NZ241290A - Hair stimulating composition containing fermentation products - Google Patents
Hair stimulating composition containing fermentation productsInfo
- Publication number
- NZ241290A NZ241290A NZ241290A NZ24129092A NZ241290A NZ 241290 A NZ241290 A NZ 241290A NZ 241290 A NZ241290 A NZ 241290A NZ 24129092 A NZ24129092 A NZ 24129092A NZ 241290 A NZ241290 A NZ 241290A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hair
- nourishing agent
- hair nourishing
- agent according
- enzyme
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K7/00—Watering equipment for stock or game
- A01K7/02—Automatic devices ; Medication dispensers
- A01K7/06—Automatic devices ; Medication dispensers actuated by the animal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Description
New Zealand Paient Spedficaiion for Paient Number £41 290
24 12 9 0
Pr.-.rf Or.'-."'"•:
Coi MlvlWLi n r,L:i: ,^A?!L..
h cv.'sihol'sto;.. —
2 5 OCT 1993
l;;!1::
P.O. JOijrrV. No: i'r.lS..
|W:
-r ^ » --Ts
Patents Form No. 5
NEW ZEALAND PATENTS ACT 1953 COMPLETE SPECIFICATION
HAIR NOURISHING AGENT AND PRODUCTION THEREOF
WE, KABUSHIKI-KAISHA TANISAKE, a Japanese company of 2957-1 Katayama, Ikeda-cho, Ibi-gun, Gifu-ken,
JAPAN
hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:
fJ.Z. PATENT OFFICE
13 JAN 1992
RECEIVE
(followed by page la)
24 12 9 0
The present invention relates to a hair nourishing agent and the production thereof. More particularly, the invention relates to a hair nourishing agent comprising fermented products obtained by applying, for example, a mixture of lipase and proteinase or rice yeast on a substrate containing vegetable protein such as rice bran and vegetable lipid, and also to the production thereof.
The true mechanism of falling-out and growth of hair is yet to be discovered. Chief causes of falling-out of hair, however, are generally believed to be interruption in blood circulation, low metabolism, excessive male hormone, skin inflammation and allergies.
0
\ hair comprises the part protruding out of skin and the part under skin. The hair bulb at the root of a hair comprises tissue called papillar cells. Numerous capillaries surround a hair bulb and papillar cells take in nutrition from blood running in the capillaries, repeating cell divisions and growing the hair.
However, if blood is not sufficiently supplied into the cells, the cell divisional activity slows down, resulting in
(followed by page 2)'
ok 12 9 0
blockage to growth of the hair. Accordingly, it is often claimed indispensable for the growth of hair to promote blood circulation in the skin and activate the functions of the cells.
Hair follicle which surrounds a hair possesses enzyme called 5 a -reductase, which gets converted into 5a-dihydrotestosteron by combining with male hormone, which is then transported via blood vessels to papillar cells, slowing down the activity of adenylcyclase thereof and leading to slowing down of the cell divisions. As a result, the hair follicle gets gradually atrophied, and the hair becomes downy, leading to generationg of baldness.
As mentioned above as examples, there are a number of views on the mechanism of falling-out and growth of hair, though, none of them are established ones. Presently there are great many types of hair growers distributed on the market. claiming they contain substances which the distributors believe are effective according to their understanding of the mechanism, for instance, for promoting blood circulation in head skin and/or activating papillar cells. However, a hair agent which is truly effective on hair is yet to appear in the market.
Under such circumstances, the inventor of the present invention has continued a long and strenuous research and finally come up with the present invention of a hair nourishing agent which works excellently on hair, comprising fermented products obtained by applying, for example, a
A 4 *'> Q
; i '«#
n Lur 9 of 1 ipas-> and proteinase or rice v ea ? t on a subs t ra t» containing vegetable protein such as rice bran and vegetable 1 l p i d.
This invention provides a hair nourishing agent comprising fermentation products obtained by decomposing a substrate comprising vegetable protein and vegetable lipids using an enzyme; and a carrier suitable for use on hair.
Said substrate may comprise anything that contains vegetable protein and vegetable lipid. Enzyme for the fermentation must possess the ability to decompose the vegetable protein and the vegetable lipid in the substrate. Such enzyme may be lipase and proteinase. Other types of enzyme such as amylase may be additionally used.
The fermented products go through a filterTng process and hair nourishing agents of the present invention are thus obtained. They are harmless to human body and show excellent effects in preventing hair from falling out as well as in grow ing hair.
The present invention will be more fully described in the following.
?. A 1 ? 9 0
.A substrate for producing a hair nourishing agent of the present invention may be anything that contains vegetable protein and vegetable lipid. It may be, for example, grain products such as rice bran, sake lees, wheat embryo buds, fusuma bran, whole buckwheat or whole barnyard millet, bean products such as soybeans, bean-curd refuse, soybpan milk, adzuki beans, soybean flour or coffee grounds, or others such as yams, taros, tea grounds, honey, sesame, peanuts, lotus seeds, ashitaba, beefsteak plants, wakame seaweed or sea tangles. Rice bran, sake lees, fnsuma bran, coffee grounds, wheat embryo buds, sesame, bean-curd refuse, soybeans and adzuki beans are especially preferred as they contain wel1-ballanced vegetable protein and vegetable lipid.
Enzyme to be used for fermentation of the present invention need be capable of decomposing both vegetable protein and vegetable lipid in said substrate. They may be lipase and proteinase and others such as amylase may also be additionally used. Besides lipase and proteinase, rice yeast
*
which possesses functions of producing a variety of enzyme in a living body may also be utilized.
Lipase to be utilized for the present invention may be spermato lipase used in the acidic range which is contained in a variety of mold, yeast, microorganisms, humors, or enzyme taken from internal organs. More particularly, pancreas lipase, liver lipase, tubercle bacteria lipase, FIB lipase and hima lipase may be used.
241290
Proteinase to be utilized for the present invention is preferred to be acidic at the most suitable pH. In this regard. pepsin, trypsin or chymotrypsin. not possessing any particular active base except amino acid residue of the enzyme itself and not requiring any particular reagent for enzymatic activities, may be utilized. Or most of enzyme or cathepsin found in vegetable enzyme and animal cells such as papain or ficin, which can be activated by a reducing agent such as hydrocyan ate. ascorbic acid, cysteine or glutathione, may also be used. More particularly, chymotrypsin, trypsin, pepsin. carboxy peptidase. cathepsin A, cathepsin B. cathepsin C', cathepsin 111, cathepsin IV, kidney acylase I. kidney acylase II, leucine amino peptidase.
aminotripeptidase, glycilglycine dipeptidase, prolitase, prolinase, plasmin, thrombin, papain, ficin, streptococcus, proteinase, CI, hitolyticum proteinase or peptidase can be utilized.
Fermented products can be obtained by applying enzyme on said substrate. Analyses were made upon the fermented products by HPLC and the following results were obtained.
Said analyses were made using a detector (LC-9A. Shimadzu Seisakusho, Co.. Ltd.) and columns (3 m in length). As an elution layer, acetonitrile solvent was used and the column temperature was kept about 30 °C and the flow speed was about 10 m 1 /m i n.
The fermented products were found to contain such fatty acids as myristic acid, palmitic acid, stearic acid, arachic acid. behenic acid, lignoceric acid, dodecenic acid, tetradecenic acid. tetradecadienic acid, pentadecenic acid.
1 2
h ex'ide o n l c acid, oleic acid, lino leu: acid, linolenic acid, eicosaenic acid, eicosadienic acid, arachidonic acid, eicosatrienic acid, dococenic acid, and docosahexanic acid. The fermented products were found to also contain such amino acids as leucine, iso leucine, lysine, methionine, cystein, phenylalanine, tyrosine, threonine, tryptophan, valine, histidine, arginine, aspartic acid, alanine, glutamin acid, glycine, proline and celin.
As is clear from the results of the analyses, the fermented products obtained according to the present invention contain a variety of amino acids and fatty acids. Amino acids are believed to function to give nutrition to papillar cells and fatty acids are believed to function to activate and expand capillary blood vessels, to supply hair with moisture to give a shining appearance as well as to inactivate 5a-reductase contained in hair follicle to prevent softening of hair. The components singly or in combination are believed to promote growth of hair as well. It should be noted that the fermented products also contain amino acids
0
which include sulphur and unsatulated fatty acids, both of which are believed to possess excellent effects on the growth of hair.
The products obtained by fermentation by applying rice yeast on the substrate according to the present invention were found to contain in small quantity vitamin A, vitamin B , vitamin Bi, vitamin B- , vitamin B : -, vitamin C, vitamin E, copper, iron, calucium, phosphorus, purine, deoxyribonucleic acid, ribonuleic acid, adenine, guanine, uracil, cytosine and
? 4 1 2 9 0
xanthine in addition to the components confirmed in said fermented products obtained using a mixture of lipase and proteinase, since a variety of enzyme besides lipase and proteinase, such as amylase, gIutaminase, cellulase and pectinase are produced in the rice yeast, decomposing not only the vegetable protein and vegetable lipid but also other components in the substrate. It is beiieved that such other components also help promote hair growth by synergism with said amino acids and fatty acids.
For preservation of the hair nourishing agents of the present invention, they may be refrigerated or boiled,
however, there is no functional change or degradation of the effects of the hair nourishing agents.
In the following a description of a method for producing the hair nourishing agent of the present invention is given. The method comparises steps of applying enzyme on a substrate containing vegetable protein and vegetable lipid and of filtering the fermented products thus obtained.
The fermentation is performed under aquerous conditions. Lipase and proteinase or rice yeast which produces other enzyme such as amylase is used as enzyme. The lipase and the proteinase may be separately applied or applied together in a form of a mixture. Said mixture can contain other enzyme such as amylase in order to promote decompositionaI function and to decompose other components in the substrate. It is preferred to apply 0.1 w % of each enzyme in said mixture against the substrate of 100. In case
7 k i ? 9
o f rice vp.ist, as the decompos i tiona ! lunct ion of said •/ .n s t :s weak compared with thai of Lipase or proteinase, it is better to add 1 w % of rice yeast against 100 of the subs trate.
The fermentation temperature is preferred to be room temperature or 35:C to 45'C, and as a buffer solution, pH 6 to 11 of hydrochloric acid-col 1 idine, primary potassium phosphate-secondary potassium phosphate, hydrochloric acid-sodium Veronal, hydrochloric acid-trisaminometnane,
hydrochloric acid-borax, boric acid-sodium carborate,
hydrochloric acid-aminomethyl propane diol. ammonium cho1 oride-ammonia, g1ycine-sodium hydroxide, boric acid-sodium hydroxide, hydrochloric acid-sodium dime thylglycinate,
sodium bicarbonate-sodium carbonate, borax-sodium hydroxide, borax-sodium carbonate, hydrochloric acid-sodium carbonate,
secondary sodium phosphate-sodium hydroxide or the like can be used. Any combination or combinations of said substances may also be used in the form of a mixture.
0
The reaction time for the fermentation is preferably 5 to 10 hours under agitation. The completion of the reaction can be known, as for lipase, by giving a predetermined coloring matter as an indicator and checking the amcuint of the extricated fatty acids which are produced by hydrolysis of ester, or by electrical titration using alkali, tohen the above is not easily performed, use colorimetry for the alcohol extricated in hydrolysis. As for proteinase, use the ninhydrine colorimetry, which is colorimetry of amino acids
»5 ' i 0 0
f ^4 1 L. ***
by the bluish matter produced as a inhydr me is heated, tiheri it is not easily performed, use of the forraol titration of S^rensen is possible. This method is a utilization of the phenomenon of divergence of the titration curve for a -amino radical or imino radical under the existence of formaldehyde. For sterilization, autoclave sterilization is pre f erred.
A hair nourishing agent of the present invention is obtained by adding water or alcohol to the fermented products after having filtered said fermented products. The hair nourishing agent thus obtained can be used as it is, or can be mixed in hair lotion, hair cream, hair liquid, hair tonic, pomade, shampoo or rinse.
It is possible to mix in the hair nourishing agent of the present invention some components which are often used in the conventional hair growers such as blood facilitator, metabolism promoter, anti-male hormone, anti-inflammatory, anti-a 11ergy, moistener, anti-bacteria, and/or refrigerant. They are, for exam pie, tocopherol acetate, capronium chloride, carbonic acid gas, h i nok i t io I, pantonyl ethylether benzoinate, glyceride pentadecanate, vitamin H, ethynil estradiol, glythylricinic acid, diphenylhydramin chloride, hyaluronic acid, '-linisasanishiki extract, monon itrogua iacol, T oga ra sh i tincture. Sh onkvo tincture, hydrocortisone, diphenic hydramin chloride. D-pantotheny I alcohol, salicylic acid, lactic acid, sodium lactate, menthol and the like.
Example1?
Example 1:
Rice bran was used as a substrate. Warm water, 1,000 ml, was added to said rice bran, 500 g, and both were mixed well. The mixture was then put in an adequate container such as a glass container or a plastic container, and rice yeast, 5 g, was added to said mixture. Soduim bicarbonate, 3 g, was also added as a buffer to control pH. The container was heated by a heating means to about 45*C and kept constant at the temperature. The mixture was left for a whole day with occasional agitations. The mixture turned pasty and said pasty liquid in the container was filtered with a cloth to obtain a semitransparent hair nourishing liquid of about 1,000 ml.
Example 2:
Soybean grounds was used as a substrate. Water, 600 ml, was added to said soybean grounds, 200 g. Animal internal organs, 100 g, was prepared and water, 200 ml, was added to said animal internal organs, which was then ground with a glass homogenizer to prepare homogenate. Said homogenate was centrifuged at 1,500 rpm. The supernatant fluid, 100 ml, was then taken and added to the substrate. Sodium carbonate-boric acid was also added at this time as a buffer to adjust pH to 10.0. The mixture was left at about 40°C. The enzume activities were observed by using a kletto photoelectric colorimeter (No. 540 filter) and the end of the
9 k 1 7 9
activities was observed after about 8 hours.
Sodium carbonate-boric acid of 0.1 M (pH 10.0), 40 ml,
was added as a buffer to the fermented liquid obtained as such. Then chymotrips in was added to be 0.1 M. The whole mixture was left at about 40=C. The confirmation of the completion of the fermentation was made by measuring by the Conway's method the amount of ammonia in the sample liquids of 0.2 ml each taken from said whole mixture. After about 10 hours, generation of ammonia stopped and the fermentation was over. The fermented liquid was then filtered and washed with water. A hair nourishing liquid was thus obtained.
Example 3:
Adzuki grounds was used as a substrate. Water, 500 ml,
was added to said adzuki grounds, 200 g, and the mixture was suspended. Separately, lipase obtained from FIB mycelium was floated in distilled water of 100 in 1, which was then agitated for about 2 minutes with a Knapp-March Blender and left at room temperature for about 20 minutes. The 'top liquid obtained after centrifuging the blend at 2,000 rpm for 30 minutes was added to said mixture of adzuki grounds and water. A Brit Ion-Robinson buffer (phosphoric acid, acetic acid, boric acid, caustic soda) was added to adjust pH to 9.0. It was kept shaken for about 8 hours at about 35'C. The fermentation process was observed by titration using 0.05 M alcoholic hydrochloric acid.
Separately, papain on the market was desolved in water
O /, 1 9
and hydrogen sulfide was sent into the mixture for several hours. Then alcohol was added to said mixture to settle the papain. Water was added to the refined papain (papain 1 g : water 100 ml) and then a Britton-Robinson buffer was also added to adjust pH to 9.0, which was added to said fermentation liquid including said substrate. The whole fermentation liquid was left at about 40 °C. The end of the fermentation was confirmed by titration using alcohol of sample liquids of 0. 2 ml each taken from said whole fermentation liquid. The fermentation was over after about 12 hours. The fermented liquid was filtered and a hair nourishing liquid was thus obtained.
Example 4:
Bean-curd refuse was used as a substrate. Water, 500 ml. was added to said bean-curd refuse. 100 g, and the mixture was kept at about 50°C. Separately, kidney lipase on the market was dissolved (1 %) in distilled water. Said distilled water containing said kidney lipase (5 ml) was added to said mixture. Phosphoric acid (0.6 .M. ptf 7.0), 5 ml, was also added as a buffer and the whole mixture was kept for about 10 hours at about 4 0°C with occasional agitations. The end of the fermentation was confirmed by observing the stoppage of generation of carbonic acid gas using a Warburg's manometer.
Separately, pepsine on the market (Cudahy. 1/10,000 USP soluble pepsin). 10 g. was dissolved in a 20 % Ethanol solution. 10 ml. which was added to said fermentation liquid.
*> A 1 ? 9 0
Hydrochloric acid amnion ium was also added to adjust pH to 7.5. This liquid was left for about 20 hours at about 35'C. Then, it was filtered by means of filter cell (5 g). The pH was 7.0 at this time. The filtered liquid was left at about 37=C. The end of fermentation was confirmed by putting sample liquids of 0.5 ml each taken from the filtered liquid from outside of a Conway's apparatus and mixing each sample with the potassium carbonate, 1 ml, which had been placed in said apparatus. The end of the fermentation was known by means of observing the changes in amount of volatilizing ammonia by titration. The end was confirmed after about 10 hours. The liquid thus obtained was filtered in an ordinary manner and a hair nourishin liquid was obtained.
Evaluation of the Effect
The hair nourishing liquids obtained according to Examples 1 to -1 were diluted with ethanol and the blends were applied on men and mice once in the morning and once in the evening everyday. After 30 days of application, both cases showed an outstanding effect of hair growth. Especially in the case of the mice, the hair-growing effect was enormous.
The hair nourishing agent of Claim 1 contains fermented products containing a variety of amino acids and fatty acids. The acids singly or combindedly activate capillary blood vessels and inactivate 5a-reductase which is contained in hair follicle. Compared with conventional types of hair growing agents, the hair nourishing agent of Claim 1 shows more excellent hair-fa 11ing-out preventive effect as well as
hair growing effect. The hair nourishing agent of the present invention is not at all harmful to human body since it is a product of fermentation and the substrate comprises vegetable protein and vegetable lipid and harmless enzyme is u t i1 i z ed.
As for the hair nourishing agent of Claim 2. lipase and proteinase used as enzyme decompose the vegetable protein and the vegetable lipid used in the substrate efficiently, providing a high production rate of fermented products per unit weight.
The hair nourishing agent of Claim 5 contains, besides amino acids and fatty acids, vitamin E. copper, purine, nucleid acid, etc. in small quantity and they together with the amino acids and the fatty acids further promote hair growth.
The process of Claim 9 provides a hair nourishing agent of the present invention which activates capillary vessels and inactivates 5 a-reductase which is contained in hair follicle. The agent. therefore. works to prevent hair's falling-out and to grow hair more outstandingly than conventional hair growers.
The process of Claim 10 produces a high rate of fermented products per unit weight since lipase and proteinase are used as enzyme, which ferment the vegetable protein and the vegetable lipid in the substrate efficiently.
24 1?
The process of Claim 11 provides a hair nourishing agent which contains, besides amino acids and fatty acids, vitamin E. copper, purine, nucleid acid, etc. in small quantity and they together with the amino acids and the fatty acids further promote hair growth.
The processes of Claim 12 provide faster decomposition by means of enzyme, leading to more efficient decomposition. and therefore provides a better production rate of a hair nourishing agent per unit weight.
Claims (15)
1. A hair nourishing agent comprising fermentation products obtained by decomposing a substrate comprising vegetable protein and vegetable lipids using an enzyme or a mixture of enzymes; and a carrier suitable for use on hair.
2. A hair nourishing agent according to claim 1 in which the enzyme is a lipase or a proteinase, or both.
3. A hair nourishing agent according to claim 2 in which the lipase is spermato lipase.
4. A hair nourishing agent according to claim 2 or claim 3 in which the proteinase is selected from chymotrypsin, trypsin, pepsin, carboxy peptidase, cathepsin A, cathepsin B, cathepsin C', cathepsin III, cathepsin IV, kidney acylase I, kidney acylase II, leucine amino peptidase, aminotripeptidase, glycylglycine, dipeptidase, prolinase, plasmin, thrombin, papain, ficin, streptococcus proteinase, CI, hitolyticum proteinase and hitolyticum peptidase.
5. A hair nourishing agent according to claim 1 in which the enzyme is an enzyme produced by rice yeast.
6. A hair nourishing agent according to any one of claims 1 to 5 in which the substrate is selected from rice bran, sake lees, fusuma bran, coffee grounds, wheat embryo buds, sesame seeds, bean curd refuse, soybeans and adzuki beans.
7. A hair nourishing agent according to any one of claims 1 to 6 in which the carrier is water or ethyl alcohol, or both.
8. A hair nourishing agent according to claim 1 and substantially as described in this specification with reference to any one of examples 1 to 4. * -i.. -17-
9. A method for producing a hair nourishing agent comprising a step of applying enzyme or a mixture of enzymes on a substrate comprising vegetable protein and vegetable lipid and a step of filtering the obtained fermented products.
10. The method for producing a hair nourishing agent according to claim 9, wherein said mixture of enzymes is a mixture of lipases and proteinases.
11. The method for producing a hair nourishing agent according to claim 9, wherein said enzyme is enzyme produced by rice yeast.
12. The method for producing a hair nourishing agent according to any one of claims 9 to 11, further comprising a step of adding as a buffer into said substrate one of any combination or combinations of the chemicals of pH 6 to 11 selected from the following: hydrochloric acid-col 1idine. primary potassium phosphatc-sccondary potassium phosphate. hydrochloric acid-sodium Veronal. hydrochloric acid-trisaminomethane. hydrochloric acid-borax, boric acid-sodium carbonate. hydrochloric acid-aminomethy 1 propane d i o1, ammonium chloride-ammonia, g 1 ycine-sodiurn hydroxide, boric acid-sodium hydroxide, hydrochloric acid-sodium dimethylglycinate. sodium bicarbonate-sodium carbonate. borax-sodium hydroxide. borax-sodium carbonate, hydrochloric acid-sodium carbonate and secondary potassium phosphate-sodium hydroxide. i t / ;~-9se; ;::3 4 1 2 9 h -18-
13. A method according to claim 9 and substantially as described in this specification with reference to any one of examples 1 to 4.
14. A hair nourishing agent whenever produced by a method according to any one of claims 9 to 13.
15. A hair cosmetic in the form of a hair lotion, a hair cream, a hair liquid, a hair tonic, a pomade, a shampoo or a rinse that includes a hair nourishing agent according to any one of claims 1 to 8 and 14. KABUSHIKI-KAISHA TANISAKE f.4 /I KiH h ivj) jBy Their Attorneys h BALDWIN SON & CAREY ' / "\ "\
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31611091 | 1991-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ241290A true NZ241290A (en) | 1993-10-26 |
Family
ID=18073362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ241290A NZ241290A (en) | 1991-11-29 | 1992-01-13 | Hair stimulating composition containing fermentation products |
Country Status (19)
Country | Link |
---|---|
KR (1) | KR0160141B1 (en) |
CN (1) | CN1053098C (en) |
AT (1) | AT405016B (en) |
AU (1) | AU663301B2 (en) |
CA (1) | CA2059314C (en) |
CH (1) | CH683317A5 (en) |
DE (1) | DE4202645A1 (en) |
DK (1) | DK292A (en) |
FI (1) | FI920035A (en) |
FR (1) | FR2684295B1 (en) |
GB (1) | GB2261818B (en) |
HK (1) | HK496A (en) |
IT (1) | IT1254612B (en) |
MY (1) | MY107936A (en) |
NL (1) | NL9200160A (en) |
NO (1) | NO920202L (en) |
NZ (1) | NZ241290A (en) |
PH (1) | PH30444A (en) |
ZA (1) | ZA92186B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9909294D0 (en) * | 1999-04-22 | 1999-06-16 | Unilever Plc | Treating hair by targeting enzymes |
JP2000327538A (en) * | 1999-05-24 | 2000-11-28 | Toyo Hakko:Kk | Agent composition for hair treatment |
EP1500386A1 (en) * | 2003-07-23 | 2005-01-26 | Wella Aktiengesellschaft | Method for time-dependent decrease of ph in a cosmetic composition and a composition for permanent hair shaping with time-dependent decrease of the wave-shaping efficiency |
KR20050041573A (en) * | 2003-10-31 | 2005-05-04 | 김민호 | Composition for straight permanent of gel type |
JP5315992B2 (en) * | 2006-06-08 | 2013-10-16 | 味の素株式会社 | Hair growth composition |
FR2951947B1 (en) * | 2009-11-03 | 2022-01-07 | Isp Investments Inc | USE OF A COMPOSITION COMPRISING AN UNFERMENTED RICE PEPTIDE EXTRACT TO STIMULATE HAIR GROWTH |
FR2963234B1 (en) | 2010-07-29 | 2020-07-17 | Isp Investments Inc | USE OF A COMPOSITION COMPRISING A PEPTIDE EXTRACT OF BEANS FOR STIMULATING HAIR GROWTH |
CN105125475A (en) * | 2015-09-27 | 2015-12-09 | 常州市奥普泰科光电有限公司 | Cosmetic film-forming moisture preserving additive |
CN112022792B (en) * | 2020-09-27 | 2022-12-09 | 黑龙江省中医药科学院 | Preparation method of edible traditional Chinese medicine hair dye with homology of medicine and food |
DE102020125874A1 (en) * | 2020-10-02 | 2022-04-07 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and skin treatment composition |
DE102020125876A1 (en) * | 2020-10-02 | 2022-04-07 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and scalp treatment composition |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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CH367937A (en) * | 1958-05-23 | 1963-03-15 | Dubois Raymond | Process for preparing a product for treating the scalp and hair |
FR1268459A (en) * | 1959-05-05 | 1961-08-04 | Product for the treatment of the scalp and hair and process for the preparation thereof | |
FR1363121A (en) * | 1961-12-19 | 1964-06-12 | Hygienic-dietetic method for preventing baldness and in particular seborrheic alopecia | |
US3395019A (en) * | 1965-10-18 | 1968-07-30 | Vylactos Lab Inc | Preparation of animal feed from oat hulls |
DE1961064A1 (en) * | 1969-12-05 | 1971-06-16 | Dragoco Gerberding Co Gmbh | Process for the production of plant extract concentrates which cannot be broken down by fermentation |
FR2283204A1 (en) * | 1974-08-28 | 1976-03-26 | Roger Et Gallet | METHOD AND DEVICE FOR THE PREPARATION OF PRODUCTS INTENDED FOR USE IN THE FORM OF AEROSOLS |
JPS51151396A (en) * | 1975-06-18 | 1976-12-25 | Kikkoman Corp | Process for preparing solid koji |
JPS5356394A (en) * | 1976-10-28 | 1978-05-22 | Fukushima Hiroo | Liquid flavoring and process for preparing same |
JPS59134710A (en) * | 1983-01-21 | 1984-08-02 | Suntory Ltd | Hair tonic from fermentation product |
JPS59141515A (en) * | 1983-02-02 | 1984-08-14 | Suntory Ltd | Fermented hair tonic cosmetic |
US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
DE3445919A1 (en) * | 1984-12-17 | 1986-06-19 | Henkel KGaA, 4000 Düsseldorf | COSMETIC PREPARATION WITH ALMOND PROTEIN HYDROLYSATE |
JP2640349B2 (en) * | 1987-10-15 | 1997-08-13 | 株式会社三光生物科学研究所 | Hair restoration |
JPH01128912A (en) * | 1987-11-13 | 1989-05-22 | Shogo Ogura | Production of hair dressing and growing agent |
-
1992
- 1992-01-02 DK DK000292A patent/DK292A/en not_active Application Discontinuation
- 1992-01-03 FI FI920035A patent/FI920035A/en unknown
- 1992-01-10 ZA ZA92186A patent/ZA92186B/en unknown
- 1992-01-13 NZ NZ241290A patent/NZ241290A/en unknown
- 1992-01-14 PH PH43776A patent/PH30444A/en unknown
- 1992-01-14 AU AU10211/92A patent/AU663301B2/en not_active Ceased
- 1992-01-14 CA CA002059314A patent/CA2059314C/en not_active Expired - Fee Related
- 1992-01-14 MY MYPI92000058A patent/MY107936A/en unknown
- 1992-01-16 NO NO92920202A patent/NO920202L/en unknown
- 1992-01-17 GB GB9200976A patent/GB2261818B/en not_active Expired - Fee Related
- 1992-01-25 KR KR1019920001091A patent/KR0160141B1/en not_active IP Right Cessation
- 1992-01-29 NL NL9200160A patent/NL9200160A/en not_active Application Discontinuation
- 1992-01-30 DE DE4202645A patent/DE4202645A1/en not_active Withdrawn
- 1992-01-31 FR FR9201361A patent/FR2684295B1/en not_active Expired - Fee Related
- 1992-01-31 CN CN92100775A patent/CN1053098C/en not_active Expired - Fee Related
- 1992-02-06 CH CH339/92A patent/CH683317A5/en not_active IP Right Cessation
- 1992-02-18 IT ITMI920349A patent/IT1254612B/en active IP Right Grant
- 1992-02-24 AT AT0034392A patent/AT405016B/en not_active IP Right Cessation
-
1996
- 1996-01-04 HK HK496A patent/HK496A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2059314C (en) | 1999-03-30 |
KR0160141B1 (en) | 1998-12-01 |
CA2059314A1 (en) | 1993-05-30 |
IT1254612B (en) | 1995-09-28 |
KR930009589A (en) | 1993-06-21 |
HK496A (en) | 1996-01-12 |
CN1072588A (en) | 1993-06-02 |
FI920035A (en) | 1993-05-30 |
FR2684295A1 (en) | 1993-06-04 |
ATA34392A (en) | 1998-09-15 |
AU1021192A (en) | 1993-06-03 |
DK292D0 (en) | 1992-01-02 |
CH683317A5 (en) | 1994-02-28 |
AT405016B (en) | 1999-04-26 |
GB2261818A (en) | 1993-06-02 |
MY107936A (en) | 1996-06-29 |
DK292A (en) | 1992-01-02 |
AU663301B2 (en) | 1995-10-05 |
GB2261818B (en) | 1995-09-27 |
FR2684295B1 (en) | 1995-05-19 |
DE4202645A1 (en) | 1993-06-03 |
NO920202D0 (en) | 1992-01-16 |
GB9200976D0 (en) | 1992-03-11 |
ZA92186B (en) | 1992-09-30 |
CN1053098C (en) | 2000-06-07 |
PH30444A (en) | 1997-05-09 |
ITMI920349A1 (en) | 1993-08-18 |
ITMI920349A0 (en) | 1992-02-18 |
NL9200160A (en) | 1993-06-16 |
FI920035A0 (en) | 1992-01-03 |
NO920202L (en) | 1993-06-01 |
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