NZ500696A - Methods and compositions for treating inflammatory bowel disease comprising mycobacterial agents, including macrolides - Google Patents
Methods and compositions for treating inflammatory bowel disease comprising mycobacterial agents, including macrolidesInfo
- Publication number
- NZ500696A NZ500696A NZ500696A NZ50069698A NZ500696A NZ 500696 A NZ500696 A NZ 500696A NZ 500696 A NZ500696 A NZ 500696A NZ 50069698 A NZ50069698 A NZ 50069698A NZ 500696 A NZ500696 A NZ 500696A
- Authority
- NZ
- New Zealand
- Prior art keywords
- composition
- clarithromycin
- clofazimine
- agents
- inflammatory bowel
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 208000022559 Inflammatory bowel disease Diseases 0.000 title claims abstract description 27
- 239000003120 macrolide antibiotic agent Substances 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims description 21
- 229940041033 macrolides Drugs 0.000 title 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ517348A NZ517348A (en) | 1997-04-01 | 1998-04-01 | Use of a mycobacterial extract in the treatment of inflammatory bowel disease |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO5940A AUPO594097A0 (en) | 1997-04-01 | 1997-04-01 | Novel methods of treating inflammatory bowel disease |
| AUPO9785A AUPO978597A0 (en) | 1997-10-14 | 1997-10-14 | Methods of treating inflammatory bowel disease |
| PCT/AU1998/000222 WO1998043667A1 (en) | 1997-04-01 | 1998-04-01 | Methods and compositions for treating inflammatory bowel disease |
Publications (1)
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|---|---|
| NZ500696A true NZ500696A (en) | 2002-05-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ500696A NZ500696A (en) | 1997-04-01 | 1998-04-01 | Methods and compositions for treating inflammatory bowel disease comprising mycobacterial agents, including macrolides |
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| US6551632B2 (en) * | 1997-04-01 | 2003-04-22 | Thomas Julius Borody | Methods and compositions for treating inflammatory bowel disease |
| AUPP325398A0 (en) | 1998-04-30 | 1998-05-21 | Borody, Thomas J. | Improved method for eradicating h. pylori |
| JP2002536404A (ja) * | 1999-02-12 | 2002-10-29 | ワシントン ユニバーシティー | 炎症性腸疾患を治療するための好中球機能の刺激 |
| UY26380A1 (es) | 1999-10-08 | 2001-04-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| JP3369535B2 (ja) | 1999-11-09 | 2003-01-20 | 松下電器産業株式会社 | プラズマディスプレイ装置 |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| HRP20020781A2 (en) * | 2000-03-28 | 2004-12-31 | Biochemie Gmbh | Granulated particles with masked taste |
| CA2495537C (en) * | 2000-08-29 | 2010-03-30 | Nobex Corporation | Immunoregulatory compounds and derivatives and methods of treating diseases therewith |
| AU2002367773A1 (en) * | 2001-04-06 | 2003-11-03 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20030118329A1 (en) * | 2001-12-21 | 2003-06-26 | Pere Obrador | Video indexing using high resolution still images |
| AUPS088702A0 (en) * | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| EP1575951B1 (en) | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| JP4880448B2 (ja) | 2003-03-17 | 2012-02-22 | アフィナム ファーマシューティカルズ，インコーポレーテッド | 複数の抗生物質を含む組成物、及びそれを用いる方法 |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| WO2005046567A2 (en) * | 2003-09-10 | 2005-05-26 | Meena Shelgaonkar | Synergistic formulation of antioxidants and antimycobacterial agents: a method of making the same |
| CA2553775A1 (en) | 2004-01-20 | 2005-08-11 | Richard F. Harty | Compositions and methods of treatment for inflammatory diseases |
| NZ549661A (en) | 2004-02-06 | 2010-07-30 | Pharmatel R & D Pty Ltd As Tru | Use of aminosalicylates in diarrhoea-predominant irritable bowel syndrome |
| DE602005022175D1 (de) * | 2004-05-28 | 2010-08-19 | Salix Pharmaceuticals Inc | Prävention, behandlung und linderung strahlungsinduzierter enteritis |
| KR101299399B1 (ko) * | 2004-06-04 | 2013-08-22 | 아피늄 파마슈티컬스, 인크. | 치료제, 및 그의 제조 및 사용 방법 |
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| US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| US7452872B2 (en) * | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| WO2007067416A2 (en) * | 2005-12-05 | 2007-06-14 | Affinium Pharmaceuticals, Inc. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| CA2531261A1 (en) * | 2005-12-21 | 2007-06-21 | Institut Pasteur | Control of intestinal inflammatory syndromes with a preparation of killed or non infectious bacteria |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| US7541384B2 (en) | 2007-06-08 | 2009-06-02 | Axcan Pharma Inc. | Mesalamine suppository |
| US8436051B2 (en) | 2007-06-08 | 2013-05-07 | Aptalis Pharma Canada Inc. | Mesalamine suppository |
| US8217083B2 (en) * | 2007-06-08 | 2012-07-10 | Aptalis Pharma Canada Inc. | Mesalamine suppository |
| JP2011500552A (ja) * | 2007-10-10 | 2011-01-06 | ルピン・リミテッド | 胃腸障害を処置するための医薬用組み合わせおよび組成物 |
| US20090098088A1 (en) * | 2007-10-10 | 2009-04-16 | The Procter & Gamble Company | Methods And Kits For The Treatment Of Diverticular Conditions |
| US20090131343A1 (en) * | 2007-11-15 | 2009-05-21 | Ly Tam Phan | Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases |
| ES2708087T3 (es) | 2008-02-08 | 2019-04-08 | Red Hill Biopharma Ltd | Procedimientos y composiciones para tratar enfermedad inflamatoria intestinal |
| CN102014926A (zh) * | 2008-05-01 | 2011-04-13 | 宝洁公司 | 用于治疗炎性肠病的方法和试剂盒 |
| US20110082120A1 (en) * | 2009-10-05 | 2011-04-07 | Milne Jill C | Substituted thioacetic acid salicylate derivatives and their uses |
| PL2493471T3 (pl) | 2009-10-26 | 2020-10-19 | Borody | Nowa skojarzona terapia jelitowa |
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| TWI573590B (zh) * | 2011-09-20 | 2017-03-11 | 雷希爾生藥有限公司 | 治療自體免疫疾病之組成物及方法 |
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| ES2717282T3 (es) | 2012-07-27 | 2019-06-20 | Redhill Biopharma Ltd | Formulaciones y métodos para fabricar formulaciones para su uso en la evacuación colónica |
| EP3145510B8 (en) * | 2014-05-22 | 2021-10-27 | Kuenstner, John, Todd | Treatment of diseases using combination of ultraviolet blood irradiation and antibiotics |
| US10751351B2 (en) | 2016-02-26 | 2020-08-25 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
| LT3923914T (lt) | 2019-02-14 | 2023-07-25 | Debiopharm International S.A. | Afabicino kompozicija, jos gamybos būdas |
| US12414958B2 (en) | 2019-06-14 | 2025-09-16 | Debiopharm International S.A. | Medicament and use thereof for treating bacterial infections involving biofilm |
| MX2023000165A (es) | 2020-06-30 | 2023-02-22 | Redhill Biopharma Ltd | Productos de combinacion de dosis fijas de tres antibioticos, regimen de dosificacion, metodos y kits para tratar infecciones micobacterianas pulmonares no tuberculosas. |
| WO2025026423A1 (en) * | 2023-08-02 | 2025-02-06 | Shenzhen Pharmacin Co., Ltd. | Compositions, their use and manufacture for treatment of gastrointestinal conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440763A (en) * | 1981-03-18 | 1984-04-03 | Block Drug Company, Inc. | Use of 4-aminosalicyclic acid as an anti-inflammatory agent |
| GB8919321D0 (en) * | 1989-08-25 | 1989-10-11 | Univ London | Treatment of chronic inflammatory conditions |
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1998
- 1998-04-01 AT AT98912149T patent/ATE389417T1/de active
- 1998-04-01 US US09/381,960 patent/US6277836B1/en not_active Expired - Lifetime
- 1998-04-01 IL IL13214598A patent/IL132145A/xx not_active IP Right Cessation
- 1998-04-01 PT PT98912149T patent/PT971735E/pt unknown
- 1998-04-01 AR ARP980101486A patent/AR012304A1/es unknown
- 1998-04-01 EP EP98912149A patent/EP0971735B1/en not_active Expired - Lifetime
- 1998-04-01 DK DK98912149T patent/DK0971735T3/da active
- 1998-04-01 JP JP54099898A patent/JP2001524951A/ja not_active Withdrawn
- 1998-04-01 DE DE69839261T patent/DE69839261T2/de not_active Expired - Lifetime
- 1998-04-01 NZ NZ500696A patent/NZ500696A/en not_active IP Right Cessation
- 1998-04-01 CA CA2285923A patent/CA2285923C/en not_active Expired - Lifetime
- 1998-04-01 WO PCT/AU1998/000222 patent/WO1998043667A1/en not_active Ceased
- 1998-04-01 SI SI9830905T patent/SI0971735T1/sl unknown
- 1998-04-01 ES ES98912149T patent/ES2303351T3/es not_active Expired - Lifetime
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1999
- 1999-09-30 NO NO19994778A patent/NO325947B1/no not_active IP Right Cessation
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2007
- 2007-09-07 JP JP2007232402A patent/JP2008024713A/ja not_active Withdrawn
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2008
- 2008-06-05 CY CY20081100591T patent/CY1109783T1/el unknown
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| JP2012126736A (ja) | 2012-07-05 |
| NO994778D0 (no) | 1999-09-30 |
| ES2303351T3 (es) | 2008-08-01 |
| EP0971735A4 (en) | 2004-02-25 |
| NO994778L (no) | 1999-11-30 |
| JP2008024713A (ja) | 2008-02-07 |
| AR012304A1 (es) | 2000-10-18 |
| EP0971735B1 (en) | 2008-03-19 |
| PT971735E (pt) | 2008-06-02 |
| DE69839261D1 (de) | 2008-04-30 |
| IL132145A (en) | 2005-11-20 |
| DK0971735T3 (da) | 2008-07-07 |
| DE69839261T2 (de) | 2009-03-26 |
| SI0971735T1 (sl) | 2008-08-31 |
| CA2285923A1 (en) | 1998-10-08 |
| US6277836B1 (en) | 2001-08-21 |
| WO1998043667A1 (en) | 1998-10-08 |
| EP0971735A1 (en) | 2000-01-19 |
| CY1109783T1 (el) | 2013-09-04 |
| IL132145A0 (en) | 2001-03-19 |
| NO325947B1 (no) | 2008-08-25 |
| CA2285923C (en) | 2013-03-12 |
| ATE389417T1 (de) | 2008-04-15 |
| JP2001524951A (ja) | 2001-12-04 |
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