ZA961477B - Redirection of cellular immunity by receptor chimeras. - Google Patents

Redirection of cellular immunity by receptor chimeras.

Info

Publication number
ZA961477B
ZA961477B ZA9601477A ZA961477A ZA961477B ZA 961477 B ZA961477 B ZA 961477B ZA 9601477 A ZA9601477 A ZA 9601477A ZA 961477 A ZA961477 A ZA 961477A ZA 961477 B ZA961477 B ZA 961477B
Authority
ZA
South Africa
Prior art keywords
cell
infective agent
chimeric receptors
target
receptor
Prior art date
Application number
ZA9601477A
Inventor
Brian Seed
Charles Romeo
Waldemar Kolanus
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of ZA961477B publication Critical patent/ZA961477B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus

Abstract

Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal at least two chimeric receptors which trigger the specific recognition and destruction of an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. One of the expressed chimeric receptors includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular or transmembrane portion which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent; and the second chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular portion which is derived from CD28. Also disclosed are pairs of useful chimeric receptors, cells which express the chimeric receptors, and DNA encoding the chimeric receptors.
ZA9601477A 1995-02-24 1996-02-23 Redirection of cellular immunity by receptor chimeras. ZA961477B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39417695A 1995-02-24 1995-02-24

Publications (1)

Publication Number Publication Date
ZA961477B true ZA961477B (en) 1997-02-03

Family

ID=23557882

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9601477A ZA961477B (en) 1995-02-24 1996-02-23 Redirection of cellular immunity by receptor chimeras.

Country Status (18)

Country Link
EP (1) EP0871495B1 (en)
JP (1) JP4170390B2 (en)
KR (1) KR100490099B1 (en)
AT (1) ATE297986T1 (en)
AU (1) AU708339B2 (en)
CA (1) CA2209300C (en)
CZ (1) CZ295428B6 (en)
DE (1) DE69634855T2 (en)
DK (1) DK0871495T3 (en)
ES (1) ES2245456T3 (en)
FI (1) FI119757B (en)
HU (1) HU225688B1 (en)
NO (1) NO323632B1 (en)
NZ (2) NZ302513A (en)
PT (1) PT871495E (en)
RU (1) RU2167676C2 (en)
WO (1) WO1996025953A1 (en)
ZA (1) ZA961477B (en)

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GB9908807D0 (en) * 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Synthetic signalling molecules
IL137419A0 (en) * 2000-07-20 2001-07-24 Yissum Res Dev Co Nk cells activating receptors and their therapeutic and diagnostic uses
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
BR122021026173B1 (en) 2010-12-09 2023-12-05 The Trustees Of The University Of Pennsylvania PHARMACEUTICAL COMPOSITION
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
GB201201511D0 (en) * 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
US9790278B2 (en) 2012-05-07 2017-10-17 The Trustees Of Dartmouth College Anti-B7-H6 antibody, fusion proteins, and methods of using the same
ES2786263T3 (en) * 2012-07-13 2020-10-09 Univ Pennsylvania Enhancement of T-lymphocyte CAR activity by co-introduction of a bispecific antibody
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014130635A1 (en) 2013-02-20 2014-08-28 Novartis Ag Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
EP3626741A1 (en) 2013-02-20 2020-03-25 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
EP3623380A1 (en) 2013-03-15 2020-03-18 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (en) 2013-03-16 2014-10-31 Novartis Ag CANCER TREATMENT USING AN ANTI-CD19 CHEMERIC ANTIGEN RECEIVER
CA2931684C (en) 2013-12-19 2024-02-20 Novartis Ag Human mesothelin chimeric antigen receptors and uses thereof
SG11201605046YA (en) * 2013-12-20 2016-07-28 Hutchinson Fred Cancer Res Tagged chimeric effector molecules and receptors thereof
JP6793902B2 (en) 2013-12-20 2020-12-02 ノバルティス アーゲー Adjustable chimeric antigen receptor
WO2015112626A1 (en) 2014-01-21 2015-07-30 June Carl H Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
PL3129470T3 (en) 2014-04-07 2021-11-29 Novartis Ag Treatment of cancer using anti-cd19 chimeric antigen receptor
TWI750110B (en) 2014-07-21 2021-12-21 瑞士商諾華公司 Treatment of cancer using humanized anti- bcma chimeric antigen receptor
MX2017001013A (en) 2014-07-21 2018-02-21 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor.
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
KR102594343B1 (en) 2014-07-21 2023-10-26 노파르티스 아게 Treatment of cancer using a cd33 chimeric antigen receptor
PT3183268T (en) 2014-08-19 2020-05-15 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
AU2015317608B2 (en) 2014-09-17 2021-03-11 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
JP6657195B2 (en) * 2014-09-19 2020-03-04 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ Co-stimulatory chimeric antigen receptor T cells targeting L13Rα2
US10774388B2 (en) 2014-10-08 2020-09-15 Novartis Ag Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
KR20170093254A (en) 2014-12-29 2017-08-14 노파르티스 아게 Methods for producing chimeric antigen receptor-expressing cells
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
IL303972A (en) 2015-04-08 2023-08-01 Novartis Ag Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
WO2017004252A1 (en) 2015-06-30 2017-01-05 The Arizona Board Of Regents On Behalf Of The University Of Arizona Redirected cells with mhc chimeric receptors and methods of use in immunotherapy
AU2016297014B2 (en) 2015-07-21 2021-06-17 Novartis Ag Methods for improving the efficacy and expansion of immune cells
GB201513540D0 (en) * 2015-07-31 2015-09-16 King S College London Therapeutic agents
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
WO2017040930A2 (en) 2015-09-03 2017-03-09 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
JP7082055B2 (en) 2015-12-22 2022-06-07 ノバルティス アーゲー Antibodies to Mesothelin Chimeric Antigen Receptor (CAR) and PD-L1 Inhibitors for Combined Use in Anticancer Treatment
CN110225927B (en) 2016-10-07 2024-01-12 诺华股份有限公司 Chimeric antigen receptor for the treatment of cancer
EP3574005B1 (en) 2017-01-26 2021-12-15 Novartis AG Cd28 compositions and methods for chimeric antigen receptor therapy
EA201992232A1 (en) 2017-03-22 2020-05-14 Новартис Аг COMPOSITIONS AND METHODS FOR IMMUNOUNCOLOGY
AU2019231205A1 (en) 2018-03-06 2020-09-24 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
CN112203725A (en) 2018-06-13 2021-01-08 诺华股份有限公司 BCMA chimeric antigen receptors and uses thereof

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US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
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US5439819A (en) * 1993-08-27 1995-08-08 The Regents Of The University Of California Chimeric protein tyrosine kinases

Also Published As

Publication number Publication date
CZ295428B6 (en) 2005-08-17
FI973437A0 (en) 1997-08-21
EP0871495B1 (en) 2005-06-15
ES2245456T3 (en) 2006-01-01
CA2209300C (en) 2011-06-28
DE69634855T2 (en) 2006-05-18
WO1996025953A1 (en) 1996-08-29
FI973437A (en) 1997-10-16
RU2167676C2 (en) 2001-05-27
CA2209300A1 (en) 1996-08-29
NO973864D0 (en) 1997-08-22
NO323632B1 (en) 2007-06-18
AU708339B2 (en) 1999-08-05
ATE297986T1 (en) 2005-07-15
AU4858896A (en) 1996-09-11
KR19980702450A (en) 1998-07-15
JP4170390B2 (en) 2008-10-22
EP0871495A1 (en) 1998-10-21
HUP9801873A2 (en) 1998-11-30
PT871495E (en) 2005-10-31
DK0871495T3 (en) 2005-10-17
EP0871495A4 (en) 2000-09-13
FI119757B (en) 2009-03-13
CZ259997A3 (en) 1998-05-13
JPH11505409A (en) 1999-05-21
NZ337002A (en) 2005-07-29
NZ302513A (en) 1999-11-29
HU225688B1 (en) 2007-06-28
NO973864L (en) 1997-10-22
DE69634855D1 (en) 2005-07-21
KR100490099B1 (en) 2005-11-28
HUP9801873A3 (en) 2000-08-28

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