MX9703724A - Antagonistas de bradiquinina heterociclicos con contenido en azufre, procedimiento para su preparacion y su empleo. - Google Patents
Antagonistas de bradiquinina heterociclicos con contenido en azufre, procedimiento para su preparacion y su empleo.Info
- Publication number
- MX9703724A MX9703724A MX9703724A MX9703724A MX9703724A MX 9703724 A MX9703724 A MX 9703724A MX 9703724 A MX9703724 A MX 9703724A MX 9703724 A MX9703724 A MX 9703724A MX 9703724 A MX9703724 A MX 9703724A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- aryl
- preparation
- equal
- different
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen compuestos de la formula I: en donde uno de los radicales X1, X2 o X3, representan C-O-R2 los respectivos otros X1, X2, X3 y X4 son entonces, iguales o diferentes, N o CR1; R1 y R3, iguales o diferentes, son H, halogeno, alquilo (C1-C6), O-R6, S-R6, NHR6, arilo (C6-C12), aril (C6-C12)-alquilo (C2-C3), C(O)-OR6, C(O)-H, alquenilo (C2-C5), NO2, SO3R7, CN o C(O)-NHR8, pudiendo estar alquilo, arilo y el alquenilo eventualmente sustituidos; R2 es un compuesto de la formula (II) R4 y R5, iguales o diferentes, son H, halogeno, OR6, SR6, CN o alquilo (C1-C5); R6, R7 y R8, iguales o diferentes, son H, alquilo (C1-C5), alquenilo (C3-C5), aril (C6-C12)-alquilo (C1-C3), cicloalquilo (C3-C10), cicloalquil (C3-C10)-alquilo (C1-C3), C(O)-(O)0-1-alquilo (C1-C5) o C(O)- (NH) 0-1-alquilo (C1-C5) o C(O)-(O)0-1-alquil (C1-C3)-arilo (C6-C10); R10 es -C(O)-D-E, -C(S)-D-E, -SO2-D-E o hidrogeno; D es alquendiilo (C2-C5), alcandiilo (C1-C8), -(CH2)n-Yo-(CH2)m-, cicloalcandiilo (C3-C10), cicloalquil (C3-C10)-alcandiilo (C1-C3), cicloalquendiilo (C3-C10) o cicloalquenil (C3-C10)-alcandiilo (c1-C3), que eventualmente pueden estar sustituidos; E es H, arilo (C6-C10) o heteroarilo (C1-C9), que eventualmente pueden estar sustituidos; Y es O, S o NR8; así como sus sales fisiologicamente compatibles, un procedimiento para su preparacion y su empleo como agentes curativos y terapéuticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19620508.5 | 1996-05-22 | ||
| DE19620508A DE19620508A1 (de) | 1996-05-22 | 1996-05-22 | Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9703724A true MX9703724A (es) | 1998-06-28 |
| MXPA97003724A MXPA97003724A (es) | 1998-10-30 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| HU9700914D0 (en) | 1997-07-28 |
| CZ154797A3 (en) | 1997-12-17 |
| JP4125803B2 (ja) | 2008-07-30 |
| DE19620508A1 (de) | 1997-11-27 |
| DE59710874D1 (de) | 2003-11-27 |
| AU2351097A (en) | 1997-11-27 |
| JPH1067762A (ja) | 1998-03-10 |
| EP0808838B1 (de) | 2003-10-22 |
| BR9703370A (pt) | 1998-09-22 |
| NO972312L (no) | 1997-11-24 |
| TR199700391A2 (xx) | 1997-12-21 |
| ES2205086T3 (es) | 2004-05-01 |
| HUP9700914A3 (en) | 1999-05-28 |
| ID16952A (id) | 1997-11-27 |
| HRP970279A2 (en) | 1998-04-30 |
| SK63197A3 (en) | 1997-12-10 |
| HUP9700914A2 (hu) | 1998-11-30 |
| CN1169992A (zh) | 1998-01-14 |
| EP0808838A1 (de) | 1997-11-26 |
| ZA974416B (en) | 1997-11-24 |
| IL120863A0 (en) | 1997-09-30 |
| KR970074781A (ko) | 1997-12-10 |
| US5834500A (en) | 1998-11-10 |
| NO972312D0 (no) | 1997-05-21 |
| PL320105A1 (en) | 1997-11-24 |
| CA2205785A1 (en) | 1997-11-22 |
| ATE252567T1 (de) | 2003-11-15 |
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