NO963131L - Endotelinreseptorantagonister - Google Patents

Endotelinreseptorantagonister

Info

Publication number
NO963131L
NO963131L NO963131A NO963131A NO963131L NO 963131 L NO963131 L NO 963131L NO 963131 A NO963131 A NO 963131A NO 963131 A NO963131 A NO 963131A NO 963131 L NO963131 L NO 963131L
Authority
NO
Norway
Prior art keywords
unsubstituted
nhsor
hal
phenyl
rsubstituted
Prior art date
Application number
NO963131A
Other languages
English (en)
Other versions
NO963131D0 (no
Inventor
Mathias Osswald
Dieter Dorsch
Werner Mederski
Claudia Wilm
Claus J Schmitges
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO963131D0 publication Critical patent/NO963131D0/no
Publication of NO963131L publication Critical patent/NO963131L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser med formel I. hvor -Y-Z- betyr -NRC0-, -N=C(OR)-eller -;betyr Ar;betyrO, CN, lH-tetrazol-5-yl ellerNHS0r;,4 og Rbetyr uavhengig av hverandre R, OR, S(0)BR\ Hal, N,', NHCOR, NHS0R, OCO, COOeller CN; R6 og' betyr uavhengig av hverandre H, alkyl med 1-6 C-atomer, benzyl eller fenyl; Rbetyr (CH)„; Rbetyr Ar eller Or; Ar betyr usubstituert eller én, to eller tre ganger med,eller Rsubstituert fenyl, eller usubstituert naftyl eller en usubstituert eller i fenyldelen én eller to ganger med R' eller Rsubstuerten usubstituert eller i sykloheksadien-yldelen én eller to ganger med Reller ' R10 substituert. , R9,og Rbetyr uavhengig av hver-. andre R,6, Hal, CF, OCF, OCHF, OCHF, N0,', NHCOR, CN, NHS0R, COOR, COR, CONHS0r, 0(CH), 0(CH2)nOR6 eller S(0)R; E betyr CH, S eller 0; D betyr karbonyl eller [C(RR')]; Hal betyr F, Cl, Br eller I; X betyr 0 eller S; m betyr 0, 1 eller 2; og n betyr 1 eller 2; samt salter derav. Forbindelsene har endo-telinreseptorantagonistiske egenskaper.
NO963131A 1995-07-28 1996-07-26 Endotelinreseptorantagonister NO963131L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19527568A DE19527568A1 (de) 1995-07-28 1995-07-28 Endothelin-Rezeptor-Antagonisten

Publications (2)

Publication Number Publication Date
NO963131D0 NO963131D0 (no) 1996-07-26
NO963131L true NO963131L (no) 1997-01-29

Family

ID=7767990

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963131A NO963131L (no) 1995-07-28 1996-07-26 Endotelinreseptorantagonister

Country Status (16)

Country Link
US (1) US5700807A (no)
EP (1) EP0755934A1 (no)
JP (1) JPH0940678A (no)
KR (1) KR970006305A (no)
AU (1) AU6060796A (no)
BR (1) BR9603164A (no)
CA (1) CA2182156A1 (no)
CZ (1) CZ219796A3 (no)
DE (1) DE19527568A1 (no)
HU (1) HUP9602054A3 (no)
MX (1) MX9603045A (no)
NO (1) NO963131L (no)
PL (1) PL315422A1 (no)
SK (1) SK92496A3 (no)
TW (1) TW367328B (no)
ZA (1) ZA966399B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291442B1 (en) 1998-02-03 2001-09-18 The General Hospital Corporation Pharmacological modulators of voltage-gated potassium ion channels
IL125659A (en) † 1998-08-05 2002-09-12 Cadent Ltd Method and device for three-dimensional simulation of a structure
US6638929B2 (en) 1999-12-29 2003-10-28 Wyeth Tricyclic protein kinase inhibitors
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
JP5082033B2 (ja) 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒのモジュレーター
NZ534255A (en) * 2002-02-22 2007-06-29 Bayer Pharmaceuticals Corp Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
WO2005020882A2 (ja) * 2003-08-29 2005-03-10 Ono Pharmaceutical Co Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途
WO2015088564A1 (en) * 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
RU2086544C1 (ru) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
CA2122820A1 (en) 1991-11-05 1993-05-13 Russell Donavan Cousins Endothelin receptor antagonists
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
DE69422742T2 (de) 1993-03-19 2000-08-17 Merck & Co Inc Phenoxyphenylessigsäurederivate
US6075037A (en) * 1994-06-09 2000-06-13 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
HU9602054D0 (en) 1996-09-30
HUP9602054A2 (en) 1997-11-28
EP0755934A1 (en) 1997-01-29
NO963131D0 (no) 1996-07-26
HUP9602054A3 (en) 1998-07-28
BR9603164A (pt) 1998-05-05
TW367328B (en) 1999-08-21
ZA966399B (en) 1997-02-19
CZ219796A3 (en) 1997-02-12
KR970006305A (ko) 1997-02-19
US5700807A (en) 1997-12-23
DE19527568A1 (de) 1997-01-30
PL315422A1 (en) 1997-02-03
MX9603045A (es) 1997-01-31
AU6060796A (en) 1997-02-06
CA2182156A1 (en) 1997-01-29
SK92496A3 (en) 1997-07-09
JPH0940678A (ja) 1997-02-10

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