NO943631L - Substituerte fenylkarbamater og urinstoffer - Google Patents

Substituerte fenylkarbamater og urinstoffer

Info

Publication number
NO943631L
NO943631L NO943631A NO943631A NO943631L NO 943631 L NO943631 L NO 943631L NO 943631 A NO943631 A NO 943631A NO 943631 A NO943631 A NO 943631A NO 943631 L NO943631 L NO 943631L
Authority
NO
Norway
Prior art keywords
ureas
substituted
ch2c2
6alkyl
phenylcarbamates
Prior art date
Application number
NO943631A
Other languages
English (en)
Other versions
NO943631D0 (no
Inventor
Alexander William Oxford
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929206989A external-priority patent/GB9206989D0/en
Priority claimed from GB929217827A external-priority patent/GB9217827D0/en
Priority claimed from GB929221718A external-priority patent/GB9221718D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO943631D0 publication Critical patent/NO943631D0/no
Publication of NO943631L publication Critical patent/NO943631L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Substituerte fenylkarbamater og urinstoffer med formel. (I). hvor Rer et hydrogen- eller halogen-atom eller en C.-alkyl-, C-t-alkoksy- eller hydroksy-gruppe; Rer en oksadiazol- eller tiadiazol-ring substituert med en gruppe valgt fra C.-alkyl, C.-cykloalkyl, -CHC_-alkenyl, -CHC.-alkynyl, fenyl eller benzyl; X er NH eller et oksygenatom; m er 0, 1 eller 2; R3 er C-alkyl, benzyl, -(CH)nRellerRer en gruppe valgt fra cyano, hydroksyl, C-alkoksy, fenoksy, C (0) C^-alkyl, C(0)CH-CON, -, -S02NR6R7 eller -N0R(hvor hver avog R7 uavhengig er hydrogen, C_-alkyl eller fenyl); n er 2 eller 3 ;. Rer COReller S0R(hvor Rer hydrogen, C-alkyl eller fenyl) ; og kvaternære ammoniumderivater, piperidin-N-oksyder og farmasøytisk godtagbare salter og solvater derav; hvilke forbindelser er kraftige og spesifikke antagonister av 5-hydroksytryptamin (5HT; seretonin).
NO943631A 1992-03-31 1994-09-29 Substituerte fenylkarbamater og urinstoffer NO943631L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929206989A GB9206989D0 (en) 1992-03-31 1992-03-31 Chemical compounds
GB929217827A GB9217827D0 (en) 1992-08-21 1992-08-21 Chemical compounds
GB929221718A GB9221718D0 (en) 1992-10-16 1992-10-16 Chemical compounds
PCT/EP1993/000779 WO1993020071A1 (en) 1992-03-31 1993-03-26 Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-ht antagonists

Publications (2)

Publication Number Publication Date
NO943631D0 NO943631D0 (no) 1994-09-29
NO943631L true NO943631L (no) 1994-11-29

Family

ID=27266122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943631A NO943631L (no) 1992-03-31 1994-09-29 Substituerte fenylkarbamater og urinstoffer

Country Status (17)

Country Link
EP (2) EP0972773A1 (no)
JP (1) JP3236298B2 (no)
AT (1) ATE188697T1 (no)
AU (1) AU663780B2 (no)
CA (1) CA2133083A1 (no)
CZ (1) CZ236894A3 (no)
DE (1) DE69327583T2 (no)
DK (1) DK0640081T3 (no)
ES (1) ES2141763T3 (no)
FI (1) FI944513A (no)
GR (1) GR3032877T3 (no)
HU (1) HUT72321A (no)
NO (1) NO943631L (no)
NZ (1) NZ251687A (no)
PT (1) PT640081E (no)
SK (1) SK116394A3 (no)
WO (1) WO1993020071A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021820A1 (fr) * 1994-02-10 1995-08-17 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive du carbamate et composition correspondante
FR2750991A1 (fr) * 1996-07-12 1998-01-16 Pf Medicament Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament
FR2752732B1 (fr) 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
UA73543C2 (uk) * 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
DE60021282T2 (de) * 1999-12-07 2006-05-18 Theravance, Inc., South San Francisco Carbamat-derivate als muscarin-rezeptor antonisten
PL365048A1 (en) * 2000-08-07 2004-12-27 Laboratoire Glaxosmithkline S.A.S. Use of 5ht4 receptor antagonists in the manufacture of a medicament for the prophylaxis or treatment of atrial fibrillation
WO2002018335A1 (fr) * 2000-08-28 2002-03-07 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amine cyclique
FR2821356A1 (fr) 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
FR2843750B1 (fr) * 2002-08-23 2004-10-22 Cerep Composes derives d'arylcarbamates, preparation et utilisations
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4851937B2 (ja) 2003-11-21 2012-01-11 セラヴァンス， インコーポレーテッド β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物
JP2008510014A (ja) 2004-08-16 2008-04-03 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
WO2006023460A2 (en) 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
GB0602778D0 (en) 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
CN102284761B (zh) * 2010-06-17 2014-05-28 纬创资通股份有限公司 电子元件解焊方法以及导热模块

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA76475B (en) * 1975-03-10 1977-08-31 Ciba Geigy Ag Indolyalkylpiperidines
JPH0140026B2 (no) * 1978-07-03 1989-08-24 Amerikan Hoomu Purodakutsu Corp
AU611976B2 (en) * 1987-12-24 1991-06-27 John Wyeth & Brother Limited Aroyl urea and carbamic acid derivatives of azabicyclo compounds
DK443489D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
FR2677019B1 (fr) * 1991-05-27 1994-11-25 Pf Medicament Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
FR2679555B1 (fr) * 1991-07-25 1993-11-19 Fabre Medicament Pierre Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CZ236894A3 (en) 1995-09-13
AU663780B2 (en) 1995-10-19
FI944513A0 (fi) 1994-09-29
SK116394A3 (en) 1995-04-12
HU9402825D0 (en) 1994-12-28
JP3236298B2 (ja) 2001-12-10
DK0640081T3 (da) 2000-06-19
ES2141763T3 (es) 2000-04-01
DE69327583D1 (de) 2000-02-17
PT640081E (pt) 2000-05-31
FI944513A (fi) 1994-11-29
JPH07505868A (ja) 1995-06-29
EP0640081A1 (en) 1995-03-01
GR3032877T3 (en) 2000-07-31
EP0972773A1 (en) 2000-01-19
NZ251687A (en) 1995-12-21
CA2133083A1 (en) 1993-10-14
HUT72321A (en) 1996-04-29
ATE188697T1 (de) 2000-01-15
WO1993020071A1 (en) 1993-10-14
NO943631D0 (no) 1994-09-29
EP0640081B1 (en) 2000-01-12
DE69327583T2 (de) 2000-05-31
AU3949793A (en) 1993-11-08

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