NO944124L - 17 yre - Google Patents

17 yre

Info

Publication number
NO944124L
NO944124L NO944124A NO944124A NO944124L NO 944124 L NO944124 L NO 944124L NO 944124 A NO944124 A NO 944124A NO 944124 A NO944124 A NO 944124A NO 944124 L NO944124 L NO 944124L
Authority
NO
Norway
Prior art keywords
compounds
steroid
methods
hours
reductase
Prior art date
Application number
NO944124A
Other languages
English (en)
Other versions
NO944124D0 (no
Inventor
Dennis Alan Holt
Mark Alan Levy
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929209408A external-priority patent/GB9209408D0/en
Priority claimed from GB929224210A external-priority patent/GB9224210D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO944124D0 publication Critical patent/NO944124D0/no
Publication of NO944124L publication Critical patent/NO944124L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Oppfinnelsen omfatter 17a- og 170-substituerte acyl-3- karboksy-aromatisk A-ring-analoger av steroide syntetiske forbindelser, farmasøytiske preparater inneholdende disse forbindelsene og metoder for anvendelse av disse forbindelsene for å hemme steroid 5-a-reduktase. Mellomprodukter og frem- gangsmåter anvendt for fremstilling av disse forbindelsene omfattes også av oppfinnelsen.
NO944124A 1992-04-30 1994-10-28 17 yre NO944124L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929209408A GB9209408D0 (en) 1992-04-30 1992-04-30 Compounds
GB929224210A GB9224210D0 (en) 1992-11-18 1992-11-18 Compounds
PCT/US1993/003778 WO1993022333A1 (en) 1992-04-30 1993-04-22 17α AND 17β-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID

Publications (2)

Publication Number Publication Date
NO944124D0 NO944124D0 (no) 1994-10-28
NO944124L true NO944124L (no) 1994-10-31

Family

ID=26300800

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944124A NO944124L (no) 1992-04-30 1994-10-28 17 yre

Country Status (21)

Country Link
US (1) US5618806A (no)
EP (1) EP0638090A4 (no)
JP (1) JPH07506363A (no)
KR (1) KR950701340A (no)
CN (1) CN1095071A (no)
AU (1) AU4291993A (no)
BG (1) BG99145A (no)
BR (1) BR9306419A (no)
CA (1) CA2134231A1 (no)
CZ (1) CZ266694A3 (no)
FI (1) FI945105A (no)
HU (1) HUT72467A (no)
IL (1) IL105527A0 (no)
MA (1) MA22886A1 (no)
NO (1) NO944124L (no)
NZ (1) NZ252866A (no)
OA (1) OA10107A (no)
RU (1) RU94045872A (no)
SI (1) SI9300228A (no)
SK (1) SK129294A3 (no)
WO (1) WO1993022333A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA883034B (en) * 1987-04-29 1989-03-29 Smithkline Beckman Corp Steroid 5-alpha-reductase inhibitors
JP2675418B2 (ja) * 1988-05-25 1997-11-12 スミスクライン・ベックマン・コーポレイション 芳香族ステロイド５‐α‐レダクターゼ抑制剤
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors
CA2045866A1 (en) * 1990-06-28 1991-12-29 Gary H. Rasmusson 17-beta-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5 alpha-reductase inhibitors
CA2045865A1 (en) * 1990-06-28 1991-12-29 Gary H. Rasmusson Intermediates on the synthesis of 17 beta-acyl-3-carboxy-androsta-3,5-dienes
IT1259419B (it) * 1991-05-24 1996-03-18 Erba Carlo Spa Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
ZA938B (en) * 1992-01-06 1994-06-16 Smithkline Beecham Corp Preparation of benzo esters and benzo acids
DE69311837T2 (de) * 1992-04-20 1998-02-12 Sankyo Co Steroide zur Behandlung von Prostatisch-Hypertrophe, ihre Herstellung und Verwendung
GB9224148D0 (en) * 1992-11-18 1993-01-06 Smithkline Beecham Corp Compounds

Also Published As

Publication number Publication date
FI945105A0 (fi) 1994-10-31
US5618806A (en) 1997-04-08
BG99145A (bg) 1995-08-28
HU9403117D0 (en) 1995-02-28
CA2134231A1 (en) 1993-11-11
NZ252866A (en) 1996-09-25
CZ266694A3 (en) 1995-07-12
EP0638090A4 (en) 1995-10-04
FI945105A (fi) 1994-10-31
IL105527A0 (en) 1993-08-18
BR9306419A (pt) 1998-09-15
SI9300228A (sl) 1993-12-31
AU4291993A (en) 1993-11-29
CN1095071A (zh) 1994-11-16
JPH07506363A (ja) 1995-07-13
WO1993022333A1 (en) 1993-11-11
NO944124D0 (no) 1994-10-28
SK129294A3 (en) 1995-07-11
RU94045872A (ru) 1996-08-27
HUT72467A (en) 1996-04-29
MA22886A1 (fr) 1993-12-31
KR950701340A (ko) 1995-03-23
OA10107A (en) 1996-12-18
EP0638090A1 (en) 1995-02-15

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