NO995687L - FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser - Google Patents

FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser

Info

Publication number
NO995687L
NO995687L NO995687A NO995687A NO995687L NO 995687 L NO995687 L NO 995687L NO 995687 A NO995687 A NO 995687A NO 995687 A NO995687 A NO 995687A NO 995687 L NO995687 L NO 995687L
Authority
NO
Norway
Prior art keywords
sterol
stanol
preparation
compounds
preparing
Prior art date
Application number
NO995687A
Other languages
English (en)
Norwegian (no)
Other versions
NO995687D0 (no
Inventor
Richard D Bruce
Brid Burruano
Michael R Hoy
Nicholas R Paquette
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Publication of NO995687D0 publication Critical patent/NO995687D0/no
Publication of NO995687L publication Critical patent/NO995687L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
NO995687A 1998-11-30 1999-11-19 FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser NO995687L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/200,623 US6242001B1 (en) 1998-11-30 1998-11-30 Method for producing dispersible sterol and stanol compounds

Publications (2)

Publication Number Publication Date
NO995687D0 NO995687D0 (no) 1999-11-19
NO995687L true NO995687L (no) 2000-05-31

Family

ID=22742487

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995687A NO995687L (no) 1998-11-30 1999-11-19 FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser

Country Status (9)

Country Link
US (2) US6242001B1 (ja)
EP (1) EP1005859B1 (ja)
JP (1) JP2000191684A (ja)
AT (1) ATE315381T1 (ja)
CA (1) CA2290315C (ja)
DE (1) DE69929411T2 (ja)
DK (1) DK1005859T3 (ja)
ES (1) ES2257011T3 (ja)
NO (1) NO995687L (ja)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376481B2 (en) * 1998-09-02 2002-04-23 Mcneil-Ppc, Inc. Sterol esters in tableted solid dosage forms
US6242001B1 (en) * 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds
ATE304799T1 (de) * 1999-06-25 2005-10-15 Cognis Ip Man Gmbh Verwendung von nanoskaligen sterolen und sterolestern
DK1227734T3 (da) * 1999-11-03 2005-05-23 Forbes Medi Tech Inc Sammensætninger bestående af spiselige olier eller fedtsyrestoffer og phytosteroler og/eller phytostanoler oplöst deri
US6391370B1 (en) * 1999-11-12 2002-05-21 Kraft Foods, Inc. Micromilling plant sterols and emulsifiers
CN1436047A (zh) 2000-04-14 2003-08-13 马尔斯公司 促进血管健康的组合物和方法
KR20020026053A (ko) * 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
US6576285B1 (en) * 2000-11-14 2003-06-10 Sunpure Ltd. Cholesterol lowering beverage
US20020107232A1 (en) * 2001-01-12 2002-08-08 Flickinger Brent D. Methods for producing sterol ester-rich compositions
WO2003004030A1 (en) * 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Oxymorphone controlled release formulations
US7012297B2 (en) * 2001-08-30 2006-03-14 Micron Technology, Inc. Scalable flash/NV structures and devices with extended endurance
US7144595B2 (en) * 2001-11-16 2006-12-05 Brandeis University Prepared foods containing triglyceride-recrystallized non-esterified phytosterols
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
WO2003077680A1 (en) * 2002-03-20 2003-09-25 Eugene Science Inc. Mixing powder of plant sterol and emulsifier, and method for preparing the same
AU2002241368B2 (en) * 2002-03-20 2009-07-09 Eugene Science Inc. Plant sterol-containing food, and method for preparing the same
US6623780B1 (en) 2002-03-26 2003-09-23 Cargill, Inc. Aqueous dispersible sterol product
JP2005529109A (ja) * 2002-04-10 2005-09-29 カーギル，インコーポレイティド 水性分散性ステリル・エステル組成物
US20060093661A1 (en) 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20030212046A1 (en) * 2002-05-07 2003-11-13 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US7306819B2 (en) * 2002-06-12 2007-12-11 The Coca-Cola Company Beverages containing plant sterols
ATE413820T1 (de) * 2002-06-12 2008-11-15 Coca Cola Co Pflanzliches sterol enthaltende getränke
IS6633A (is) * 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
US20060182820A1 (en) * 2004-02-10 2006-08-17 Cargill, Incorporated Homogeneous Dispersions Containing Citrus Pulp and Applications Thereof
US20050175672A1 (en) * 2004-02-10 2005-08-11 Kluetz Michael D. Particulate plant sterol compositions
US20080213444A1 (en) * 2004-02-26 2008-09-04 Tasker Products, Inc. Compositions and methods for reducing microbial contamination in meat processing
MXPA06009797A (es) * 2004-02-26 2007-08-14 Tasker Products Ip Holdings Co Composicion anti-microbiana para tratamiento pre-cosecha y post-cosecha de plantas y animales.
KR20130079645A (ko) * 2005-07-18 2013-07-10 유니버시티 오브 메사츄세츠 로웰 나노에멀젼 조성물 및 이의 제조 및 사용 방법
CA2623678A1 (en) * 2005-09-29 2007-04-05 Repros Therapeutics Inc. Formulations with improved bioavailability, comprising a steroid derivative and a polyglycolysed glyceride
DK1959994T3 (en) 2005-12-01 2017-12-04 Univ Massachusetts Lowell Botulinum nanoemulsions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US20070190175A1 (en) * 2005-12-08 2007-08-16 Tasker Products Ip Holding Corp Skin care composition for dermatological disorders
WO2007101581A2 (de) * 2006-03-08 2007-09-13 Cognis Ip Management Gmbh Sterolhaltige pulver
US20080124387A1 (en) 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
BRPI0719732A2 (pt) * 2006-12-01 2017-05-16 Anterios Inc nanopartículas de peptídeo e usos para as mesmas
SG177184A1 (en) 2006-12-01 2012-01-30 Anterios Inc Amphiphilic entity nanoparticles
CN103961315A (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
US20090088393A1 (en) * 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
US20090092727A1 (en) * 2007-10-04 2009-04-09 Daniel Perlman Water-dispersible phytosterol-surfactant conglomerate particles
KR102080429B1 (ko) * 2008-06-26 2020-02-21 안테리오스, 인코퍼레이티드 경피 운반
US20110223312A1 (en) * 2009-11-30 2011-09-15 Daniel Perlman Triglyceride-encapsulated phytosterol microparticles dispersed in beverages
AU2017360346B2 (en) 2016-11-21 2023-11-23 Eirion Therapeutics, Inc. Transdermal delivery of large agents

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3085939A (en) 1959-05-11 1963-04-16 Upjohn Co Oil-in-water emulsion for oral administration, and process for preparation
US3004043A (en) 1959-10-09 1961-10-10 Eastman Kodak Co Water-soluble vegetable oil sterol derivatives
CA928140A (en) 1969-07-17 1973-06-12 A. Erickson Billy Clear cooking and salad oils having hypocholesterolemic properties
US3865939A (en) 1973-02-23 1975-02-11 Procter & Gamble Edible oils having hypocholesterolemic properties
US3881005A (en) 1973-08-13 1975-04-29 Lilly Co Eli Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof
US4391732A (en) 1975-06-06 1983-07-05 Henkel Corporation Phytosterol blends
US4005196A (en) 1976-02-12 1977-01-25 The Procter & Gamble Company Vitaminized compositions for treating hypercholesterolemia
US4195084A (en) 1977-01-07 1980-03-25 Eli Lilly And Company Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof
US4423041A (en) 1979-06-25 1983-12-27 Johnson & Johnson Products, Inc. Detackifying compositions
DE3172630D1 (en) 1980-12-02 1985-11-14 Duphar Int Res Method of isolating sterols in commercial quantities from sterol-containing material
FI63423C (fi) 1981-01-27 1983-06-10 Farmos Oy Foerfarande foer separering av beta-sitosterol fraon en sterolblandning utvunnen ur raosaopans neutralfraktion
EP0179583A1 (en) 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
US5219733A (en) 1985-03-06 1993-06-15 Yoshikawa Oil & Fat Co., Ltd. Process for preparing fatty acid esters
JPS62186936A (ja) 1986-02-13 1987-08-15 Asahi Denka Kogyo Kk ステリン乳化乃至可溶化組成物
DE3829643A1 (de) 1988-09-01 1990-03-15 Roecar Holdings Nv Phyto- und zoosterole und deren derivate mit verbesserter wasserloeslichkeit
JP2656997B2 (ja) 1989-07-21 1997-09-24 マリゲン ソシエテ アノニム ステロールの脂肪酸エステルの抗腫瘍剤のための自発的分散性濃縮物及びそれを含む医薬組成物
US5723747A (en) 1991-02-22 1998-03-03 Calgene, Inc. Wax esters in transformed plants
US5502045A (en) 1991-05-03 1996-03-26 Raision Tehtaat Oy Ab Use of a stanol fatty acid ester for reducing serum cholesterol level
PT100726A (pt) * 1991-07-26 1993-09-30 Smithkline Beecham Corp Microemulsoes de agua em oleo, auto-emulsionantes, estaveis e farmaceuticamente aceitaveis e seu uso
US5244887A (en) 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
JPH06329588A (ja) * 1993-05-19 1994-11-29 Riken Vitamin Co Ltd 水分散性モノグリセリド
AU676315B2 (en) 1993-06-30 1997-03-06 Takeda Chemical Industries Ltd. Stabilized solid pharmaceutical preparation and method of producing the same
BR9509119A (pt) 1994-09-29 1997-10-28 Univ British Columbia Processo para o isolamento de uma composição de fitoesteróis a partir de um sabão de polpa composição diminuidora de colesterol e produto terapeuticamente eficaz para prevenir ou tratar aterosclerose ou dislipidemias primárias ou secundárias
US5492714A (en) 1994-11-08 1996-02-20 The Procter & Gamble Company Reduced calorie fats which comprise reduced calorie triglycerides containing medium and long chain fatty acids and which exhibit rapid crystallization to beta phase
US5486318A (en) 1994-12-29 1996-01-23 The Boc Group, Inc. Liquid-vapor contact column
US5578334A (en) 1995-04-07 1996-11-26 Brandeis University Increasing the HDL level and the HDL/LDL ratio in human serum with fat blends
BR9608914A (pt) 1995-06-01 1999-03-02 Unilever Nv Produto alimentício á base de gorgura pasta de gordura amarela e uso de um concentrado oleoso
US5698527A (en) 1995-08-08 1997-12-16 Merck & Co., Inc. Steroidal glycosides as antihyperlipidemic agents
GB9613858D0 (en) * 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
US6139872A (en) 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
CA2273341A1 (en) * 1996-11-28 1998-06-04 Henkel Kommanditgesellschaft Auf Aktien Use of mixtures of active substances, containing phytostenols and/or phytostenol esters and potentiators, for the production of hypocholesterolemic preparations
US5837714A (en) 1997-03-03 1998-11-17 Sanofi Solid pharmaceutical dispersions
DE69827330T2 (de) 1997-08-22 2006-02-02 Unilever N.V. Stanolester enthaltende Zusammensetzung
WO1999018977A1 (en) 1997-10-16 1999-04-22 Medical Isotopes Inc. Readily absorbable phytosterol glycosides to treat hypercholesterolemia
US6025010A (en) 1997-11-21 2000-02-15 Lipton, Division Of Conopco, Inc. Multifunctional spread
US6045853A (en) 1997-12-05 2000-04-04 Lipton, Division Of Conopco, Inc. Fat continuous spread and process for making the same
US6110502A (en) 1998-02-19 2000-08-29 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
US6025348A (en) 1998-04-30 2000-02-15 Kao Corporation Oil and fat composition containing phytosterol
SE512958C2 (sv) 1998-04-30 2000-06-12 Triple Crown Ab Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning
US5932562A (en) 1998-05-26 1999-08-03 Washington University Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same
AU771960B2 (en) 1998-06-05 2004-04-08 Forbes Medi-Tech Inc. Compositions comprising phytosterol and/or phytostanol having enhanced solubility and dispersability
US6242001B1 (en) * 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds

Also Published As

Publication number Publication date
US6387411B2 (en) 2002-05-14
ATE315381T1 (de) 2006-02-15
US6242001B1 (en) 2001-06-05
US20010012521A1 (en) 2001-08-09
EP1005859A1 (en) 2000-06-07
EP1005859B1 (en) 2006-01-11
DE69929411D1 (de) 2006-04-06
CA2290315A1 (en) 2000-05-30
NO995687D0 (no) 1999-11-19
CA2290315C (en) 2008-11-18
DE69929411T2 (de) 2006-08-24
DK1005859T3 (da) 2006-04-03
JP2000191684A (ja) 2000-07-11
ES2257011T3 (es) 2006-07-16

Similar Documents

Publication Publication Date Title
NO995687L (no) FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser
CA2022465A1 (en) Process for micronizing slightly-soluble drug
AU4161589A (en) 7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acid, a process for the preparation thereof, the use thereof as pharmaceuticals, and intermediates
HUT55795A (en) Process for producing aromatic steroide 5-alpha-reductase inhibitors and pharmaceutical compositions containing them
CA2227761A1 (en) Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizers
AU609149B2 (en) 3-demthylmevalonic acid derivatives, a process for their preparation pharmaceutical products based on these compounds, their use and intermediates
FI934869A (fi) Menetelmä seerumin korkean kolesterolitason alentamiseen käytettävän aineen valmistamiseksi
JP2003522124A (ja) フィトステロール又はフィトスタノールとアスコルビン酸との複合体及び心臓血管疾患の治療と予防におけるそれらの使用
JPS6029470B2 (ja) ９α−ヒドロキシアンドロステンジオンを生産する微生物
WO2001040240A3 (en) Mono- and disaccharide derivatives
WO2000015201A2 (en) Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other disorders
Shikita et al. 20α-Hydroxysteroid dehydrogenase of testes
NO990747L (no) Fremgangsmåte for fremstilling av vann-dispergerbare sterolformuleringer
RU94029667A (ru) ПРОИЗВОДНЫЕ 11β -БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ЛЕКАРСТВЕННЫЕ СРЕДСТВА
AU2753292A (en) Cholesterol lowering compounds and process for making them
AU777377B2 (en) Dibenzo(a,g)quinolizinium derivatives and the salts thereof
AU580086B2 (en) New steroids substituted at position 10 by a radical including a double or triple bond, their preparation process, their use as medicaments, pharmaceutical compositions containing them
JP3366324B2 (ja) 化粧品用、または特に皮膚科の医薬用抗アレルギー性組成物の調製のためのククルビチンの用途、及び、その投与を含む方法
NZ232207A (en) Dihydrobenz(c)acridine derivatives and pharmaceutical compositions
JP2004521941A (ja) 水分散性ステロール類含有自由流動粉体の製造方法
AU3929789A (en) New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates
KR100436036B1 (ko) Ｗｋ-5344ａ 물질 및 ｗｋ-5344ｂ 물질 그리고 그의 제조법
AU5411099A (en) Improved process for the preparation of salts and esters of clavulanic acid
Barranco et al. Extraction of mitochondrial protein-lipid complexes into organic solvents: Inhibition of cytochrome oxidase electron transport by dicyclohexylcarbodiimide and triphenyltin chloride
JPS6111206B2 (ja)

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application