NO972771L - Ny reseptor - Google Patents

Ny reseptor

Info

Publication number
NO972771L
NO972771L NO972771A NO972771A NO972771L NO 972771 L NO972771 L NO 972771L NO 972771 A NO972771 A NO 972771A NO 972771 A NO972771 A NO 972771A NO 972771 L NO972771 L NO 972771L
Authority
NO
Norway
Prior art keywords
binds
compound
tissue
brain tissue
rat
Prior art date
Application number
NO972771A
Other languages
English (en)
Other versions
NO972771D0 (no
Inventor
Hugh Jonathan Herdon
Jeffrey Clifford Jerman
Wai Ngor Chan
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO972771D0 publication Critical patent/NO972771D0/no
Publication of NO972771L publication Critical patent/NO972771L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Det beskrives en reseptor i tilnærmet ren form, som kan oppnås fra vev fra rotte forhjerne, og som kjennetegnes ved at: a) Forbindelse A binder seg til den med en Kd på 40 nM for vev fra rotte-forhjerne, b) Forbindelse A binder seg til den med en Bpå 220 pmol/g protein for vev fra rotte-forhjerne, c) Forbindelse B binder seg til den med en Kd på 2 nM for vev fra rotte-forhjerne, d) Forbindelse B binder seg til den med en på 220 pmol/g protein for vev fra rotte-forhjerne; og homologe reseptorer fra andre kilder som har minst 85% homologi med vevet fra rotte-forhjerne.
NO972771A 1994-12-17 1997-06-16 Ny reseptor NO972771L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9425502.3A GB9425502D0 (en) 1994-12-17 1994-12-17 Novel receptor
PCT/EP1995/004998 WO1996018650A1 (en) 1994-12-17 1995-12-11 Novel receptor

Publications (2)

Publication Number Publication Date
NO972771D0 NO972771D0 (no) 1997-06-16
NO972771L true NO972771L (no) 1997-08-15

Family

ID=10766105

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972771A NO972771L (no) 1994-12-17 1997-06-16 Ny reseptor

Country Status (15)

Country Link
US (1) US5985334A (no)
EP (1) EP0807122A1 (no)
JP (1) JPH10511083A (no)
CN (1) CN1175262A (no)
AU (1) AU710150B2 (no)
BR (1) BR9510060A (no)
CA (1) CA2207921A1 (no)
CZ (1) CZ187697A3 (no)
FI (1) FI972558A (no)
GB (1) GB9425502D0 (no)
HU (1) HUT77077A (no)
NO (1) NO972771L (no)
NZ (1) NZ298059A (no)
PL (1) PL320747A1 (no)
WO (1) WO1996018650A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245893B1 (en) * 1994-12-17 2001-06-12 Smithkline Beecham P.L.C. Receptor that binds anti-convulsant compounds
US20230136109A1 (en) * 2020-03-10 2023-05-04 Epic Ventures Inc. Light-activated pathogen-killing molecules and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
GB9225860D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
WO1995006117A1 (en) * 1993-08-20 1995-03-02 Smithkline Beecham Plc Human 5-ht2 receptor

Also Published As

Publication number Publication date
CZ187697A3 (en) 1997-10-15
US5985334A (en) 1999-11-16
NZ298059A (en) 2000-03-27
AU710150B2 (en) 1999-09-16
WO1996018650A1 (en) 1996-06-20
GB9425502D0 (en) 1995-02-15
NO972771D0 (no) 1997-06-16
AU4345896A (en) 1996-07-03
CN1175262A (zh) 1998-03-04
MX9704560A (es) 1997-10-31
EP0807122A1 (en) 1997-11-19
PL320747A1 (en) 1997-10-27
CA2207921A1 (en) 1996-06-20
JPH10511083A (ja) 1998-10-27
BR9510060A (pt) 1998-06-02
HUT77077A (hu) 1998-03-02
FI972558A0 (fi) 1997-06-16
FI972558A (fi) 1997-06-16

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NO972771L (no) Ny reseptor

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application