NZ503815A - Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal trauma - Google Patents

Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal trauma

Info

Publication number
NZ503815A
NZ503815A NZ503815A NZ50381598A NZ503815A NZ 503815 A NZ503815 A NZ 503815A NZ 503815 A NZ503815 A NZ 503815A NZ 50381598 A NZ50381598 A NZ 50381598A NZ 503815 A NZ503815 A NZ 503815A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
methoxy
trifluoromethyl
free base
Prior art date
Application number
NZ503815A
Other languages
English (en)
Inventor
Manuel Koller
Silvio Ofner
Robert Swoboda
Villar Esteban Pombo
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9723134.4A external-priority patent/GB9723134D0/en
Priority claimed from GBGB9723133.6A external-priority patent/GB9723133D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NZ503815A publication Critical patent/NZ503815A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
NZ503815A 1997-11-03 1998-10-30 Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal trauma NZ503815A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9723134.4A GB9723134D0 (en) 1997-11-03 1997-11-03 Organic compounds
GBGB9723133.6A GB9723133D0 (en) 1997-11-03 1997-11-03 Organic compounds
PCT/EP1998/006880 WO1999023073A1 (en) 1997-11-03 1998-10-30 Biphenyl derivatives as pharmaceuticals

Publications (1)

Publication Number Publication Date
NZ503815A true NZ503815A (en) 2002-05-31

Family

ID=26312535

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ503815A NZ503815A (en) 1997-11-03 1998-10-30 Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal trauma

Country Status (18)

Country Link
EP (1) EP1037876A1 (ja)
JP (1) JP2001521923A (ja)
KR (1) KR20010031699A (ja)
CN (1) CN1278249A (ja)
AR (1) AR016148A1 (ja)
AU (1) AU740448B2 (ja)
BR (1) BR9813897A (ja)
CA (1) CA2308151A1 (ja)
CO (1) CO5011067A1 (ja)
ID (1) ID24413A (ja)
IL (1) IL135580A0 (ja)
NO (1) NO20002321D0 (ja)
NZ (1) NZ503815A (ja)
PE (1) PE123599A1 (ja)
PL (1) PL339922A1 (ja)
SK (1) SK6412000A3 (ja)
TR (1) TR200001122T2 (ja)
WO (1) WO1999023073A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US8575364B2 (en) * 2008-10-30 2013-11-05 Janssen Pharmaceutica Nv Modulators of serotonin receptor
WO2010059393A1 (en) 2008-10-30 2010-05-27 Janssen Pharmaceutica Nv Serotonin receptor modulators
DE102009015697A1 (de) 2009-03-31 2010-10-07 Markus Dr. Heinrich Verfahren zur Arylierung von ringsubstituierten Phenolen und Phenylethern

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2114122A (en) * 1938-04-12 Alcohols and process fob making
DE674968C (de) * 1935-01-15 1939-04-26 Roehm & Haas Company Verfahren zur Herstellung von phenolartigen Aralkylaminoalkoholen
US2040039A (en) * 1935-02-26 1936-05-05 Rohm & Haas Phenolic morpholines
US2485550A (en) * 1946-06-25 1949-10-25 Hoffmann La Roche Quaternary salts of carbamic acid esters of tertiary-hydroxybenzyl-amines
US2493710A (en) * 1947-03-21 1950-01-03 Hoffmann La Roche Carbamic acid esters
US2872477A (en) * 1957-04-05 1959-02-03 Dow Chemical Co alpha-(dialkylamino)-6-phenyl-o-cresol esters
JPS5328150A (en) * 1976-08-25 1978-03-16 Sugai Chemical Ind Co Ltd Novel orthophenyl phenol derivative process for preparing same
CN1029227C (zh) * 1989-02-08 1995-07-05 大制药株式会社 苯衍生物的制备方法
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
JPH072655A (ja) * 1993-06-18 1995-01-06 Otsuka Pharmaceut Co Ltd 末梢神経変性修復又は保護剤
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
MX9703671A (es) * 1994-11-23 1997-12-31 Neurogen Corp Compuesto de aminometil arilo y ligandos selectivos del subtipo de receptor de la dopamina.
IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate

Also Published As

Publication number Publication date
CN1278249A (zh) 2000-12-27
ID24413A (id) 2000-07-20
NO20002321L (no) 2000-05-02
EP1037876A1 (en) 2000-09-27
IL135580A0 (en) 2001-05-20
PL339922A1 (en) 2001-01-15
AR016148A1 (es) 2001-06-20
TR200001122T2 (tr) 2000-08-21
CA2308151A1 (en) 1999-05-14
NO20002321D0 (no) 2000-05-02
BR9813897A (pt) 2000-09-26
KR20010031699A (ko) 2001-04-16
AU740448B2 (en) 2001-11-01
WO1999023073A1 (en) 1999-05-14
AU1487299A (en) 1999-05-24
PE123599A1 (es) 1999-12-20
CO5011067A1 (es) 2001-02-28
JP2001521923A (ja) 2001-11-13
SK6412000A3 (en) 2000-09-12

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