NO983945L - Isokinoliner som er nyttige som analgetika - Google Patents
Isokinoliner som er nyttige som analgetikaInfo
- Publication number
- NO983945L NO983945L NO983945A NO983945A NO983945L NO 983945 L NO983945 L NO 983945L NO 983945 A NO983945 A NO 983945A NO 983945 A NO983945 A NO 983945A NO 983945 L NO983945 L NO 983945L
- Authority
- NO
- Norway
- Prior art keywords
- analgesics
- isoquinolines
- useful
- compounds
- isoquinolines useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600769A SE9600769D0 (sv) | 1996-02-28 | 1996-02-28 | Compounds useful as analgesic |
| PCT/SE1997/000315 WO1997031940A1 (en) | 1996-02-28 | 1997-02-25 | Isoquinolines useful as analgesics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO983945D0 NO983945D0 (no) | 1998-08-27 |
| NO983945L true NO983945L (no) | 1998-10-06 |
Family
ID=20401594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO983945A NO983945L (no) | 1996-02-28 | 1998-08-27 | Isokinoliner som er nyttige som analgetika |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6034097A (cs) |
| EP (1) | EP0914332B1 (cs) |
| JP (1) | JP2000506138A (cs) |
| KR (1) | KR19990087322A (cs) |
| CN (1) | CN1211990A (cs) |
| AT (1) | ATE217322T1 (cs) |
| AU (1) | AU722032B2 (cs) |
| BR (1) | BR9707767A (cs) |
| CA (1) | CA2244219A1 (cs) |
| CZ (1) | CZ272098A3 (cs) |
| DE (1) | DE69712490D1 (cs) |
| EE (1) | EE9800266A (cs) |
| IL (1) | IL125925A0 (cs) |
| IS (1) | IS4834A (cs) |
| NO (1) | NO983945L (cs) |
| NZ (1) | NZ331119A (cs) |
| PL (1) | PL328734A1 (cs) |
| SE (1) | SE9600769D0 (cs) |
| SK (1) | SK113498A3 (cs) |
| WO (1) | WO1997031940A1 (cs) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9604789D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Ab | New Compounds |
| RU2221786C2 (ru) * | 1999-02-04 | 2004-01-20 | СК Корпорейшн | Производные тетрагидроизохинолиналканола, способы лечения и фармацевтические композиции на их основе |
| DE69916663T2 (de) * | 1999-02-04 | 2005-03-31 | Sk Corp. | Tetrahydroisochinolinalkanol-derivate und diese enthaltende pharmazeutische zubereitungen |
| IL144583A0 (en) * | 2001-07-26 | 2002-05-23 | Peptor Ltd | Chimeric protein kinase inhibitors |
| EP1499306A4 (en) | 2002-04-12 | 2007-03-28 | Merck & Co Inc | BICYCLIC AMIDE |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| IL156429A0 (en) * | 2003-06-12 | 2004-01-04 | Peptor Ltd | Cell permeable conjugates of peptides for inhibition of protein kinases |
| CN100503571C (zh) | 2006-07-12 | 2009-06-24 | 中国药科大学 | 四氢异喹啉类衍生物、其制备方法及其医药用途 |
| WO2008016913A1 (en) * | 2006-07-31 | 2008-02-07 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Biologically potent analogues of the dmt-tic pharmacophore and methods of use |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| CA2676066C (en) | 2007-01-22 | 2016-06-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| CA2789606A1 (en) | 2010-02-25 | 2011-09-01 | Pfizer Limited | Peptide analogues as opioid receptor agonists |
| WO2014100695A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| HRP20182037T1 (hr) | 2012-12-21 | 2019-02-08 | Epizyme, Inc. | Inhibitori prmt5 i njihova uporaba |
| EP2935247B1 (en) | 2012-12-21 | 2019-08-28 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3406607A1 (en) | 2012-12-21 | 2018-11-28 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| CN103450079B (zh) * | 2013-08-14 | 2015-07-29 | 中国药科大学 | 四氢异喹啉羟基衍生物、其制备方法及其医药用途 |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2018129393A1 (en) * | 2017-01-06 | 2018-07-12 | The Regents Of The University Of California | Mu opioid receptor modulators |
| AU2019247842B2 (en) | 2018-04-04 | 2023-08-31 | Epiodyne, Inc. | Opioid receptor modulators and products and methods related thereto |
| TW202304869A (zh) | 2021-04-05 | 2023-02-01 | 美商艾碧奧戴股份有限公司 | 類鴉片受體調節劑 |
| CN115260096B (zh) * | 2022-08-19 | 2024-04-09 | 武汉大学 | 一种基于一氧化碳气体或一氧化碳替代源合成二氢异喹啉酮类化合物的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599325A (en) * | 1984-02-16 | 1986-07-08 | G. D. Searle & Co. | Substituted tyrosyl alanine dipeptide amides |
| US5648333A (en) * | 1988-11-24 | 1997-07-15 | Hoechst Aktiengesellschaft | Peptides having bradykinin antagonist action |
| SE9300012D0 (sv) * | 1993-01-05 | 1993-01-05 | Astra Ab | New peptides |
| CA2090171A1 (en) * | 1993-02-23 | 1994-08-24 | Peter W. Schiller | Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds |
| CA2118985A1 (en) * | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Heterocyclic inhibitors of farnesyl protein transferase |
| SE9402880D0 (sv) * | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
-
1996
- 1996-02-28 SE SE9600769A patent/SE9600769D0/xx unknown
-
1997
- 1997-02-25 EP EP97906381A patent/EP0914332B1/en not_active Expired - Lifetime
- 1997-02-25 WO PCT/SE1997/000315 patent/WO1997031940A1/en not_active Ceased
- 1997-02-25 JP JP9530865A patent/JP2000506138A/ja active Pending
- 1997-02-25 US US08/930,867 patent/US6034097A/en not_active Expired - Fee Related
- 1997-02-25 NZ NZ331119A patent/NZ331119A/xx unknown
- 1997-02-25 KR KR1019980706731A patent/KR19990087322A/ko not_active Withdrawn
- 1997-02-25 CN CN97192558A patent/CN1211990A/zh active Pending
- 1997-02-25 CA CA002244219A patent/CA2244219A1/en not_active Abandoned
- 1997-02-25 SK SK1134-98A patent/SK113498A3/sk unknown
- 1997-02-25 AU AU21090/97A patent/AU722032B2/en not_active Ceased
- 1997-02-25 IL IL12592597A patent/IL125925A0/xx unknown
- 1997-02-25 PL PL97328734A patent/PL328734A1/xx unknown
- 1997-02-25 EE EE9800266A patent/EE9800266A/xx unknown
- 1997-02-25 BR BR9707767A patent/BR9707767A/pt active Search and Examination
- 1997-02-25 DE DE69712490T patent/DE69712490D1/de not_active Expired - Lifetime
- 1997-02-25 CZ CZ982720A patent/CZ272098A3/cs unknown
- 1997-02-25 AT AT97906381T patent/ATE217322T1/de not_active IP Right Cessation
-
1998
- 1998-08-26 IS IS4834A patent/IS4834A/is unknown
- 1998-08-27 NO NO983945A patent/NO983945L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE217322T1 (de) | 2002-05-15 |
| EP0914332B1 (en) | 2002-05-08 |
| BR9707767A (pt) | 1999-07-27 |
| IL125925A0 (en) | 1999-04-11 |
| AU722032B2 (en) | 2000-07-20 |
| EE9800266A (et) | 1999-02-15 |
| NZ331119A (en) | 2000-05-26 |
| NO983945D0 (no) | 1998-08-27 |
| SE9600769D0 (sv) | 1996-02-28 |
| CN1211990A (zh) | 1999-03-24 |
| WO1997031940A1 (en) | 1997-09-04 |
| CZ272098A3 (cs) | 1999-03-17 |
| DE69712490D1 (de) | 2002-06-13 |
| EP0914332A1 (en) | 1999-05-12 |
| KR19990087322A (ko) | 1999-12-27 |
| CA2244219A1 (en) | 1997-09-04 |
| JP2000506138A (ja) | 2000-05-23 |
| SK113498A3 (en) | 1999-02-11 |
| PL328734A1 (en) | 1999-02-15 |
| US6034097A (en) | 2000-03-07 |
| IS4834A (is) | 1998-08-26 |
| AU2109097A (en) | 1997-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |