NO973864L - Omdirigering av cellulær immunitet med reseptor-kimærer - Google Patents

Omdirigering av cellulær immunitet med reseptor-kimærer

Info

Publication number
NO973864L
NO973864L NO973864A NO973864A NO973864L NO 973864 L NO973864 L NO 973864L NO 973864 A NO973864 A NO 973864A NO 973864 A NO973864 A NO 973864A NO 973864 L NO973864 L NO 973864L
Authority
NO
Norway
Prior art keywords
cell
infective agent
chimeric receptors
target
receptor
Prior art date
Application number
NO973864A
Other languages
English (en)
Other versions
NO973864D0 (no
NO323632B1 (no
Inventor
Brian Seed
Charles Romeo
Waldemar Kolanus
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of NO973864D0 publication Critical patent/NO973864D0/no
Publication of NO973864L publication Critical patent/NO973864L/no
Publication of NO323632B1 publication Critical patent/NO323632B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus
NO19973864A 1995-02-24 1997-08-22 Celler som uttrykker minst to kimaerreseptorer, kimaert reseptorpar og par av DNA-molekyl som hver koder for en kimaer reseptor. NO323632B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39417695A 1995-02-24 1995-02-24
PCT/US1996/001056 WO1996025953A1 (en) 1995-02-24 1996-01-25 Redirection of cellular immunity by receptor chimeras

Publications (3)

Publication Number Publication Date
NO973864D0 NO973864D0 (no) 1997-08-22
NO973864L true NO973864L (no) 1997-10-22
NO323632B1 NO323632B1 (no) 2007-06-18

Family

ID=23557882

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19973864A NO323632B1 (no) 1995-02-24 1997-08-22 Celler som uttrykker minst to kimaerreseptorer, kimaert reseptorpar og par av DNA-molekyl som hver koder for en kimaer reseptor.

Country Status (18)

Country Link
EP (1) EP0871495B1 (no)
JP (1) JP4170390B2 (no)
KR (1) KR100490099B1 (no)
AT (1) ATE297986T1 (no)
AU (1) AU708339B2 (no)
CA (1) CA2209300C (no)
CZ (1) CZ295428B6 (no)
DE (1) DE69634855T2 (no)
DK (1) DK0871495T3 (no)
ES (1) ES2245456T3 (no)
FI (1) FI119757B (no)
HU (1) HU225688B1 (no)
NO (1) NO323632B1 (no)
NZ (2) NZ302513A (no)
PT (1) PT871495E (no)
RU (1) RU2167676C2 (no)
WO (1) WO1996025953A1 (no)
ZA (1) ZA961477B (no)

Families Citing this family (47)

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KR100620481B1 (ko) * 1996-10-23 2006-09-06 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 개선된 백신
AU6692298A (en) * 1997-03-07 1998-09-22 Ariad Gene Therapeutics, Inc. New applications of gene therapy technology
ES2329741T3 (es) * 1998-09-23 2009-11-30 Zymogenetics, Inc. Receptor de citoquinas zalpha11.
GB9908807D0 (en) * 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Synthetic signalling molecules
IL137419A0 (en) * 2000-07-20 2001-07-24 Yissum Res Dev Co Nk cells activating receptors and their therapeutic and diagnostic uses
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
SG10201510092QA (en) 2010-12-09 2016-01-28 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
GB201201511D0 (en) * 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
EP2847223B1 (en) 2012-05-07 2019-03-27 Trustees of Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
ES2786263T3 (es) 2012-07-13 2020-10-09 Univ Pennsylvania Mejora de la actividad de los CAR de linfocitos T mediante la introducción conjunta de un anticuerpo biespecífico
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
KR102313997B1 (ko) 2013-02-20 2021-10-20 노파르티스 아게 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료
TW201446794A (zh) 2013-02-20 2014-12-16 Novartis Ag 利用抗－ｃｄ１２３嵌合抗原受體工程化ｔ細胞之初級人類白血病有效靶向
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症
JP6779785B2 (ja) 2013-12-19 2020-11-04 ノバルティス アーゲー ヒトメソテリンキメラ抗原受容体およびその使用
KR102483822B1 (ko) * 2013-12-20 2023-01-03 프레드 허친슨 캔서 센터 태그된 키메라 이펙터 분자 및 그의 리셉터
WO2015090229A1 (en) 2013-12-20 2015-06-25 Novartis Ag Regulatable chimeric antigen receptor
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
PL3129470T3 (pl) 2014-04-07 2021-11-29 Novartis Ag Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19
BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
KR102594343B1 (ko) 2014-07-21 2023-10-26 노파르티스 아게 Cd33 키메라 항원 수용체를 사용한 암의 치료
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
SG11201700418VA (en) 2014-07-21 2017-02-27 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
CN107108744B (zh) 2014-08-19 2020-09-25 诺华股份有限公司 抗cd123嵌合抗原受体(car)用于癌症治疗
BR112017005390A2 (pt) 2014-09-17 2017-12-12 Novartis Ag células citotóxicas alvo com receptores quiméricos para imunoterapia adotiva
BR122024000360A2 (pt) * 2014-09-19 2024-02-27 City Of Hope Molécula de ácido nucleico, população de células t humanas transduzidas por um vetor que compreende um cassete de expressão que codifica um receptor de antígeno quimérico e seu uso
JP6815992B2 (ja) 2014-10-08 2021-01-20 ノバルティス アーゲー キメラ抗原受容体療法に対する治療応答性を予測するバイオマーカーおよびその使用
CN107567461A (zh) 2014-12-29 2018-01-09 诺华股份有限公司 制备嵌合抗原受体表达细胞的方法
WO2016115482A1 (en) 2015-01-16 2016-07-21 Novartis Pharma Ag Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
WO2016164731A2 (en) 2015-04-08 2016-10-13 Novartis Ag Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
EP4234685A3 (en) 2015-04-17 2023-09-06 Novartis AG Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
US11059880B2 (en) 2015-06-30 2021-07-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Redirected cells with MHC chimeric receptors and methods of use in immunotherapy
JP7146632B2 (ja) 2015-07-21 2022-10-04 ノバルティス アーゲー 免疫細胞の有効性および増大を改善する方法
GB201513540D0 (en) * 2015-07-31 2015-09-16 King S College London Therapeutic agents
EP3331913A1 (en) 2015-08-07 2018-06-13 Novartis AG Treatment of cancer using chimeric cd3 receptor proteins
CN108780084B (zh) 2015-09-03 2022-07-22 诺华股份有限公司 预测细胞因子释放综合征的生物标志物
WO2017112741A1 (en) 2015-12-22 2017-06-29 Novartis Ag Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy
BR112019006781A2 (pt) 2016-10-07 2019-07-30 Novartis Ag receptores de antígeno quiméricos para o tratamento de câncer
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
EA201992232A1 (ru) 2017-03-22 2020-05-14 Новартис Аг Композиции и способы для иммуноонкологии
JP2021514658A (ja) 2018-03-06 2021-06-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 前立腺特異的膜抗原ｃａｒおよびその使用方法
BR112020025048A2 (pt) 2018-06-13 2021-04-06 Novartis Ag Receptores de antígeno quimérico de bcma e usos dos mesmos

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EP0732402A3 (en) * 1990-12-14 1997-05-21 Cell Genesys Inc Chimeric chains for transduction of receptor-linked signaling pathways
IL101147A (en) * 1991-03-07 2004-06-20 Gen Hospital Corp Change of direction of cellular immunity by chimera receptors
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US5439819A (en) * 1993-08-27 1995-08-08 The Regents Of The University Of California Chimeric protein tyrosine kinases

Also Published As

Publication number Publication date
HUP9801873A2 (hu) 1998-11-30
AU4858896A (en) 1996-09-11
PT871495E (pt) 2005-10-31
ES2245456T3 (es) 2006-01-01
FI973437A (fi) 1997-10-16
KR19980702450A (ko) 1998-07-15
AU708339B2 (en) 1999-08-05
CA2209300A1 (en) 1996-08-29
NO973864D0 (no) 1997-08-22
NZ337002A (en) 2005-07-29
NZ302513A (en) 1999-11-29
JPH11505409A (ja) 1999-05-21
EP0871495A1 (en) 1998-10-21
FI973437A0 (fi) 1997-08-21
CA2209300C (en) 2011-06-28
HU225688B1 (en) 2007-06-28
DE69634855D1 (de) 2005-07-21
JP4170390B2 (ja) 2008-10-22
RU2167676C2 (ru) 2001-05-27
DK0871495T3 (da) 2005-10-17
CZ259997A3 (cs) 1998-05-13
ATE297986T1 (de) 2005-07-15
ZA961477B (en) 1997-02-03
DE69634855T2 (de) 2006-05-18
HUP9801873A3 (en) 2000-08-28
EP0871495B1 (en) 2005-06-15
FI119757B (fi) 2009-03-13
EP0871495A4 (en) 2000-09-13
WO1996025953A1 (en) 1996-08-29
KR100490099B1 (ko) 2005-11-28
CZ295428B6 (cs) 2005-08-17
NO323632B1 (no) 2007-06-18

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