NZ516097A - Method of promoting bone growth with hyaluronic acid and growth factors - Google Patents
Method of promoting bone growth with hyaluronic acid and growth factorsInfo
- Publication number
- NZ516097A NZ516097A NZ516097A NZ51609700A NZ516097A NZ 516097 A NZ516097 A NZ 516097A NZ 516097 A NZ516097 A NZ 516097A NZ 51609700 A NZ51609700 A NZ 51609700A NZ 516097 A NZ516097 A NZ 516097A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hyaluronic acid
- bone growth
- growth
- promoting bone
- growth factors
- Prior art date
Links
- 230000008468 bone growth Effects 0.000 title abstract 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 239000003102 growth factor Substances 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 230000001737 promoting effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/360,543 US6221854B1 (en) | 1996-03-05 | 1999-07-26 | Method of promoting bone growth with hyaluronic acid and growth factors |
| PCT/US2000/020373 WO2001007056A1 (en) | 1999-07-26 | 2000-07-26 | Method of promoting bone growth with hyaluronic acid and growth factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ516097A true NZ516097A (en) | 2004-02-27 |
Family
ID=23418431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ516097A NZ516097A (en) | 1999-07-26 | 2000-07-26 | Method of promoting bone growth with hyaluronic acid and growth factors |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6221854B1 (https=) |
| EP (1) | EP1198235A4 (https=) |
| JP (2) | JP2003505422A (https=) |
| AU (1) | AU777328B2 (https=) |
| CA (1) | CA2378328A1 (https=) |
| NZ (1) | NZ516097A (https=) |
| WO (1) | WO2001007056A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| US20110207666A1 (en) * | 1996-03-05 | 2011-08-25 | Depuy Spine, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| US20050043234A1 (en) * | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| US6907679B2 (en) * | 1998-11-12 | 2005-06-21 | Qlt Usa, Inc. | Method for lyophilizing an active agent |
| US6722054B2 (en) | 1998-11-12 | 2004-04-20 | Atrix Laboratories, Inc. | Process and delivery container for lyophilizing active agent |
| US6566144B1 (en) * | 2000-03-27 | 2003-05-20 | Atrix Laboratories | Cover plate for use in lyophilization |
| WO2002085422A1 (en) * | 2001-04-25 | 2002-10-31 | Eidgenössische Technische Hochschule Zürich | Drug delivery matrices to enhance wound healing |
| US7008626B2 (en) | 2001-11-05 | 2006-03-07 | Seikagaku Corporation | Medical composition for protuberance of epithelium |
| US7247609B2 (en) * | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| JP5449638B2 (ja) * | 2002-07-31 | 2014-03-19 | デンツプライ インターナショナル インコーポレーテッド | 多孔性粒子およびキャリアゲルを含む骨修復パテ |
| US8876532B2 (en) | 2002-07-31 | 2014-11-04 | Dentsply International Inc. | Bone repair putty |
| ES2493840T3 (es) * | 2002-10-07 | 2014-09-12 | Zymogenetics, Inc. | Procedimiento de administración de FGF-18 |
| WO2004062588A2 (en) * | 2003-01-06 | 2004-07-29 | University Of Utah | Water-soluble polymeric bone-targeting drug delivery system |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| FR2866571B1 (fr) * | 2004-02-20 | 2007-09-21 | Philippe Zanchetta | Utilisation d'un melange de polysaccharides specifiques denomme par l'inventeur ezbone, comprenant de l'acide hyaluronique, de la chondroitine 6 sulfate, du dermatane sulfate et de l'heparine en cicatrisation osseuse. |
| ES2706848T3 (es) | 2004-07-06 | 2019-04-01 | Zymogenetics Inc | Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20060147443A1 (en) * | 2004-12-22 | 2006-07-06 | Kuros Biosurgery Ag | Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| MX2007008319A (es) * | 2005-01-06 | 2007-10-04 | Kuros Biosurgery Ag | Matrices suplementadas para la reparacion de fracturas oseas. |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| AU2006286158A1 (en) * | 2005-09-02 | 2007-03-08 | Colbar Lifescience Ltd. | Cross-linked polysaccharide and protein matrices and methods for their preparation |
| JP2009508596A (ja) | 2005-09-19 | 2009-03-05 | ヒストジェニックス コーポレイション | 細胞支持基材及びその調製方法 |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US20080255041A1 (en) * | 2007-04-11 | 2008-10-16 | Ebi, L.P. | Treatment of annulus fibrosis defects |
| US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
| US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| WO2009012367A1 (en) * | 2007-07-18 | 2009-01-22 | Aesthetic Science | Composition and method of use for soft tissue augmentation/drug delivery |
| CN101855248B (zh) * | 2007-11-13 | 2012-08-22 | 生物技术通用（以色列）有限公司 | 用于粘弹性生物聚合物的稀释过滤灭菌方法 |
| WO2009111069A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| EP2686027B1 (en) | 2011-03-16 | 2021-05-05 | Kuros Biosurgery AG | Pharmaceutical formulation for use in spinal fusion |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| EP3411647A4 (en) | 2016-02-05 | 2019-09-25 | Tolmar Therapeutics, Inc. | VENTED COVER PLATE FOR AN ARRANGEMENT OF SPRAY |
| US20210155896A1 (en) * | 2017-06-28 | 2021-05-27 | Rutgers, The State University Of New Jersey | Single brain cell-derived organoids |
| US11834680B2 (en) | 2017-06-28 | 2023-12-05 | Rutgers, The State University Of New Jersey | Single kidney cell-derived organoids |
| USD908916S1 (en) | 2018-06-19 | 2021-01-26 | Tolmar Therapeutics, Inc. | Syringe restrictor plate |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
| US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4409332A (en) | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| IT1212892B (it) * | 1983-10-11 | 1989-11-30 | Della Valle Francesco | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
| US5128326A (en) | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| US5133755A (en) * | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
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| US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5079236A (en) * | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
| NZ226171A (en) | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| JPH02213A (ja) | 1987-10-19 | 1990-01-05 | Taiho Yakuhin Kogyo Kk | 生理活性ペプチド持続製剤 |
| GB2215209B (en) * | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
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| US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
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| US5100668A (en) | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
| US5202311A (en) | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
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| DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
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| US5344644A (en) | 1991-08-01 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release |
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| SE469653B (sv) | 1992-01-13 | 1993-08-16 | Lucocer Ab | Poroest implantat |
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| US5399352A (en) | 1993-04-14 | 1995-03-21 | Emory University | Device for local drug delivery and methods for using the same |
| US5531794A (en) * | 1993-09-13 | 1996-07-02 | Asahi Kogaku Kogyo Kabushiki Kaisha | Ceramic device providing an environment for the promotion and formation of new bone |
| ES2225840T3 (es) * | 1994-03-08 | 2005-03-16 | Osteosa Liquidation Trust | Utilizacion de factores de crecimiento de fibroblasto para estimular el crecimiento oseo. |
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| RU2165415C2 (ru) * | 1996-02-27 | 2001-04-20 | Санкио Компани Лимитед | Производные изоксазола и фармацевтическая композиция на их основе |
| US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| CA2246747C (en) | 1996-03-05 | 2011-01-04 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| US6645945B1 (en) * | 1996-03-05 | 2003-11-11 | Depuy Acromed, Inc. | Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors |
| NZ331238A (en) * | 1996-03-05 | 2000-05-26 | Orquest Inc | Method of promoting bone growth with hyaluronic acid and growth factors (bFGF) |
| JP2002504083A (ja) * | 1996-03-05 | 2002-02-05 | オーケスト インコーポレイテッド | ヒアルロン酸および増殖因子による骨の増殖を促進する方法 |
| KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
| IT1288290B1 (it) * | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
| WO1998014222A1 (en) * | 1996-09-30 | 1998-04-09 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
| JP4388602B2 (ja) | 1997-02-07 | 2009-12-24 | ストライカー コーポレイション | マトリクスを含まない骨形成デバイス、移植片、およびその使用方法 |
| JP4247846B2 (ja) * | 1997-07-03 | 2009-04-02 | デュピュイ・スパイン・インコーポレーテッド | 架橋ポリサッカリド薬物キャリア |
-
1999
- 1999-07-26 US US09/360,543 patent/US6221854B1/en not_active Expired - Lifetime
-
2000
- 2000-07-26 EP EP00950736A patent/EP1198235A4/en not_active Ceased
- 2000-07-26 AU AU63797/00A patent/AU777328B2/en not_active Ceased
- 2000-07-26 CA CA002378328A patent/CA2378328A1/en not_active Abandoned
- 2000-07-26 JP JP2001511940A patent/JP2003505422A/ja active Pending
- 2000-07-26 NZ NZ516097A patent/NZ516097A/xx not_active IP Right Cessation
- 2000-07-26 WO PCT/US2000/020373 patent/WO2001007056A1/en not_active Ceased
-
2001
- 2001-04-03 US US09/825,688 patent/US6703377B2/en not_active Expired - Fee Related
-
2004
- 2004-03-08 US US10/796,441 patent/US7902172B2/en not_active Expired - Fee Related
-
2009
- 2009-02-12 JP JP2009030095A patent/JP2009143949A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US6703377B2 (en) | 2004-03-09 |
| JP2003505422A (ja) | 2003-02-12 |
| EP1198235A4 (en) | 2006-04-05 |
| AU777328B2 (en) | 2004-10-14 |
| EP1198235A1 (en) | 2002-04-24 |
| AU6379700A (en) | 2001-02-13 |
| US7902172B2 (en) | 2011-03-08 |
| US6221854B1 (en) | 2001-04-24 |
| US20040176295A1 (en) | 2004-09-09 |
| WO2001007056A1 (en) | 2001-02-01 |
| US20010014664A1 (en) | 2001-08-16 |
| CA2378328A1 (en) | 2001-02-01 |
| JP2009143949A (ja) | 2009-07-02 |
| WO2001007056A9 (en) | 2002-07-25 |
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