NO975484D0 - 2-(1H-4(5)-imidazoyl)sykloprylderivater - Google Patents

2-(1H-4(5)-imidazoyl)sykloprylderivater

Info

Publication number
NO975484D0
NO975484D0 NO975484A NO975484A NO975484D0 NO 975484 D0 NO975484 D0 NO 975484D0 NO 975484 A NO975484 A NO 975484A NO 975484 A NO975484 A NO 975484A NO 975484 D0 NO975484 D0 NO 975484D0
Authority
NO
Norway
Prior art keywords
methyl
hydrogen
ethyl group
alkyl
group
Prior art date
Application number
NO975484A
Other languages
English (en)
Norwegian (no)
Inventor
James G Phillips
Clark E Tedford
Amin Mohammed Khan
Stephen L Yates
Original Assignee
Gliatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gliatech Inc filed Critical Gliatech Inc
Publication of NO975484D0 publication Critical patent/NO975484D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Paints Or Removers (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO975484A 1995-05-30 1997-11-28 2-(1H-4(5)-imidazoyl)sykloprylderivater NO975484D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/453,359 US5652258A (en) 1995-05-30 1995-05-30 2-(4-imidazoyl) cyclopropyl derivatives
PCT/US1996/007833 WO1996038141A1 (en) 1995-05-30 1996-05-29 2-(1h-4(5)-imidazoyl) cyclopropyl derivatives

Publications (1)

Publication Number Publication Date
NO975484D0 true NO975484D0 (no) 1997-11-28

Family

ID=23800267

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975484A NO975484D0 (no) 1995-05-30 1997-11-28 2-(1H-4(5)-imidazoyl)sykloprylderivater

Country Status (17)

Country Link
US (2) US5652258A (fi)
EP (1) EP0837679B1 (fi)
JP (1) JP2001503013A (fi)
KR (1) KR19990022137A (fi)
CN (1) CN1100534C (fi)
AT (1) ATE207354T1 (fi)
AU (1) AU713767B2 (fi)
CA (1) CA2222101A1 (fi)
DE (1) DE69616328T2 (fi)
DK (1) DK0837679T3 (fi)
ES (1) ES2163019T3 (fi)
FI (1) FI974363A0 (fi)
MX (1) MX9709211A (fi)
NO (1) NO975484D0 (fi)
NZ (1) NZ308410A (fi)
PT (1) PT837679E (fi)
WO (1) WO1996038141A1 (fi)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652258A (en) * 1995-05-30 1997-07-29 Gliatech, Inc. 2-(4-imidazoyl) cyclopropyl derivatives
US6008240A (en) * 1997-12-15 1999-12-28 Gliatech, Inc. 2-(1H-4(5)-imidazoyl) cyclopropyl derivatives
WO2000042023A1 (en) 1999-01-18 2000-07-20 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6114350A (en) * 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
US6610721B2 (en) 2000-03-17 2003-08-26 Novo Nordisk A/S Imidazo heterocyclic compounds
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
AU2001285442A1 (en) * 2000-08-17 2002-02-25 Gliatech, Inc. Novel alicyclic imidazoles as H3 agents
WO2002015905A1 (en) * 2000-08-21 2002-02-28 Gliatech, Inc. The use of histamine h3 receptor inverse agonists for the control of appetite and treatment of obesity
WO2002067938A2 (en) * 2000-10-30 2002-09-06 Schering Corporation Treating or reducing the risk of cardiovascular disease
MXPA04005557A (es) * 2002-03-01 2005-05-17 Warner Lambert Co Metodo para tratar la osteoartritis.
BRPI0507374A (pt) * 2004-02-02 2007-07-10 Pfizer Prod Inc moduladores do receptor de histamina-3
US7902191B2 (en) 2004-02-25 2011-03-08 Eli Lilly And Company Histamine H3 receptor antagonists, preparation and therapeutic uses
PL1735278T3 (pl) 2004-04-01 2010-06-30 Lilly Co Eli Związki receptora histaminowego H3, wytwarzanie i zastosowania terapeutyczne
BRPI0511642A (pt) 2004-06-02 2008-01-02 Lilly Co Eli composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para inibir o receptor h3 da histamina em um mamìfero, para tratamento ou prevenção de um distúrbio do sistema nervoso ou outro distúrbio associado com o receptor h3 da histamina, para tratamento ou prevenção da obesidade, para tratamento ou prevenção de um distúrbio ou doença, e, uso de um composto ou um sal do mesmo
JP4942654B2 (ja) 2004-08-23 2012-05-30 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体薬剤、製剤及び治療的使用
DE602005011988D1 (de) 2004-10-18 2009-02-05 Lilly Co Eli Histamin-h3-rezeptor inhibitoren, ihre herstellung und therapeutische anwendungen
JP5052497B2 (ja) * 2005-03-17 2012-10-17 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体アンタゴニストとしてのピロリジン誘導体
EP1707203A1 (en) 2005-04-01 2006-10-04 Bioprojet Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
CN101151244B (zh) 2005-04-01 2014-09-03 伊莱利利公司 组胺h3受体活性剂、制备和治疗用途
EP1717235A3 (en) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
EP1717233A1 (en) * 2005-04-29 2006-11-02 Bioprojet Histamine H3-receptor ligands and their therapeutic application
JPWO2007032536A1 (ja) * 2005-09-15 2009-03-19 萬有製薬株式会社 脂質・糖代謝性疾患の治療剤としてのヒスタミンｈ３アゴニスト
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
CA2812683C (en) 2009-09-25 2017-10-10 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
WO2011042217A1 (en) 2009-10-09 2011-04-14 Oryzon Genomics S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
WO2011106574A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
CN102947265B (zh) 2010-04-19 2015-07-29 奥瑞泽恩基因组学股份有限公司 赖氨酸特异性脱甲基酶-1抑制剂及其应用
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
WO2012013728A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
EP3981395A1 (en) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
RS58475B1 (sr) 2011-10-20 2019-04-30 Oryzon Genomics Sa Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori
EP3736265A1 (en) 2011-10-20 2020-11-11 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
FR2671083B1 (fr) * 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
DE69222757T2 (de) * 1991-02-27 1998-02-12 Seed Capital Investments Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
US5217986A (en) * 1992-03-26 1993-06-08 Harbor Branch Oceanographic Institution, Inc. Anti-allergy agent
US5652258A (en) * 1995-05-30 1997-07-29 Gliatech, Inc. 2-(4-imidazoyl) cyclopropyl derivatives

Also Published As

Publication number Publication date
FI974363A (fi) 1997-11-28
AU5804796A (en) 1996-12-18
ES2163019T3 (es) 2002-01-16
US5990317A (en) 1999-11-23
AU713767B2 (en) 1999-12-09
EP0837679B1 (en) 2001-10-24
WO1996038141A1 (en) 1996-12-05
KR19990022137A (ko) 1999-03-25
US5652258A (en) 1997-07-29
CA2222101A1 (en) 1996-12-05
FI974363A0 (fi) 1997-11-28
JP2001503013A (ja) 2001-03-06
MX9709211A (es) 1998-07-31
NZ308410A (en) 2001-06-29
EP0837679A4 (en) 1999-03-03
DE69616328T2 (de) 2002-07-04
DK0837679T3 (da) 2002-02-11
CN1100534C (zh) 2003-02-05
EP0837679A1 (en) 1998-04-29
PT837679E (pt) 2002-03-28
ATE207354T1 (de) 2001-11-15
DE69616328D1 (de) 2001-11-29
CN1192143A (zh) 1998-09-02

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