NO951442L - 3,5-disubstituerte tetrahydrofuran-2-oner - Google Patents
3,5-disubstituerte tetrahydrofuran-2-onerInfo
- Publication number
- NO951442L NO951442L NO951442A NO951442A NO951442L NO 951442 L NO951442 L NO 951442L NO 951442 A NO951442 A NO 951442A NO 951442 A NO951442 A NO 951442A NO 951442 L NO951442 L NO 951442L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- allyl
- amino
- ones
- cycloalphatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Forbindelser med formel (I) hvori RI betyr eventuelt forestret karboksy, hydroksymetyl eller formyl, R£ og 84 betyr uavhengig av hverandre allfatlske, cykloallfatlsk-allfatlske, arallfatleke eller heteroarylallfatlske rester og RS betyr azldo eller allfatlsk eller arallfatlsk substituert og/eller med en amlnobeskyttelsesgruppe beskyttet amlno og deres salter er verdifulle mellomprodukter for fremstillingen av legemlddel- vlrkestoffer, eksempelvis forbindelser med formel (II) OH R4 OH ("b). hvori RA betyr en aromatisk eller heteroaronatisk rest, R2 og R4 betyr uavhengig av hverandre allfatlske, cykloallfatlske, cykloallfatlsk-allfatlske eller arallfatlske rester, R3 står for usubstltuert eller KHDOUO- eller N,N-dllaverealkylert eller N-laverealkanoylert amlno og RB betyr en allfatisk, cykloallfatisk eller heteroaromatlsk-allfatlsk substituert amlnogruppe, og deres salter, som eksempelvis kan anvendes som antlhypertenslva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH116994 | 1994-04-18 | ||
CH24695 | 1995-01-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO951442D0 NO951442D0 (no) | 1995-04-12 |
NO951442L true NO951442L (no) | 1995-10-19 |
Family
ID=25684014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951442A NO951442L (no) | 1994-04-18 | 1995-04-12 | 3,5-disubstituerte tetrahydrofuran-2-oner |
Country Status (11)
Country | Link |
---|---|
US (1) | US5606078A (no) |
EP (1) | EP0678514A1 (no) |
JP (1) | JPH0853434A (no) |
KR (1) | KR950032161A (no) |
AU (1) | AU1642095A (no) |
CA (1) | CA2147052A1 (no) |
FI (1) | FI951772A (no) |
HU (1) | HUT72110A (no) |
IL (1) | IL113402A0 (no) |
NO (1) | NO951442L (no) |
NZ (1) | NZ270939A (no) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6833460B2 (en) * | 1999-06-18 | 2004-12-21 | E. I. Du Pont De Nemours And Company | Preparation and use of gamma-butyrolactones as cross-linking agents |
US6423850B1 (en) | 1999-06-18 | 2002-07-23 | E.I. Du Pont De Nemours And Company | Preparation and use of gamma-butyrolactones as cross-linking agents |
IL153717A0 (en) * | 2000-07-05 | 2003-07-06 | Speedel Pharma Ag | Process for teh preparation of substituted octanoyl amides |
DE122007000077I2 (de) * | 2000-07-25 | 2008-08-21 | Speedel Pharma Ag Hirchgaessle | Verfahren zur herstellung von substituierten octanoyl-amiden |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
GB0212410D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
AU2003238007A1 (en) * | 2002-06-11 | 2003-12-22 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
AU2003293155A1 (en) | 2002-11-27 | 2004-06-23 | Elan Pharmaceutical, Inc. | Substituted ureas and carbamates |
EP1689702B1 (en) | 2003-11-26 | 2013-01-30 | Novartis AG | Organic compounds |
GB0327839D0 (en) * | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
EP1725530A1 (en) * | 2004-03-19 | 2006-11-29 | Speedel Experimenta AG | Organic compounds |
PT1717226E (pt) * | 2004-03-19 | 2009-04-03 | Novartis Ag | Derivados de 5-amino-4-hidroxi-8-(1h-indol-5-il)-octan amida 2,7-substituída como inibidores da renina para o tratamento da hipertensão |
GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
GB2431654A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431651A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
GB2431643A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
GB2431650A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431647A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
GB2431644A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
GB2431652A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
EP1966113A1 (de) * | 2005-12-23 | 2008-09-10 | Basf Se | Verfahren zur herstellung einer alpha-chiralen chlormethylverbindung in reiner form |
GB0605688D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
CA2645260A1 (en) * | 2006-04-03 | 2007-10-18 | Novartis Ag | Renin inhibitors for the treatment of hypertension |
CA2681203A1 (en) * | 2007-04-03 | 2008-10-09 | Novartis Ag | New methods |
EP2062874B1 (en) * | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
WO2009143423A1 (en) * | 2008-05-23 | 2009-11-26 | Teva Pharmaceutical Industries Ltd. | Aliskiren monofumarate and processes for preparation thereof |
CN101774986B (zh) | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
WO2012034065A1 (en) | 2010-09-09 | 2012-03-15 | Teva Pharmaceutical Industries Ltd. | Aliskiren intermediates and a process for analyzing the purity of aliskiren |
CN102351734B (zh) * | 2011-09-05 | 2014-02-26 | 浙江普洛医药科技有限公司 | 一种阿利克仑的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
JPS6363673A (ja) * | 1986-09-04 | 1988-03-22 | Suntory Ltd | α−アミノ−γ−ラクトン誘導体の製造法 |
DE3706877A1 (de) * | 1987-03-04 | 1988-09-15 | Bayer Ag | Cyclohexencarbonsaeureester, verfahren zu ihrer herstellung und ihre verwendung |
JPH03505577A (ja) * | 1988-06-30 | 1991-12-05 | ジ・アップジョン・カンパニー | ジペプチドヒドロキシエチレン等配電子体の合成 |
AU629867B2 (en) * | 1988-11-17 | 1992-10-15 | Imperial Chemical Industries Plc | Triazolo (4,3a) pyrazine derivatives |
GB8912659D0 (en) * | 1989-06-02 | 1989-07-19 | Ici Plc | Process |
-
1995
- 1995-04-04 US US08/416,237 patent/US5606078A/en not_active Expired - Fee Related
- 1995-04-07 EP EP95810237A patent/EP0678514A1/de not_active Withdrawn
- 1995-04-12 NO NO951442A patent/NO951442L/no unknown
- 1995-04-12 AU AU16420/95A patent/AU1642095A/en not_active Abandoned
- 1995-04-12 FI FI951772A patent/FI951772A/fi not_active Application Discontinuation
- 1995-04-13 NZ NZ270939A patent/NZ270939A/en unknown
- 1995-04-13 CA CA002147052A patent/CA2147052A1/en not_active Abandoned
- 1995-04-14 HU HU9501077A patent/HUT72110A/hu unknown
- 1995-04-17 IL IL11340295A patent/IL113402A0/xx unknown
- 1995-04-17 KR KR1019950008957A patent/KR950032161A/ko not_active Application Discontinuation
- 1995-04-18 JP JP7092526A patent/JPH0853434A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FI951772A (fi) | 1995-10-19 |
NO951442D0 (no) | 1995-04-12 |
EP0678514A1 (de) | 1995-10-25 |
AU1642095A (en) | 1995-10-26 |
US5606078A (en) | 1997-02-25 |
FI951772A0 (fi) | 1995-04-12 |
IL113402A0 (en) | 1995-07-31 |
HU9501077D0 (en) | 1995-06-28 |
KR950032161A (ko) | 1995-12-20 |
HUT72110A (en) | 1996-03-28 |
NZ270939A (en) | 1996-12-20 |
CA2147052A1 (en) | 1995-10-19 |
JPH0853434A (ja) | 1996-02-27 |
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