NO976065L - Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A - Google Patents
Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis AInfo
- Publication number
- NO976065L NO976065L NO976065A NO976065A NO976065L NO 976065 L NO976065 L NO 976065L NO 976065 A NO976065 A NO 976065A NO 976065 A NO976065 A NO 976065A NO 976065 L NO976065 L NO 976065L
- Authority
- NO
- Norway
- Prior art keywords
- sialyl
- lewis
- mimetics
- diglucosylated
- diols
- Prior art date
Links
- XBSNXOHQOTUENA-KRAHZTDDSA-N alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)C(O)O[C@@H]1CO XBSNXOHQOTUENA-KRAHZTDDSA-N 0.000 title abstract 2
- NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 title abstract 2
- 150000000180 1,2-diols Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101000986989 Naja kaouthia Acidic phospholipase A2 CM-II Proteins 0.000 abstract 1
- -1 aliphatic 1,2-diol Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH191495 | 1995-06-29 | ||
| PCT/EP1996/002785 WO1997001569A1 (en) | 1995-06-29 | 1996-06-26 | Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO976065D0 NO976065D0 (no) | 1997-12-23 |
| NO976065L true NO976065L (no) | 1998-02-17 |
Family
ID=4221546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO976065A NO976065L (no) | 1995-06-29 | 1997-12-23 | Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0836610A1 (cs) |
| JP (1) | JPH11508548A (cs) |
| KR (1) | KR19990028543A (cs) |
| CN (1) | CN1196731A (cs) |
| AU (1) | AU707474B2 (cs) |
| BR (1) | BR9609285A (cs) |
| CA (1) | CA2224346A1 (cs) |
| CZ (1) | CZ419797A3 (cs) |
| EA (1) | EA001356B1 (cs) |
| HU (1) | HUP9801805A3 (cs) |
| IL (1) | IL118740A0 (cs) |
| MX (1) | MX9800218A (cs) |
| NO (1) | NO976065L (cs) |
| NZ (1) | NZ311686A (cs) |
| PL (1) | PL324258A1 (cs) |
| SI (1) | SI9620099A (cs) |
| SK (1) | SK177897A3 (cs) |
| TR (1) | TR199701728T1 (cs) |
| WO (1) | WO1997001569A1 (cs) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564713B2 (ja) | 2000-11-01 | 2010-10-20 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法 |
| CA2486106C (en) | 2002-05-16 | 2013-07-16 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| DE602004011272T2 (de) | 2003-11-19 | 2008-12-24 | Glycomimetics, Inc. | Spezifischer antagonist sowohl für e- als auch p-selektine |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| ES2375979T3 (es) | 2005-08-09 | 2012-03-07 | Glycomimetics, Inc. | Inhibidores glicomiméticos de la lectina pa-il, lectina pa-iil o ambas lectinas de pseudomonas. |
| DK1934236T3 (da) * | 2005-09-02 | 2013-02-25 | Glycomimetics Inc | Heterobifunktionelle pan-selektininhibitorer |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP2074132B1 (en) * | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| JP5511390B2 (ja) * | 2007-02-09 | 2014-06-04 | グリコミメティクス， インコーポレイテッド | ヘキソースおよびｎ−アセチルヘキソサミンの置換体を有する糖模倣体の使用方法 |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| BR112014014547B1 (pt) | 2011-12-22 | 2022-09-27 | Glycomimetics, Inc | Composto, composição e métodos de uso |
| WO2014089269A1 (en) | 2012-12-07 | 2014-06-12 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
| PL3227310T3 (pl) | 2014-12-03 | 2020-02-28 | Glycomimetics, Inc. | Heterodwufunkcyjne inhibitory selektyn E i receptorów chemokinowych CXCR4” |
| WO2017127422A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| KR20240046288A (ko) | 2016-10-07 | 2024-04-08 | 글리코미메틱스, 인크. | 매우 강력한 다량체성 e-셀렉틴 길항물질 |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| US11548908B2 (en) | 2017-12-29 | 2023-01-10 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CA3091454A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
| WO1993023031A1 (en) * | 1992-05-08 | 1993-11-25 | The Biomembrane Institute | Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response |
| CA2100412A1 (en) * | 1992-07-15 | 1994-01-16 | Yutaka Yamada | Glycolipid derivatives |
-
1996
- 1996-06-26 JP JP9504171A patent/JPH11508548A/ja active Pending
- 1996-06-26 CN CN96196452A patent/CN1196731A/zh active Pending
- 1996-06-26 NZ NZ311686A patent/NZ311686A/xx unknown
- 1996-06-26 TR TR97/01728T patent/TR199701728T1/xx unknown
- 1996-06-26 BR BR9609285A patent/BR9609285A/pt not_active Application Discontinuation
- 1996-06-26 AU AU63053/96A patent/AU707474B2/en not_active Ceased
- 1996-06-26 IL IL11874096A patent/IL118740A0/xx unknown
- 1996-06-26 WO PCT/EP1996/002785 patent/WO1997001569A1/en not_active Application Discontinuation
- 1996-06-26 EP EP96922034A patent/EP0836610A1/en not_active Ceased
- 1996-06-26 HU HU9801805A patent/HUP9801805A3/hu unknown
- 1996-06-26 CZ CZ974197A patent/CZ419797A3/cs unknown
- 1996-06-26 KR KR1019970709861A patent/KR19990028543A/ko not_active Withdrawn
- 1996-06-26 EA EA199800103A patent/EA001356B1/ru not_active IP Right Cessation
- 1996-06-26 PL PL96324258A patent/PL324258A1/xx unknown
- 1996-06-26 CA CA002224346A patent/CA2224346A1/en not_active Abandoned
- 1996-06-26 SI SI9620099A patent/SI9620099A/sl unknown
- 1996-06-26 SK SK1778-97A patent/SK177897A3/sk unknown
-
1997
- 1997-12-23 NO NO976065A patent/NO976065L/no not_active Application Discontinuation
-
1998
- 1998-01-07 MX MX9800218A patent/MX9800218A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11508548A (ja) | 1999-07-27 |
| WO1997001569A1 (en) | 1997-01-16 |
| NO976065D0 (no) | 1997-12-23 |
| MX9800218A (es) | 1998-07-31 |
| CA2224346A1 (en) | 1997-01-16 |
| EP0836610A1 (en) | 1998-04-22 |
| IL118740A0 (en) | 1996-10-16 |
| CN1196731A (zh) | 1998-10-21 |
| AU6305396A (en) | 1997-01-30 |
| TR199701728T1 (xx) | 1998-03-21 |
| AU707474B2 (en) | 1999-07-08 |
| EA001356B1 (ru) | 2001-02-26 |
| SK177897A3 (en) | 1998-08-05 |
| NZ311686A (en) | 2000-01-28 |
| KR19990028543A (ko) | 1999-04-15 |
| SI9620099A (sl) | 1998-08-31 |
| BR9609285A (pt) | 1999-05-11 |
| CZ419797A3 (cs) | 1998-06-17 |
| HUP9801805A3 (en) | 2002-01-28 |
| EA199800103A1 (ru) | 1998-08-27 |
| PL324258A1 (en) | 1998-05-11 |
| HUP9801805A2 (hu) | 1998-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |