NO953967L - Indolderivater som 5-HT1A og/eller 5-HT2 ligander - Google Patents

Indolderivater som 5-HT1A og/eller 5-HT2 ligander

Info

Publication number
NO953967L
NO953967L NO953967A NO953967A NO953967L NO 953967 L NO953967 L NO 953967L NO 953967 A NO953967 A NO 953967A NO 953967 A NO953967 A NO 953967A NO 953967 L NO953967 L NO 953967L
Authority
NO
Norway
Prior art keywords
indole derivatives
ht1a
ligands
derivatives
processes
Prior art date
Application number
NO953967A
Other languages
English (en)
Other versions
NO953967D0 (no
Inventor
Myrna Gil Quintero
Vincenzo Martino
Franco Borsini
Carlo Maria Pellegrini
Marco Turconi
Ettore Giraldo
Original Assignee
Boehringer Ingelheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia
Publication of NO953967D0 publication Critical patent/NO953967D0/no
Publication of NO953967L publication Critical patent/NO953967L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Farmakologisk, aktive indolderivater med sentral- serotonergisk aktivitet og som kan brukes for behandling av lidelser som angår det sentrale nervesystem, med formel (I)hvor R, R! og R2 er som beskrevet i foreliggende beskrivelse, fremgangsmåter for deres fremstilling og farmasøytiske preparater som inneholder slike derivater.
NO953967A 1993-04-08 1995-10-05 Indolderivater som 5-HT1A og/eller 5-HT2 ligander NO953967L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI930699A IT1271352B (it) 1993-04-08 1993-04-08 Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
PCT/EP1994/001016 WO1994024125A1 (en) 1993-04-08 1994-03-31 Indole derivatives as 5-ht1a and/or 5-ht2 ligands

Publications (2)

Publication Number Publication Date
NO953967D0 NO953967D0 (no) 1995-10-05
NO953967L true NO953967L (no) 1995-12-05

Family

ID=11365694

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953967A NO953967L (no) 1993-04-08 1995-10-05 Indolderivater som 5-HT1A og/eller 5-HT2 ligander

Country Status (20)

Country Link
US (1) US5834493A (no)
EP (1) EP0694033A1 (no)
JP (1) JPH08508738A (no)
CN (1) CN1124960A (no)
AU (1) AU684276B2 (no)
BG (1) BG100040A (no)
BR (1) BR9406206A (no)
CA (1) CA2160020A1 (no)
CZ (1) CZ283398B6 (no)
FI (1) FI954734A (no)
HU (1) HUT74090A (no)
IL (1) IL109234A (no)
IT (1) IT1271352B (no)
NO (1) NO953967L (no)
NZ (1) NZ265055A (no)
PL (1) PL310995A1 (no)
SG (1) SG50507A1 (no)
SK (1) SK119795A3 (no)
WO (1) WO1994024125A1 (no)
ZA (1) ZA942383B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
TR199902759T2 (xx) * 1997-05-09 2000-01-21 H. Lundbeck A/S Sertindole �retimi i�in bir y�ntem
JP2002509149A (ja) 1998-01-14 2002-03-26 ザ ユーエイビー リサーチ ファウンデイション 細菌ｎａｄシンテターゼ酵素の阻害剤の合成およびスクリーニング方法、その化合物、ならびに細菌ｎａｄシンテターゼ酵素の阻害剤を用いる細菌および微生物感染の治療方法
US6673827B1 (en) 1999-06-29 2004-01-06 The Uab Research Foundation Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
US6861448B2 (en) * 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
ATE223379T1 (de) * 1998-04-08 2002-09-15 Wyeth Corp N-aryloxyethylaminderivate zur behandlung der depression
WO1999055697A1 (en) * 1998-04-29 1999-11-04 American Home Products Corporation Serotonergic agents
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
DE19951360A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
JP2004520325A (ja) * 2000-12-22 2004-07-08 ワイス ５−ヒドロキシトリプトアミン−６−リガンドとしてのヘテロシクリルアルキルインドールまたは−アザインドール化合物
US7135479B2 (en) 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
CA2796756A1 (en) 2010-04-22 2011-10-27 Intra-Cellular Therapies, Inc. Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders
US9428506B2 (en) 2012-04-14 2016-08-30 Intra-Cellular Therapies, Inc. Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
PL2968320T3 (pl) 2013-03-15 2021-05-17 Intra-Cellular Therapies, Inc. Związki organiczne
WO2015085004A1 (en) 2013-12-03 2015-06-11 Intra-Cellular Therapies, Inc. Novel methods
MX2021014508A (es) 2014-04-04 2023-05-18 Intra Cellular Therapies Inc Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio.
RU2016143091A (ru) 2014-04-04 2018-05-08 Интра-Селлулар Терапиз, Инк. Органические соединения
WO2017023894A1 (en) * 2015-08-03 2017-02-09 Raze Therapeutics, Inc. Mthfd2 inhibitors and uses thereof
PT3838274T (pt) 2016-01-26 2023-12-18 Intra Cellular Therapies Inc Derivado de pirido[3',4':4,5]pirrolo[1,2,3-de]quinoxalina para utilização no tratamento de distúrbios do snc
CN113754661A (zh) 2016-03-25 2021-12-07 细胞内治疗公司 有机化合物
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
JP6987868B2 (ja) 2016-12-29 2022-01-05 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
US11427587B2 (en) 2017-07-26 2022-08-30 Intra-Cellular Therapies, Inc. Organic compounds
AU2018307479B2 (en) 2017-07-26 2024-06-20 Intra-Cellular Therapies, Inc. Organic compounds
MX2020013335A (es) 2018-06-08 2021-05-27 Intra Cellular Therapies Inc Metodos novedosos.
EP3843739A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
CN112584837A (zh) 2018-08-31 2021-03-30 细胞内治疗公司 新方法
CN114072150A (zh) 2019-07-07 2022-02-18 细胞内治疗公司 新方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
HU225055B1 (en) * 1990-10-15 2006-05-29 Pfizer Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
JP3140155B2 (ja) * 1992-03-09 2001-03-05 杏林製薬株式会社 Ｎ，ｎ’−ジ置換アミド誘導体
TW226019B (no) * 1992-03-23 1994-07-01 Sankyo Co

Also Published As

Publication number Publication date
IT1271352B (it) 1997-05-27
SG50507A1 (en) 1998-07-20
PL310995A1 (en) 1996-01-22
AU6538294A (en) 1994-11-08
ZA942383B (en) 1995-10-09
SK119795A3 (en) 1996-04-03
CN1124960A (zh) 1996-06-19
HUT74090A (en) 1996-11-28
WO1994024125A1 (en) 1994-10-27
BG100040A (bg) 1996-03-29
CA2160020A1 (en) 1994-10-27
IL109234A (en) 1998-04-05
US5834493A (en) 1998-11-10
NZ265055A (en) 1996-09-25
IL109234A0 (en) 1994-07-31
FI954734A0 (fi) 1995-10-05
ITMI930699A1 (it) 1994-10-08
FI954734A (fi) 1995-10-05
NO953967D0 (no) 1995-10-05
BR9406206A (pt) 1996-02-06
CZ260295A3 (en) 1996-01-17
EP0694033A1 (en) 1996-01-31
AU684276B2 (en) 1997-12-11
JPH08508738A (ja) 1996-09-17
ITMI930699A0 (it) 1993-04-08
HU9502913D0 (en) 1995-11-28
CZ283398B6 (cs) 1998-04-15

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