IL125925A0 - Isoquinolines useful as analgesics - Google Patents
Isoquinolines useful as analgesicsInfo
- Publication number
- IL125925A0 IL125925A0 IL12592597A IL12592597A IL125925A0 IL 125925 A0 IL125925 A0 IL 125925A0 IL 12592597 A IL12592597 A IL 12592597A IL 12592597 A IL12592597 A IL 12592597A IL 125925 A0 IL125925 A0 IL 125925A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- hydrogen
- aralkyl
- aryl
- pct
- Prior art date
Links
- 229940035676 analgesics Drugs 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 150000002537 isoquinolines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600769A SE9600769D0 (sv) | 1996-02-28 | 1996-02-28 | Compounds useful as analgesic |
| PCT/SE1997/000315 WO1997031940A1 (en) | 1996-02-28 | 1997-02-25 | Isoquinolines useful as analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL125925A0 true IL125925A0 (en) | 1999-04-11 |
Family
ID=20401594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12592597A IL125925A0 (en) | 1996-02-28 | 1997-02-25 | Isoquinolines useful as analgesics |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6034097A (cs) |
| EP (1) | EP0914332B1 (cs) |
| JP (1) | JP2000506138A (cs) |
| KR (1) | KR19990087322A (cs) |
| CN (1) | CN1211990A (cs) |
| AT (1) | ATE217322T1 (cs) |
| AU (1) | AU722032B2 (cs) |
| BR (1) | BR9707767A (cs) |
| CA (1) | CA2244219A1 (cs) |
| CZ (1) | CZ272098A3 (cs) |
| DE (1) | DE69712490D1 (cs) |
| EE (1) | EE9800266A (cs) |
| IL (1) | IL125925A0 (cs) |
| IS (1) | IS4834A (cs) |
| NO (1) | NO983945L (cs) |
| NZ (1) | NZ331119A (cs) |
| PL (1) | PL328734A1 (cs) |
| SE (1) | SE9600769D0 (cs) |
| SK (1) | SK113498A3 (cs) |
| WO (1) | WO1997031940A1 (cs) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9604789D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Ab | New Compounds |
| CA2361805A1 (en) * | 1999-02-04 | 2000-08-10 | Sk Corporation | Tetrahydro isoquino linealkanol derivatives and pharmaceutical compositions containing same |
| RU2221786C2 (ru) * | 1999-02-04 | 2004-01-20 | СК Корпорейшн | Производные тетрагидроизохинолиналканола, способы лечения и фармацевтические композиции на их основе |
| IL144583A0 (en) * | 2001-07-26 | 2002-05-23 | Peptor Ltd | Chimeric protein kinase inhibitors |
| AU2003223510B2 (en) | 2002-04-12 | 2008-05-08 | Merck Sharp & Dohme Corp. | Bicyclic amides |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| IL156429A0 (en) * | 2003-06-12 | 2004-01-04 | Peptor Ltd | Cell permeable conjugates of peptides for inhibition of protein kinases |
| CN100503571C (zh) * | 2006-07-12 | 2009-06-24 | 中国药科大学 | 四氢异喹啉类衍生物、其制备方法及其医药用途 |
| WO2008016913A1 (en) * | 2006-07-31 | 2008-02-07 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Biologically potent analogues of the dmt-tic pharmacophore and methods of use |
| EP2106212B1 (en) | 2007-01-22 | 2014-04-02 | GTX, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| EP2539358A1 (en) | 2010-02-25 | 2013-01-02 | Pfizer Limited | Peptide analogues |
| EP3406607A1 (en) | 2012-12-21 | 2018-11-28 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| RS58040B1 (sr) | 2012-12-21 | 2019-02-28 | Epizyme Inc | Prmt5 inhibitori i njihove upotrebe |
| CN103450079B (zh) * | 2013-08-14 | 2015-07-29 | 中国药科大学 | 四氢异喹啉羟基衍生物、其制备方法及其医药用途 |
| CA2953572A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US20200109126A1 (en) * | 2017-01-06 | 2020-04-09 | The Regents Of The University Of California | Mu opioid receptor modulators |
| WO2019195634A1 (en) | 2018-04-04 | 2019-10-10 | Epiodyne, Inc. | Opioid receptor modulators and products and methods related thereto |
| TW202304869A (zh) | 2021-04-05 | 2023-02-01 | 美商艾碧奧戴股份有限公司 | 類鴉片受體調節劑 |
| CN115260096B (zh) * | 2022-08-19 | 2024-04-09 | 武汉大学 | 一种基于一氧化碳气体或一氧化碳替代源合成二氢异喹啉酮类化合物的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599325A (en) * | 1984-02-16 | 1986-07-08 | G. D. Searle & Co. | Substituted tyrosyl alanine dipeptide amides |
| US5648333A (en) * | 1988-11-24 | 1997-07-15 | Hoechst Aktiengesellschaft | Peptides having bradykinin antagonist action |
| SE9300012D0 (sv) * | 1993-01-05 | 1993-01-05 | Astra Ab | New peptides |
| CA2090171A1 (en) * | 1993-02-23 | 1994-08-24 | Peter W. Schiller | Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds |
| CA2118985A1 (en) * | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Heterocyclic inhibitors of farnesyl protein transferase |
| SE9402880D0 (sv) * | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
-
1996
- 1996-02-28 SE SE9600769A patent/SE9600769D0/xx unknown
-
1997
- 1997-02-25 CZ CZ982720A patent/CZ272098A3/cs unknown
- 1997-02-25 EP EP97906381A patent/EP0914332B1/en not_active Expired - Lifetime
- 1997-02-25 CA CA002244219A patent/CA2244219A1/en not_active Abandoned
- 1997-02-25 KR KR1019980706731A patent/KR19990087322A/ko not_active Withdrawn
- 1997-02-25 EE EE9800266A patent/EE9800266A/xx unknown
- 1997-02-25 AT AT97906381T patent/ATE217322T1/de not_active IP Right Cessation
- 1997-02-25 NZ NZ331119A patent/NZ331119A/xx unknown
- 1997-02-25 WO PCT/SE1997/000315 patent/WO1997031940A1/en not_active Application Discontinuation
- 1997-02-25 CN CN97192558A patent/CN1211990A/zh active Pending
- 1997-02-25 DE DE69712490T patent/DE69712490D1/de not_active Expired - Lifetime
- 1997-02-25 PL PL97328734A patent/PL328734A1/xx unknown
- 1997-02-25 SK SK1134-98A patent/SK113498A3/sk unknown
- 1997-02-25 BR BR9707767A patent/BR9707767A/pt active Search and Examination
- 1997-02-25 US US08/930,867 patent/US6034097A/en not_active Expired - Fee Related
- 1997-02-25 IL IL12592597A patent/IL125925A0/xx unknown
- 1997-02-25 JP JP9530865A patent/JP2000506138A/ja active Pending
- 1997-02-25 AU AU21090/97A patent/AU722032B2/en not_active Ceased
-
1998
- 1998-08-26 IS IS4834A patent/IS4834A/is unknown
- 1998-08-27 NO NO983945A patent/NO983945L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2244219A1 (en) | 1997-09-04 |
| IS4834A (is) | 1998-08-26 |
| KR19990087322A (ko) | 1999-12-27 |
| EP0914332A1 (en) | 1999-05-12 |
| SE9600769D0 (sv) | 1996-02-28 |
| CN1211990A (zh) | 1999-03-24 |
| NO983945L (no) | 1998-10-06 |
| EE9800266A (et) | 1999-02-15 |
| NZ331119A (en) | 2000-05-26 |
| EP0914332B1 (en) | 2002-05-08 |
| CZ272098A3 (cs) | 1999-03-17 |
| AU2109097A (en) | 1997-09-16 |
| PL328734A1 (en) | 1999-02-15 |
| WO1997031940A1 (en) | 1997-09-04 |
| AU722032B2 (en) | 2000-07-20 |
| SK113498A3 (en) | 1999-02-11 |
| DE69712490D1 (de) | 2002-06-13 |
| ATE217322T1 (de) | 2002-05-15 |
| BR9707767A (pt) | 1999-07-27 |
| JP2000506138A (ja) | 2000-05-23 |
| US6034097A (en) | 2000-03-07 |
| NO983945D0 (no) | 1998-08-27 |
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