NO974508L - Transdermalt administrerbart medikament med ACE-inhibitorer - Google Patents
Transdermalt administrerbart medikament med ACE-inhibitorerInfo
- Publication number
- NO974508L NO974508L NO974508A NO974508A NO974508L NO 974508 L NO974508 L NO 974508L NO 974508 A NO974508 A NO 974508A NO 974508 A NO974508 A NO 974508A NO 974508 L NO974508 L NO 974508L
- Authority
- NO
- Norway
- Prior art keywords
- layer
- transdermal system
- cover layer
- adhesive
- torn
- Prior art date
Links
- 239000005541 ACE inhibitor Substances 0.000 title claims abstract description 26
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title claims abstract description 26
- 229940079593 drug Drugs 0.000 title description 3
- 239000003814 drug Substances 0.000 title description 3
- 229940100640 transdermal system Drugs 0.000 claims abstract description 24
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims abstract 2
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims abstract 2
- 239000010410 layer Substances 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 19
- 239000011159 matrix material Substances 0.000 claims description 17
- 239000000853 adhesive Substances 0.000 claims description 13
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 claims description 11
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 229960002051 trandolapril Drugs 0.000 claims description 11
- 239000012790 adhesive layer Substances 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- 229920002367 Polyisobutene Polymers 0.000 claims description 9
- 239000011888 foil Substances 0.000 claims description 8
- -1 polypropylene Polymers 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000006260 foam Substances 0.000 claims description 6
- 229920005549 butyl rubber Polymers 0.000 claims description 5
- 229940002612 prodrug Drugs 0.000 claims description 5
- 239000000651 prodrug Substances 0.000 claims description 5
- 229960003401 ramipril Drugs 0.000 claims description 5
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 2
- 239000004821 Contact adhesive Substances 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 229920000728 polyester Polymers 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 229920001971 elastomer Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 230000036765 blood level Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000002775 capsule Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229960000830 captopril Drugs 0.000 description 3
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 2
- 108010061435 Enalapril Proteins 0.000 description 2
- 229960004530 benazepril Drugs 0.000 description 2
- 239000013039 cover film Substances 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 229960000873 enalapril Drugs 0.000 description 2
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000037317 transdermal delivery Effects 0.000 description 2
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 description 1
- 108010066671 Enalaprilat Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960002680 enalaprilat Drugs 0.000 description 1
- LZFZMUMEGBBDTC-QEJZJMRPSA-N enalaprilat (anhydrous) Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 LZFZMUMEGBBDTC-QEJZJMRPSA-N 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 229960002490 fosinopril Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19512181A DE19512181C2 (de) | 1995-03-31 | 1995-03-31 | Transdermales System mit Ramipril und/oder Trandolapril als ACE-Hemmer |
| PCT/EP1996/001402 WO1996029999A1 (de) | 1995-03-31 | 1996-03-29 | Transdermal applizierbares arzneimittel mit ace-hemmern |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO974508D0 NO974508D0 (no) | 1997-09-29 |
| NO974508L true NO974508L (no) | 1997-10-27 |
Family
ID=7758491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO974508A NO974508L (no) | 1995-03-31 | 1997-09-29 | Transdermalt administrerbart medikament med ACE-inhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6303141B1 (cs) |
| EP (1) | EP0817622B1 (cs) |
| JP (1) | JP3924008B2 (cs) |
| AT (1) | ATE209482T1 (cs) |
| AU (1) | AU700418B2 (cs) |
| BR (1) | BR9607872A (cs) |
| CA (1) | CA2216278A1 (cs) |
| CZ (1) | CZ287373B6 (cs) |
| DE (2) | DE19512181C2 (cs) |
| DK (1) | DK0817622T3 (cs) |
| ES (1) | ES2167558T3 (cs) |
| HU (1) | HUP9801989A3 (cs) |
| NO (1) | NO974508L (cs) |
| NZ (1) | NZ306429A (cs) |
| PL (1) | PL322576A1 (cs) |
| PT (1) | PT817622E (cs) |
| SK (1) | SK125897A3 (cs) |
| WO (1) | WO1996029999A1 (cs) |
| ZA (1) | ZA962592B (cs) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
| DE19820151A1 (de) * | 1998-05-06 | 1999-11-11 | Hexal Ag | Transdermales therapeutisches System zur Anwendung von Candesartan |
| CN1320880C (zh) | 1998-12-23 | 2007-06-13 | 伊迪亚股份公司 | 改进的体内局部无创伤用制剂 |
| EP1031346B1 (en) | 1999-01-27 | 2002-05-02 | Idea Ag | Noninvasive vaccination through the skin |
| PT1031347E (pt) | 1999-01-27 | 2002-09-30 | Idea Ag | Transporte/imunizacao transnasal com veiculos muitissimo adaptaveis |
| MXPA02000053A (es) | 1999-07-05 | 2003-07-21 | Idea Ag | Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables. |
| DE10033855A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Matrixkontrolliertes transdermales System mit Sulfonsäuresalz eines ACE-Hemmers |
| DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| TWI277418B (en) * | 2001-06-18 | 2007-04-01 | Noven Pharma | Enhanced drug delivery in transdermal systems |
| US6805878B2 (en) | 2001-09-13 | 2004-10-19 | Noven Pharmaceuticals, Inc. | Transdermal administration of ACE inhibitors |
| US20040105881A1 (en) * | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
| EP1811961A2 (en) * | 2004-11-12 | 2007-08-01 | Idea Ag | Extended surface aggregates in the treatment of skin conditions |
| EP1704876A1 (en) * | 2005-03-24 | 2006-09-27 | NOLabs AB | Cosmetic treatment, device for performing said treatment and manufacturing method thereof |
| DK1871433T3 (da) | 2005-03-24 | 2009-08-10 | Nolabs Ab | Kosmetisk behandling med nitrogenoxid, anordning til udförelse af denne behandling samt fremstillingsproces dertil |
| JP5058531B2 (ja) | 2005-09-09 | 2012-10-24 | 日東電工株式会社 | ビソプロロール含有貼付製剤 |
| DE102005058166A1 (de) | 2005-12-05 | 2007-06-06 | Hexal Ag | Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren |
| JP4945228B2 (ja) | 2005-12-13 | 2012-06-06 | 日東電工株式会社 | ビソプロロール含有貼付製剤 |
| JP5015562B2 (ja) * | 2005-12-13 | 2012-08-29 | 日東電工株式会社 | 貼付製剤 |
| US7943655B2 (en) * | 2006-04-05 | 2011-05-17 | Universitat Zurich | Polymorphic and pseudopolymorphic forms of trandolaprilat, pharmaceutical compositions and methods for production and use |
| AR065610A1 (es) | 2007-03-08 | 2009-06-17 | Nitto Denko Corp | Dispositivo para la administracion percutanea de bisoprolol |
| EP2729131B1 (en) | 2011-07-05 | 2020-04-15 | Novan, Inc. | Topical compositions |
| US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
| EP3030266B1 (en) | 2013-08-08 | 2020-10-28 | Novan Inc. | Topical compositions and methods of using the same |
| EP3177262A4 (en) | 2014-08-08 | 2018-04-18 | Novan Inc. | Topical emulsions |
| EP3423100A4 (en) | 2016-03-02 | 2019-10-16 | Novan, Inc. | COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION AND METHOD FOR THE TREATMENT THEREOF |
| WO2017180822A1 (en) | 2016-04-13 | 2017-10-19 | Novan, Inc. | Compositions, systems, kits, and methods for treating an infection |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256687A (en) * | 1985-09-09 | 1993-10-26 | Hoechst Aktiengesellschaft | Pharmaceutical composition for the treatment of high blood pressure |
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US4898732A (en) * | 1988-05-04 | 1990-02-06 | The Clinipad Corporation | Inhibiting of tumor growth with an antagonist of the renin-angioten-sin system |
| JPH0774116B2 (ja) * | 1989-10-05 | 1995-08-09 | 信越半導体株式会社 | Ｓｉ単結晶中の酸素濃度調整方法およびその装置 |
| US5269875A (en) | 1989-10-05 | 1993-12-14 | Shin-Etsu Handotai Company, Limited | Method of adjusting concentration of oxygen in silicon single crystal and apparatus for use in the method |
| US5073539A (en) | 1990-01-22 | 1991-12-17 | Ciba-Geigy Corporation | Transdermal administration of zwitterionic drugs |
| JP2849937B2 (ja) | 1990-04-18 | 1999-01-27 | 日東電工株式会社 | 医療用貼付剤 |
| FR2664815B1 (fr) * | 1990-07-23 | 1994-11-04 | Adir | Systeme matriciel autoadhesif pour la liberation prolongee du piribedil par voie transcutanee. |
| US5464387A (en) * | 1991-07-24 | 1995-11-07 | Alza Corporation | Transdermal delivery device |
| WO1993023019A1 (en) * | 1992-05-11 | 1993-11-25 | Sri International | Transdermal drug delivery systems and related compositions and methods of use |
-
1995
- 1995-03-31 DE DE19512181A patent/DE19512181C2/de not_active Expired - Fee Related
-
1996
- 1996-03-29 PT PT96911973T patent/PT817622E/pt unknown
- 1996-03-29 PL PL96322576A patent/PL322576A1/xx unknown
- 1996-03-29 HU HU9801989A patent/HUP9801989A3/hu unknown
- 1996-03-29 CZ CZ19973028A patent/CZ287373B6/cs unknown
- 1996-03-29 AT AT96911973T patent/ATE209482T1/de active
- 1996-03-29 AU AU54982/96A patent/AU700418B2/en not_active Ceased
- 1996-03-29 DE DE59608323T patent/DE59608323D1/de not_active Expired - Lifetime
- 1996-03-29 DK DK96911973T patent/DK0817622T3/da active
- 1996-03-29 JP JP52894896A patent/JP3924008B2/ja not_active Expired - Fee Related
- 1996-03-29 ES ES96911973T patent/ES2167558T3/es not_active Expired - Lifetime
- 1996-03-29 BR BR9607872-3A patent/BR9607872A/pt not_active Application Discontinuation
- 1996-03-29 NZ NZ306429A patent/NZ306429A/en unknown
- 1996-03-29 WO PCT/EP1996/001402 patent/WO1996029999A1/de not_active Ceased
- 1996-03-29 CA CA002216278A patent/CA2216278A1/en not_active Abandoned
- 1996-03-29 EP EP96911973A patent/EP0817622B1/de not_active Expired - Lifetime
- 1996-03-29 SK SK1258-97A patent/SK125897A3/sk unknown
- 1996-04-01 ZA ZA9602592A patent/ZA962592B/xx unknown
-
1997
- 1997-09-29 NO NO974508A patent/NO974508L/no not_active Application Discontinuation
-
1999
- 1999-09-29 US US09/407,348 patent/US6303141B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU700418B2 (en) | 1999-01-07 |
| HUP9801989A3 (en) | 2000-06-28 |
| ATE209482T1 (de) | 2001-12-15 |
| PT817622E (pt) | 2002-05-31 |
| EP0817622B1 (de) | 2001-11-28 |
| SK125897A3 (en) | 1998-02-04 |
| DK0817622T3 (da) | 2002-03-25 |
| US6303141B1 (en) | 2001-10-16 |
| AU5498296A (en) | 1996-10-16 |
| PL322576A1 (en) | 1998-02-02 |
| JPH11502827A (ja) | 1999-03-09 |
| ZA962592B (en) | 1997-10-01 |
| MX9707507A (es) | 1997-11-29 |
| WO1996029999A1 (de) | 1996-10-03 |
| CZ302897A3 (cs) | 1998-02-18 |
| DE59608323D1 (de) | 2002-01-10 |
| JP3924008B2 (ja) | 2007-06-06 |
| CA2216278A1 (en) | 1996-10-03 |
| DE19512181C2 (de) | 2003-11-06 |
| DE19512181A1 (de) | 1996-10-02 |
| NZ306429A (en) | 2000-07-28 |
| NO974508D0 (no) | 1997-09-29 |
| HUP9801989A2 (hu) | 1999-02-01 |
| ES2167558T3 (es) | 2002-05-16 |
| EP0817622A1 (de) | 1998-01-14 |
| CZ287373B6 (en) | 2000-11-15 |
| BR9607872A (pt) | 1999-11-30 |
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