ES2099031A1 - Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen. - Google Patents

Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.

Info

Publication number
ES2099031A1
ES2099031A1 ES09501086A ES9501086A ES2099031A1 ES 2099031 A1 ES2099031 A1 ES 2099031A1 ES 09501086 A ES09501086 A ES 09501086A ES 9501086 A ES9501086 A ES 9501086A ES 2099031 A1 ES2099031 A1 ES 2099031A1
Authority
ES
Spain
Prior art keywords
lesopitron
dichlorohydrate
compositions containing
preparation methods
hydrated forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09501086A
Other languages
English (en)
Other versions
ES2099031B1 (es
Inventor
Roses Pilar Lupon
Navarro Jaime Tomas
Torres Salvador Puig
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to ES09501086A priority Critical patent/ES2099031B1/es
Priority to ARP960102643A priority patent/AR003952A1/es
Priority to IN921CA1996 priority patent/IN186820B/en
Priority to ZA9604139A priority patent/ZA964139B/xx
Priority to GEAP19963558A priority patent/GEP20002241B/en
Priority to US08/776,113 priority patent/US5872125A/en
Priority to HU9700284A priority patent/HUP9700284A3/hu
Priority to PCT/ES1996/000121 priority patent/WO1996038439A1/es
Priority to NZ308110A priority patent/NZ308110A/xx
Priority to EE9700067A priority patent/EE9700067A/xx
Priority to AU57650/96A priority patent/AU699210B2/en
Priority to SK126-97A priority patent/SK12697A3/sk
Priority to MA24252A priority patent/MA23883A1/fr
Priority to CN96190703A priority patent/CN1076020C/zh
Priority to PL96318280A priority patent/PL318280A1/xx
Priority to CZ97247A priority patent/CZ24797A3/cs
Priority to MX9700792A priority patent/MX9700792A/es
Priority to EP96914220A priority patent/EP0771798A1/en
Priority to JP8536224A priority patent/JPH10503532A/ja
Priority to RU97102703/04A priority patent/RU2178789C2/ru
Priority to CA002196425A priority patent/CA2196425A1/en
Priority to CO96027954A priority patent/CO4700461A1/es
Priority to IL11849496A priority patent/IL118494A0/xx
Priority to UY24241A priority patent/UY24241A1/es
Priority to YU32396A priority patent/YU32396A/sh
Priority to TR96/00455A priority patent/TR199600455A2/xx
Priority to BG101176A priority patent/BG62966B1/bg
Priority to IS4420A priority patent/IS4420A/is
Priority to NO970392A priority patent/NO310073B1/no
Publication of ES2099031A1 publication Critical patent/ES2099031A1/es
Application granted granted Critical
Publication of ES2099031B1 publication Critical patent/ES2099031B1/es
Priority to IL13176199A priority patent/IL131761A0/xx
Priority to IL13176099A priority patent/IL131760A0/xx
Priority to IL13176299A priority patent/IL131762A0/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NUEVOS POLIMORFOS DE DICLORHIDRATO DE LESOPITRON Y SUS FORMAS HIDRATADAS, PROCEDIMIENTOS DE PREPARACION Y COMPOSICIONES QUE LOS CONTIENEN. COMPRENDE LOS NUEVOS POLIMORFOS I Y II DE DICLORHIDRATO DE LESOPITRON CARACTERIZADOS POR SUS ESPECTROS INFRARROJO Y DIFRACTOGRAMAS DE RAYOS-X. SE OBTIENEN POR CRISTALIZACION DEL DICLORHIDRATO DE LESOPITRON. ASIMISMO COMPRENDE LAS FORMAS I-HIDRATO Y II-HIDRATO, QUE SE OBTIENEN DE LOS CORRESPONDIENTES POLIMORFOS, QUE POSEEN UN CONTENIDO EN AGUA DEL 3 AL 6 POR CIENTO Y DEL 1,5 AL 2,5 POR CIENTO, RESPECTIVAMENTE. TALES PRODUCTOS SE UTILIZAN EN MEDICINA HUMANA PRINCIPALMENTE POR SU ACTIVIDAD FARMACOLOGICA SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES09501086A 1995-05-31 1995-05-31 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen. Expired - Fee Related ES2099031B1 (es)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ES09501086A ES2099031B1 (es) 1995-05-31 1995-05-31 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
ARP960102643A AR003952A1 (es) 1995-05-31 1996-05-21 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimiento de preparacion y composiciones farmacologicas que los contienen
IN921CA1996 IN186820B (es) 1995-05-31 1996-05-21
ZA9604139A ZA964139B (en) 1995-05-31 1996-05-23 Polymorphs of Lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it.
EP96914220A EP0771798A1 (en) 1995-05-31 1996-05-29 Novel polymorphs of lesopitron dichlorohydrate and its hydrated forms, preparation methods and compositions containing them
HU9700284A HUP9700284A3 (en) 1995-05-31 1996-05-29 Novel polymorphs of lesopitron dichlorohydrate and its hydrated forms, preparation methods and compositions containing them
PCT/ES1996/000121 WO1996038439A1 (es) 1995-05-31 1996-05-29 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen
NZ308110A NZ308110A (en) 1995-05-31 1996-05-29 Polymorphs of lesopitron dihydrochloride, ie 2-[4-[4-[4- (chloropyrazole-1-yl)butyl]-1-piperazinyl]pyrimidine, and its hydrated forms, preparation and pharmaceutical compositions
EE9700067A EE9700067A (et) 1995-05-31 1996-05-29 Lesopitrooni dihüdrokloriidi uued polümorfsed modifikatsioonid ja hüdrateeritud vormid, nende valmistamise meetodid ja kasutamine ning neid sisaldavad kompositsioonid
AU57650/96A AU699210B2 (en) 1995-05-31 1996-05-29 New polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it
SK126-97A SK12697A3 (en) 1995-05-31 1996-05-29 Polymorphs of lesopitron dichlorochloride and its hydrated forms, preparation method and compositions containing them
MA24252A MA23883A1 (fr) 1995-05-31 1996-05-29 Nouvelles varietes polymorphiques de dichlorhydrate de lesopitron et ses formes hydratees, processus de preparation et compositions les contenant
CN96190703A CN1076020C (zh) 1995-05-31 1996-05-29 来苏必通二盐酸盐的新晶型和其水合物、制备方法和组合物
PL96318280A PL318280A1 (en) 1995-05-31 1996-05-29 Novel polymorphous modifications of lesopitrone dihydrochloride and theirhydrogenated forms, methods of obtaining them and compositions containing them
CZ97247A CZ24797A3 (en) 1995-05-31 1996-05-29 Polymorphs of lesopitron dihydrochloride and their hydrated forms, process of their preparation and pharmaceutical composition containing thereof
MX9700792A MX9700792A (es) 1995-05-31 1996-05-29 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
GEAP19963558A GEP20002241B (en) 1995-05-31 1996-05-29 Polymorphs and Hydrated Forms of Lesopitron Dichlorohydrate, Methods for Its Preparation and Pharmaceutical Compositions Containing Same
JP8536224A JPH10503532A (ja) 1995-05-31 1996-05-29 レソピトロン二塩酸塩の新規多形およびその水和形その製造方法およびそれを含有する組成物
RU97102703/04A RU2178789C2 (ru) 1995-05-31 1996-05-29 Новые полиморфные формы дигидрохлорида лесопитрона и их гидратные формы, способы получения и композиции на их основе
CA002196425A CA2196425A1 (en) 1995-05-31 1996-05-29 Novel polymorphs of lesopitron dichlorohydrate and its hydrated forms, preparation methods and compositions containing them
US08/776,113 US5872125A (en) 1995-05-31 1996-05-29 Polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it
CO96027954A CO4700461A1 (es) 1995-05-31 1996-05-30 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimiento de preparacion y composiciones que los contienen
IL11849496A IL118494A0 (en) 1995-05-31 1996-05-30 New polymorphs of lesopitron dihydrochloride and its hydrated forms preparation processes and compositions containing them
UY24241A UY24241A1 (es) 1995-05-31 1996-05-30 Procedimiento de preparación de nuevos polimorfos de diclorhidrato de lesopitron.-
YU32396A YU32396A (sh) 1995-05-31 1996-05-30 Novi polimorfi lisopitron dihidrohlorida i njegovi hidrantni oblici, postupci za izradu i sastavi koji ga sadrže
TR96/00455A TR199600455A2 (tr) 1995-05-31 1996-05-31 Lesopitron dihidroklorid'in yeni polimorflari ve hidratlanmis bicimleri, hazirlama prosesleri ve bunu iceren bilesimler.
BG101176A BG62966B1 (bg) 1995-05-31 1997-01-27 Нови полиморфни форми на лезопитрон дихидрохлорида и неговите хидратни форми, методи за тяхното получаване и състави, които ги съдържат
NO970392A NO310073B1 (no) 1995-05-31 1997-01-29 Nye polymorfer av lesopitron-diklorhydrat og dets hydratiserte former, fremstillingsmetoder og sammensetning inneholdende dem
IS4420A IS4420A (is) 1995-05-31 1997-01-29 Nýir fjölgervingar af lesópítróndíklóróhýdrati oghýdreruðum myndum þess, framleiðsluaðferðir og efnablöndur sem innihalda þá
IL13176199A IL131761A0 (en) 1995-05-31 1999-09-06 Polymorph ii of lesopitron dihydrochloride preparation processes and compositions containing it
IL13176099A IL131760A0 (en) 1995-05-31 1999-09-06 New polymorph of lesopitron dihydrochloride termed i-hydrate reparation processes and compositions containing
IL13176299A IL131762A0 (en) 1995-05-31 1999-09-06 Polymorph ii of lesopitron dihydrochloride preparation processes and compositions containing it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09501086A ES2099031B1 (es) 1995-05-31 1995-05-31 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.

Publications (2)

Publication Number Publication Date
ES2099031A1 true ES2099031A1 (es) 1997-05-01
ES2099031B1 ES2099031B1 (es) 1997-12-01

Family

ID=8290585

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09501086A Expired - Fee Related ES2099031B1 (es) 1995-05-31 1995-05-31 Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.

Country Status (29)

Country Link
US (1) US5872125A (es)
EP (1) EP0771798A1 (es)
JP (1) JPH10503532A (es)
CN (1) CN1076020C (es)
AR (1) AR003952A1 (es)
AU (1) AU699210B2 (es)
BG (1) BG62966B1 (es)
CA (1) CA2196425A1 (es)
CO (1) CO4700461A1 (es)
CZ (1) CZ24797A3 (es)
EE (1) EE9700067A (es)
ES (1) ES2099031B1 (es)
GE (1) GEP20002241B (es)
HU (1) HUP9700284A3 (es)
IL (1) IL118494A0 (es)
IN (1) IN186820B (es)
IS (1) IS4420A (es)
MA (1) MA23883A1 (es)
MX (1) MX9700792A (es)
NO (1) NO310073B1 (es)
NZ (1) NZ308110A (es)
PL (1) PL318280A1 (es)
RU (1) RU2178789C2 (es)
SK (1) SK12697A3 (es)
TR (1) TR199600455A2 (es)
UY (1) UY24241A1 (es)
WO (1) WO1996038439A1 (es)
YU (1) YU32396A (es)
ZA (1) ZA964139B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869970B2 (en) 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382637A1 (fr) * 1989-02-09 1990-08-16 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
EP0429360A2 (fr) * 1989-11-22 1991-05-29 Laboratorios Del Dr. Esteve, S.A. Inhibition du syndrome d'abstinence
EP0497658A1 (fr) * 1991-01-25 1992-08-05 Laboratorios Del Dr. Esteve, S.A. Utilisation de dérivés 1-H-azole-(omega-(4-(2-pyrimidinyl)-1-pipérazinyl)-alkyl) pour la préparation de médicaments destinés au traitement des troubles des fonctions cognitives
EP0497659A1 (fr) * 1991-01-28 1992-08-05 Laboratorios Del Dr. Esteve, S.A. Dérivés d'aryl (ou hétéroaryl)-piperaz inyl-alkyl-azoles, leur préparation et leur application en tant que médicaments
EP0502786A1 (fr) * 1991-03-07 1992-09-09 Laboratorios Del Dr. Esteve, S.A. Procédé de préparation de dérivés d'aryl (ou hétéroaryl)-pipérazinyl-butyl-azoles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382637A1 (fr) * 1989-02-09 1990-08-16 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
EP0429360A2 (fr) * 1989-11-22 1991-05-29 Laboratorios Del Dr. Esteve, S.A. Inhibition du syndrome d'abstinence
EP0497658A1 (fr) * 1991-01-25 1992-08-05 Laboratorios Del Dr. Esteve, S.A. Utilisation de dérivés 1-H-azole-(omega-(4-(2-pyrimidinyl)-1-pipérazinyl)-alkyl) pour la préparation de médicaments destinés au traitement des troubles des fonctions cognitives
EP0497659A1 (fr) * 1991-01-28 1992-08-05 Laboratorios Del Dr. Esteve, S.A. Dérivés d'aryl (ou hétéroaryl)-piperaz inyl-alkyl-azoles, leur préparation et leur application en tant que médicaments
EP0502786A1 (fr) * 1991-03-07 1992-09-09 Laboratorios Del Dr. Esteve, S.A. Procédé de préparation de dérivés d'aryl (ou hétéroaryl)-pipérazinyl-butyl-azoles

Also Published As

Publication number Publication date
GEP20002241B (en) 2000-09-25
PL318280A1 (en) 1997-06-09
IS4420A (is) 1997-01-29
CA2196425A1 (en) 1996-12-05
WO1996038439A1 (es) 1996-12-05
AU5765096A (en) 1996-12-18
UY24241A1 (es) 1996-06-14
HUP9700284A3 (en) 1998-01-28
CN1076020C (zh) 2001-12-12
IL118494A0 (en) 1996-09-12
CZ24797A3 (en) 1997-05-14
CN1158128A (zh) 1997-08-27
AU699210B2 (en) 1998-11-26
RU2178789C2 (ru) 2002-01-27
EE9700067A (et) 1997-10-15
BG101176A (en) 1997-08-29
HU9700284D0 (en) 1997-04-28
AR003952A1 (es) 1998-09-30
NO970392D0 (no) 1997-01-29
EP0771798A1 (en) 1997-05-07
BG62966B1 (bg) 2000-12-29
IN186820B (es) 2001-11-17
MX9700792A (es) 1997-05-31
HUP9700284A2 (en) 1997-11-28
NZ308110A (en) 1997-08-22
MA23883A1 (fr) 1996-12-31
NO310073B1 (no) 2001-05-14
CO4700461A1 (es) 1998-12-29
ZA964139B (en) 1997-02-06
TR199600455A2 (tr) 1996-12-21
ES2099031B1 (es) 1997-12-01
US5872125A (en) 1999-02-16
JPH10503532A (ja) 1998-03-31
YU32396A (sh) 1999-07-28
NO970392L (no) 1997-04-01
SK12697A3 (en) 1997-07-09

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