NO943763L - 4-arylamino-benzopyraner og beslektede forbindelser - Google Patents

4-arylamino-benzopyraner og beslektede forbindelser

Info

Publication number
NO943763L
NO943763L NO943763A NO943763A NO943763L NO 943763 L NO943763 L NO 943763L NO 943763 A NO943763 A NO 943763A NO 943763 A NO943763 A NO 943763A NO 943763 L NO943763 L NO 943763L
Authority
NO
Norway
Prior art keywords
compounds
benzopyrans
arylamino
alkyl
related compounds
Prior art date
Application number
NO943763A
Other languages
English (en)
Other versions
NO943763D0 (no
Inventor
George C Rovnyak
Karnail Atwal
Dinos P Santafianos
Charles Z Ding
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO943763D0 publication Critical patent/NO943763D0/no
Publication of NO943763L publication Critical patent/NO943763L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formelen og farmasøytisk akseptable salter av slike forbindelser, hvor X er alkyl, Y er en enkeltbinding; -CH2, -C(O)-, -O-, -S- eller -N(R8)-, hvor R* er hydrogen, alkyl, halogenalkyl, aryl, arylalkyl, cykloalkyl eller (cykloalkyl)alkyl, og R1 til R7 er som definert her. Disse forbindelser har kaliumkanalaktiver- ende aktivitet og kan derfor brukes f.eks. som kardiovaskulære midler.
NO943763A 1993-10-07 1994-10-06 4-arylamino-benzopyraner og beslektede forbindelser NO943763L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13403493A 1993-10-07 1993-10-07

Publications (2)

Publication Number Publication Date
NO943763D0 NO943763D0 (no) 1994-10-06
NO943763L true NO943763L (no) 1995-04-10

Family

ID=22461465

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943763A NO943763L (no) 1993-10-07 1994-10-06 4-arylamino-benzopyraner og beslektede forbindelser

Country Status (15)

Country Link
US (1) US5837702A (no)
EP (1) EP0648758A1 (no)
JP (1) JPH07242650A (no)
KR (1) KR950011433A (no)
CN (1) CN1107473A (no)
AU (1) AU7446194A (no)
CA (1) CA2132766A1 (no)
CZ (1) CZ235894A3 (no)
FI (1) FI944624A (no)
HU (1) HUT72447A (no)
IL (1) IL110988A0 (no)
NO (1) NO943763L (no)
PL (1) PL305355A1 (no)
RU (1) RU94035686A (no)
ZA (1) ZA947833B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
FR2774987B1 (fr) * 1998-02-13 2000-03-17 Rhone Poulenc Rorer Sa Nouveaux derives de systemes heterocycliques condenses, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments
AU2428799A (en) * 1998-02-13 1999-08-30 Aventis Pharma S.A. Condensed heterocyclic system derivatives, preparation, pharmaceutical compositions containing them
WO2000067754A1 (en) 1999-05-12 2000-11-16 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
FR2796948A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromannes, leur preparation et leur utilisation en therapeutique
FR2796947A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
JP2001151767A (ja) * 1999-09-17 2001-06-05 Nissan Chem Ind Ltd ベンゾピラン誘導体
IL149336A0 (en) * 1999-11-05 2002-11-10 Emisphere Tech Inc Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
KR100389127B1 (ko) * 2000-10-09 2003-06-25 동부한농화학 주식회사 벤조피라닐 헤테로고리 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1478233B1 (en) * 2002-02-20 2016-11-09 Emisphere Technologies, Inc. Method for administering glp-1 molecules
US7414068B2 (en) * 2002-04-10 2008-08-19 Dongbu Hannong Chemical Co., Ltd. Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them
KR100492252B1 (ko) * 2002-08-09 2005-05-30 한국화학연구원 이미다졸을 포함하는 이차아민으로 치환된 벤조피란유도체 및 그의 제조방법
US20060286129A1 (en) * 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
KR100687522B1 (ko) * 2005-05-28 2007-02-27 한국화학연구원 2,2-디메틸-3-에스테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 pge2 활성에 관련된 염증질환 치료제
US7838553B2 (en) * 2005-09-01 2010-11-23 Janssen Pharmaceutica Nv Benzopyran derivatives as potassium channel openers
EP1993551A4 (en) * 2006-02-01 2011-10-19 Merck Sharp & Dohme INHIBITORS OF THE POTASSIUM CANAL
US20070219193A1 (en) * 2006-03-17 2007-09-20 Kalypsys, Inc Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
FR2914920B1 (fr) * 2007-04-11 2011-09-09 Clariant Specialty Fine Chem F Procede de deacetalisation d'alpha-aminoacetals.
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US20140018402A1 (en) * 2011-03-30 2014-01-16 Catholic University Industry Academic Cooperation Foundation Pharmaceutical composition for preventing or treating macular degeneration
KR102484846B1 (ko) * 2015-11-27 2023-01-05 한림제약(주) 벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004468A (en) * 1963-08-21 1965-09-15 Pfizer Ltd Chroman derivatives
US3812157A (en) * 1972-03-31 1974-05-21 Ncr Benzopyran compounds
US4391815A (en) * 1976-04-02 1983-07-05 Beecham Group Limited Cyanobenzano[b]pyrans
NZ183551A (en) * 1976-04-02 1978-09-20 Beecham Group Ltd Aminochromanols and pharmaceutical compositions containingthem
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
EP0028449B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064286D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0046652B1 (en) * 1980-08-21 1985-05-22 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
DE3368057D1 (en) * 1982-05-21 1987-01-15 Beecham Group Plc Pharmaceutically active aminobenzopyrans
ES8503669A1 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
EP0126311B1 (en) * 1983-05-18 1989-09-13 Beecham Group Plc Benzopyran derivatives.
EP0139992B1 (en) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
DE3411993A1 (de) * 1984-03-31 1985-10-10 Bayer Ag, 5090 Leverkusen Substituierte benzopyrane, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimittel
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
DE3682331D1 (de) * 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
US5210234A (en) * 1986-05-03 1993-05-11 Beecham Group P.L.C. Benzopyran intermediates
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
GB8613786D0 (en) * 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
GB8625185D0 (en) * 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
US4734421A (en) * 1986-10-29 1988-03-29 Merck & Co., Inc. Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
CH674984A5 (no) * 1987-05-16 1990-08-15 Sandoz Ag
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
US5310750A (en) * 1987-10-19 1994-05-10 Beecham Group P.L.C. Heterocyclic compounds useful as α2 -adrenoceptor antagonists
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
ATE139775T1 (de) * 1988-09-16 1996-07-15 Beecham Group Plc Benzopyranderivate mit einer blutdrucksenkenden wirkung
FR2639349B1 (fr) * 1988-11-23 1991-02-22 Sanofi Sa Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
HU207861B (en) * 1989-07-21 1993-06-28 Alkaloida Vegyeszeti Gyar Process for producing benzopirane derivative of blood pressure lowering activity
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
US5095016A (en) * 1989-08-11 1992-03-10 Kaken Pharmaceutical Co., Ltd. Benzopyran compounds, processes for their production and pharmaceutical compositions
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
GB8924376D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
US5061813A (en) * 1990-04-02 1991-10-29 E. R. Squibb & Sons, Inc. Substituted cyanoimino benzopyranes
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
DK0471515T3 (da) * 1990-08-15 1997-07-21 Lilly Co Eli Ringsubstituerede 2-amino-1,2,3,4-tetrahydronphtalener, 3-aminochromaner og 3-aminothiochromaner
DE4038752A1 (de) * 1990-12-05 1992-06-11 Merck Patent Gmbh Chromanderivate
CA2074864A1 (en) * 1991-07-30 1993-01-31 Carmen Almansa Tetralones with pharmacological activity
JP3502403B2 (ja) * 1991-12-16 2004-03-02 アベンティス ファーマ株式会社 骨吸収抑制剤

Also Published As

Publication number Publication date
CA2132766A1 (en) 1995-04-08
ZA947833B (en) 1995-04-13
KR950011433A (ko) 1995-05-15
FI944624A (fi) 1995-04-08
HU9402884D0 (en) 1995-01-30
IL110988A0 (en) 1994-11-28
RU94035686A (ru) 1996-09-10
AU7446194A (en) 1995-04-27
PL305355A1 (en) 1995-04-18
CN1107473A (zh) 1995-08-30
EP0648758A1 (en) 1995-04-19
FI944624A0 (fi) 1994-10-04
NO943763D0 (no) 1994-10-06
JPH07242650A (ja) 1995-09-19
HUT72447A (en) 1996-04-29
US5837702A (en) 1998-11-17
CZ235894A3 (en) 1995-04-12

Similar Documents

Publication Publication Date Title
NO943763L (no) 4-arylamino-benzopyraner og beslektede forbindelser
NO20045235L (no) Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet
WO2002003984A3 (en) Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
DK0869946T3 (da) Phenylimidazolidiner og deres anvendelse som anti-androgent middel
WO2003016291A1 (fr) Activateur du recepteur $g(d) sensible au proliferateur de peroxysome
ES8609313A1 (es) Un procedimiento para la preparacion de tetrahidroftalimidas.
NO954564L (no) N-acylsulfaminsyre-estere (eller-tioestere), N-acylsulfonamider og N-sulfonyl-karbaminsyre-estere (eller-tioestere) som hypercholesterolemiske midler
DK249089D0 (da) Benzamid-forbindelser, der er nyttige som protease-inhibitorer
MY101579A (en) Benzothiazolones, and their production and use
ES443361A1 (es) Un procedimiento de preparacion de 4-benciliden-piperidinas sustituidas en la posicion 1.
FI941424A (fi) Fluoratut 17beta-substituoidut 4-atsa-5alfa-androstan-3-onijohdannaiset
NO934196L (no) N,N-disubstituerte arylcykloalkylaminer, deres salter, legemidler inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for deres fremstilling
ATE497948T1 (de) Bicyclische verbindungen
NZ318843A (en) Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine
DK243185D0 (da) Aminderivater, fremgangsmaade til fremstilling deraf og fungicider indeholdende dem
YU99792A (sh) Postupak za dobijanje derivata piridina
HUP0004588A2 (hu) Szubsztituált 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocin-10-ol-származékok, eljárás előállításukra és alkalmazásuk gyógyszerként, valamint a vegyületeket tartalmazó gyógyszerkészítmények
MY102135A (en) A benzoylurea derivative and its production and use.
WO2000042995A3 (en) Use of anticonvulsant derivatives for treating transformed migraine
DK0452204T3 (da) Hidtil ukendte 3-aminochromanderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
MY109517A (en) Carboxylic acid derivatives
ES449430A1 (es) Procedimiento para preparar n-metilcarbamatos de 2, 3-dihi- drobenzofuranil-(7) n-sulfenilados.
NO994764L (no) Nye pyridinderivater og farmasöytiske preparater inneholdende disse
NO20050764L (no) Forbindelser
DK0566455T3 (da) 7-ethynyl-alfa-(methoxymethylen)-1-naphthaleneddikesyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse som pesticider