NZ337578A - Leukocyte elastase inhibitory activity by hydrophobic tetracycline - Google Patents
Leukocyte elastase inhibitory activity by hydrophobic tetracyclineInfo
- Publication number
- NZ337578A NZ337578A NZ337578A NZ33757898A NZ337578A NZ 337578 A NZ337578 A NZ 337578A NZ 337578 A NZ337578 A NZ 337578A NZ 33757898 A NZ33757898 A NZ 33757898A NZ 337578 A NZ337578 A NZ 337578A
- Authority
- NZ
- New Zealand
- Prior art keywords
- tetracycline
- leukocyte elastase
- dimethylamino
- cmt
- activity
- Prior art date
Links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
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| US08/816,551 US5773430A (en) | 1997-03-13 | 1997-03-13 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
| PCT/US1998/003782 WO1998040079A1 (en) | 1997-03-13 | 1998-02-26 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
Publications (1)
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| NZ337578A true NZ337578A (en) | 2001-08-31 |
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| NZ337578A NZ337578A (en) | 1997-03-13 | 1998-02-26 | Leukocyte elastase inhibitory activity by hydrophobic tetracycline |
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| US (1) | US5773430A (enExample) |
| EP (1) | EP0975349B1 (enExample) |
| JP (1) | JP4339411B2 (enExample) |
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| AT (1) | ATE292972T1 (enExample) |
| AU (1) | AU733308B2 (enExample) |
| CA (1) | CA2283071C (enExample) |
| DE (1) | DE69829748T2 (enExample) |
| DK (1) | DK0975349T3 (enExample) |
| ES (1) | ES2241124T3 (enExample) |
| NZ (1) | NZ337578A (enExample) |
| PT (1) | PT975349E (enExample) |
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| AU7688998A (en) * | 1997-05-20 | 1998-12-11 | Trustees Of Columbia University In The City Of New York, The | Use of metalloproteinase inhibitors in the treatment and prevention of pulmonaryemphysema |
| US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| US6946453B2 (en) | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
| US6506740B1 (en) | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6887678B2 (en) * | 1998-12-02 | 2005-05-03 | Cindy L. Bristow | Method for the quantitative determination of proteinase inhibitors |
| CA2372443C (en) * | 1999-04-30 | 2010-07-13 | Apt Pharmaceuticals, L.L.C. | Local administration of anti-malarial agents for the treatment of inflammatory diseases |
| GB0004531D0 (en) * | 2000-02-25 | 2000-04-19 | Richards Andrew J M | The treatment of respiratory diseases |
| US6627785B1 (en) * | 2000-02-29 | 2003-09-30 | Virginia Commwealth University | Wound dressings with protease-lowering activity |
| US6503892B2 (en) | 2000-04-26 | 2003-01-07 | New England Medical Center Hospitals Inc. | Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7247704B2 (en) * | 2000-12-18 | 2007-07-24 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
| CA2447008A1 (en) * | 2001-04-05 | 2002-10-24 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| WO2002099134A1 (en) * | 2001-06-05 | 2002-12-12 | Auckland Uniservices Limited | Methods and compositions for assessment of pulmonary function and disorders |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP1408987B1 (en) * | 2001-07-13 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
| US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
| EP2311797A1 (en) | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| JP2005526754A (ja) | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| EP1503981A4 (en) | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
| WO2004006850A2 (en) | 2002-07-12 | 2004-01-22 | Paratek Pharmaceuticals, Inc | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS |
| US20040092491A1 (en) * | 2002-11-09 | 2004-05-13 | The Research Foundation Of State University Of New York | Method of treating sepsis-induced ARDS |
| CA2521885C (en) * | 2003-04-07 | 2013-06-25 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| EP1624866A2 (en) * | 2003-05-16 | 2006-02-15 | Arriva Pharmaceuticals, Inc. | Treatment of respiratory disease by inhalation of synthetic matrix metalloprotease inhibitors |
| WO2005009943A2 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| JP4738333B2 (ja) | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
| EP2332904A3 (en) * | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derivatives of tetracycline compounds |
| JP2008518025A (ja) | 2004-10-25 | 2008-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | ４−アミノテトラサイクリンおよびその使用の方法 |
| WO2006047756A2 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1896607A4 (en) * | 2005-05-10 | 2009-12-16 | Synergenz Bioscience Ltd | METHOD AND COMPOSITIONS FOR THE ASSESSMENT OF LUNG FUNCTION AND RESPIRATORY DISEASE |
| JP2008545390A (ja) * | 2005-05-19 | 2008-12-18 | シナージェンズ バイオサイエンス リミティド | 遺伝的多型を用いた肺癌を発達させるリスクの評価方法 |
| WO2006123943A1 (en) * | 2005-05-20 | 2006-11-23 | Synergenz Bioscience Limited | Methods of analysis of polymorphisms and uses thereof |
| CA2616224A1 (en) * | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| US8795730B2 (en) * | 2006-01-31 | 2014-08-05 | David John Vachon | Compositions and methods for promoting the healing of tissue of multicellular organisms |
| PL2120963T3 (pl) | 2006-12-21 | 2019-05-31 | Paratek Pharm Innc | Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry |
| IL270446B2 (en) * | 2006-12-21 | 2023-10-01 | Paratek Pharm Innc | A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition |
| EP2144870A2 (en) * | 2007-04-27 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| WO2009009042A1 (en) * | 2007-07-06 | 2009-01-15 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing substituted tetracycline compounds |
| TWI585071B (zh) | 2008-05-19 | 2017-06-01 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| HUE026562T2 (hu) | 2008-08-08 | 2016-06-28 | Tetraphase Pharmaceuticals Inc | C7-fluor-helyettesített tetraciklin vegyületek |
| JP2012501456A (ja) | 2008-08-28 | 2012-01-19 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| CN102459153A (zh) | 2009-05-08 | 2012-05-16 | 四相制药公司 | 四环素类化合物 |
| EP2470500B1 (en) | 2009-08-28 | 2017-10-04 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| WO2011123536A1 (en) | 2010-03-31 | 2011-10-06 | Tetraphase Pharmaceuticals, Inc. | Polycyclic tetracycline compounds |
| TR201902057T4 (tr) | 2012-08-31 | 2019-03-21 | Tetraphase Pharmaceuticals Inc | Tetrasiklin bileşikleri. |
| MA46567A (fr) | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
| WO2020097450A1 (en) | 2018-11-09 | 2020-05-14 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
| EP4460313A4 (en) * | 2022-01-04 | 2026-01-14 | Univ New York State Res Found | CMT-3 FORMULATIONS AND THEIR METHODS OF USE |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666897A (en) * | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US4935412A (en) * | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) * | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
| US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| JPH06256280A (ja) * | 1992-11-17 | 1994-09-13 | Univ New York State | 糖尿病における過度のコラーゲン架橋結合を阻害する非抗菌性化学修飾テトラサイクリンを含むテトラサイクリン |
| US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| CA2170030A1 (en) * | 1993-09-14 | 1995-03-23 | Robert A. Lazarus | Pharmaceutical compositions containing ecotin and homologs thereof |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| GB9502152D0 (en) * | 1995-02-03 | 1995-03-29 | Zeneca Ltd | Proline derivatives |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
-
1997
- 1997-03-13 US US08/816,551 patent/US5773430A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 PT PT98908747T patent/PT975349E/pt unknown
- 1998-02-26 JP JP53959398A patent/JP4339411B2/ja not_active Expired - Fee Related
- 1998-02-26 NZ NZ337578A patent/NZ337578A/en not_active IP Right Cessation
- 1998-02-26 AU AU66698/98A patent/AU733308B2/en not_active Ceased
- 1998-02-26 CA CA002283071A patent/CA2283071C/en not_active Expired - Fee Related
- 1998-02-26 EP EP98908747A patent/EP0975349B1/en not_active Expired - Lifetime
- 1998-02-26 ES ES98908747T patent/ES2241124T3/es not_active Expired - Lifetime
- 1998-02-26 AT AT98908747T patent/ATE292972T1/de active
- 1998-02-26 DK DK98908747T patent/DK0975349T3/da active
- 1998-02-26 DE DE69829748T patent/DE69829748T2/de not_active Expired - Lifetime
- 1998-02-26 WO PCT/US1998/003782 patent/WO1998040079A1/en not_active Ceased
- 1998-02-26 KR KR10-1999-7008325A patent/KR100530683B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100530683B1 (ko) | 2005-11-24 |
| JP2001524948A (ja) | 2001-12-04 |
| DE69829748T2 (de) | 2006-03-09 |
| EP0975349B1 (en) | 2005-04-13 |
| CA2283071A1 (en) | 1998-09-17 |
| DE69829748D1 (de) | 2005-05-19 |
| ATE292972T1 (de) | 2005-04-15 |
| CA2283071C (en) | 2009-01-27 |
| EP0975349A4 (en) | 2002-10-30 |
| DK0975349T3 (da) | 2005-08-01 |
| PT975349E (pt) | 2005-08-31 |
| ES2241124T3 (es) | 2005-10-16 |
| AU6669898A (en) | 1998-09-29 |
| KR20000076231A (ko) | 2000-12-26 |
| EP0975349A1 (en) | 2000-02-02 |
| AU733308B2 (en) | 2001-05-10 |
| JP4339411B2 (ja) | 2009-10-07 |
| WO1998040079A1 (en) | 1998-09-17 |
| US5773430A (en) | 1998-06-30 |
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