NO976065L - Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A - Google Patents

Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A

Info

Publication number
NO976065L
NO976065L NO976065A NO976065A NO976065L NO 976065 L NO976065 L NO 976065L NO 976065 A NO976065 A NO 976065A NO 976065 A NO976065 A NO 976065A NO 976065 L NO976065 L NO 976065L
Authority
NO
Norway
Prior art keywords
sialyl
lewis
mimetics
diglucosylated
diols
Prior art date
Application number
NO976065A
Other languages
English (en)
Norwegian (no)
Other versions
NO976065D0 (no
Inventor
Hartmuth Christian Kolb
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO976065D0 publication Critical patent/NO976065D0/no
Publication of NO976065L publication Critical patent/NO976065L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Hydrogenated Pyridines (AREA)
NO976065A 1995-06-29 1997-12-23 Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A NO976065L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH191495 1995-06-29
PCT/EP1996/002785 WO1997001569A1 (en) 1995-06-29 1996-06-26 Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a

Publications (2)

Publication Number Publication Date
NO976065D0 NO976065D0 (no) 1997-12-23
NO976065L true NO976065L (no) 1998-02-17

Family

ID=4221546

Family Applications (1)

Application Number Title Priority Date Filing Date
NO976065A NO976065L (no) 1995-06-29 1997-12-23 Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A

Country Status (19)

Country Link
EP (1) EP0836610A1 (cs)
JP (1) JPH11508548A (cs)
KR (1) KR19990028543A (cs)
CN (1) CN1196731A (cs)
AU (1) AU707474B2 (cs)
BR (1) BR9609285A (cs)
CA (1) CA2224346A1 (cs)
CZ (1) CZ419797A3 (cs)
EA (1) EA001356B1 (cs)
HU (1) HUP9801805A3 (cs)
IL (1) IL118740A0 (cs)
MX (1) MX9800218A (cs)
NO (1) NO976065L (cs)
NZ (1) NZ311686A (cs)
PL (1) PL324258A1 (cs)
SI (1) SI9620099A (cs)
SK (1) SK177897A3 (cs)
TR (1) TR199701728T1 (cs)
WO (1) WO1997001569A1 (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036587A2 (en) 2000-11-01 2002-05-10 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
EP1577289A1 (en) * 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
JP5209476B2 (ja) * 2005-09-02 2013-06-12 グリコミメティクス， インコーポレイテッド ヘテロ二官能性全セレクチン阻害剤
EP1764096A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764095A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP2074132B1 (en) * 2006-10-12 2013-05-15 GlycoMimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
CA2677747A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
AU2012358150B2 (en) 2011-12-22 2017-07-20 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
CA2891514C (en) 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
CA2968391C (en) 2014-12-03 2022-04-26 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
JP7069136B2 (ja) 2016-10-07 2022-05-17 グリコミメティクス， インコーポレイテッド 極めて強力な多量体ｅ－セレクチンアンタゴニスト
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
CN111867601A (zh) 2018-03-05 2020-10-30 糖模拟物有限公司 用于治疗急性髓系白血病及相关病症的方法
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326752A (en) * 1991-11-27 1994-07-05 Glycomed Incorporated Substituted lactose and lactosamine derivatives as cell adhesion inhibitors
WO1993023031A1 (en) * 1992-05-08 1993-11-25 The Biomembrane Institute Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
CA2100412A1 (en) * 1992-07-15 1994-01-16 Yutaka Yamada Glycolipid derivatives

Also Published As

Publication number Publication date
SK177897A3 (en) 1998-08-05
CN1196731A (zh) 1998-10-21
AU707474B2 (en) 1999-07-08
MX9800218A (es) 1998-07-31
IL118740A0 (en) 1996-10-16
EA199800103A1 (ru) 1998-08-27
CA2224346A1 (en) 1997-01-16
EA001356B1 (ru) 2001-02-26
SI9620099A (sl) 1998-08-31
AU6305396A (en) 1997-01-30
HUP9801805A3 (en) 2002-01-28
BR9609285A (pt) 1999-05-11
NO976065D0 (no) 1997-12-23
CZ419797A3 (cs) 1998-06-17
TR199701728T1 (xx) 1998-03-21
EP0836610A1 (en) 1998-04-22
JPH11508548A (ja) 1999-07-27
HUP9801805A2 (hu) 1998-12-28
KR19990028543A (ko) 1999-04-15
PL324258A1 (en) 1998-05-11
WO1997001569A1 (en) 1997-01-16
NZ311686A (en) 2000-01-28

Similar Documents

Publication Publication Date Title
NO976065L (no) Diglucosylerte 1,2-dioler som mimetika av sialyl-Lewis X og sialyl-Lewis A
FI934426A (fi) Tiazolidindionderivat, framstaellning och anvaendning daerav
NO970495L (no) Aryltioforbindelser som anti-bakterielle og antivirale midler
GB2145080B (en) Trihalo-trideoxy galactosucrose compounds
AU4251485A (en) Benzoxazole and benzthiazole derivatives
EP0640586A4 (en) STILBENE DERIVATIVE AND STILBENE ANALOG DERIVATIVE, AND USE OF SUCH DERIVATIVES.
DK537389A (da) Glycosidase-inhibitoren salbostatin, dens fremstilling og anvendelse
AU541413B2 (en) 2-(1,4-benzodioxan-2-ylalicyl)imidazoles
FI933065A (fi) Foerfarande foer framstaellning av azabicyklo (2.2.2)oktan-3-iminer och foerfarandet anvaenda mellanprodukter
JPS56161393A (en) Beta-lactam compound
AU534187B2 (en) Fungicidal :isoxazolyl carboxanilides:
AU547858B2 (en) Azole fungicides
MY111439A (en) Thymosin alpha 1 derivatives
EP0516860A4 (en) Chromone derivative and aldose reductase inhibitor containing the same as active ingredient
FI890798A0 (fi) Foerfarande foer diacylering av foereningar som innehaoller tvao aromatiska kaernor.
EP0236916A3 (en) N-aryltetrahydrophthalimide derivatives and their precursors
CA2111096A1 (en) Thiazolidinedione Hypoglycemic Agents
NO964735L (no) Adenosin-derivater
ES8506011A1 (es) Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol
IL67360A0 (en) Alpha-azolylglycols and their use as fungicides
ATE244060T1 (de) Hydroxyester enthaltende kationische zusammensetzungen
DK0413223T3 (da) N-heterocyclomethyl-spiroheterocycler og fungicider indeholdende disse
ES2073951T3 (es) Derivados de 2-amino-n-(((4-(aminocarbonil)pirimidin-2-il)amino)alquil)pirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica.
DE69214280D1 (de) Thiocarbamat-sulfo-oxid enthaltende zubereitung zur abschreckung gegen ethanoleinnahme
JPS55164671A (en) Azetidine derivative and its preparation

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application