NO995687L - FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser - Google Patents
FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelserInfo
- Publication number
- NO995687L NO995687L NO995687A NO995687A NO995687L NO 995687 L NO995687 L NO 995687L NO 995687 A NO995687 A NO 995687A NO 995687 A NO995687 A NO 995687A NO 995687 L NO995687 L NO 995687L
- Authority
- NO
- Norway
- Prior art keywords
- sterol
- stanol
- preparation
- compounds
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/200,623 US6242001B1 (en) | 1998-11-30 | 1998-11-30 | Method for producing dispersible sterol and stanol compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
NO995687D0 NO995687D0 (no) | 1999-11-19 |
NO995687L true NO995687L (no) | 2000-05-31 |
Family
ID=22742487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO995687A NO995687L (no) | 1998-11-30 | 1999-11-19 | FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser |
Country Status (9)
Country | Link |
---|---|
US (2) | US6242001B1 (ja) |
EP (1) | EP1005859B1 (ja) |
JP (1) | JP2000191684A (ja) |
AT (1) | ATE315381T1 (ja) |
CA (1) | CA2290315C (ja) |
DE (1) | DE69929411T2 (ja) |
DK (1) | DK1005859T3 (ja) |
ES (1) | ES2257011T3 (ja) |
NO (1) | NO995687L (ja) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376481B2 (en) * | 1998-09-02 | 2002-04-23 | Mcneil-Ppc, Inc. | Sterol esters in tableted solid dosage forms |
US6242001B1 (en) * | 1998-11-30 | 2001-06-05 | Mcneil-Ppc, Inc. | Method for producing dispersible sterol and stanol compounds |
ATE304799T1 (de) * | 1999-06-25 | 2005-10-15 | Cognis Ip Man Gmbh | Verwendung von nanoskaligen sterolen und sterolestern |
DK1227734T3 (da) * | 1999-11-03 | 2005-05-23 | Forbes Medi Tech Inc | Sammensætninger bestående af spiselige olier eller fedtsyrestoffer og phytosteroler og/eller phytostanoler oplöst deri |
US6391370B1 (en) * | 1999-11-12 | 2002-05-21 | Kraft Foods, Inc. | Micromilling plant sterols and emulsifiers |
CN1436047A (zh) | 2000-04-14 | 2003-08-13 | 马尔斯公司 | 促进血管健康的组合物和方法 |
KR20020026053A (ko) * | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
US6576285B1 (en) * | 2000-11-14 | 2003-06-10 | Sunpure Ltd. | Cholesterol lowering beverage |
US20020107232A1 (en) * | 2001-01-12 | 2002-08-08 | Flickinger Brent D. | Methods for producing sterol ester-rich compositions |
WO2003004030A1 (en) * | 2001-07-06 | 2003-01-16 | Endo Pharmaceuticals, Inc. | Oxymorphone controlled release formulations |
US7012297B2 (en) * | 2001-08-30 | 2006-03-14 | Micron Technology, Inc. | Scalable flash/NV structures and devices with extended endurance |
US7144595B2 (en) * | 2001-11-16 | 2006-12-05 | Brandeis University | Prepared foods containing triglyceride-recrystallized non-esterified phytosterols |
US7763663B2 (en) * | 2001-12-19 | 2010-07-27 | University Of Massachusetts | Polysaccharide-containing block copolymer particles and uses thereof |
WO2003077680A1 (en) * | 2002-03-20 | 2003-09-25 | Eugene Science Inc. | Mixing powder of plant sterol and emulsifier, and method for preparing the same |
AU2002241368B2 (en) * | 2002-03-20 | 2009-07-09 | Eugene Science Inc. | Plant sterol-containing food, and method for preparing the same |
US6623780B1 (en) | 2002-03-26 | 2003-09-23 | Cargill, Inc. | Aqueous dispersible sterol product |
JP2005529109A (ja) * | 2002-04-10 | 2005-09-29 | カーギル,インコーポレイティド | 水性分散性ステリル・エステル組成物 |
US20060093661A1 (en) | 2002-05-07 | 2006-05-04 | Kapac, Llc | Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs |
US20030212046A1 (en) * | 2002-05-07 | 2003-11-13 | Kapac, Llc | Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs |
US7306819B2 (en) * | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
ATE413820T1 (de) * | 2002-06-12 | 2008-11-15 | Coca Cola Co | Pflanzliches sterol enthaltende getränke |
IS6633A (is) * | 2002-11-22 | 2004-05-23 | Omega Farma Ehf. | Samsetningar af fínasteríð töflum |
US20060182820A1 (en) * | 2004-02-10 | 2006-08-17 | Cargill, Incorporated | Homogeneous Dispersions Containing Citrus Pulp and Applications Thereof |
US20050175672A1 (en) * | 2004-02-10 | 2005-08-11 | Kluetz Michael D. | Particulate plant sterol compositions |
US20080213444A1 (en) * | 2004-02-26 | 2008-09-04 | Tasker Products, Inc. | Compositions and methods for reducing microbial contamination in meat processing |
MXPA06009797A (es) * | 2004-02-26 | 2007-08-14 | Tasker Products Ip Holdings Co | Composicion anti-microbiana para tratamiento pre-cosecha y post-cosecha de plantas y animales. |
KR20130079645A (ko) * | 2005-07-18 | 2013-07-10 | 유니버시티 오브 메사츄세츠 로웰 | 나노에멀젼 조성물 및 이의 제조 및 사용 방법 |
CA2623678A1 (en) * | 2005-09-29 | 2007-04-05 | Repros Therapeutics Inc. | Formulations with improved bioavailability, comprising a steroid derivative and a polyglycolysed glyceride |
DK1959994T3 (en) | 2005-12-01 | 2017-12-04 | Univ Massachusetts Lowell | Botulinum nanoemulsions |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US20070190175A1 (en) * | 2005-12-08 | 2007-08-16 | Tasker Products Ip Holding Corp | Skin care composition for dermatological disorders |
WO2007101581A2 (de) * | 2006-03-08 | 2007-09-13 | Cognis Ip Management Gmbh | Sterolhaltige pulver |
US20080124387A1 (en) | 2006-11-27 | 2008-05-29 | Kapac, Llc | Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients |
BRPI0719732A2 (pt) * | 2006-12-01 | 2017-05-16 | Anterios Inc | nanopartículas de peptídeo e usos para as mesmas |
SG177184A1 (en) | 2006-12-01 | 2012-01-30 | Anterios Inc | Amphiphilic entity nanoparticles |
CN103961315A (zh) | 2007-05-31 | 2014-08-06 | 安特里奥公司 | 核酸纳米粒子和其用途 |
US20090088393A1 (en) * | 2007-09-28 | 2009-04-02 | Zomanex, Llc | Methods and formulations for converting intravenous and injectable drugs into oral dosage forms |
US20090092727A1 (en) * | 2007-10-04 | 2009-04-09 | Daniel Perlman | Water-dispersible phytosterol-surfactant conglomerate particles |
KR102080429B1 (ko) * | 2008-06-26 | 2020-02-21 | 안테리오스, 인코퍼레이티드 | 경피 운반 |
US20110223312A1 (en) * | 2009-11-30 | 2011-09-15 | Daniel Perlman | Triglyceride-encapsulated phytosterol microparticles dispersed in beverages |
AU2017360346B2 (en) | 2016-11-21 | 2023-11-23 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3085939A (en) | 1959-05-11 | 1963-04-16 | Upjohn Co | Oil-in-water emulsion for oral administration, and process for preparation |
US3004043A (en) | 1959-10-09 | 1961-10-10 | Eastman Kodak Co | Water-soluble vegetable oil sterol derivatives |
CA928140A (en) | 1969-07-17 | 1973-06-12 | A. Erickson Billy | Clear cooking and salad oils having hypocholesterolemic properties |
US3865939A (en) | 1973-02-23 | 1975-02-11 | Procter & Gamble | Edible oils having hypocholesterolemic properties |
US3881005A (en) | 1973-08-13 | 1975-04-29 | Lilly Co Eli | Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof |
US4391732A (en) | 1975-06-06 | 1983-07-05 | Henkel Corporation | Phytosterol blends |
US4005196A (en) | 1976-02-12 | 1977-01-25 | The Procter & Gamble Company | Vitaminized compositions for treating hypercholesterolemia |
US4195084A (en) | 1977-01-07 | 1980-03-25 | Eli Lilly And Company | Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof |
US4423041A (en) | 1979-06-25 | 1983-12-27 | Johnson & Johnson Products, Inc. | Detackifying compositions |
DE3172630D1 (en) | 1980-12-02 | 1985-11-14 | Duphar Int Res | Method of isolating sterols in commercial quantities from sterol-containing material |
FI63423C (fi) | 1981-01-27 | 1983-06-10 | Farmos Oy | Foerfarande foer separering av beta-sitosterol fraon en sterolblandning utvunnen ur raosaopans neutralfraktion |
EP0179583A1 (en) | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | A system for enhancing the water dissolution rate and solubility of poorly soluble drugs |
US5219733A (en) | 1985-03-06 | 1993-06-15 | Yoshikawa Oil & Fat Co., Ltd. | Process for preparing fatty acid esters |
JPS62186936A (ja) | 1986-02-13 | 1987-08-15 | Asahi Denka Kogyo Kk | ステリン乳化乃至可溶化組成物 |
DE3829643A1 (de) | 1988-09-01 | 1990-03-15 | Roecar Holdings Nv | Phyto- und zoosterole und deren derivate mit verbesserter wasserloeslichkeit |
JP2656997B2 (ja) | 1989-07-21 | 1997-09-24 | マリゲン ソシエテ アノニム | ステロールの脂肪酸エステルの抗腫瘍剤のための自発的分散性濃縮物及びそれを含む医薬組成物 |
US5723747A (en) | 1991-02-22 | 1998-03-03 | Calgene, Inc. | Wax esters in transformed plants |
US5502045A (en) | 1991-05-03 | 1996-03-26 | Raision Tehtaat Oy Ab | Use of a stanol fatty acid ester for reducing serum cholesterol level |
PT100726A (pt) * | 1991-07-26 | 1993-09-30 | Smithkline Beecham Corp | Microemulsoes de agua em oleo, auto-emulsionantes, estaveis e farmaceuticamente aceitaveis e seu uso |
US5244887A (en) | 1992-02-14 | 1993-09-14 | Straub Carl D | Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof |
JPH06329588A (ja) * | 1993-05-19 | 1994-11-29 | Riken Vitamin Co Ltd | 水分散性モノグリセリド |
AU676315B2 (en) | 1993-06-30 | 1997-03-06 | Takeda Chemical Industries Ltd. | Stabilized solid pharmaceutical preparation and method of producing the same |
BR9509119A (pt) | 1994-09-29 | 1997-10-28 | Univ British Columbia | Processo para o isolamento de uma composição de fitoesteróis a partir de um sabão de polpa composição diminuidora de colesterol e produto terapeuticamente eficaz para prevenir ou tratar aterosclerose ou dislipidemias primárias ou secundárias |
US5492714A (en) | 1994-11-08 | 1996-02-20 | The Procter & Gamble Company | Reduced calorie fats which comprise reduced calorie triglycerides containing medium and long chain fatty acids and which exhibit rapid crystallization to beta phase |
US5486318A (en) | 1994-12-29 | 1996-01-23 | The Boc Group, Inc. | Liquid-vapor contact column |
US5578334A (en) | 1995-04-07 | 1996-11-26 | Brandeis University | Increasing the HDL level and the HDL/LDL ratio in human serum with fat blends |
BR9608914A (pt) | 1995-06-01 | 1999-03-02 | Unilever Nv | Produto alimentício á base de gorgura pasta de gordura amarela e uso de um concentrado oleoso |
US5698527A (en) | 1995-08-08 | 1997-12-16 | Merck & Co., Inc. | Steroidal glycosides as antihyperlipidemic agents |
GB9613858D0 (en) * | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
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CA2273341A1 (en) * | 1996-11-28 | 1998-06-04 | Henkel Kommanditgesellschaft Auf Aktien | Use of mixtures of active substances, containing phytostenols and/or phytostenol esters and potentiators, for the production of hypocholesterolemic preparations |
US5837714A (en) | 1997-03-03 | 1998-11-17 | Sanofi | Solid pharmaceutical dispersions |
DE69827330T2 (de) | 1997-08-22 | 2006-02-02 | Unilever N.V. | Stanolester enthaltende Zusammensetzung |
WO1999018977A1 (en) | 1997-10-16 | 1999-04-22 | Medical Isotopes Inc. | Readily absorbable phytosterol glycosides to treat hypercholesterolemia |
US6025010A (en) | 1997-11-21 | 2000-02-15 | Lipton, Division Of Conopco, Inc. | Multifunctional spread |
US6045853A (en) | 1997-12-05 | 2000-04-04 | Lipton, Division Of Conopco, Inc. | Fat continuous spread and process for making the same |
US6110502A (en) | 1998-02-19 | 2000-08-29 | Mcneil-Ppc, Inc. | Method for producing water dispersible sterol formulations |
US6025348A (en) | 1998-04-30 | 2000-02-15 | Kao Corporation | Oil and fat composition containing phytosterol |
SE512958C2 (sv) | 1998-04-30 | 2000-06-12 | Triple Crown Ab | Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning |
US5932562A (en) | 1998-05-26 | 1999-08-03 | Washington University | Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same |
AU771960B2 (en) | 1998-06-05 | 2004-04-08 | Forbes Medi-Tech Inc. | Compositions comprising phytosterol and/or phytostanol having enhanced solubility and dispersability |
US6242001B1 (en) * | 1998-11-30 | 2001-06-05 | Mcneil-Ppc, Inc. | Method for producing dispersible sterol and stanol compounds |
-
1998
- 1998-11-30 US US09/200,623 patent/US6242001B1/en not_active Expired - Lifetime
-
1999
- 1999-11-19 NO NO995687A patent/NO995687L/no not_active Application Discontinuation
- 1999-11-24 CA CA002290315A patent/CA2290315C/en not_active Expired - Fee Related
- 1999-11-29 EP EP99309492A patent/EP1005859B1/en not_active Expired - Lifetime
- 1999-11-29 AT AT99309492T patent/ATE315381T1/de active
- 1999-11-29 JP JP11338407A patent/JP2000191684A/ja active Pending
- 1999-11-29 ES ES99309492T patent/ES2257011T3/es not_active Expired - Lifetime
- 1999-11-29 DE DE69929411T patent/DE69929411T2/de not_active Expired - Lifetime
- 1999-11-29 DK DK99309492T patent/DK1005859T3/da active
-
2001
- 2001-04-04 US US09/826,072 patent/US6387411B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6387411B2 (en) | 2002-05-14 |
ATE315381T1 (de) | 2006-02-15 |
US6242001B1 (en) | 2001-06-05 |
US20010012521A1 (en) | 2001-08-09 |
EP1005859A1 (en) | 2000-06-07 |
EP1005859B1 (en) | 2006-01-11 |
DE69929411D1 (de) | 2006-04-06 |
CA2290315A1 (en) | 2000-05-30 |
NO995687D0 (no) | 1999-11-19 |
CA2290315C (en) | 2008-11-18 |
DE69929411T2 (de) | 2006-08-24 |
DK1005859T3 (da) | 2006-04-03 |
JP2000191684A (ja) | 2000-07-11 |
ES2257011T3 (es) | 2006-07-16 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |