CN1053098C - Hair nourishing agent and production thereof - Google Patents
Hair nourishing agent and production thereof Download PDFInfo
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- CN1053098C CN1053098C CN92100775A CN92100775A CN1053098C CN 1053098 C CN1053098 C CN 1053098C CN 92100775 A CN92100775 A CN 92100775A CN 92100775 A CN92100775 A CN 92100775A CN 1053098 C CN1053098 C CN 1053098C
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- Prior art keywords
- acid
- hair
- add
- substrate
- enzyme
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
The hair nourishing agent is a fermentation product obtained by enzyme action on a substrate comprising vegetable protein and vegetable lipid, the enzymes particularly being a protease and a lipase or the enzymes produced by rice yeast, and contains various amino acids and fatty acids. The substrate may particularly be rice bran, soybean grounds, adzuki grounds or bean-curd refuse. The agent may be used as it is or mixed into a hair lotion, cream, liquid or tonic or into a pomade, shampoo or rinse, together with various other components.
Description
The present invention relates to hair nourishing agent and production method thereof.More particularly, the present invention relates to contain the mixture of for example lipase and protease or rice yeast be added to and contain vegetable protein, as the hair nourishing agent and the production method thereof of gained tunning in the substrate of Testa oryzae and vegetable butter.
The alopecia and the cutter reason of growing really remain to be explored.But ectillotic main cause is commonly considered as blood circulation and is interrupted, low metabolism, excessive androgen, dermatitis and allergy.
Hair comprises the part and the subcutaneous part of stretching out skin.The hair stem of hair root comprises the tissue that is called papillose cell.There are various capillary tubies to surround and send out stems, and papillose cell mobile blood absorption nutrition from blood capillary, repetitive cell differentiation and make hair growth.
But if blood supply deficiency in the cell, then the cell differentiation effect reduces, and hinders hair growth.Therefore often think and promote that the effect of blood circulation in the cortex and active cell is essential.
The hair follicle that surrounds hair has the enzyme that is called 5, can combine with androgen and changes into 5 α-dihydrotestosterone, and intravascular is delivered to papillose cell then, thereby reduces the active of its adenyl cyclase and cause cell differentiation effect reduction.The result is hair follicle atrophy gradually, makes hair become fine hair, causes bald head etc.
As above give an example,, also do not have a kind of mechanism to be generally acknowledged though proposed a series of alopecia and growth mechanism.Existing in the market various hair growth agents, seller claims these growth stimulators to play a role by hair growth mechanism, as promoting blood circulation and/or activation papillose cell in the cortex.But also do not occur on the market really to the effective hair growth promoter of hair.
In this case, the inventor has carried out long-term and arduous research, the hair nourishing agent of the present invention to hair effect excellence finally proposed, comprising will be for example the mixture of lipase and protease or rice yeast be added to and contain vegetable protein, as the tunning of gained on the substrate of Testa oryzae and vegetable butter.
Therefore the present invention proposes hair nourishing agent, is added to comprising the mixture of for example lipase and protease or rice enzyme mother to contain vegetable protein, sends out the enzyme product as gained on the substrate of Testa oryzae and vegetable butter.
This substrate can be made of any material that contains vegetable protein and vegetable butter.Fermentation enzyme must have the ability of decomposing contained vegetable protein and vegetable butter in the substrate, can be lipase and protease, and also available other enzyme is as amylase.
Fermented product promptly gets hair nourishing agent of the present invention through filtering technique.Harmless and the action effect of this nutrient to preventing that alopecia and promotion hair growth have excellence.
The present invention below is described in detail in detail.
The substrate of production hair nourishing agent of the present invention can be any material that contains vegetable protein and vegetable butter, as pelletized product, and as Testa oryzae, sake mud, wheat germ, wheat bran, thick Semen Fagopyri Esculenti or thick Carex baccans Nees powder, bean product, as Semen sojae atricolor, Glycine max (L.) Merr., soyabean milk, Semen Phaseoli, Semen Glycines powder or coffee grounds or other, as Rhizoma Dioscoreae, taro, tea grounds, Mel, Semen Sesami, Semen arachidis hypogaeae, lotus, angelica keiskei koidzumi, if the beefsteak plant is cloth zostera marina or Thallus Laminariae (Thallus Eckloniae).Testa oryzae, sake mud, wheat bran, coffee grounds, wheat germ, Semen Sesami, Glycine max (L.) Merr., Semen sojae atricolor and Semen Phaseoli are preferred especially, because wherein contain the vegetable protein and the vegetable butter of well balanced amount.
The enzyme that is used for the present invention's fermentation needs to decompose the vegetable protein and the vegetable butter of substrate.Wherein can fatty enzyme and protease and other enzyme, also available as amylase.Except that lipase and protease and, the rice yeast is also available, because have the function that can produce various enzymes in vivo.
The used lipase of the present invention can be the sperm lipase that uses in the acid range, is contained in a large amount of mycetes, yeast, and microorganism, body fluid also can be the enzyme of taking from the internal.More particularly, available pancreas lipase, hepatic lipase, Tubercle bacterium lipase, FIB lipase and hima lipase.
Be used for protease of the present invention and preferably under optimum PH, be acid.Therefore, available stomach egg is from enzyme, trypsin or chymase, dezymotize itself amino acid residue and outer, do not have any sp act alkali and do not require any specific enzymes active ingredient.The enzyme or the cathepsin that find in also available most of phytoenzymes and the zooblast, as papain or ficin, available Reducing agent, as hydrocyanic acid ester (salt), ascorbic acid, cysteine or glutathion activation.More particularly, available chymase, trypsin; pepsin, carboxypeptidase, cathepsin A; cathepsin B, cathepsin C ', cathepsin III; cathepsin IV; kidney acyltransferase I, kidney acyltransferase II, leucine aminopeptidase; aminotripeptidase; sweet (aminoacyl) sweet (propylhomoserin) dipeptidase (glycilglycine dipectitase), aminoacylproline (dipeptides) enzyme (prolitase), dried meat (propylhomoserin) peptidase; plasmin; thrompin, papain, ficin Streptococcus protease; Cl, historyticum protease or peptidase.
With enzyme add get final product on the said substrate fermented product, HPLC analyzes fermented product and gets following result, analyzes with detector (LC-9A, ShimadzuSeisakusho, Co., Ltd.) and post (3m long), eluting layer acetonitrile, column temperature keep about 30 ℃, the about 10ml/ of flow velocity minute.
Found the tunning fatty acids, as myristic acid, Palmic acid, stearic acid, arachidic acid behenic acid, 24 (carbon) alkanoic acid, 12 (carbon) olefin(e) acid, 14 (carbon) olefin(e) acid, 14 (carbon) dienoic acid, 15 (carbon) olefin(e) acid, 16 (carbon) olefin(e) acid, oleic acid, linoleic acid, linolenic acid, 20 (carbon) olefin(e) acid, 20 (carbon) dienoic acid, arachidonic acid, 20 (carbon) trienic acid, 22 (carbon) olefin(e) acid (dococenic acid) and 22 (carbon) acid (docosahexanic acid).Found that fermented product also contains aminoacid, as leucine, isoleucine, lysine, methionine, cysteine, phenylalanine, tyrosine, threonine, tryptophan, valine, histidine, arginine, aspartic acid, alanine, glutamic acid, glycine, proline and celin.
From analysis result as can be seen, gained fermented product of the present invention contains a large amount of aminoacid and fatty acid.It is believed that aminoacid can provide nutrition to papillose cell, fatty acid then can activate and expand blood capillary, makes hair wet and manifests gloss and make contained 5 purification in the hair capsule and prevent that hair is softening.It is believed that each composition also can promote hair growth alone or in combination.It should be noted that fermented product also comprises sulfur-containing amino acid and unsaturated fatty acid, the two it is believed that all can play excellent effect to hair growth.
Found the rice yeast to be added in the products obtained therefrom that ferments in the substrate, except with the composition of determining in the mixture gained fermented product of lipase and protease, also contained a small amount of vitamin A, vitamin B by the present invention
1, vitamin B
2, vitamin B
6, vitamin B
12, vitamin C, vitamin E, copper, ferrum, calcium (Calucium), phosphorus, purine, DNA (deoxyribonucleic acid), ribonucleic acid, adenine, guanine, uracil, cytosine and xanthine because in the rice yeast, except lipase and protease and, also can generate a large amount of enzymes, as amylase, transglutaminase, cellulase and pectase not only decompose vegetable protein and vegetable butter, and decompose other composition in the substrate.It is believed that these other compositions also can be with said aminoacid and fatty acid synergism and promoted hair growth.
For preserving hair nourishing agent of the present invention, can or boil its cold preservation, this can not make hair nourishing agent that functional variation takes place or action effect reduces.
Following explanation trichotrophy agent and process for producing same of the present invention, step comprise and add enzyme in the substrate contain vegetable protein and vegetable butter and filter the gained fermented product.
Fermentation is carried out under aqueous conditions, can produce other enzyme, as diastatic lipase and protease or rice yeast as enzyme.Lipase and protease add separately or mix and adds.This mixture can contain other enzyme, as amylase, in order that promote decomposition function and make other composition decomposition in the substrate.At the substrate of index 100, preferably each enzyme with 0.1w% adds in this mixture.During with the rice yeast, because of this yeast decomposition function than lipase or protease a little less than, so preferably add 1w% rice yeast at the substrate of index 100.
The preferred room temperature of fermentation temperature or 35-45 ℃, and can use hydrochloric acid-clothianadin of PH:6-11 as buffer agent, generation potassium phosphate-secondary potassium phosphate, hydrochloric acid-veronal sodium, hydrochloric acid-Trisaminomethane, hydrochloric acid-Borax, boric acid-sodium carbonate, hydrochloric acid-amino-methyl-propanediol, ammonium chloride-ammonia, glycine-sodium hydroxide, boric acid-sodium hydroxide, hydrochloric acid-dimethylglycine sodium, sodium bicarbonate-sodium carbonate, Borax-sodium hydroxide, Borax-sodium carbonate, hydrochloric acid-sodium carbonate and secondary potassium phosphate (sodium)-sodium hydroxide etc.Mixture after any of these material combination in any is also available.
Under the fermentation time stirring condition preferred 5-10 hour.For lipase, provide predetermined coloring matter and make indicator and measure ester hydrolysis gained and emit fatty acid amount or can the principal reaction end with the alkali electrometric titration.When aforesaid operations is difficult for carrying out, the alcohol that available colorimetric method for determining hydrolysis is emitted.For protease, available (hydration) ninhydrin colorimetry, the band blue material that generates when wherein using the heating of (hydration) 1,2,3-indantrione monohydrate carries out the aminoacid colorimetric test.When this operation is difficult for carrying out, available S rensen formol titration.Used the phenomenon of dispersing of following alpha-amido of formaldehyde existence or imino group titration curve in this method.Disinfect available still kettle sterilization.
Hair nourishing agent of the present invention is to add water or pure obtaining after fermented product filters.The gained hair nourishing agent can so use or can with shampoo, hair oil, washing liquid, hair tonic, hair cream, hair conditioner or rinse are used with.
Can in hair nourishing agent of the present invention, sneak into other composition commonly used in the common hair growth agent, as blood circulation accelerant, metabolic improver, the antiandrogen preparation, antiinflammatory, antiallergic preparation, wetting agent, antibiotics and/or cryogen can be for example tocopherol acetate, Ytterbium trichloride, carbonic acid gas, hinokitiol, Pantonyl ethylether benzoate, glyceride 15 (carbon) alkanoic acid ester, biotin, ethinylestradiol, the glythyl ricinoleic acid, diphenyl hydramine chloride, hyaluronic acid, the Minisasanishiki extract, single nitroguaiacol, field Semen Sinapis stain, loose torch stain, hydrocortisone, biphenyl hydroxylamine chloride, D-panthenol, salicylic acid, lactic acid, sodium lactate and menthol etc.
Example 1
Make substrate with Testa oryzae, add warm water 1000ml among the Testa oryzae 500g and mix, then mixture is sent into appropriate containers, in glass container or plastic containers, to mixture with rice yeast 5g.Add sodium bicarbonate 3g again and make buffer agent with control PH.With heater container is heated to 45 ℃ and keep under this temperature.Mixture is placed a whole day, stirs sometimes, the pasty liquid in this container is filtered with cloth after in the pasty state and must the translucent hair nutritional agent of about 1000ml.
Example 2
Make substrate with bean dregs, in these bean dregs 200g, add water 600ml, make pluck organ 100g and add water 200ml, grind with the homogenization of glass device then and make the homogenize thing, carry out centrifugalize with 1500rpm again.Take out supernatant 100ml and add substrate.At this moment also add sodium carbonate-boric acid so that PH is adjusted to 10.0.Mixture is positioned under about 40 ℃.With Kletto electrophotometer (№ .540 filter) observation enzymatic activity, observe active the termination after about 8 hours.
Make buffer in sodium carbonate-boric acid 40ml adding gained fermentation liquid with 0.1M (PH10.0).Add chymase then to 0.1M.Whole mixture is placed under about 40 ℃.Measure in the sample liquid that 0.2ml all takes from this complete mixture the ammonia amount with the Conway method and determine that fermentation stops.After about 10 hours, stop to generate ammonia and finish fermentation.Filtering fermentation liquor and washing and hair nourishing agent.
Example 3
Make substrate with the Semen Phaseoli slag, water 500ml is added among this Semen Phaseoli slag 200g and with mixture make suspension.In addition, float among the distilled water 100ml, stir after 20 minutes room temperature with Knapp-March Blender and placed about 20 minutes with FIB mycelium gained lipase.Under the mixture 2000rpm centrifugalize after 30 minutes gained top layer liquid add in the mixture of little bean dregs and water.Add Britton-Robinson buffer (phosphoric acid, acetic acid, boric acid, caustic soda) PH is adjusted to 9.0.About 35 ℃ keep about 8 hours of vibration down.Observe fermentation with 0.05M alcohol dissolved salt acidometric titration.
In addition, it is soluble in water and send into hydrogen sulfide in mixture that papain is buied in market, lasts several hours.In mixture, add alcohol afterwards so that the papain sedimentation.(papain 1g: water 100ml) also adding the Britton-Robinson buffer equally is adjusted to 9 with PH to add water again in refining papain.0, afterwards its adding is comprised in the fermentation liquid of substrate.Whole fermentation liquid is put under about 40 ℃, all takes from the sample liquid of this whole beer with pure titration 0.2ml and can determine that fermentation stops.After fermentation in about 12 hours is finished.Get hair nourishing agent behind the filtering fermentation liquor.
Example 4
Glycine max (L.) Merr. is used as substrate, water 500ml is added among this Glycine max (L.) Merr. 100g and with mixture be maintained at about 50 ℃.In addition, the kidney lipase of buying on the market is dissolved in (1%) in the distilled water.This distilled water (5ml) that contains the kidney lipase is added in this mixture.Add phosphoric acid (0.6M, PH7.0), 5ml makes buffer and full mixture kept about 10 hours down for about 40 ℃, or stir.Observe carbonic acid gas with the Warburg manometer and stop to generate then definite fermentation termination.
In addition, pepsin (Cudahy, the solvable pepsin of the 1/10000USP) 10g that buys on the market is dissolved among the 20% ethanol liquid 10ml, it is added in the said fermentation liquid again.Add the hydrochloric acid ammonium then PH is adjusted to 7.5.This liquid was placed about 20 hours in about 35 ℃.Use filter tank (5g) to filter afterwards, at this moment PH is 7.0.Filtrate is positioned under 37 ℃.The sample liquid of 0.5ml all being taken from filtrate outside the Conway device is taken out and each sample is mixed with the potassium carbonate 1ml that puts into this device and can determine the termination of fermenting.Titration is observed the volatile ammonia quantitative changeization and is learnt that fermentation stops.Finish after about 10 hours.Gained liquid filter in common mode and hair nourishing agent.
The present invention example 1-4 trichotrophy liquid with ethanol dilution after mixture each once is coated onto on man and the Mus sooner or later every day.Be coated with after 30 days, two kinds of situations all have outstanding hair growth effect.Particularly after being coated with usefulness on the Mus, particular significant effect becomes mildewed.
The described hair nourishing agent of claim 1 comprises the product that contains each seed amino acid and fatty acid.Acid makes the blood capillary activation alone or in combination and makes contained 5 passivation in the hair follicle.Compare with common hair growth agent, the described hair nourishing agent of claim 1 has more excellent alopecia prevention effect and hair growth effect.Hair nourishing agent of the present invention is harmless fully to human body.Because be that fermented product and substrate comprise vegetable protein and vegetable butter, usefulness be harmless enzyme.
For the hair nourishing agent of claim 2, the lipase and the protease that are used as enzyme can be used for making vegetable protein and vegetable butter in the substrate to decompose and the fermented product/Unit Weight of acquisition high yield effectively.
In the hair nourishing agent of claim 3 except that aminoacid and fatty acid and, also contain a small amount of vitamin E, copper, purine, nucleic acid etc., these other compositions further promote hair growth with aminoacid and fatty acid.
The method of claim 4 provides hair nourishing agent of the present invention, and this nutrient can activate blood capillary and make 5 passivation contained in the hair capsule.Therefore this nutrient can prevent alopecia and promote that hair growth is faster than common hair growth agent.
The method of claim 5 obtains the fermented product/Unit Weight of high yield, because lipase and protease as enzyme, make vegetable protein and vegetable butter in the substrate ferment effectively.
The method of claim 6 provide except that aminoacid and fatty acid and also contain a small amount of vitamin E, copper, purine, other composition such as nucleic acid is in order to further to promote hair growth with aminoacid and fatty acid.
The method of claim 7-9 makes ferment reach decomposition rate faster, therefore reaches the hair nourishing agent/Unit Weight of higher yield.
Claims (1)
1. hair nourishing agent, prepare as key component by fermented product, described fermented product is preparation as described below: add the enzyme that can decompose vegetable protein and vegetable butter or add aspergillosis (koji mold) in hydrated matrix, the addition of enzyme is that per 1000 weight portion hydrated matrix add 1 weight portion, and aspergillar addition is that per 100 weight portion hydrated matrix add 1 weight portion; It is 6-11 that the adding buffer agent makes the pH value of described hydrated matrix; Described water-bearing media was fermented 5-10 hour at 35 ℃-45 ℃; Filtration obtains fermented product.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03316,110/1991 | 1991-11-29 | ||
| JP31611091 | 1991-11-29 | ||
| JP316,110/91 | 1991-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1072588A CN1072588A (en) | 1993-06-02 |
| CN1053098C true CN1053098C (en) | 2000-06-07 |
Family
ID=18073362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92100775A Expired - Fee Related CN1053098C (en) | 1991-11-29 | 1992-01-31 | Hair nourishing agent and production thereof |
Country Status (19)
| Country | Link |
|---|---|
| KR (1) | KR0160141B1 (en) |
| CN (1) | CN1053098C (en) |
| AT (1) | AT405016B (en) |
| AU (1) | AU663301B2 (en) |
| CA (1) | CA2059314C (en) |
| CH (1) | CH683317A5 (en) |
| DE (1) | DE4202645A1 (en) |
| DK (1) | DK292A (en) |
| FI (1) | FI920035A (en) |
| FR (1) | FR2684295B1 (en) |
| GB (1) | GB2261818B (en) |
| HK (1) | HK496A (en) |
| IT (1) | IT1254612B (en) |
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| NZ (1) | NZ241290A (en) |
| PH (1) | PH30444A (en) |
| ZA (1) | ZA92186B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9909294D0 (en) * | 1999-04-22 | 1999-06-16 | Unilever Plc | Treating hair by targeting enzymes |
| JP2000327538A (en) * | 1999-05-24 | 2000-11-28 | Toyo Hakko:Kk | Agent composition for hair treatment |
| EP1500386A1 (en) * | 2003-07-23 | 2005-01-26 | Wella Aktiengesellschaft | Method for time-dependent decrease of ph in a cosmetic composition and a composition for permanent hair shaping with time-dependent decrease of the wave-shaping efficiency |
| KR20050041573A (en) * | 2003-10-31 | 2005-05-04 | 김민호 | Composition for straight permanent of gel type |
| ES2612269T3 (en) * | 2006-06-08 | 2017-05-16 | Ajinomoto Co., Inc. | Composition for hair growth |
| FR2951947B1 (en) * | 2009-11-03 | 2022-01-07 | Isp Investments Inc | USE OF A COMPOSITION COMPRISING AN UNFERMENTED RICE PEPTIDE EXTRACT TO STIMULATE HAIR GROWTH |
| FR2963234B1 (en) * | 2010-07-29 | 2020-07-17 | Isp Investments Inc | USE OF A COMPOSITION COMPRISING A PEPTIDE EXTRACT OF BEANS FOR STIMULATING HAIR GROWTH |
| CN105125475A (en) * | 2015-09-27 | 2015-12-09 | 常州市奥普泰科光电有限公司 | Cosmetic film-forming moisture preserving additive |
| CN112022792B (en) * | 2020-09-27 | 2022-12-09 | 黑龙江省中医药科学院 | Preparation method of edible traditional Chinese medicine hair dye with homology of medicine and food |
| DE102020125874A1 (en) * | 2020-10-02 | 2022-04-07 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and skin treatment composition |
| DE102020125876A1 (en) * | 2020-10-02 | 2022-04-07 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and scalp treatment composition |
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| EP0117087A1 (en) * | 1983-02-02 | 1984-08-29 | Suntory Limited | Hair tonic composition |
| US4670255A (en) * | 1983-01-21 | 1987-06-02 | Suntory Limited | Hair tonic composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CH367937A (en) * | 1958-05-23 | 1963-03-15 | Dubois Raymond | Process for preparing a product for treating the scalp and hair |
| FR1268459A (en) * | 1959-05-05 | 1961-08-04 | Product for the treatment of the scalp and hair and process for the preparation thereof | |
| FR1363121A (en) * | 1961-12-19 | 1964-06-12 | Hygienic-dietetic method for preventing baldness and in particular seborrheic alopecia | |
| US3395019A (en) * | 1965-10-18 | 1968-07-30 | Vylactos Lab Inc | Preparation of animal feed from oat hulls |
| DE1961064A1 (en) * | 1969-12-05 | 1971-06-16 | Dragoco Gerberding Co Gmbh | Process for the production of plant extract concentrates which cannot be broken down by fermentation |
| FR2283204A1 (en) * | 1974-08-28 | 1976-03-26 | Roger Et Gallet | METHOD AND DEVICE FOR THE PREPARATION OF PRODUCTS INTENDED FOR USE IN THE FORM OF AEROSOLS |
| JPS51151396A (en) * | 1975-06-18 | 1976-12-25 | Kikkoman Corp | Process for preparing solid koji |
| JPS5356394A (en) * | 1976-10-28 | 1978-05-22 | Fukushima Hiroo | Liquid flavoring and process for preparing same |
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1992
- 1992-01-02 DK DK000292A patent/DK292A/en not_active Application Discontinuation
- 1992-01-03 FI FI920035A patent/FI920035A/en unknown
- 1992-01-10 ZA ZA92186A patent/ZA92186B/en unknown
- 1992-01-13 NZ NZ241290A patent/NZ241290A/en unknown
- 1992-01-14 CA CA002059314A patent/CA2059314C/en not_active Expired - Fee Related
- 1992-01-14 AU AU10211/92A patent/AU663301B2/en not_active Ceased
- 1992-01-14 MY MYPI92000058A patent/MY107936A/en unknown
- 1992-01-14 PH PH43776A patent/PH30444A/en unknown
- 1992-01-16 NO NO92920202A patent/NO920202L/en unknown
- 1992-01-17 GB GB9200976A patent/GB2261818B/en not_active Expired - Fee Related
- 1992-01-25 KR KR1019920001091A patent/KR0160141B1/en not_active IP Right Cessation
- 1992-01-29 NL NL9200160A patent/NL9200160A/en not_active Application Discontinuation
- 1992-01-30 DE DE4202645A patent/DE4202645A1/en not_active Withdrawn
- 1992-01-31 CN CN92100775A patent/CN1053098C/en not_active Expired - Fee Related
- 1992-01-31 FR FR9201361A patent/FR2684295B1/en not_active Expired - Fee Related
- 1992-02-06 CH CH339/92A patent/CH683317A5/en not_active IP Right Cessation
- 1992-02-18 IT ITMI920349A patent/IT1254612B/en active IP Right Grant
- 1992-02-24 AT AT0034392A patent/AT405016B/en not_active IP Right Cessation
-
1996
- 1996-01-04 HK HK496A patent/HK496A/en not_active IP Right Cessation
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| US4670255A (en) * | 1983-01-21 | 1987-06-02 | Suntory Limited | Hair tonic composition |
| EP0117087A1 (en) * | 1983-02-02 | 1984-08-29 | Suntory Limited | Hair tonic composition |
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI920349A0 (en) | 1992-02-18 |
| GB2261818B (en) | 1995-09-27 |
| PH30444A (en) | 1997-05-09 |
| DK292D0 (en) | 1992-01-02 |
| GB2261818A (en) | 1993-06-02 |
| KR930009589A (en) | 1993-06-21 |
| FI920035A (en) | 1993-05-30 |
| MY107936A (en) | 1996-06-29 |
| CN1072588A (en) | 1993-06-02 |
| FR2684295B1 (en) | 1995-05-19 |
| NL9200160A (en) | 1993-06-16 |
| NZ241290A (en) | 1993-10-26 |
| AT405016B (en) | 1999-04-26 |
| NO920202D0 (en) | 1992-01-16 |
| ATA34392A (en) | 1998-09-15 |
| GB9200976D0 (en) | 1992-03-11 |
| DK292A (en) | 1992-01-02 |
| ZA92186B (en) | 1992-09-30 |
| NO920202L (en) | 1993-06-01 |
| AU1021192A (en) | 1993-06-03 |
| ITMI920349A1 (en) | 1993-08-18 |
| CH683317A5 (en) | 1994-02-28 |
| CA2059314A1 (en) | 1993-05-30 |
| DE4202645A1 (en) | 1993-06-03 |
| CA2059314C (en) | 1999-03-30 |
| IT1254612B (en) | 1995-09-28 |
| KR0160141B1 (en) | 1998-12-01 |
| FR2684295A1 (en) | 1993-06-04 |
| HK496A (en) | 1996-01-12 |
| FI920035A0 (en) | 1992-01-03 |
| AU663301B2 (en) | 1995-10-05 |
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