NZ292991A - Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them - Google Patents
Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing themInfo
- Publication number
- NZ292991A NZ292991A NZ292991A NZ29299195A NZ292991A NZ 292991 A NZ292991 A NZ 292991A NZ 292991 A NZ292991 A NZ 292991A NZ 29299195 A NZ29299195 A NZ 29299195A NZ 292991 A NZ292991 A NZ 292991A
- Authority
- NZ
- New Zealand
- Prior art keywords
- tetrahydropyrazolopyridines
- pde
- phosphodiesterase
- tnf
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32643494A | 1994-10-20 | 1994-10-20 | |
| PCT/IB1995/000847 WO1996012720A1 (en) | 1994-10-20 | 1995-10-06 | Bicyclic tetrahydro pyrazolopyridines and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ292991A true NZ292991A (en) | 1999-02-25 |
Family
ID=23272184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ292991A NZ292991A (en) | 1994-10-20 | 1995-10-06 | Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0787132A1 (xx) |
| JP (1) | JPH09511758A (xx) |
| KR (1) | KR970707124A (xx) |
| CN (1) | CN1050129C (xx) |
| AU (1) | AU702105B2 (xx) |
| BR (1) | BR9504491A (xx) |
| CZ (1) | CZ120097A3 (xx) |
| FI (1) | FI954991A (xx) |
| HU (1) | HUT77517A (xx) |
| IL (1) | IL115667A0 (xx) |
| MX (1) | MX9504422A (xx) |
| NO (1) | NO971811L (xx) |
| NZ (1) | NZ292991A (xx) |
| PL (1) | PL319758A1 (xx) |
| WO (1) | WO1996012720A1 (xx) |
| ZA (1) | ZA958839B (xx) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1147A (en) * | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
| WO1997048697A1 (en) | 1996-06-19 | 1997-12-24 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| TR199802685T2 (xx) * | 1996-06-25 | 1999-03-22 | Pfizer Inc | �kameli/katk�l� indazol t�revleri |
| DK0983249T3 (da) * | 1997-05-08 | 2002-07-08 | Pfizer Prod Inc | Fremgangsmåder og mellemprodukter til fremstilling af substituerede indazolderivater |
| IL126745A (en) * | 1997-11-04 | 2003-09-17 | Pfizer Prod Inc | Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors |
| US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
| KR100628407B1 (ko) | 1998-12-23 | 2006-09-26 | 브리스톨-마이어스 스퀴브 파마 컴파니 | Ｘａ 인자 억제제로서의 질소 함유 헤테로비시클릭 화합물 |
| US6326495B2 (en) | 1999-04-30 | 2001-12-04 | Pfizer Inc. | Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| MXPA03001169A (es) * | 2000-08-10 | 2003-06-30 | Pharmacia Italia Spa | Biciclo-pirazoles activos como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que comprenden los mismos. |
| US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
| CA2444571A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors |
| CA2441772A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor xa inhibitors |
| US7902179B2 (en) | 2001-04-26 | 2011-03-08 | Ajinomoto Co., Inc. | Heterocyclic compounds |
| CH1427415H1 (de) | 2001-09-21 | 2023-12-21 | Bristol Myers Squibb Holdings Ireland | Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer |
| TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
| MXPA05000947A (es) * | 2002-07-25 | 2005-05-16 | Pharmacia Italia Spa | Biciclo-pirazoles activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
| FR2857363B1 (fr) * | 2003-07-10 | 2007-09-07 | Aventis Pharma Sa | 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation |
| AR045037A1 (es) * | 2003-07-10 | 2005-10-12 | Aventis Pharma Sa | Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion. |
| BRPI0619633A2 (pt) | 2005-12-01 | 2011-10-04 | Elan Pharm Inc | 5-(arilsulfonil)-pirazolopiperidinas |
| CN102066385A (zh) * | 2008-04-30 | 2011-05-18 | 弗雷德里克·阿尔姆奎斯特 | 新的拟肽化合物 |
| CN102282147B (zh) | 2009-01-28 | 2015-09-30 | 卡拉治疗学股份有限公司 | 二环吡唑并-杂环 |
| US7741350B1 (en) | 2009-01-28 | 2010-06-22 | Cara Therapeutics, Inc. | Bicyclic pyrazolo-heterocycles |
| WO2015188051A1 (en) * | 2014-06-06 | 2015-12-10 | Biogen Ma Inc. | Atx modulating agents |
| CN115043768A (zh) * | 2022-06-20 | 2022-09-13 | 新乡市润宇新材料科技有限公司 | 一种酸促进环丙基开环合成n-芳基吡咯烷-2-酮的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
| US3340269A (en) * | 1964-09-08 | 1967-09-05 | Ciba Geigy Corp | 1-substituted 4-acyl-2, 3-dioxo-piperidine |
| FR1463883A (fr) * | 1964-09-08 | 1966-07-22 | Ciba Geigy | Procédé de préparation de triaza-composés bicycliques |
| CN1048015C (zh) * | 1993-07-06 | 2000-01-05 | 美国辉瑞有限公司 | 双环四氢吡唑并吡啶类化合物 |
-
1995
- 1995-10-06 WO PCT/IB1995/000847 patent/WO1996012720A1/en not_active Application Discontinuation
- 1995-10-06 KR KR1019970702557A patent/KR970707124A/ko active IP Right Grant
- 1995-10-06 JP JP8513751A patent/JPH09511758A/ja active Pending
- 1995-10-06 NZ NZ292991A patent/NZ292991A/xx unknown
- 1995-10-06 HU HU9702289A patent/HUT77517A/hu unknown
- 1995-10-06 PL PL95319758A patent/PL319758A1/xx unknown
- 1995-10-06 EP EP95932148A patent/EP0787132A1/en not_active Withdrawn
- 1995-10-06 CN CN95195743A patent/CN1050129C/zh not_active Expired - Fee Related
- 1995-10-06 AU AU35317/95A patent/AU702105B2/en not_active Ceased
- 1995-10-06 CZ CZ971200A patent/CZ120097A3/cs unknown
- 1995-10-18 IL IL11566795A patent/IL115667A0/xx unknown
- 1995-10-19 ZA ZA958839A patent/ZA958839B/xx unknown
- 1995-10-19 MX MX9504422A patent/MX9504422A/es unknown
- 1995-10-19 FI FI954991A patent/FI954991A/fi unknown
- 1995-10-20 BR BR9504491A patent/BR9504491A/pt not_active Application Discontinuation
-
1997
- 1997-04-18 NO NO971811A patent/NO971811L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA958839B (en) | 1997-04-21 |
| AU702105B2 (en) | 1999-02-11 |
| AU3531795A (en) | 1996-05-15 |
| CZ120097A3 (cs) | 1998-01-14 |
| EP0787132A1 (en) | 1997-08-06 |
| PL319758A1 (en) | 1997-08-18 |
| FI954991A0 (fi) | 1995-10-19 |
| BR9504491A (pt) | 1997-05-20 |
| JPH09511758A (ja) | 1997-11-25 |
| IL115667A0 (en) | 1996-01-19 |
| MX9504422A (es) | 1997-04-30 |
| CN1161040A (zh) | 1997-10-01 |
| FI954991A (fi) | 1996-04-21 |
| NO971811L (no) | 1997-06-18 |
| KR970707124A (ko) | 1997-12-01 |
| HUT77517A (hu) | 1998-05-28 |
| NO971811D0 (no) | 1997-04-18 |
| WO1996012720A1 (en) | 1996-05-02 |
| CN1050129C (zh) | 2000-03-08 |
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