ATE188697T1 - Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonisten - Google Patents
Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonistenInfo
- Publication number
- ATE188697T1 ATE188697T1 AT93908861T AT93908861T ATE188697T1 AT E188697 T1 ATE188697 T1 AT E188697T1 AT 93908861 T AT93908861 T AT 93908861T AT 93908861 T AT93908861 T AT 93908861T AT E188697 T1 ATE188697 T1 AT E188697T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- substituted
- antagonists
- ureas
- phenylcarbamates
- Prior art date
Links
- -1 PHENYL UREAS Chemical class 0.000 title 1
- 239000003523 serotonin 4 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 235000013877 carbamide Nutrition 0.000 abstract 2
- 150000003672 ureas Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical group C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- PWXJULSLLONQHY-UHFFFAOYSA-N phenylcarbamic acid Chemical class OC(=O)NC1=CC=CC=C1 PWXJULSLLONQHY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929206989A GB9206989D0 (en) | 1992-03-31 | 1992-03-31 | Chemical compounds |
| GB929217827A GB9217827D0 (en) | 1992-08-21 | 1992-08-21 | Chemical compounds |
| GB929221718A GB9221718D0 (en) | 1992-10-16 | 1992-10-16 | Chemical compounds |
| PCT/EP1993/000779 WO1993020071A1 (en) | 1992-03-31 | 1993-03-26 | Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-ht antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE188697T1 true ATE188697T1 (de) | 2000-01-15 |
Family
ID=27266122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93908861T ATE188697T1 (de) | 1992-03-31 | 1993-03-26 | Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonisten |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0640081B1 (de) |
| JP (1) | JP3236298B2 (de) |
| AT (1) | ATE188697T1 (de) |
| AU (1) | AU663780B2 (de) |
| CA (1) | CA2133083A1 (de) |
| CZ (1) | CZ236894A3 (de) |
| DE (1) | DE69327583T2 (de) |
| DK (1) | DK0640081T3 (de) |
| ES (1) | ES2141763T3 (de) |
| FI (1) | FI944513A7 (de) |
| GR (1) | GR3032877T3 (de) |
| HU (1) | HUT72321A (de) |
| NO (1) | NO943631L (de) |
| NZ (1) | NZ251687A (de) |
| PT (1) | PT640081E (de) |
| SK (1) | SK116394A3 (de) |
| WO (1) | WO1993020071A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT76289A (en) * | 1994-02-10 | 1997-07-28 | Yamanouchi Pharma Co Ltd | Carbamate derivative and medicinal composition containing the same |
| FR2750991A1 (fr) * | 1996-07-12 | 1998-01-16 | Pf Medicament | Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament |
| FR2752732B1 (fr) | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| JP2003516390A (ja) | 1999-12-07 | 2003-05-13 | セラヴァンス インコーポレーテッド | ムスカリンレセプターアンタゴニスト活性を有するカルバメート誘導体 |
| UA73543C2 (uk) * | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| US20050032866A1 (en) * | 2000-08-07 | 2005-02-10 | Bonhomme Mireille Marguerite Jeanne | The use of 5ht4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions |
| AU2001280187A1 (en) * | 2000-08-28 | 2002-03-13 | Toray Industries, Inc. | Cyclic amine derivatives |
| FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
| FR2843750B1 (fr) * | 2002-08-23 | 2004-10-22 | Cerep | Composes derives d'arylcarbamates, preparation et utilisations |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| DE602004021959D1 (de) | 2003-11-21 | 2009-08-20 | Theravance Inc | Verbindungen mit agonistischer wirkung am beta2-adrenergen rezeptor und am muscarinischen rezeptor |
| US7528253B2 (en) | 2004-08-16 | 2009-05-05 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| JP2008510015A (ja) | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA76475B (en) * | 1975-03-10 | 1977-08-31 | Ciba Geigy Ag | Indolyalkylpiperidines |
| JPH0140026B2 (de) * | 1978-07-03 | 1989-08-24 | Amerikan Hoomu Purodakutsu Corp | |
| IE63474B1 (en) * | 1987-12-24 | 1995-04-19 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| DK443489D0 (da) * | 1989-09-08 | 1989-09-08 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| FR2677019B1 (fr) * | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
| FR2679555B1 (fr) * | 1991-07-25 | 1993-11-19 | Fabre Medicament Pierre | Nouveaux derives de l'uree, leur preparation et leur application en therapeutique. |
-
1993
- 1993-03-26 WO PCT/EP1993/000779 patent/WO1993020071A1/en not_active Ceased
- 1993-03-26 DK DK93908861T patent/DK0640081T3/da active
- 1993-03-26 DE DE69327583T patent/DE69327583T2/de not_active Expired - Fee Related
- 1993-03-26 PT PT93908861T patent/PT640081E/pt unknown
- 1993-03-26 CA CA002133083A patent/CA2133083A1/en not_active Abandoned
- 1993-03-26 SK SK1163-94A patent/SK116394A3/sk unknown
- 1993-03-26 HU HU9402825A patent/HUT72321A/hu unknown
- 1993-03-26 AT AT93908861T patent/ATE188697T1/de not_active IP Right Cessation
- 1993-03-26 JP JP51708893A patent/JP3236298B2/ja not_active Expired - Fee Related
- 1993-03-26 CZ CZ942368A patent/CZ236894A3/cs unknown
- 1993-03-26 EP EP93908861A patent/EP0640081B1/de not_active Expired - Lifetime
- 1993-03-26 AU AU39497/93A patent/AU663780B2/en not_active Ceased
- 1993-03-26 ES ES93908861T patent/ES2141763T3/es not_active Expired - Lifetime
- 1993-03-26 EP EP99201608A patent/EP0972773A1/de not_active Withdrawn
- 1993-03-26 NZ NZ251687A patent/NZ251687A/en unknown
-
1994
- 1994-09-29 NO NO943631A patent/NO943631L/no unknown
- 1994-09-29 FI FI944513A patent/FI944513A7/fi unknown
-
2000
- 2000-03-07 GR GR20000400570T patent/GR3032877T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO943631L (no) | 1994-11-29 |
| NO943631D0 (no) | 1994-09-29 |
| CA2133083A1 (en) | 1993-10-14 |
| CZ236894A3 (en) | 1995-09-13 |
| AU663780B2 (en) | 1995-10-19 |
| GR3032877T3 (en) | 2000-07-31 |
| HU9402825D0 (en) | 1994-12-28 |
| JPH07505868A (ja) | 1995-06-29 |
| EP0972773A1 (de) | 2000-01-19 |
| SK116394A3 (en) | 1995-04-12 |
| NZ251687A (en) | 1995-12-21 |
| DK0640081T3 (da) | 2000-06-19 |
| ES2141763T3 (es) | 2000-04-01 |
| FI944513A0 (fi) | 1994-09-29 |
| DE69327583T2 (de) | 2000-05-31 |
| EP0640081A1 (de) | 1995-03-01 |
| PT640081E (pt) | 2000-05-31 |
| FI944513A7 (fi) | 1994-11-29 |
| WO1993020071A1 (en) | 1993-10-14 |
| EP0640081B1 (de) | 2000-01-12 |
| DE69327583D1 (de) | 2000-02-17 |
| AU3949793A (en) | 1993-11-08 |
| JP3236298B2 (ja) | 2001-12-10 |
| HUT72321A (en) | 1996-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |