JP2003505422A5 - - Google Patents
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- Publication number
- JP2003505422A5 JP2003505422A5 JP2001511940A JP2001511940A JP2003505422A5 JP 2003505422 A5 JP2003505422 A5 JP 2003505422A5 JP 2001511940 A JP2001511940 A JP 2001511940A JP 2001511940 A JP2001511940 A JP 2001511940A JP 2003505422 A5 JP2003505422 A5 JP 2003505422A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hyaluronic acid
- site
- growth
- bone growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
- 230000008468 bone growth Effects 0.000 claims 6
- 229920002674 hyaluronan Polymers 0.000 claims 6
- 229960003160 hyaluronic acid Drugs 0.000 claims 6
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 4
- 239000003102 growth factor Substances 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/360,543 | 1999-07-26 | ||
| US09/360,543 US6221854B1 (en) | 1996-03-05 | 1999-07-26 | Method of promoting bone growth with hyaluronic acid and growth factors |
| PCT/US2000/020373 WO2001007056A1 (en) | 1999-07-26 | 2000-07-26 | Method of promoting bone growth with hyaluronic acid and growth factors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009030095A Division JP2009143949A (ja) | 1999-07-26 | 2009-02-12 | ヒアルロン酸と成長因子を用いた骨成長促進方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003505422A JP2003505422A (ja) | 2003-02-12 |
| JP2003505422A5 true JP2003505422A5 (https=) | 2012-06-07 |
Family
ID=23418431
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001511940A Pending JP2003505422A (ja) | 1999-07-26 | 2000-07-26 | ヒアルロン酸と成長因子を用いた骨成長促進方法 |
| JP2009030095A Pending JP2009143949A (ja) | 1999-07-26 | 2009-02-12 | ヒアルロン酸と成長因子を用いた骨成長促進方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009030095A Pending JP2009143949A (ja) | 1999-07-26 | 2009-02-12 | ヒアルロン酸と成長因子を用いた骨成長促進方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6221854B1 (https=) |
| EP (1) | EP1198235A4 (https=) |
| JP (2) | JP2003505422A (https=) |
| AU (1) | AU777328B2 (https=) |
| CA (1) | CA2378328A1 (https=) |
| NZ (1) | NZ516097A (https=) |
| WO (1) | WO2001007056A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| US20110207666A1 (en) * | 1996-03-05 | 2011-08-25 | Depuy Spine, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| US20050043234A1 (en) * | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| US6907679B2 (en) * | 1998-11-12 | 2005-06-21 | Qlt Usa, Inc. | Method for lyophilizing an active agent |
| US6722054B2 (en) | 1998-11-12 | 2004-04-20 | Atrix Laboratories, Inc. | Process and delivery container for lyophilizing active agent |
| US6566144B1 (en) * | 2000-03-27 | 2003-05-20 | Atrix Laboratories | Cover plate for use in lyophilization |
| WO2002085422A1 (en) * | 2001-04-25 | 2002-10-31 | Eidgenössische Technische Hochschule Zürich | Drug delivery matrices to enhance wound healing |
| US7008626B2 (en) | 2001-11-05 | 2006-03-07 | Seikagaku Corporation | Medical composition for protuberance of epithelium |
| US7247609B2 (en) * | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| JP5449638B2 (ja) * | 2002-07-31 | 2014-03-19 | デンツプライ インターナショナル インコーポレーテッド | 多孔性粒子およびキャリアゲルを含む骨修復パテ |
| US8876532B2 (en) | 2002-07-31 | 2014-11-04 | Dentsply International Inc. | Bone repair putty |
| ES2493840T3 (es) * | 2002-10-07 | 2014-09-12 | Zymogenetics, Inc. | Procedimiento de administración de FGF-18 |
| WO2004062588A2 (en) * | 2003-01-06 | 2004-07-29 | University Of Utah | Water-soluble polymeric bone-targeting drug delivery system |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| FR2866571B1 (fr) * | 2004-02-20 | 2007-09-21 | Philippe Zanchetta | Utilisation d'un melange de polysaccharides specifiques denomme par l'inventeur ezbone, comprenant de l'acide hyaluronique, de la chondroitine 6 sulfate, du dermatane sulfate et de l'heparine en cicatrisation osseuse. |
| ES2706848T3 (es) | 2004-07-06 | 2019-04-01 | Zymogenetics Inc | Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20060147443A1 (en) * | 2004-12-22 | 2006-07-06 | Kuros Biosurgery Ag | Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| MX2007008319A (es) * | 2005-01-06 | 2007-10-04 | Kuros Biosurgery Ag | Matrices suplementadas para la reparacion de fracturas oseas. |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| AU2006286158A1 (en) * | 2005-09-02 | 2007-03-08 | Colbar Lifescience Ltd. | Cross-linked polysaccharide and protein matrices and methods for their preparation |
| JP2009508596A (ja) | 2005-09-19 | 2009-03-05 | ヒストジェニックス コーポレイション | 細胞支持基材及びその調製方法 |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US20080255041A1 (en) * | 2007-04-11 | 2008-10-16 | Ebi, L.P. | Treatment of annulus fibrosis defects |
| US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
| US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| WO2009012367A1 (en) * | 2007-07-18 | 2009-01-22 | Aesthetic Science | Composition and method of use for soft tissue augmentation/drug delivery |
| CN101855248B (zh) * | 2007-11-13 | 2012-08-22 | 生物技术通用（以色列）有限公司 | 用于粘弹性生物聚合物的稀释过滤灭菌方法 |
| WO2009111069A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| EP2686027B1 (en) | 2011-03-16 | 2021-05-05 | Kuros Biosurgery AG | Pharmaceutical formulation for use in spinal fusion |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| EP3411647A4 (en) | 2016-02-05 | 2019-09-25 | Tolmar Therapeutics, Inc. | VENTED COVER PLATE FOR AN ARRANGEMENT OF SPRAY |
| US20210155896A1 (en) * | 2017-06-28 | 2021-05-27 | Rutgers, The State University Of New Jersey | Single brain cell-derived organoids |
| US11834680B2 (en) | 2017-06-28 | 2023-12-05 | Rutgers, The State University Of New Jersey | Single kidney cell-derived organoids |
| USD908916S1 (en) | 2018-06-19 | 2021-01-26 | Tolmar Therapeutics, Inc. | Syringe restrictor plate |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
| US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4409332A (en) | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| IT1212892B (it) * | 1983-10-11 | 1989-11-30 | Della Valle Francesco | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
| US5128326A (en) | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| US5133755A (en) * | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
| US6005161A (en) * | 1986-01-28 | 1999-12-21 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
| US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5079236A (en) * | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
| NZ226171A (en) | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| JPH02213A (ja) | 1987-10-19 | 1990-01-05 | Taiho Yakuhin Kogyo Kk | 生理活性ペプチド持続製剤 |
| GB2215209B (en) * | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
| JP2820415B2 (ja) * | 1988-03-14 | 1998-11-05 | ティーエイチエム・バイオメディカル・インコーポレイテッド | 生分解性および骨形成性を有する移植骨片代用組成体 |
| US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5100668A (en) | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
| US5202311A (en) | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
| US5470829A (en) * | 1988-11-17 | 1995-11-28 | Prisell; Per | Pharmaceutical preparation |
| US5013714A (en) | 1988-12-15 | 1991-05-07 | Lindstrom Richard L | Viscoelastic solution |
| US5130418A (en) | 1989-05-02 | 1992-07-14 | California Biotechnology Inc. | Method to stabilize basic fibroblast growth factor |
| US5077049A (en) | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
| WO1991001720A1 (en) | 1989-08-07 | 1991-02-21 | Herman Wade Schlameus | Composition and method of promoting hard tissue healing |
| US5030457A (en) | 1989-08-28 | 1991-07-09 | Pharmaceutical Delivery Systems, Inc. | Bioerodible polymers useful for the controlled release of therapeutic agents |
| US5158934A (en) | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
| US5422340A (en) | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
| US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
| US5217954A (en) | 1990-04-04 | 1993-06-08 | Scios Nova Inc. | Formulations for stabilizing fibroblast growth factor |
| US5425769A (en) | 1990-04-23 | 1995-06-20 | Snyders, Jr.; Robert V. | Composition of material for osseous repair |
| ATE164080T1 (de) | 1990-05-10 | 1998-04-15 | Bechgaard Int Res | Pharmazeutische zubereitung enthaltend n- glykofurole und n-äthylenglykole |
| US5645591A (en) * | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| US5206354A (en) | 1990-11-23 | 1993-04-27 | American Cyanamid Company | Dna sequence encoding active fragment of fibroblast growth factor, hbf-2 |
| SE501217C2 (sv) * | 1990-12-06 | 1994-12-12 | Skandigen Ab | Cellproliferationsmatris och användning därav |
| JP3135138B2 (ja) | 1990-12-19 | 2001-02-13 | 科研製薬株式会社 | 骨疾患治療剤 |
| US5206023A (en) | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| US5143662A (en) | 1991-02-12 | 1992-09-01 | United States Surgical Corporation | Process for preparing particles of bioabsorbable polymer |
| JPH04282322A (ja) * | 1991-03-08 | 1992-10-07 | Denki Kagaku Kogyo Kk | 生物活性ペプチド製剤 |
| US5416071A (en) | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
| US5356629A (en) | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
| US5344644A (en) | 1991-08-01 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release |
| US5302397A (en) | 1991-11-19 | 1994-04-12 | Amsden Brian G | Polymer-based drug delivery system |
| WO1993010847A1 (en) | 1991-12-06 | 1993-06-10 | North Shore University Hospital Research Corporation | Method of reducing medical device related infections |
| US5482929A (en) | 1991-12-26 | 1996-01-09 | Kaken Pharmaceutical Co., Ltd. | Composition of stabilized fibroblast growth factor |
| SE469653B (sv) | 1992-01-13 | 1993-08-16 | Lucocer Ab | Poroest implantat |
| CA2117379C (en) * | 1992-02-14 | 1999-11-16 | Kypriacos A. Athanasiou | Multi-phase bioerodible implant/carrier and method of manufacturing and using same |
| US5348941A (en) | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
| US5318957A (en) | 1992-09-02 | 1994-06-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method of stimulating angiogenesis |
| US5399352A (en) | 1993-04-14 | 1995-03-21 | Emory University | Device for local drug delivery and methods for using the same |
| US5531794A (en) * | 1993-09-13 | 1996-07-02 | Asahi Kogaku Kogyo Kabushiki Kaisha | Ceramic device providing an environment for the promotion and formation of new bone |
| ES2225840T3 (es) * | 1994-03-08 | 2005-03-16 | Osteosa Liquidation Trust | Utilizacion de factores de crecimiento de fibroblasto para estimular el crecimiento oseo. |
| US5769899A (en) * | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
| US5577792A (en) * | 1995-02-21 | 1996-11-26 | Prince Corporation | Multiple visor system with aligned pivot axes |
| US5776193A (en) * | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
| RU2165415C2 (ru) * | 1996-02-27 | 2001-04-20 | Санкио Компани Лимитед | Производные изоксазола и фармацевтическая композиция на их основе |
| US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| CA2246747C (en) | 1996-03-05 | 2011-01-04 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| US6645945B1 (en) * | 1996-03-05 | 2003-11-11 | Depuy Acromed, Inc. | Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors |
| NZ331238A (en) * | 1996-03-05 | 2000-05-26 | Orquest Inc | Method of promoting bone growth with hyaluronic acid and growth factors (bFGF) |
| JP2002504083A (ja) * | 1996-03-05 | 2002-02-05 | オーケスト インコーポレイテッド | ヒアルロン酸および増殖因子による骨の増殖を促進する方法 |
| KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
| IT1288290B1 (it) * | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
| WO1998014222A1 (en) * | 1996-09-30 | 1998-04-09 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
| JP4388602B2 (ja) | 1997-02-07 | 2009-12-24 | ストライカー コーポレイション | マトリクスを含まない骨形成デバイス、移植片、およびその使用方法 |
| JP4247846B2 (ja) * | 1997-07-03 | 2009-04-02 | デュピュイ・スパイン・インコーポレーテッド | 架橋ポリサッカリド薬物キャリア |
-
1999
- 1999-07-26 US US09/360,543 patent/US6221854B1/en not_active Expired - Lifetime
-
2000
- 2000-07-26 EP EP00950736A patent/EP1198235A4/en not_active Ceased
- 2000-07-26 AU AU63797/00A patent/AU777328B2/en not_active Ceased
- 2000-07-26 CA CA002378328A patent/CA2378328A1/en not_active Abandoned
- 2000-07-26 JP JP2001511940A patent/JP2003505422A/ja active Pending
- 2000-07-26 NZ NZ516097A patent/NZ516097A/xx not_active IP Right Cessation
- 2000-07-26 WO PCT/US2000/020373 patent/WO2001007056A1/en not_active Ceased
-
2001
- 2001-04-03 US US09/825,688 patent/US6703377B2/en not_active Expired - Fee Related
-
2004
- 2004-03-08 US US10/796,441 patent/US7902172B2/en not_active Expired - Fee Related
-
2009
- 2009-02-12 JP JP2009030095A patent/JP2009143949A/ja active Pending
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