CN1053098C - Hair nourishing agent and production thereof - Google Patents
Hair nourishing agent and production thereof Download PDFInfo
- Publication number
- CN1053098C CN1053098C CN92100775A CN92100775A CN1053098C CN 1053098 C CN1053098 C CN 1053098C CN 92100775 A CN92100775 A CN 92100775A CN 92100775 A CN92100775 A CN 92100775A CN 1053098 C CN1053098 C CN 1053098C
- Authority
- CN
- China
- Prior art keywords
- acid
- hair
- add
- substrate
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title description 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 34
- 102000004190 Enzymes Human genes 0.000 claims abstract description 29
- 108090000790 Enzymes Proteins 0.000 claims abstract description 29
- 108010082495 Dietary Plant Proteins Proteins 0.000 claims abstract description 15
- 235000013311 vegetables Nutrition 0.000 claims abstract description 15
- 235000014121 butter Nutrition 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000872 buffer Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims 4
- 201000002909 Aspergillosis Diseases 0.000 claims 1
- 208000036641 Aspergillus infections Diseases 0.000 claims 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims 1
- 240000006439 Aspergillus oryzae Species 0.000 claims 1
- 239000004365 Protease Substances 0.000 abstract description 26
- 239000000758 substrate Substances 0.000 abstract description 25
- 102000004882 Lipase Human genes 0.000 abstract description 22
- 108090001060 Lipase Proteins 0.000 abstract description 22
- 239000004367 Lipase Substances 0.000 abstract description 22
- 235000019421 lipase Nutrition 0.000 abstract description 22
- 108091005804 Peptidases Proteins 0.000 abstract description 20
- 238000000855 fermentation Methods 0.000 abstract description 19
- 230000004151 fermentation Effects 0.000 abstract description 19
- 239000007788 liquid Substances 0.000 abstract description 15
- 240000007594 Oryza sativa Species 0.000 abstract description 12
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract description 12
- 150000001413 amino acids Chemical class 0.000 abstract description 12
- 235000009566 rice Nutrition 0.000 abstract description 12
- 235000014113 dietary fatty acids Nutrition 0.000 abstract description 11
- 229930195729 fatty acid Natural products 0.000 abstract description 11
- 239000000194 fatty acid Substances 0.000 abstract description 11
- 150000004665 fatty acids Chemical class 0.000 abstract description 11
- 244000068988 Glycine max Species 0.000 abstract description 6
- 235000010469 Glycine max Nutrition 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 3
- 239000006071 cream Substances 0.000 abstract description 2
- 239000002453 shampoo Substances 0.000 abstract description 2
- 230000001256 tonic effect Effects 0.000 abstract description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 235000013527 bean curd Nutrition 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 32
- 229940088598 enzyme Drugs 0.000 description 24
- 102000035195 Peptidases Human genes 0.000 description 19
- 230000003779 hair growth Effects 0.000 description 17
- 239000000047 product Substances 0.000 description 17
- 235000019419 proteases Nutrition 0.000 description 17
- 239000002253 acid Substances 0.000 description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 11
- 229940024606 amino acid Drugs 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 210000000582 semen Anatomy 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 108090000526 Papain Proteins 0.000 description 6
- 150000001336 alkenes Chemical class 0.000 description 6
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 6
- 229940055729 papain Drugs 0.000 description 6
- 235000019834 papain Nutrition 0.000 description 6
- 201000004384 Alopecia Diseases 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 5
- 231100000360 alopecia Toxicity 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000004448 titration Methods 0.000 description 5
- 239000004382 Amylase Substances 0.000 description 4
- 102000013142 Amylases Human genes 0.000 description 4
- 108010065511 Amylases Proteins 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 244000046052 Phaseolus vulgaris Species 0.000 description 4
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 235000019418 amylase Nutrition 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 108090000227 Chymases Proteins 0.000 description 3
- 102000003858 Chymases Human genes 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 102000057297 Pepsin A Human genes 0.000 description 3
- 108090000284 Pepsin A Proteins 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 230000024245 cell differentiation Effects 0.000 description 3
- 238000004737 colorimetric analysis Methods 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- HXOLFXRMWWHLMH-UHFFFAOYSA-L disodium boric acid carbonate Chemical compound [Na+].[Na+].OB(O)O.[O-]C([O-])=O HXOLFXRMWWHLMH-UHFFFAOYSA-L 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 229940111202 pepsin Drugs 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- 102000057234 Acyl transferases Human genes 0.000 description 2
- 108700016155 Acyl transferases Proteins 0.000 description 2
- 239000006171 Britton–Robinson buffer Substances 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108010084457 Cathepsins Proteins 0.000 description 2
- 102000005600 Cathepsins Human genes 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 108090000270 Ficain Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241000053227 Themus Species 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 235000011089 carbon dioxide Nutrition 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 229960002433 cysteine Drugs 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 235000019836 ficin Nutrition 0.000 description 2
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 235000019256 formaldehyde Nutrition 0.000 description 2
- 229960004279 formaldehyde Drugs 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 238000002161 passivation Methods 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000019833 protease Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 235000015099 wheat brans Nutrition 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- WRXFJKBQZVRPHI-UHFFFAOYSA-N 2-methoxy-6-nitrophenol Chemical compound COC1=CC=CC([N+]([O-])=O)=C1O WRXFJKBQZVRPHI-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- NIPYQLPZPLBOLF-UHFFFAOYSA-N 3'-hydroxy-6'-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound OC1C(O)C(O)C(CO)OC1OC1=CC=C2C3(C4=CC=CC=C4C(=O)O3)C3=CC=C(O)C=C3OC2=C1 NIPYQLPZPLBOLF-UHFFFAOYSA-N 0.000 description 1
- JAHNNCNAYSSENI-UHFFFAOYSA-N 3-aminobutane-2,2-diol hydrochloride Chemical compound NC(C(O)(O)C)C.Cl JAHNNCNAYSSENI-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 241001105098 Angelica keiskei Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 241000986012 Carex baccans Species 0.000 description 1
- 102000005572 Cathepsin A Human genes 0.000 description 1
- 108010059081 Cathepsin A Proteins 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 102000003902 Cathepsin C Human genes 0.000 description 1
- 108090000267 Cathepsin C Proteins 0.000 description 1
- 102100026657 Cathepsin Z Human genes 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000205754 Colocasia esculenta Species 0.000 description 1
- 235000006481 Colocasia esculenta Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 102000004860 Dipeptidases Human genes 0.000 description 1
- 108090001081 Dipeptidases Proteins 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 description 1
- 101000910979 Homo sapiens Cathepsin Z Proteins 0.000 description 1
- 101000941289 Homo sapiens Hepatic triacylglycerol lipase Proteins 0.000 description 1
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 241000220645 Leonotis nepetifolia Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010004098 Leucyl aminopeptidase Proteins 0.000 description 1
- 102000002704 Leucyl aminopeptidase Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- GWKSVSLVUNNSGW-UHFFFAOYSA-N NO.C1(=CC=CC=C1)C1=CC=CC=C1.Cl Chemical compound NO.C1(=CC=CC=C1)C1=CC=CC=C1.Cl GWKSVSLVUNNSGW-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 235000016374 Perilla frutescens var crispa Nutrition 0.000 description 1
- 235000015640 Perilla frutescens var frutescens Nutrition 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 108060008539 Transglutaminase Proteins 0.000 description 1
- 108010070926 Tripeptide aminopeptidase Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 241001148683 Zostera marina Species 0.000 description 1
- PICKAGXPNZYMPX-UHFFFAOYSA-N [Na].Cl.CN(C)CC(O)=O Chemical compound [Na].Cl.CN(C)CC(O)=O PICKAGXPNZYMPX-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 102000030621 adenylate cyclase Human genes 0.000 description 1
- 108060000200 adenylate cyclase Proteins 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- ZRBROGSAUIUIJE-UHFFFAOYSA-N azanium;azane;chloride Chemical compound N.[NH4+].[Cl-] ZRBROGSAUIUIJE-UHFFFAOYSA-N 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- TXSFFZYXHRAMBM-UHFFFAOYSA-N benzoic acid;ethoxyethane Chemical compound CCOCC.OC(=O)C1=CC=CC=C1 TXSFFZYXHRAMBM-UHFFFAOYSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- 230000002478 diastatic effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- SDCJMBBHNJPYGW-UHFFFAOYSA-L disodium;hydrogen carbonate;chloride Chemical compound [Na+].[Na+].Cl.[O-]C([O-])=O SDCJMBBHNJPYGW-UHFFFAOYSA-L 0.000 description 1
- KAHRQPGKVRVNQV-UHFFFAOYSA-N docosanoic acid;icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCCCCCC(O)=O KAHRQPGKVRVNQV-UHFFFAOYSA-N 0.000 description 1
- 235000015177 dried meat Nutrition 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000010931 ester hydrolysis Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- JCHMFMSWRWHRFI-HMMYKYKNSA-N ethyl (2e)-2-[(2,5-dichlorophenyl)hydrazinylidene]-2-(2,6-dimethylmorpholin-4-yl)acetate Chemical compound C1C(C)OC(C)CN1/C(C(=O)OCC)=N/NC1=CC(Cl)=CC=C1Cl JCHMFMSWRWHRFI-HMMYKYKNSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 239000003324 growth hormone secretagogue Substances 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- -1 hydrocyanic acid ester Chemical class 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- CVGSWVDBRMDWPX-UHFFFAOYSA-N methanetriamine;hydrochloride Chemical compound Cl.NC(N)N CVGSWVDBRMDWPX-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- CIJQGPVMMRXSQW-UHFFFAOYSA-M sodium;2-aminoacetic acid;hydroxide Chemical compound O.[Na+].NCC([O-])=O CIJQGPVMMRXSQW-UHFFFAOYSA-M 0.000 description 1
- QXADHXQCAQTNGW-UHFFFAOYSA-M sodium;boric acid;hydroxide Chemical compound [OH-].[Na+].OB(O)O QXADHXQCAQTNGW-UHFFFAOYSA-M 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000000954 titration curve Methods 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000014393 valine Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- CKLHRQNQYIJFFX-UHFFFAOYSA-K ytterbium(III) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Yb+3] CKLHRQNQYIJFFX-UHFFFAOYSA-K 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K7/00—Watering equipment for stock or game
- A01K7/02—Automatic devices ; Medication dispensers
- A01K7/06—Automatic devices ; Medication dispensers actuated by the animal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Environmental Sciences (AREA)
- Emergency Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The hair nourishing agent is a fermentation product obtained by enzyme action on a substrate comprising vegetable protein and vegetable lipid, the enzymes particularly being a protease and a lipase or the enzymes produced by rice yeast, and contains various amino acids and fatty acids. The substrate may particularly be rice bran, soybean grounds, adzuki grounds or bean-curd refuse. The agent may be used as it is or mixed into a hair lotion, cream, liquid or tonic or into a pomade, shampoo or rinse, together with various other components.
Description
The present invention relates to hair nourishing agent and production method thereof.More particularly, the present invention relates to contain the mixture of for example lipase and protease or rice yeast be added to and contain vegetable protein, as the hair nourishing agent and the production method thereof of gained tunning in the substrate of Testa oryzae and vegetable butter.
The alopecia and the cutter reason of growing really remain to be explored.But ectillotic main cause is commonly considered as blood circulation and is interrupted, low metabolism, excessive androgen, dermatitis and allergy.
Hair comprises the part and the subcutaneous part of stretching out skin.The hair stem of hair root comprises the tissue that is called papillose cell.There are various capillary tubies to surround and send out stems, and papillose cell mobile blood absorption nutrition from blood capillary, repetitive cell differentiation and make hair growth.
But if blood supply deficiency in the cell, then the cell differentiation effect reduces, and hinders hair growth.Therefore often think and promote that the effect of blood circulation in the cortex and active cell is essential.
The hair follicle that surrounds hair has the enzyme that is called 5, can combine with androgen and changes into 5 α-dihydrotestosterone, and intravascular is delivered to papillose cell then, thereby reduces the active of its adenyl cyclase and cause cell differentiation effect reduction.The result is hair follicle atrophy gradually, makes hair become fine hair, causes bald head etc.
As above give an example,, also do not have a kind of mechanism to be generally acknowledged though proposed a series of alopecia and growth mechanism.Existing in the market various hair growth agents, seller claims these growth stimulators to play a role by hair growth mechanism, as promoting blood circulation and/or activation papillose cell in the cortex.But also do not occur on the market really to the effective hair growth promoter of hair.
In this case, the inventor has carried out long-term and arduous research, the hair nourishing agent of the present invention to hair effect excellence finally proposed, comprising will be for example the mixture of lipase and protease or rice yeast be added to and contain vegetable protein, as the tunning of gained on the substrate of Testa oryzae and vegetable butter.
Therefore the present invention proposes hair nourishing agent, is added to comprising the mixture of for example lipase and protease or rice enzyme mother to contain vegetable protein, sends out the enzyme product as gained on the substrate of Testa oryzae and vegetable butter.
This substrate can be made of any material that contains vegetable protein and vegetable butter.Fermentation enzyme must have the ability of decomposing contained vegetable protein and vegetable butter in the substrate, can be lipase and protease, and also available other enzyme is as amylase.
Fermented product promptly gets hair nourishing agent of the present invention through filtering technique.Harmless and the action effect of this nutrient to preventing that alopecia and promotion hair growth have excellence.
The present invention below is described in detail in detail.
The substrate of production hair nourishing agent of the present invention can be any material that contains vegetable protein and vegetable butter, as pelletized product, and as Testa oryzae, sake mud, wheat germ, wheat bran, thick Semen Fagopyri Esculenti or thick Carex baccans Nees powder, bean product, as Semen sojae atricolor, Glycine max (L.) Merr., soyabean milk, Semen Phaseoli, Semen Glycines powder or coffee grounds or other, as Rhizoma Dioscoreae, taro, tea grounds, Mel, Semen Sesami, Semen arachidis hypogaeae, lotus, angelica keiskei koidzumi, if the beefsteak plant is cloth zostera marina or Thallus Laminariae (Thallus Eckloniae).Testa oryzae, sake mud, wheat bran, coffee grounds, wheat germ, Semen Sesami, Glycine max (L.) Merr., Semen sojae atricolor and Semen Phaseoli are preferred especially, because wherein contain the vegetable protein and the vegetable butter of well balanced amount.
The enzyme that is used for the present invention's fermentation needs to decompose the vegetable protein and the vegetable butter of substrate.Wherein can fatty enzyme and protease and other enzyme, also available as amylase.Except that lipase and protease and, the rice yeast is also available, because have the function that can produce various enzymes in vivo.
The used lipase of the present invention can be the sperm lipase that uses in the acid range, is contained in a large amount of mycetes, yeast, and microorganism, body fluid also can be the enzyme of taking from the internal.More particularly, available pancreas lipase, hepatic lipase, Tubercle bacterium lipase, FIB lipase and hima lipase.
Be used for protease of the present invention and preferably under optimum PH, be acid.Therefore, available stomach egg is from enzyme, trypsin or chymase, dezymotize itself amino acid residue and outer, do not have any sp act alkali and do not require any specific enzymes active ingredient.The enzyme or the cathepsin that find in also available most of phytoenzymes and the zooblast, as papain or ficin, available Reducing agent, as hydrocyanic acid ester (salt), ascorbic acid, cysteine or glutathion activation.More particularly, available chymase, trypsin; pepsin, carboxypeptidase, cathepsin A; cathepsin B, cathepsin C ', cathepsin III; cathepsin IV; kidney acyltransferase I, kidney acyltransferase II, leucine aminopeptidase; aminotripeptidase; sweet (aminoacyl) sweet (propylhomoserin) dipeptidase (glycilglycine dipectitase), aminoacylproline (dipeptides) enzyme (prolitase), dried meat (propylhomoserin) peptidase; plasmin; thrompin, papain, ficin Streptococcus protease; Cl, historyticum protease or peptidase.
With enzyme add get final product on the said substrate fermented product, HPLC analyzes fermented product and gets following result, analyzes with detector (LC-9A, ShimadzuSeisakusho, Co., Ltd.) and post (3m long), eluting layer acetonitrile, column temperature keep about 30 ℃, the about 10ml/ of flow velocity minute.
Found the tunning fatty acids, as myristic acid, Palmic acid, stearic acid, arachidic acid behenic acid, 24 (carbon) alkanoic acid, 12 (carbon) olefin(e) acid, 14 (carbon) olefin(e) acid, 14 (carbon) dienoic acid, 15 (carbon) olefin(e) acid, 16 (carbon) olefin(e) acid, oleic acid, linoleic acid, linolenic acid, 20 (carbon) olefin(e) acid, 20 (carbon) dienoic acid, arachidonic acid, 20 (carbon) trienic acid, 22 (carbon) olefin(e) acid (dococenic acid) and 22 (carbon) acid (docosahexanic acid).Found that fermented product also contains aminoacid, as leucine, isoleucine, lysine, methionine, cysteine, phenylalanine, tyrosine, threonine, tryptophan, valine, histidine, arginine, aspartic acid, alanine, glutamic acid, glycine, proline and celin.
From analysis result as can be seen, gained fermented product of the present invention contains a large amount of aminoacid and fatty acid.It is believed that aminoacid can provide nutrition to papillose cell, fatty acid then can activate and expand blood capillary, makes hair wet and manifests gloss and make contained 5 purification in the hair capsule and prevent that hair is softening.It is believed that each composition also can promote hair growth alone or in combination.It should be noted that fermented product also comprises sulfur-containing amino acid and unsaturated fatty acid, the two it is believed that all can play excellent effect to hair growth.
Found the rice yeast to be added in the products obtained therefrom that ferments in the substrate, except with the composition of determining in the mixture gained fermented product of lipase and protease, also contained a small amount of vitamin A, vitamin B by the present invention
1, vitamin B
2, vitamin B
6, vitamin B
12, vitamin C, vitamin E, copper, ferrum, calcium (Calucium), phosphorus, purine, DNA (deoxyribonucleic acid), ribonucleic acid, adenine, guanine, uracil, cytosine and xanthine because in the rice yeast, except lipase and protease and, also can generate a large amount of enzymes, as amylase, transglutaminase, cellulase and pectase not only decompose vegetable protein and vegetable butter, and decompose other composition in the substrate.It is believed that these other compositions also can be with said aminoacid and fatty acid synergism and promoted hair growth.
For preserving hair nourishing agent of the present invention, can or boil its cold preservation, this can not make hair nourishing agent that functional variation takes place or action effect reduces.
Following explanation trichotrophy agent and process for producing same of the present invention, step comprise and add enzyme in the substrate contain vegetable protein and vegetable butter and filter the gained fermented product.
Fermentation is carried out under aqueous conditions, can produce other enzyme, as diastatic lipase and protease or rice yeast as enzyme.Lipase and protease add separately or mix and adds.This mixture can contain other enzyme, as amylase, in order that promote decomposition function and make other composition decomposition in the substrate.At the substrate of index 100, preferably each enzyme with 0.1w% adds in this mixture.During with the rice yeast, because of this yeast decomposition function than lipase or protease a little less than, so preferably add 1w% rice yeast at the substrate of index 100.
The preferred room temperature of fermentation temperature or 35-45 ℃, and can use hydrochloric acid-clothianadin of PH:6-11 as buffer agent, generation potassium phosphate-secondary potassium phosphate, hydrochloric acid-veronal sodium, hydrochloric acid-Trisaminomethane, hydrochloric acid-Borax, boric acid-sodium carbonate, hydrochloric acid-amino-methyl-propanediol, ammonium chloride-ammonia, glycine-sodium hydroxide, boric acid-sodium hydroxide, hydrochloric acid-dimethylglycine sodium, sodium bicarbonate-sodium carbonate, Borax-sodium hydroxide, Borax-sodium carbonate, hydrochloric acid-sodium carbonate and secondary potassium phosphate (sodium)-sodium hydroxide etc.Mixture after any of these material combination in any is also available.
Under the fermentation time stirring condition preferred 5-10 hour.For lipase, provide predetermined coloring matter and make indicator and measure ester hydrolysis gained and emit fatty acid amount or can the principal reaction end with the alkali electrometric titration.When aforesaid operations is difficult for carrying out, the alcohol that available colorimetric method for determining hydrolysis is emitted.For protease, available (hydration) ninhydrin colorimetry, the band blue material that generates when wherein using the heating of (hydration) 1,2,3-indantrione monohydrate carries out the aminoacid colorimetric test.When this operation is difficult for carrying out, available S rensen formol titration.Used the phenomenon of dispersing of following alpha-amido of formaldehyde existence or imino group titration curve in this method.Disinfect available still kettle sterilization.
Hair nourishing agent of the present invention is to add water or pure obtaining after fermented product filters.The gained hair nourishing agent can so use or can with shampoo, hair oil, washing liquid, hair tonic, hair cream, hair conditioner or rinse are used with.
Can in hair nourishing agent of the present invention, sneak into other composition commonly used in the common hair growth agent, as blood circulation accelerant, metabolic improver, the antiandrogen preparation, antiinflammatory, antiallergic preparation, wetting agent, antibiotics and/or cryogen can be for example tocopherol acetate, Ytterbium trichloride, carbonic acid gas, hinokitiol, Pantonyl ethylether benzoate, glyceride 15 (carbon) alkanoic acid ester, biotin, ethinylestradiol, the glythyl ricinoleic acid, diphenyl hydramine chloride, hyaluronic acid, the Minisasanishiki extract, single nitroguaiacol, field Semen Sinapis stain, loose torch stain, hydrocortisone, biphenyl hydroxylamine chloride, D-panthenol, salicylic acid, lactic acid, sodium lactate and menthol etc.
Example 1
Make substrate with Testa oryzae, add warm water 1000ml among the Testa oryzae 500g and mix, then mixture is sent into appropriate containers, in glass container or plastic containers, to mixture with rice yeast 5g.Add sodium bicarbonate 3g again and make buffer agent with control PH.With heater container is heated to 45 ℃ and keep under this temperature.Mixture is placed a whole day, stirs sometimes, the pasty liquid in this container is filtered with cloth after in the pasty state and must the translucent hair nutritional agent of about 1000ml.
Example 2
Make substrate with bean dregs, in these bean dregs 200g, add water 600ml, make pluck organ 100g and add water 200ml, grind with the homogenization of glass device then and make the homogenize thing, carry out centrifugalize with 1500rpm again.Take out supernatant 100ml and add substrate.At this moment also add sodium carbonate-boric acid so that PH is adjusted to 10.0.Mixture is positioned under about 40 ℃.With Kletto electrophotometer (№ .540 filter) observation enzymatic activity, observe active the termination after about 8 hours.
Make buffer in sodium carbonate-boric acid 40ml adding gained fermentation liquid with 0.1M (PH10.0).Add chymase then to 0.1M.Whole mixture is placed under about 40 ℃.Measure in the sample liquid that 0.2ml all takes from this complete mixture the ammonia amount with the Conway method and determine that fermentation stops.After about 10 hours, stop to generate ammonia and finish fermentation.Filtering fermentation liquor and washing and hair nourishing agent.
Example 3
Make substrate with the Semen Phaseoli slag, water 500ml is added among this Semen Phaseoli slag 200g and with mixture make suspension.In addition, float among the distilled water 100ml, stir after 20 minutes room temperature with Knapp-March Blender and placed about 20 minutes with FIB mycelium gained lipase.Under the mixture 2000rpm centrifugalize after 30 minutes gained top layer liquid add in the mixture of little bean dregs and water.Add Britton-Robinson buffer (phosphoric acid, acetic acid, boric acid, caustic soda) PH is adjusted to 9.0.About 35 ℃ keep about 8 hours of vibration down.Observe fermentation with 0.05M alcohol dissolved salt acidometric titration.
In addition, it is soluble in water and send into hydrogen sulfide in mixture that papain is buied in market, lasts several hours.In mixture, add alcohol afterwards so that the papain sedimentation.(papain 1g: water 100ml) also adding the Britton-Robinson buffer equally is adjusted to 9 with PH to add water again in refining papain.0, afterwards its adding is comprised in the fermentation liquid of substrate.Whole fermentation liquid is put under about 40 ℃, all takes from the sample liquid of this whole beer with pure titration 0.2ml and can determine that fermentation stops.After fermentation in about 12 hours is finished.Get hair nourishing agent behind the filtering fermentation liquor.
Example 4
Glycine max (L.) Merr. is used as substrate, water 500ml is added among this Glycine max (L.) Merr. 100g and with mixture be maintained at about 50 ℃.In addition, the kidney lipase of buying on the market is dissolved in (1%) in the distilled water.This distilled water (5ml) that contains the kidney lipase is added in this mixture.Add phosphoric acid (0.6M, PH7.0), 5ml makes buffer and full mixture kept about 10 hours down for about 40 ℃, or stir.Observe carbonic acid gas with the Warburg manometer and stop to generate then definite fermentation termination.
In addition, pepsin (Cudahy, the solvable pepsin of the 1/10000USP) 10g that buys on the market is dissolved among the 20% ethanol liquid 10ml, it is added in the said fermentation liquid again.Add the hydrochloric acid ammonium then PH is adjusted to 7.5.This liquid was placed about 20 hours in about 35 ℃.Use filter tank (5g) to filter afterwards, at this moment PH is 7.0.Filtrate is positioned under 37 ℃.The sample liquid of 0.5ml all being taken from filtrate outside the Conway device is taken out and each sample is mixed with the potassium carbonate 1ml that puts into this device and can determine the termination of fermenting.Titration is observed the volatile ammonia quantitative changeization and is learnt that fermentation stops.Finish after about 10 hours.Gained liquid filter in common mode and hair nourishing agent.
The present invention example 1-4 trichotrophy liquid with ethanol dilution after mixture each once is coated onto on man and the Mus sooner or later every day.Be coated with after 30 days, two kinds of situations all have outstanding hair growth effect.Particularly after being coated with usefulness on the Mus, particular significant effect becomes mildewed.
The described hair nourishing agent of claim 1 comprises the product that contains each seed amino acid and fatty acid.Acid makes the blood capillary activation alone or in combination and makes contained 5 passivation in the hair follicle.Compare with common hair growth agent, the described hair nourishing agent of claim 1 has more excellent alopecia prevention effect and hair growth effect.Hair nourishing agent of the present invention is harmless fully to human body.Because be that fermented product and substrate comprise vegetable protein and vegetable butter, usefulness be harmless enzyme.
For the hair nourishing agent of claim 2, the lipase and the protease that are used as enzyme can be used for making vegetable protein and vegetable butter in the substrate to decompose and the fermented product/Unit Weight of acquisition high yield effectively.
In the hair nourishing agent of claim 3 except that aminoacid and fatty acid and, also contain a small amount of vitamin E, copper, purine, nucleic acid etc., these other compositions further promote hair growth with aminoacid and fatty acid.
The method of claim 4 provides hair nourishing agent of the present invention, and this nutrient can activate blood capillary and make 5 passivation contained in the hair capsule.Therefore this nutrient can prevent alopecia and promote that hair growth is faster than common hair growth agent.
The method of claim 5 obtains the fermented product/Unit Weight of high yield, because lipase and protease as enzyme, make vegetable protein and vegetable butter in the substrate ferment effectively.
The method of claim 6 provide except that aminoacid and fatty acid and also contain a small amount of vitamin E, copper, purine, other composition such as nucleic acid is in order to further to promote hair growth with aminoacid and fatty acid.
The method of claim 7-9 makes ferment reach decomposition rate faster, therefore reaches the hair nourishing agent/Unit Weight of higher yield.
Claims (1)
1. hair nourishing agent, prepare as key component by fermented product, described fermented product is preparation as described below: add the enzyme that can decompose vegetable protein and vegetable butter or add aspergillosis (koji mold) in hydrated matrix, the addition of enzyme is that per 1000 weight portion hydrated matrix add 1 weight portion, and aspergillar addition is that per 100 weight portion hydrated matrix add 1 weight portion; It is 6-11 that the adding buffer agent makes the pH value of described hydrated matrix; Described water-bearing media was fermented 5-10 hour at 35 ℃-45 ℃; Filtration obtains fermented product.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03316,110/1991 | 1991-11-29 | ||
| JP31611091 | 1991-11-29 | ||
| JP316,110/91 | 1991-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1072588A CN1072588A (en) | 1993-06-02 |
| CN1053098C true CN1053098C (en) | 2000-06-07 |
Family
ID=18073362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92100775A Expired - Fee Related CN1053098C (en) | 1991-11-29 | 1992-01-31 | Hair nourishing agent and production thereof |
Country Status (19)
| Country | Link |
|---|---|
| KR (1) | KR0160141B1 (en) |
| CN (1) | CN1053098C (en) |
| AT (1) | AT405016B (en) |
| AU (1) | AU663301B2 (en) |
| CA (1) | CA2059314C (en) |
| CH (1) | CH683317A5 (en) |
| DE (1) | DE4202645A1 (en) |
| DK (1) | DK292A (en) |
| FI (1) | FI920035A (en) |
| FR (1) | FR2684295B1 (en) |
| GB (1) | GB2261818B (en) |
| HK (1) | HK496A (en) |
| IT (1) | IT1254612B (en) |
| MY (1) | MY107936A (en) |
| NL (1) | NL9200160A (en) |
| NO (1) | NO920202L (en) |
| NZ (1) | NZ241290A (en) |
| PH (1) | PH30444A (en) |
| ZA (1) | ZA92186B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9909294D0 (en) * | 1999-04-22 | 1999-06-16 | Unilever Plc | Treating hair by targeting enzymes |
| JP2000327538A (en) * | 1999-05-24 | 2000-11-28 | Toyo Hakko:Kk | Agent composition for hair treatment |
| EP1500386A1 (en) * | 2003-07-23 | 2005-01-26 | Wella Aktiengesellschaft | Method for time-dependent decrease of ph in a cosmetic composition and a composition for permanent hair shaping with time-dependent decrease of the wave-shaping efficiency |
| KR20050041573A (en) * | 2003-10-31 | 2005-05-04 | 김민호 | Composition for straight permanent of gel type |
| JP5315992B2 (en) * | 2006-06-08 | 2013-10-16 | 味の素株式会社 | Hair growth composition |
| FR2951947B1 (en) | 2009-11-03 | 2022-01-07 | Isp Investments Inc | USE OF A COMPOSITION COMPRISING AN UNFERMENTED RICE PEPTIDE EXTRACT TO STIMULATE HAIR GROWTH |
| FR2963234B1 (en) | 2010-07-29 | 2020-07-17 | Isp Investments Inc | USE OF A COMPOSITION COMPRISING A PEPTIDE EXTRACT OF BEANS FOR STIMULATING HAIR GROWTH |
| CN105125475A (en) * | 2015-09-27 | 2015-12-09 | 常州市奥普泰科光电有限公司 | Cosmetic film-forming moisture preserving additive |
| CN112022792B (en) * | 2020-09-27 | 2022-12-09 | 黑龙江省中医药科学院 | Preparation method of edible traditional Chinese medicine hair dye with homology of medicine and food |
| DE102020125874A1 (en) * | 2020-10-02 | 2022-04-07 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and skin treatment composition |
| DE102020125876A1 (en) * | 2020-10-02 | 2022-04-07 | Dr. Kurt Wolff Gmbh & Co. Kg | Hair and scalp treatment composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0117087A1 (en) * | 1983-02-02 | 1984-08-29 | Suntory Limited | Hair tonic composition |
| US4670255A (en) * | 1983-01-21 | 1987-06-02 | Suntory Limited | Hair tonic composition |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH367937A (en) * | 1958-05-23 | 1963-03-15 | Dubois Raymond | Process for preparing a product for treating the scalp and hair |
| FR1268459A (en) * | 1959-05-05 | 1961-08-04 | Product for the treatment of the scalp and hair and process for the preparation thereof | |
| FR1363121A (en) * | 1961-12-19 | 1964-06-12 | Hygienic-dietetic method for preventing baldness and in particular seborrheic alopecia | |
| US3395019A (en) * | 1965-10-18 | 1968-07-30 | Vylactos Lab Inc | Preparation of animal feed from oat hulls |
| DE1961064A1 (en) * | 1969-12-05 | 1971-06-16 | Dragoco Gerberding Co Gmbh | Process for the production of plant extract concentrates which cannot be broken down by fermentation |
| FR2283204A1 (en) * | 1974-08-28 | 1976-03-26 | Roger Et Gallet | METHOD AND DEVICE FOR THE PREPARATION OF PRODUCTS INTENDED FOR USE IN THE FORM OF AEROSOLS |
| JPS51151396A (en) * | 1975-06-18 | 1976-12-25 | Kikkoman Corp | Process for preparing solid koji |
| JPS5356394A (en) * | 1976-10-28 | 1978-05-22 | Fukushima Hiroo | Liquid flavoring and process for preparing same |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| DE3445919A1 (en) * | 1984-12-17 | 1986-06-19 | Henkel KGaA, 4000 Düsseldorf | COSMETIC PREPARATION WITH ALMOND PROTEIN HYDROLYSATE |
| JP2640349B2 (en) * | 1987-10-15 | 1997-08-13 | 株式会社三光生物科学研究所 | Hair restoration |
| JPH01128912A (en) * | 1987-11-13 | 1989-05-22 | Shogo Ogura | Production of hair dressing and growing agent |
-
1992
- 1992-01-02 DK DK000292A patent/DK292A/en not_active Application Discontinuation
- 1992-01-03 FI FI920035A patent/FI920035A/en unknown
- 1992-01-10 ZA ZA92186A patent/ZA92186B/en unknown
- 1992-01-13 NZ NZ241290A patent/NZ241290A/en unknown
- 1992-01-14 PH PH43776A patent/PH30444A/en unknown
- 1992-01-14 MY MYPI92000058A patent/MY107936A/en unknown
- 1992-01-14 AU AU10211/92A patent/AU663301B2/en not_active Ceased
- 1992-01-14 CA CA002059314A patent/CA2059314C/en not_active Expired - Fee Related
- 1992-01-16 NO NO92920202A patent/NO920202L/en unknown
- 1992-01-17 GB GB9200976A patent/GB2261818B/en not_active Expired - Fee Related
- 1992-01-25 KR KR1019920001091A patent/KR0160141B1/en not_active IP Right Cessation
- 1992-01-29 NL NL9200160A patent/NL9200160A/en not_active Application Discontinuation
- 1992-01-30 DE DE4202645A patent/DE4202645A1/en not_active Withdrawn
- 1992-01-31 FR FR9201361A patent/FR2684295B1/en not_active Expired - Fee Related
- 1992-01-31 CN CN92100775A patent/CN1053098C/en not_active Expired - Fee Related
- 1992-02-06 CH CH339/92A patent/CH683317A5/en not_active IP Right Cessation
- 1992-02-18 IT ITMI920349A patent/IT1254612B/en active IP Right Grant
- 1992-02-24 AT AT0034392A patent/AT405016B/en not_active IP Right Cessation
-
1996
- 1996-01-04 HK HK496A patent/HK496A/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670255A (en) * | 1983-01-21 | 1987-06-02 | Suntory Limited | Hair tonic composition |
| EP0117087A1 (en) * | 1983-02-02 | 1984-08-29 | Suntory Limited | Hair tonic composition |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2261818A (en) | 1993-06-02 |
| CH683317A5 (en) | 1994-02-28 |
| FI920035A0 (en) | 1992-01-03 |
| ATA34392A (en) | 1998-09-15 |
| NL9200160A (en) | 1993-06-16 |
| IT1254612B (en) | 1995-09-28 |
| CN1072588A (en) | 1993-06-02 |
| NO920202D0 (en) | 1992-01-16 |
| CA2059314A1 (en) | 1993-05-30 |
| AU663301B2 (en) | 1995-10-05 |
| GB9200976D0 (en) | 1992-03-11 |
| DE4202645A1 (en) | 1993-06-03 |
| FR2684295A1 (en) | 1993-06-04 |
| KR930009589A (en) | 1993-06-21 |
| NZ241290A (en) | 1993-10-26 |
| AU1021192A (en) | 1993-06-03 |
| NO920202L (en) | 1993-06-01 |
| AT405016B (en) | 1999-04-26 |
| FR2684295B1 (en) | 1995-05-19 |
| DK292D0 (en) | 1992-01-02 |
| FI920035A (en) | 1993-05-30 |
| ZA92186B (en) | 1992-09-30 |
| HK496A (en) | 1996-01-12 |
| DK292A (en) | 1992-01-02 |
| MY107936A (en) | 1996-06-29 |
| PH30444A (en) | 1997-05-09 |
| CA2059314C (en) | 1999-03-30 |
| GB2261818B (en) | 1995-09-27 |
| ITMI920349A0 (en) | 1992-02-18 |
| ITMI920349A1 (en) | 1993-08-18 |
| KR0160141B1 (en) | 1998-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1053098C (en) | Hair nourishing agent and production thereof | |
| CN102845711B (en) | Production technology for producing nutrient seasoning paste by enzymatic method using avian skeleton | |
| CN103815119A (en) | Method for producing microbial feed by fermenting corn deep processing byproducts | |
| CN105238831A (en) | Moringa seed micro-molecular peptide extracted from moringa seeds, and extraction method thereof | |
| CN101218338B (en) | Method for producing liquid koji | |
| CN106566861B (en) | Preparation method of black-bone chicken oligopeptide mixed powder with high F value | |
| CN104745665A (en) | Collagen peptide with function of promoting bone growth as well as preparation method and application thereof | |
| CN105852104A (en) | Preparation method of health-care instantly-dissolved protein powder | |
| CN106235021A (en) | A kind of technique of fermenting and producing Semen Sojae Preparatum | |
| CN103966291A (en) | Yeast peptone | |
| CN108552526A (en) | A kind of preparation method of richness GABA brown rice enzymes | |
| CN106868068A (en) | A kind of utilization corn protein powder hydrolyzate substitutes the temperature sensitive type aminoglutaric acid fermentation production method of part soybean meal hydrolysate | |
| JP2000000088A (en) | Glutaminase activity-enhanced microorganism-cultured material and its use | |
| CN105779317A (en) | Pichia pastoris strain for high yield of methanol protein and application thereof | |
| CN101658289A (en) | Preparing method of cordyceps sinensis dark soy sauce | |
| CA3153377A1 (en) | Nitrogen-enhanced yeast-based fertilizer | |
| CN110663813B (en) | Fish meal microbial fermentation and enzymolysis method | |
| CN105746891B (en) | A method of utilizing aquatic product protein and feather meal fermentation preparation fowl growth promotion small peptide | |
| US4418080A (en) | Natural red coloring prepared from wheat and barley substrates | |
| CN106561361A (en) | Selenium-enrichment rice cultivation technology | |
| RU2189395C2 (en) | Method of mushroom protein biomass preparing | |
| KR20000058843A (en) | The method for manufacturing of health drink | |
| KR100253695B1 (en) | Method for preparing extract of fermented rice bran | |
| CN104126837B (en) | A kind of preparation method of germinating unpolished rice beverage | |
| CN102845709B (en) | Production technology for producing nutrient seasoning paste by enzymatic method with comprehensive utilization of avian skeleton |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |