NZ324168A - Improved methods for the treatment of squamous cell carcinomas by providing expression construct comprising functional p53 and CMV promoter and method for determining effectiveness of the therapy on residual cancer - Google Patents

Improved methods for the treatment of squamous cell carcinomas by providing expression construct comprising functional p53 and CMV promoter and method for determining effectiveness of the therapy on residual cancer

Info

Publication number
NZ324168A
NZ324168A NZ324168A NZ32416896A NZ324168A NZ 324168 A NZ324168 A NZ 324168A NZ 324168 A NZ324168 A NZ 324168A NZ 32416896 A NZ32416896 A NZ 32416896A NZ 324168 A NZ324168 A NZ 324168A
Authority
NZ
New Zealand
Prior art keywords
tumor
cells
gene
expression
vector
Prior art date
Application number
NZ324168A
Other languages
English (en)
Inventor
Gary L Clayman
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of NZ324168A publication Critical patent/NZ324168A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NZ324168A 1995-11-30 1996-11-27 Improved methods for the treatment of squamous cell carcinomas by providing expression construct comprising functional p53 and CMV promoter and method for determining effectiveness of the therapy on residual cancer NZ324168A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US781095P 1995-11-30 1995-11-30
PCT/US1996/019083 WO1997020047A1 (en) 1995-11-30 1996-11-27 Methods and compositions for the diagnosis and treatment of cancer

Publications (1)

Publication Number Publication Date
NZ324168A true NZ324168A (en) 2004-11-26

Family

ID=21728237

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ324168A NZ324168A (en) 1995-11-30 1996-11-27 Improved methods for the treatment of squamous cell carcinomas by providing expression construct comprising functional p53 and CMV promoter and method for determining effectiveness of the therapy on residual cancer

Country Status (19)

Country Link
US (3) US20020077313A1 (show.php)
EP (1) EP0863984B1 (show.php)
JP (1) JP2000501394A (show.php)
KR (1) KR19990071795A (show.php)
CN (2) CN101028523A (show.php)
AT (1) ATE325872T1 (show.php)
AU (1) AU722042B2 (show.php)
CA (1) CA2238829A1 (show.php)
CZ (1) CZ296810B6 (show.php)
DE (1) DE69636120T2 (show.php)
DK (1) DK0863984T3 (show.php)
ES (1) ES2264145T3 (show.php)
HU (1) HUP9902068A3 (show.php)
NO (1) NO982481L (show.php)
NZ (1) NZ324168A (show.php)
PL (1) PL186018B1 (show.php)
RU (1) RU2174409C2 (show.php)
SK (1) SK70598A3 (show.php)
WO (1) WO1997020047A1 (show.php)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE348155T1 (de) * 1996-11-20 2007-01-15 Introgen Therapeutics Inc Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
RU2219553C2 (ru) * 2001-10-18 2003-12-20 Ростовский научно-исследовательский онкологический институт Способ определения эффективности аутогемохимиотерапии рака ректосигмоидного отдела прямой кишки и сигмовидной кишки, а также аутогемохимиотерапии в сочетании с свч-гипертермией рака прямой кишки
GB0212046D0 (en) * 2002-05-24 2002-07-03 Glaxo Group Ltd Vaccines
EP1585964A4 (en) * 2002-08-28 2008-07-16 Introgen Therapeutics Inc CHROMATOGRAPHIC METHODS FOR PURIFYING ADENOVIRUSES
US20050032728A1 (en) * 2002-12-17 2005-02-10 Sidney Kimmel Cancer Center Tumor suppression through bicistronic co-expression of p53 and p14ARF
EP1587544A4 (en) * 2002-12-27 2006-05-10 Introgen Therapeutics Inc P53 TREATMENT OF PAPILLOMA VIRUSES AND CELLS TRANSFORMED BY CARCINOGEN IN HYPERPLASTIC LESIONS
US7534427B2 (en) * 2002-12-31 2009-05-19 Immunomedics, Inc. Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
CA2518169C (en) * 2003-03-06 2012-01-24 Zhaohui Peng A recombinant constructed by a virus vector and a human tumor suppressor gene and its use
RU2234099C1 (ru) * 2003-03-18 2004-08-10 Российская медицинская академия последипломного образования Способ дифференциальной диагностики стадий канцерогенеза
RU2242936C1 (ru) * 2003-04-21 2004-12-27 Ростовский научно-исследовательский онкологический институт Способ лечения рака легкого
CA2555542A1 (en) * 2004-02-23 2005-09-01 Novartis Ag P53 wild-type as biomarker for the treatment with mtor inhibitors in combination with a cytotoxic agent
US20080293652A1 (en) * 2004-02-24 2008-11-27 Introgen Therapeutics, Inc. Combination of Ad-P53 and Chemotherapy for the Treatment of Tumours
CN100333797C (zh) * 2005-01-26 2007-08-29 彭朝晖 重组腺病毒p53制品在肿瘤治疗中的新用途
RU2245551C1 (ru) * 2004-04-23 2005-01-27 Белохвостов Александр Сергеевич Способ диагностики онкологических заболеваний
RU2263494C1 (ru) * 2004-06-08 2005-11-10 ГУ НИИ глазных болезней РАМН Способ моделирования меланомы роговицы
US20090075972A1 (en) * 2004-08-31 2009-03-19 Jan Cools Use of Midostaurin for Treating Gastrointestinal Stromal Tumors
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
PL1846030T3 (pl) * 2005-01-21 2019-05-31 Genentech Inc Ustalone dawkowanie przeciwciał her
EP1846020B1 (en) * 2005-01-27 2013-08-21 Novartis Vaccines and Diagnostics, Inc. Methods for treating renal cell carcinoma
US7327306B2 (en) * 2005-05-06 2008-02-05 Orthosoft Inc. RF system for tracking objects
US20070231304A1 (en) * 2006-01-30 2007-10-04 Introgen Therapeutics, Inc. Prognostic factors for anti-hyperproliferative disease gene therapy
US8052968B2 (en) 2006-10-16 2011-11-08 Genelux Corporation Modified vaccinia virus strains for use in diagnostic and therapeutic methods
US20080299182A1 (en) * 2007-03-01 2008-12-04 Shuyuan Zhang Methods and formulations for topical gene therapy
US20090081639A1 (en) * 2007-05-31 2009-03-26 Phil Hill Assay for sensitivity to chemotherapeutic agents
RU2371202C2 (ru) * 2007-07-30 2009-10-27 Государственное учреждение научно-исследовательский институт онкологии Томского Научного центра Сибирского отделения Российской академии медицинских наук (ГУ НИИ онкологии ТНЦ СО РАМН) Способ радионуклидной диагностики рака молочной железы
PL2245464T3 (pl) 2008-01-25 2017-08-31 Multivir Inc. Biomarkery p53
US8314068B2 (en) * 2008-04-14 2012-11-20 University Hospitals Of Cleveland P2X7 inhibition of epithelial cancers and papillomas
US20120052003A9 (en) * 2008-05-16 2012-03-01 Szalay Aladar A Microorganisms for preventing and treating neoplasms accompanying cellular therapy
JP5923306B2 (ja) 2008-12-04 2016-05-24 クルナ・インコーポレーテッド 腫瘍抑制遺伝子に対する天然アンチセンス転写物の抑制による腫瘍抑制遺伝子関連疾患の治療
RU2384845C1 (ru) * 2008-12-18 2010-03-20 ФГУП Государственный научно-исследовательский институт особо чистых биопрепаратов ФМБА Способ диагностики онкологических заболеваний
SG172935A1 (en) * 2009-02-02 2011-08-29 Okairos Ag Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
US9050276B2 (en) 2009-06-16 2015-06-09 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof
RU2395234C1 (ru) * 2009-07-24 2010-07-27 Учреждение Российской Академии Наук Институт Молекулярной Биологии Им. В.А. Энгельгардта Ран (Имб Ран) ОПРЕДЕЛЕНИЕ СНИЖЕНИЯ УРОВНЯ мРНК ГЕНА ZG16 КАК СПОСОБ ДИАГНОСТИКИ РАКА ТОЛСТОЙ КИШКИ И НАБОР ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ
BR112013009196A2 (pt) 2010-10-15 2020-08-25 The Trustees Of Columbia University In The City Of New York usos de polipeptídeo para redução da aquisição de ácido graxo e da ingestão de alimento, bem como para promoção de saciedade relacionados à obesidade
PL2635299T3 (pl) 2010-11-02 2020-03-31 The Trustees Of Columbia University In The City Of New York Sposoby leczenia zaburzeń utraty włosów
EP2697368B1 (en) 2011-04-15 2019-06-05 Genelux Corporation Clonal strains of attenuated vaccinia viruses and methods of use thereof
CN102352368B (zh) * 2011-09-29 2013-12-04 苏州大学 Ing4与osm双基因共表达载体及其应用
JP5998229B2 (ja) * 2011-12-08 2016-09-28 ビロベック・インコーポレイテッドVirovek,Inc. 毒性遺伝子を保有するベクター、そのための方法および使用
WO2013106773A2 (en) 2012-01-12 2013-07-18 Synaptics Incorporated Single layer capacitive imaging sensors
WO2013123266A1 (en) * 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2013139861A1 (en) 2012-03-20 2013-09-26 Luc Montagnier Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
SI2830662T1 (sl) 2012-03-29 2019-01-31 The Trustees Of Columbia University In The City Of New York Postopki zdravljenja motenj izgube las
CA2907152A1 (en) 2013-03-15 2014-09-25 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
WO2014158965A1 (en) * 2013-03-27 2014-10-02 Ge Healthcare As Method and reagent for preparing a diagnostic composition
CN105722518A (zh) * 2013-06-18 2016-06-29 德那翠丝有限公司 使用溶瘤腺病毒的脑癌治疗
US9552089B2 (en) 2013-08-07 2017-01-24 Synaptics Incorporated Capacitive sensing using a matrix electrode pattern
US9298325B2 (en) 2013-09-30 2016-03-29 Synaptics Incorporated Processing system for a capacitive sensing device
US10042489B2 (en) 2013-09-30 2018-08-07 Synaptics Incorporated Matrix sensor for image touch sensing
US20150091842A1 (en) 2013-09-30 2015-04-02 Synaptics Incorporated Matrix sensor for image touch sensing
US9459367B2 (en) 2013-10-02 2016-10-04 Synaptics Incorporated Capacitive sensor driving technique that enables hybrid sensing or equalization
US9274662B2 (en) 2013-10-18 2016-03-01 Synaptics Incorporated Sensor matrix pad for performing multiple capacitive sensing techniques
US9081457B2 (en) 2013-10-30 2015-07-14 Synaptics Incorporated Single-layer muti-touch capacitive imaging sensor
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
US9798429B2 (en) 2014-02-28 2017-10-24 Synaptics Incorporated Guard electrodes in a sensing stack
CN104357408A (zh) * 2014-03-13 2015-02-18 哈尔滨博翱生物医药技术开发有限公司 一种重组新城疫病毒及其应用
US10133421B2 (en) 2014-04-02 2018-11-20 Synaptics Incorporated Display stackups for matrix sensor
US9927832B2 (en) 2014-04-25 2018-03-27 Synaptics Incorporated Input device having a reduced border region
US9690397B2 (en) 2014-05-20 2017-06-27 Synaptics Incorporated System and method for detecting an active pen with a matrix sensor
PT3201234T (pt) 2014-09-30 2019-02-05 Diadem S R L Anticorpo que se liga a um epitopo linear de p53 humana e suas aplicações em diagnóstico
US10175827B2 (en) 2014-12-23 2019-01-08 Synaptics Incorporated Detecting an active pen using a capacitive sensing device
WO2016105517A1 (en) 2014-12-23 2016-06-30 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
US9778713B2 (en) 2015-01-05 2017-10-03 Synaptics Incorporated Modulating a reference voltage to preform capacitive sensing
US9939972B2 (en) 2015-04-06 2018-04-10 Synaptics Incorporated Matrix sensor with via routing
US9720541B2 (en) 2015-06-30 2017-08-01 Synaptics Incorporated Arrangement of sensor pads and display driver pads for input device
US10095948B2 (en) 2015-06-30 2018-10-09 Synaptics Incorporated Modulation scheme for fingerprint sensing
US9715304B2 (en) 2015-06-30 2017-07-25 Synaptics Incorporated Regular via pattern for sensor-based input device
CN205028263U (zh) 2015-09-07 2016-02-10 辛纳普蒂克斯公司 一种电容传感器
US10037112B2 (en) 2015-09-30 2018-07-31 Synaptics Incorporated Sensing an active device'S transmission using timing interleaved with display updates
US10067587B2 (en) 2015-12-29 2018-09-04 Synaptics Incorporated Routing conductors in an integrated display device and sensing device
CN106933400B (zh) 2015-12-31 2021-10-29 辛纳普蒂克斯公司 单层传感器图案和感测方法
WO2018071814A1 (en) 2016-10-14 2018-04-19 The Trustees Of Columbia University In The City Of New York Methods of treating alcohol abuse disorder
RU2760993C1 (ru) * 2021-02-15 2021-12-02 Сергей Александрович Никитин Способ рентгеновской терапии рака легких

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740463A (en) * 1984-04-13 1988-04-26 Massachusetts Institute Of Technology Methods and artificial genes for antagonizing the function of an oncogene
ZA858044B (en) * 1984-11-01 1987-05-27 American Home Prod Oral vaccines
US4748022A (en) * 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4822605A (en) * 1986-02-18 1989-04-18 Exovir, Inc. Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like
US5055400A (en) * 1986-11-26 1991-10-08 University Of Guelph Leukotoxin gene of pasteurella haemolytica
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US4980289A (en) * 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
US5532220A (en) * 1987-08-31 1996-07-02 The Regents Of The University Of California Genetic mechanisms of tumor suppression
US5017524A (en) * 1989-02-13 1991-05-21 Iscar Ltd. Ceramic cutting tool
US6800617B1 (en) * 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US6677312B1 (en) * 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5362623A (en) * 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5585362A (en) * 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US6410010B1 (en) * 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
WO1992015680A1 (en) * 1991-03-06 1992-09-17 Board Of Regents, The University Of Texas System Methods and compositions for the selective inhibition of gene expression
US5252479A (en) * 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) * 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
US5496731A (en) * 1993-03-25 1996-03-05 Xu; Hong-Ji Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy
TW442569B (en) * 1993-10-25 2001-06-23 Canji Inc Recombinant adenoviral vector
EP1548118A2 (en) * 1994-06-10 2005-06-29 Genvec, Inc. Complementary adenoviral vector systems and cell lines

Also Published As

Publication number Publication date
US20030166603A1 (en) 2003-09-04
NO982481L (no) 1998-07-29
AU722042B2 (en) 2000-07-20
KR19990071795A (ko) 1999-09-27
CN1308450C (zh) 2007-04-04
ATE325872T1 (de) 2006-06-15
RU2174409C2 (ru) 2001-10-10
DE69636120D1 (de) 2006-06-14
ES2264145T3 (es) 2006-12-16
AU1126397A (en) 1997-06-19
JP2000501394A (ja) 2000-02-08
DE69636120T2 (de) 2006-11-30
PL327009A1 (en) 1998-11-09
CA2238829A1 (en) 1997-06-05
PL186018B1 (pl) 2003-09-30
NO982481D0 (no) 1998-05-29
WO1997020047A1 (en) 1997-06-05
DK0863984T3 (da) 2006-08-28
CN101028523A (zh) 2007-09-05
US20020077313A1 (en) 2002-06-20
SK70598A3 (en) 1999-04-13
HUP9902068A2 (hu) 1999-10-28
CZ296810B6 (cs) 2006-06-14
EP0863984B1 (en) 2006-05-10
CN1207771A (zh) 1999-02-10
CZ165798A3 (cs) 1998-12-16
HUP9902068A3 (en) 2001-02-28
EP0863984A1 (en) 1998-09-16
US20060035857A1 (en) 2006-02-16

Similar Documents

Publication Publication Date Title
AU722042B2 (en) Methods and compositions for the diagnosis and treatment of cancer
AU694216B2 (en) Compositions comprising DNA damaging agents and P53
US6251871B1 (en) P16 expression constructs and their application in cancer therapy
WO1998030585A9 (en) Use of pea3 in tumor suppression
CA2277880A1 (en) Use of pea3 in tumor suppression
US6482803B1 (en) Modification of mutated P53 gene in tumors by retroviral delivery of ribozyme A
WO1997016547A1 (en) ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY
WO1997016547A9 (en) ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY
US7163925B1 (en) p16 expression constructs and their application in cancer therapy
EP1724350A1 (en) Method and compositions for the diagnosis and treatment of cancer
HK1100393A (en) Method and compositions for the diagnosis and treatment of cancer

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
EXPY Patent expired