NZ226955A - Anti-tumour drug - monoclonal antibody conjugate and pharmaceutical composition - Google Patents

Anti-tumour drug - monoclonal antibody conjugate and pharmaceutical composition

Info

Publication number
NZ226955A
NZ226955A NZ226955A NZ22695588A NZ226955A NZ 226955 A NZ226955 A NZ 226955A NZ 226955 A NZ226955 A NZ 226955A NZ 22695588 A NZ22695588 A NZ 22695588A NZ 226955 A NZ226955 A NZ 226955A
Authority
NZ
New Zealand
Prior art keywords
drug
group
carbon atoms
substituted
moiety
Prior art date
Application number
NZ226955A
Other languages
English (en)
Inventor
Peter D Senter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of NZ226955A publication Critical patent/NZ226955A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
NZ226955A 1987-11-23 1988-11-14 Anti-tumour drug - monoclonal antibody conjugate and pharmaceutical composition NZ226955A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/124,313 US4952394A (en) 1987-11-23 1987-11-23 Drug-monoclonal antibody conjugates

Publications (1)

Publication Number Publication Date
NZ226955A true NZ226955A (en) 1991-11-26

Family

ID=22414122

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ226955A NZ226955A (en) 1987-11-23 1988-11-14 Anti-tumour drug - monoclonal antibody conjugate and pharmaceutical composition

Country Status (16)

Country Link
US (1) US4952394A (ja)
EP (1) EP0317957B1 (ja)
JP (1) JPH02111731A (ja)
KR (1) KR910005887B1 (ja)
AT (1) ATE81986T1 (ja)
AU (1) AU617380B2 (ja)
CA (1) CA1303524C (ja)
DE (1) DE3875700T2 (ja)
DK (1) DK651088A (ja)
FI (1) FI885361A (ja)
GR (1) GR3006211T3 (ja)
IL (1) IL88428A0 (ja)
NO (1) NO169958C (ja)
NZ (1) NZ226955A (ja)
PT (1) PT89062B (ja)
ZA (1) ZA886811B (ja)

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Also Published As

Publication number Publication date
PT89062A (pt) 1989-11-30
EP0317957B1 (en) 1992-11-04
NO169958C (no) 1992-08-26
FI885361A (fi) 1989-05-24
FI885361A0 (fi) 1988-11-18
ZA886811B (en) 1989-07-26
DK651088A (da) 1989-05-24
JPH02111731A (ja) 1990-04-24
DE3875700T2 (de) 1993-03-18
NO169958B (no) 1992-05-18
KR910005887B1 (ko) 1991-08-06
PT89062B (pt) 1993-07-30
DE3875700D1 (de) 1992-12-10
AU2582488A (en) 1989-05-25
KR890007724A (ko) 1989-07-05
AU617380B2 (en) 1991-11-28
US4952394A (en) 1990-08-28
EP0317957A2 (en) 1989-05-31
ATE81986T1 (de) 1992-11-15
EP0317957A3 (en) 1989-07-05
DK651088D0 (da) 1988-11-22
IL88428A0 (en) 1989-06-30
CA1303524C (en) 1992-06-16
NO885199L (no) 1989-05-24
GR3006211T3 (ja) 1993-06-21
NO885199D0 (no) 1988-11-22

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