NZ308110A - Polymorphs of lesopitron dihydrochloride, ie 2-[4-[4-[4- (chloropyrazole-1-yl)butyl]-1-piperazinyl]pyrimidine, and its hydrated forms, preparation and pharmaceutical compositions - Google Patents

Polymorphs of lesopitron dihydrochloride, ie 2-[4-[4-[4- (chloropyrazole-1-yl)butyl]-1-piperazinyl]pyrimidine, and its hydrated forms, preparation and pharmaceutical compositions

Info

Publication number
NZ308110A
NZ308110A NZ308110A NZ30811096A NZ308110A NZ 308110 A NZ308110 A NZ 308110A NZ 308110 A NZ308110 A NZ 308110A NZ 30811096 A NZ30811096 A NZ 30811096A NZ 308110 A NZ308110 A NZ 308110A
Authority
NZ
New Zealand
Prior art keywords
chloropyrazole
polymorphs
piperazinyl
pyrimidine
butyl
Prior art date
Application number
NZ308110A
Other languages
English (en)
Inventor
Roses Pilar Lupon
Navarro Jaime Tomas
Torres Salvador Puig
Constansa Jordi Frigola
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of NZ308110A publication Critical patent/NZ308110A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ308110A 1995-05-31 1996-05-29 Polymorphs of lesopitron dihydrochloride, ie 2-[4-[4-[4- (chloropyrazole-1-yl)butyl]-1-piperazinyl]pyrimidine, and its hydrated forms, preparation and pharmaceutical compositions NZ308110A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09501086A ES2099031B1 (es) 1995-05-31 1995-05-31 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.

Publications (1)

Publication Number Publication Date
NZ308110A true NZ308110A (en) 1997-08-22

Family

ID=8290585

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ308110A NZ308110A (en) 1995-05-31 1996-05-29 Polymorphs of lesopitron dihydrochloride, ie 2-[4-[4-[4- (chloropyrazole-1-yl)butyl]-1-piperazinyl]pyrimidine, and its hydrated forms, preparation and pharmaceutical compositions

Country Status (29)

Country Link
US (1) US5872125A (cg-RX-API-DMAC7.html)
EP (1) EP0771798A1 (cg-RX-API-DMAC7.html)
JP (1) JPH10503532A (cg-RX-API-DMAC7.html)
CN (1) CN1076020C (cg-RX-API-DMAC7.html)
AR (1) AR003952A1 (cg-RX-API-DMAC7.html)
AU (1) AU699210B2 (cg-RX-API-DMAC7.html)
BG (1) BG62966B1 (cg-RX-API-DMAC7.html)
CA (1) CA2196425A1 (cg-RX-API-DMAC7.html)
CO (1) CO4700461A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ24797A3 (cg-RX-API-DMAC7.html)
EE (1) EE9700067A (cg-RX-API-DMAC7.html)
ES (1) ES2099031B1 (cg-RX-API-DMAC7.html)
GE (1) GEP20002241B (cg-RX-API-DMAC7.html)
HU (1) HUP9700284A3 (cg-RX-API-DMAC7.html)
IL (1) IL118494A0 (cg-RX-API-DMAC7.html)
IN (1) IN186820B (cg-RX-API-DMAC7.html)
IS (1) IS4420A (cg-RX-API-DMAC7.html)
MA (1) MA23883A1 (cg-RX-API-DMAC7.html)
MX (1) MX9700792A (cg-RX-API-DMAC7.html)
NO (1) NO310073B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ308110A (cg-RX-API-DMAC7.html)
PL (1) PL318280A1 (cg-RX-API-DMAC7.html)
RU (1) RU2178789C2 (cg-RX-API-DMAC7.html)
SK (1) SK12697A3 (cg-RX-API-DMAC7.html)
TR (1) TR199600455A2 (cg-RX-API-DMAC7.html)
UY (1) UY24241A1 (cg-RX-API-DMAC7.html)
WO (1) WO1996038439A1 (cg-RX-API-DMAC7.html)
YU (1) YU32396A (cg-RX-API-DMAC7.html)
ZA (1) ZA964139B (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869970B2 (en) 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173180B (es) * 1987-10-26 1994-02-07 Pfizer Procedimiento para preparar agentes ansioliticos
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
JP3001281B2 (ja) * 1991-03-06 2000-01-24 日本碍子株式会社 ハニカムモノリスヒータ
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Also Published As

Publication number Publication date
EE9700067A (et) 1997-10-15
CN1076020C (zh) 2001-12-12
RU2178789C2 (ru) 2002-01-27
ES2099031A1 (es) 1997-05-01
UY24241A1 (es) 1996-06-14
PL318280A1 (en) 1997-06-09
MA23883A1 (fr) 1996-12-31
AU699210B2 (en) 1998-11-26
BG101176A (en) 1997-08-29
ZA964139B (en) 1997-02-06
MX9700792A (es) 1997-05-31
NO310073B1 (no) 2001-05-14
AU5765096A (en) 1996-12-18
ES2099031B1 (es) 1997-12-01
EP0771798A1 (en) 1997-05-07
JPH10503532A (ja) 1998-03-31
GEP20002241B (en) 2000-09-25
CN1158128A (zh) 1997-08-27
CO4700461A1 (es) 1998-12-29
HUP9700284A3 (en) 1998-01-28
US5872125A (en) 1999-02-16
AR003952A1 (es) 1998-09-30
CA2196425A1 (en) 1996-12-05
NO970392D0 (no) 1997-01-29
NO970392L (no) 1997-04-01
CZ24797A3 (en) 1997-05-14
HU9700284D0 (en) 1997-04-28
WO1996038439A1 (es) 1996-12-05
TR199600455A2 (tr) 1996-12-21
IL118494A0 (en) 1996-09-12
IN186820B (cg-RX-API-DMAC7.html) 2001-11-17
SK12697A3 (en) 1997-07-09
HUP9700284A2 (en) 1997-11-28
BG62966B1 (bg) 2000-12-29
IS4420A (is) 1997-01-29
YU32396A (sh) 1999-07-28

Similar Documents

Publication Publication Date Title
IL146707A0 (en) Novel use of 1-[4-(5-cyanoindol-3-yl) butyl]-4-(2-carbamoyl-benzofuran-5-yl)- piperazine and its physiologically acceptable salts
WO2000017190A3 (fr) Derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
EE200900043A (et) Tert-butl-(E)-(6-{2-[4-(4-fluorofenl)-6-isopropl-2-[metl(metlsulfonl)amino] primidiin-5-l]vinl}(4R, 6S)-2,2-dimetl[1,3]dioksaan-4-l)atsetaadi valmistamismeetod
DK0904273T3 (da) Mesylat-trihydratsalt af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl-6-chlor-1,3-dihydro-2(1H)-indol-2-on(=ziprasidon), dets fremstilling og dets anvendelse som dipamin D2 antagonist
IE823067L (en) Piperidinedione derivatives
SI0775704T1 (en) Crystalline hydrochloride of (R)-(-)-2-(N-(4-(1,1-Dioxido-3-oxo-2,3-dihydrobenzisothiazol-2-yl)-butyl)-aminomethyl)-chroman
EE04929B1 (et) Mitteinterageeruvate ravimite kombinatsioon, farmatseutiline ravimkoostis ja farmatseutiline pakend, mis sisaldab (E) -7-[4-(4-fluorofenl)-6-isopropl-2-[metl(metlsulfonl)amino]primidiin-5-l]-(3R ,3S)-3,5-dihdrokshept-6-eenhapet ja P450
IL121461A0 (en) Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]butyl]-1H-azole derivatives
HUP0000960A3 (en) Spray-dried paroxetine hydrochloride, process for it's preparation,use of the compound and pharmaceutical compositions containing the same
ES2076894A1 (es) Derivados de 2-(4-(4-azolibutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.
NZ308110A (en) Polymorphs of lesopitron dihydrochloride, ie 2-[4-[4-[4- (chloropyrazole-1-yl)butyl]-1-piperazinyl]pyrimidine, and its hydrated forms, preparation and pharmaceutical compositions
YU31600A (sh) Pseudopolimorfni oblici 2-(2-(4-bis(4-fluorofenil)metil)-1-piperazinil)etoksi)sirćetne kiseline dihidrohlorida
HUP9800511A3 (en) Phosphorylized derivatives of 4-{4-[4-(hydroxy-diphenyl)-1-pipe
FI942159A7 (fi) Menetelmä 2-(4-(4-(4-kloori-1-pyratsolyyli)butyyli)-1-piperatsinyyli)pyrimidiinin (lesopitron) valmistamiseksi
PL348601A1 (en) New pharmaceutical composition and the process for its preparation
AU3022201A (en) Novel use of (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)- chromane and its physiologically aceptable salts
IL139405A0 (en) Reduced particle size form of 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(4-pyridyl) benzoyl] piperazine
IL112661A0 (en) 1-[2-(1h-inden-3-yl) ethyl]-4-(naphth-1-yl) piperazine derivatives, their preparation and their application in therapeutics
AU6165798A (en) Non-sedating histamine antagonist compounds, compositions and methods of use thereof
AU6705396A (en) 1-(2-(2,3-Dihydro-1H-inden-1-yl)ethyl)-4-(naphthalen-1-YL) piperazine derivatives, their preparation and their application in therapeutics
IL122975A0 (en) Use of 1-[6-chloro-5- (trifluoromethyl)-2-pyridinyl] piperazine
HK1010880A (en) 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4-(naphthalen-1-yl)piperazine derivatives, preparation thereof and therapeutical use thereof
HUP0105124A3 (en) 1-(6-methylpyridine-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone and method for its preparation
AU4261196A (en) Use of 2-(4-(azolylbutyl)piperazinyl-(methyl)benzimidazole derivatives for preparing drugs for treating or preventing asthma
HUP9700274A3 (en) Optically active (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)-piperazin-1-yl]-phenoxy}-butiric acid as inhibitor of celle-adhesion, preparation and use of this compound, pharmaceutical composition containing this compound