NZ245170A - Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions - Google Patents

Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions

Info

Publication number
NZ245170A
NZ245170A NZ24517092A NZ24517092A NZ245170A NZ 245170 A NZ245170 A NZ 245170A NZ 24517092 A NZ24517092 A NZ 24517092A NZ 24517092 A NZ24517092 A NZ 24517092A NZ 245170 A NZ245170 A NZ 245170A
Authority
NZ
New Zealand
Prior art keywords
arg
insulin
pharmaceutical compositions
proinsulin analogues
proinsulin
Prior art date
Application number
NZ24517092A
Other languages
English (en)
Inventor
James Arthur Hoffmann
Peter Karl Lambooy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NZ245170A publication Critical patent/NZ245170A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ24517092A 1991-11-26 1992-11-18 Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions NZ245170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80116391A 1991-11-26 1991-11-26

Publications (1)

Publication Number Publication Date
NZ245170A true NZ245170A (en) 1994-07-26

Family

ID=25180362

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ24517092A NZ245170A (en) 1991-11-26 1992-11-18 Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions

Country Status (17)

Country Link
US (2) US5491216A (OSRAM)
EP (1) EP0544466A1 (OSRAM)
JP (1) JP3304442B2 (OSRAM)
KR (1) KR930009591A (OSRAM)
CN (1) CN1072723A (OSRAM)
AU (1) AU2857692A (OSRAM)
BR (1) BR9204542A (OSRAM)
CA (1) CA2083360A1 (OSRAM)
CZ (1) CZ342492A3 (OSRAM)
FI (1) FI925343A7 (OSRAM)
HU (2) HU9203688D0 (OSRAM)
IL (1) IL103849A0 (OSRAM)
MX (1) MX9206724A (OSRAM)
NO (1) NO924525L (OSRAM)
NZ (1) NZ245170A (OSRAM)
TW (1) TW224471B (OSRAM)
ZA (1) ZA928916B (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69637130T2 (de) * 1995-02-20 2008-02-21 The Walter And Eliza Hall Institute Of Medical Research, Parkville Immunoreaktive und immunotherapeutische moleküle welche in individuen mit insulin-abhängiger diabetes mellitus interagieren
DE59711533D1 (de) * 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
DE60120372T2 (de) 2000-03-24 2007-07-05 Genentech Inc., San Francisco Verwendung von insulin zur behandlung von knorpelkrankheiten
US20050014679A1 (en) * 2001-12-20 2005-01-20 Beals John Michael Insulin molecule having protracted time action
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
JP5550338B2 (ja) 2006-07-31 2014-07-16 ノボ・ノルデイスク・エー／エス ペグ化持続型インスリン
ES2601839T3 (es) 2006-09-22 2017-02-16 Novo Nordisk A/S Análogos de insulina resistentes a proteasas
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
EP2910571B1 (en) 2008-03-18 2016-10-05 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
US20110195896A1 (en) * 2008-04-22 2011-08-11 Case Western Reserve University Isoform-specific insulin analogues
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
AU2010327949A1 (en) 2009-12-11 2012-06-28 Case Western Reserve University Insulin analogues with chlorinated amino acids
WO2012123519A2 (en) * 2011-03-15 2012-09-20 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
JP6199956B2 (ja) 2012-04-11 2017-09-20 ノヴォ ノルディスク アー／エス インスリン製剤
WO2015052088A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
CN104017809A (zh) * 2014-06-05 2014-09-03 山东省农业科学院生物技术研究中心 改造的人Insulin蛋白表达基因及表达方法
EP3204410B1 (en) 2014-10-06 2021-01-20 Case Western Reserve University Biphasic single-chain insulin analogues
CA2979397A1 (en) 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
TW201726702A (zh) * 2015-09-24 2017-08-01 韓美藥品股份有限公司 生產胰島素之方法
PE20210857A1 (es) 2016-12-16 2021-05-18 Novo Nordisk As Composiciones farmaceuticas que contienen insulina

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
US4569792A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4581165A (en) * 1984-06-14 1986-04-08 Eli Lilly And Company Anti-diabetic compounds
US4569791A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
ZA877505B (en) * 1986-10-14 1989-05-30 Lilly Co Eli Process for transforming a human insulin precursor to human insulin
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
ATE101620T1 (de) * 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
US5139716A (en) * 1990-02-20 1992-08-18 Loral Aerospace Corp. Method of fabricating coolable ceramic structures

Also Published As

Publication number Publication date
ZA928916B (en) 1994-05-18
FI925343L (fi) 1993-05-27
HU9203688D0 (en) 1993-03-29
AU2857692A (en) 1993-05-27
NO924525D0 (no) 1992-11-24
IL103849A0 (en) 1993-04-04
KR930009591A (ko) 1993-06-21
CA2083360A1 (en) 1993-05-27
CZ342492A3 (en) 1993-06-16
FI925343A0 (fi) 1992-11-25
JP3304442B2 (ja) 2002-07-22
FI925343A7 (fi) 1993-05-27
MX9206724A (es) 1993-05-01
EP0544466A1 (en) 1993-06-02
NO924525L (no) 1993-05-27
US5698669A (en) 1997-12-16
BR9204542A (pt) 1993-06-01
TW224471B (OSRAM) 1994-06-01
CN1072723A (zh) 1993-06-02
JPH05286998A (ja) 1993-11-02
US5491216A (en) 1996-02-13
HUT63457A (en) 1993-08-30

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