AU733308B2 - Serine proteinase inhibitory activity by hydrophobic tetracycline - Google Patents

Serine proteinase inhibitory activity by hydrophobic tetracycline Download PDF

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Publication number
AU733308B2
AU733308B2 AU66698/98A AU6669898A AU733308B2 AU 733308 B2 AU733308 B2 AU 733308B2 AU 66698/98 A AU66698/98 A AU 66698/98A AU 6669898 A AU6669898 A AU 6669898A AU 733308 B2 AU733308 B2 AU 733308B2
Authority
AU
Australia
Prior art keywords
tetracycline
dimethylamino
leukocyte elastase
activity
cmt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66698/98A
Other languages
English (en)
Other versions
AU6669898A (en
Inventor
Lorne M. Golub
Nungavaram S. Ramamurthy
Elizabeth J. Roemer
Sanford R. Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of AU6669898A publication Critical patent/AU6669898A/en
Application granted granted Critical
Publication of AU733308B2 publication Critical patent/AU733308B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
AU66698/98A 1997-03-13 1998-02-26 Serine proteinase inhibitory activity by hydrophobic tetracycline Ceased AU733308B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/816,551 US5773430A (en) 1997-03-13 1997-03-13 Serine proteinase inhibitory activity by hydrophobic tetracycline
US08/816551 1997-03-13
PCT/US1998/003782 WO1998040079A1 (en) 1997-03-13 1998-02-26 Serine proteinase inhibitory activity by hydrophobic tetracycline

Publications (2)

Publication Number Publication Date
AU6669898A AU6669898A (en) 1998-09-29
AU733308B2 true AU733308B2 (en) 2001-05-10

Family

ID=25220936

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66698/98A Ceased AU733308B2 (en) 1997-03-13 1998-02-26 Serine proteinase inhibitory activity by hydrophobic tetracycline

Country Status (13)

Country Link
US (1) US5773430A (enExample)
EP (1) EP0975349B1 (enExample)
JP (1) JP4339411B2 (enExample)
KR (1) KR100530683B1 (enExample)
AT (1) ATE292972T1 (enExample)
AU (1) AU733308B2 (enExample)
CA (1) CA2283071C (enExample)
DE (1) DE69829748T2 (enExample)
DK (1) DK0975349T3 (enExample)
ES (1) ES2241124T3 (enExample)
NZ (1) NZ337578A (enExample)
PT (1) PT975349E (enExample)
WO (1) WO1998040079A1 (enExample)

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US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
US6946453B2 (en) 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US6887678B2 (en) * 1998-12-02 2005-05-03 Cindy L. Bristow Method for the quantitative determination of proteinase inhibitors
WO2000066107A2 (en) * 1999-04-30 2000-11-09 Apt Pharmaceuticals, L.L.C. Antimalarian agents for the treatment of asthma
GB0004531D0 (en) * 2000-02-25 2000-04-19 Richards Andrew J M The treatment of respiratory diseases
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
US6503892B2 (en) 2000-04-26 2003-01-07 New England Medical Center Hospitals Inc. Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
AU2002256092C1 (en) * 2001-04-05 2009-10-15 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
EP1801240A1 (en) * 2001-06-05 2007-06-27 Auckland Uniservices Limited Methods and compositions for assessment of pulmonary function and disorders
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332546A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EA201000491A1 (ru) 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EA012136B1 (ru) 2002-07-12 2009-08-28 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
US20040092491A1 (en) * 2002-11-09 2004-05-13 The Research Foundation Of State University Of New York Method of treating sepsis-induced ARDS
JP5586123B2 (ja) * 2003-04-07 2014-09-10 スパーナス ファーマシューティカルズ インコーポレイテッド テトラサイクリンの１日１回製剤
CA2526222A1 (en) * 2003-05-16 2004-12-02 Arriva Pharmaceuticals, Inc. Treatment of respiratory disease associated with matrix metalloprotease inhibitors
EP1648859B1 (en) 2003-07-09 2013-02-27 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
EP2284152A3 (en) 2004-10-25 2011-10-05 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
CA2608142A1 (en) * 2005-05-10 2006-11-16 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
JP2008545390A (ja) * 2005-05-19 2008-12-18 シナージェンズ バイオサイエンス リミティド 遺伝的多型を用いた肺癌を発達させるリスクの評価方法
AU2006248189A1 (en) * 2005-05-20 2006-11-23 Synergenz Bioscience Limited Methods of analysis of polymorphisms and uses thereof
AU2006272698B2 (en) * 2005-07-21 2012-11-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
US8795730B2 (en) * 2006-01-31 2014-08-05 David John Vachon Compositions and methods for promoting the healing of tissue of multicellular organisms
ES2548261T3 (es) 2006-12-21 2015-10-15 Paratek Pharmaceuticals, Inc. Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
AU2007338681B2 (en) 2006-12-21 2013-09-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
WO2008134048A2 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
CN101784517A (zh) * 2007-07-06 2010-07-21 帕拉特克药品公司 合成取代的四环素化合物的方法
TW202021946A (zh) * 2008-05-19 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
ES2655911T3 (es) 2008-08-08 2018-02-22 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina sustituidos con C7-fluoro
NZ610356A (en) 2008-08-28 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2627772T3 (es) 2009-05-08 2017-07-31 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
JP5944825B2 (ja) 2009-08-28 2016-07-05 テトラフェース ファーマシューティカルズ，インコーポレイテッド テトラサイクリン化合物
JP5820462B2 (ja) 2010-03-31 2015-11-24 テトラフェース ファーマシューティカルズ，インコーポレイテッド 多環式テトラサイクリン化合物
BR112015004523B1 (pt) 2012-08-31 2020-08-04 Tetraphase Pharmaceuticals, Inc Compostos de tetraciclina, composições farmacêuticas e seus usos
ES2978198T3 (es) 2016-10-19 2024-09-06 Tetraphase Pharmaceuticals Inc Formas cristalinas de eravaciclina
WO2020097450A1 (en) 2018-11-09 2020-05-14 Tetraphase Pharmaceuticals, Inc. Polymorphic forms of a compound and uses thereof
WO2023133096A1 (en) * 2022-01-04 2023-07-13 The Research Foundation For The State University Of New York Cmt-3 formulations and methods of using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines

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US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
USRE34656E (en) * 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
US4666897A (en) * 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5045538A (en) * 1990-06-28 1991-09-03 The Research Foundation Of State University Of New York Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
US5223248A (en) * 1991-02-11 1993-06-29 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing antiplaque properties
US5258371A (en) * 1992-05-29 1993-11-02 Kuraray Co., Ltd. Method to reduce connective tissue destruction
CA2103189C (en) * 1992-11-17 2005-05-03 Lorne M. Golub Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes
JP3929484B2 (ja) * 1993-09-14 2007-06-13 ジェネンテック・インコーポレーテッド エコチンおよびその同族体を含む医薬的組成物
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines

Also Published As

Publication number Publication date
DK0975349T3 (da) 2005-08-01
JP4339411B2 (ja) 2009-10-07
EP0975349B1 (en) 2005-04-13
ATE292972T1 (de) 2005-04-15
EP0975349A4 (en) 2002-10-30
CA2283071A1 (en) 1998-09-17
KR20000076231A (ko) 2000-12-26
PT975349E (pt) 2005-08-31
AU6669898A (en) 1998-09-29
WO1998040079A1 (en) 1998-09-17
DE69829748T2 (de) 2006-03-09
NZ337578A (en) 2001-08-31
JP2001524948A (ja) 2001-12-04
CA2283071C (en) 2009-01-27
EP0975349A1 (en) 2000-02-02
US5773430A (en) 1998-06-30
ES2241124T3 (es) 2005-10-16
KR100530683B1 (ko) 2005-11-24
DE69829748D1 (de) 2005-05-19

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