID=7909229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2373094A Expired - Lifetime CA2373094C (en) | 1999-05-26 | 2000-05-24 | Stainless steel canister for propellant-driven metering aerosols |
Country Status (37)
| Country | Link |
|---|---|
| EP (2) | EP1198395B1 (en) |
| JP (1) | JP4048027B2 (en) |
| KR (1) | KR100715138B1 (en) |
| CN (1) | CN1106999C (en) |
| AR (1) | AR024113A1 (en) |
| AT (1) | ATE289276T1 (en) |
| AU (1) | AU772768B2 (en) |
| BG (1) | BG64861B1 (en) |
| BR (1) | BR0011546A (en) |
| CA (1) | CA2373094C (en) |
| CO (1) | CO5271757A1 (en) |
| CZ (1) | CZ305422B6 (en) |
| DE (2) | DE19924098A1 (en) |
| EA (1) | EA003690B1 (en) |
| EE (1) | EE04394B1 (en) |
| EG (1) | EG22571A (en) |
| ES (1) | ES2238292T3 (en) |
| HK (1) | HK1045973B (en) |
| HR (1) | HRP20010874B1 (en) |
| HU (1) | HU224648B1 (en) |
| IL (2) | IL146713A0 (en) |
| ME (1) | ME01657B (en) |
| MX (1) | MXPA01011839A (en) |
| MY (1) | MY128067A (en) |
| NO (1) | NO325134B1 (en) |
| NZ (1) | NZ516317A (en) |
| PE (1) | PE20010107A1 (en) |
| PL (1) | PL205866B1 (en) |
| PT (1) | PT1198395E (en) |
| RS (1) | RS49749B (en) |
| SK (1) | SK286477B6 (en) |
| TR (1) | TR200103410T2 (en) |
| TW (1) | TW522124B (en) |
| UA (1) | UA74338C2 (en) |
| UY (1) | UY26165A1 (en) |
| WO (1) | WO2000073170A1 (en) |
| ZA (1) | ZA200109597B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10479550B2 (en) | 2012-03-26 | 2019-11-19 | Kraft Foods R & D, Inc. | Packaging and method of opening |
| US10507970B2 (en) | 2013-03-07 | 2019-12-17 | Mondelez Uk R&D Limited | Confectionery packaging and method of opening |
| US10513388B2 (en) | 2013-03-07 | 2019-12-24 | Mondelez Uk R&D Limited | Packaging and method of opening |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9616237D0 (en) | 1996-08-01 | 1996-09-11 | Norton Healthcare Ltd | Aerosol formulations |
| US6739333B1 (en) | 1999-05-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Stainless steel canister for propellant-driven metering aerosols |
| GB0106046D0 (en) | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Canister |
| DE20218974U1 (en) * | 2002-12-07 | 2003-07-10 | Boehringer Ingelheim Pharma | Atomizers for liquids |
| DE102005002444A1 (en) * | 2005-01-19 | 2006-07-27 | Wella Ag | Container with a valve |
| EP2799160B1 (en) | 2005-08-12 | 2021-10-13 | JFE Steel Corporation | Method for forming two-piece can |
| CN100447283C (en) * | 2006-01-13 | 2008-12-31 | 宝山钢铁股份有限公司 | Stainless teel casting material for anti-high temp, sulfide, ammonium salt corrosion and mfg. process thereof |
| WO2007107174A1 (en) * | 2006-03-21 | 2007-09-27 | Coster Tecnologie Speciali S.P.A. | Structural unit for a dispensing valve for dispensing pressurized fluids, and container having a structural unit of this type |
| JP4972771B2 (en) | 2006-12-05 | 2012-07-11 | Ｊｆｅスチール株式会社 | Method for producing aerosol drawn can and aerosol drawn can |
| EP2201934A1 (en) | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Tiotropium aerosol formulation products with improved chemical stability |
| KR20150099602A (en) * | 2012-12-24 | 2015-08-31 | 페타팍 아이피 리미티드 | Mounting cup and collar assembly for plastics aerosol container |
| FR3065176B1 (en) * | 2017-04-13 | 2019-06-07 | Aptar France Sas | DOSING VALVE FOR FLUID PRODUCT DISPENSER |
| CN113768906B (en) * | 2021-10-25 | 2023-05-09 | 上海方予健康医药科技有限公司 | Novel glucocorticoid inhalation aerosol and pharmaceutical assembly |
| CN114293103B (en) * | 2021-12-31 | 2022-07-29 | 台州绿创包装容器股份有限公司 | Metal aerosol can |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB872052A (en) * | 1956-10-19 | 1961-07-05 | United States Steel Corp | Stainless steel resistant to nitric acid corrosion |
| FR2231766B1 (en) * | 1973-06-04 | 1976-09-17 | Creusot Loire | |
| FR2394618A1 (en) * | 1977-06-13 | 1979-01-12 | Commissariat Energie Atomique | AUSTENITIC STAINLESS STEEL |
| DE3724629A1 (en) * | 1987-07-22 | 1989-02-02 | Siemens Ag | PIEZOELECTRICALLY REQUIRED RESONANCE SYSTEM |
| DE3736579C3 (en) * | 1987-10-26 | 1996-10-17 | Mannesmann Ag | Pressure tank for storing gases of high purity |
| JPH02195543A (en) * | 1989-01-24 | 1990-08-02 | Sumitomo Metal Mining Co Ltd | Magneto-optical disk |
| US5340838A (en) * | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
| JP3001614B2 (en) * | 1990-07-11 | 2000-01-24 | 日新製鋼株式会社 | Extremely soft austenitic stainless steel |
| DE4112303A1 (en) * | 1991-04-15 | 1992-10-22 | Minnesota Mining & Mfg | Nitroglycerin, propellant gas-free spray prepn. - stored in container in which the steel parts are made of V4A series steels to inhibit nitroglycerin decomposition |
| JPH0539545A (en) * | 1991-08-03 | 1993-02-19 | Nippon Steel Corp | Stainless steel for ultrahigh vacuum equipment excellent in corrosion resistance and production of ultrahigh vacuum vessel |
| ES2099415T3 (en) * | 1991-12-18 | 1997-05-16 | Minnesota Mining & Mfg | SUSPENSION AEROSOL FORMULATIONS. |
| JPH05340838A (en) * | 1992-06-04 | 1993-12-24 | Ricoh Co Ltd | Method and instrument for measuring eccentricity of aspherical lens |
| FR2711674B1 (en) * | 1993-10-21 | 1996-01-12 | Creusot Loire | Austenitic stainless steel with high characteristics having great structural stability and uses. |
| DE69412626T2 (en) * | 1993-07-15 | 1999-01-28 | Minnesota Mining & Mfg | GASKETS FOR AN AEROSOL DISPENSER |
| US5421492A (en) * | 1993-11-02 | 1995-06-06 | Glaxo Inc. | Metered aerosol dispensing apparatus and method of use thereof |
| US5513767A (en) * | 1994-01-03 | 1996-05-07 | Materials Engineering Inc. | Pressurized container |
| DE19504502A1 (en) * | 1995-02-13 | 1996-08-14 | Henkel Kgaa | Corrosive agent and dispenser |
| JP3514889B2 (en) * | 1995-10-04 | 2004-03-31 | 株式会社日本製鋼所 | Austenitic stainless clad steel sheet with excellent corrosion resistance and method for producing the same |
-
1999
- 1999-05-26 DE DE19924098A patent/DE19924098A1/en not_active Ceased
-
2000
- 2000-05-24 PT PT00943730T patent/PT1198395E/en unknown
- 2000-05-24 CO CO00038310A patent/CO5271757A1/en active IP Right Grant
- 2000-05-24 EP EP00943730A patent/EP1198395B1/en not_active Expired - Lifetime
- 2000-05-24 DE DE50009558T patent/DE50009558D1/en not_active Expired - Lifetime
- 2000-05-24 CA CA2373094A patent/CA2373094C/en not_active Expired - Lifetime
- 2000-05-24 SK SK1709-2001A patent/SK286477B6/en not_active IP Right Cessation
- 2000-05-24 KR KR1020017014997A patent/KR100715138B1/en active IP Right Grant
- 2000-05-24 PE PE2000000495A patent/PE20010107A1/en active IP Right Grant
- 2000-05-24 NZ NZ516317A patent/NZ516317A/en not_active IP Right Cessation
- 2000-05-24 ME MEP-2001-833A patent/ME01657B/en unknown
- 2000-05-24 WO PCT/EP2000/004662 patent/WO2000073170A1/en active IP Right Grant
- 2000-05-24 AT AT00943730T patent/ATE289276T1/en active
- 2000-05-24 EA EA200101158A patent/EA003690B1/en not_active IP Right Cessation
- 2000-05-24 EG EG20000668A patent/EG22571A/en active
- 2000-05-24 MY MYPI20002274A patent/MY128067A/en unknown
- 2000-05-24 IL IL14671300A patent/IL146713A0/en active IP Right Grant
- 2000-05-24 ES ES00943730T patent/ES2238292T3/en not_active Expired - Lifetime
- 2000-05-24 HU HU0201330A patent/HU224648B1/en active IP Right Grant
- 2000-05-24 AU AU58092/00A patent/AU772768B2/en not_active Expired
- 2000-05-24 CN CN00808003A patent/CN1106999C/en not_active Expired - Lifetime
- 2000-05-24 RS YUP-833/01A patent/RS49749B/en unknown
- 2000-05-24 CZ CZ2001-4225A patent/CZ305422B6/en not_active IP Right Cessation
- 2000-05-24 BR BR0011546-0A patent/BR0011546A/en active Pending
- 2000-05-24 EE EEP200100620A patent/EE04394B1/en unknown
- 2000-05-24 UA UA2001129044A patent/UA74338C2/en unknown
- 2000-05-24 PL PL352052A patent/PL205866B1/en unknown
- 2000-05-24 EP EP03027354A patent/EP1413528A3/en not_active Withdrawn
- 2000-05-24 MX MXPA01011839A patent/MXPA01011839A/en active IP Right Grant
- 2000-05-24 JP JP2000621251A patent/JP4048027B2/en not_active Expired - Lifetime
- 2000-05-24 TR TR2001/03410T patent/TR200103410T2/en unknown
- 2000-05-25 UY UY26165A patent/UY26165A1/en not_active IP Right Cessation
- 2000-05-26 AR ARP000102576A patent/AR024113A1/en active Pending
- 2000-05-26 TW TW089110269A patent/TW522124B/en not_active IP Right Cessation
-
2001
- 2001-11-13 BG BG106108A patent/BG64861B1/en active Active
- 2001-11-21 ZA ZA200109597A patent/ZA200109597B/en unknown
- 2001-11-23 HR HR20010874A patent/HRP20010874B1/en not_active IP Right Cessation
- 2001-11-23 NO NO20015718A patent/NO325134B1/en not_active IP Right Cessation
- 2001-11-23 IL IL146713A patent/IL146713A/en not_active IP Right Cessation
-
2002
- 2002-10-16 HK HK02107496.2A patent/HK1045973B/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10479550B2 (en) | 2012-03-26 | 2019-11-19 | Kraft Foods R & D, Inc. | Packaging and method of opening |
| US10507970B2 (en) | 2013-03-07 | 2019-12-17 | Mondelez Uk R&D Limited | Confectionery packaging and method of opening |
| US10513388B2 (en) | 2013-03-07 | 2019-12-24 | Mondelez Uk R&D Limited | Packaging and method of opening |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20200524 |