ATE188697T1 - Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonisten - Google Patents
Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonistenInfo
- Publication number
- ATE188697T1 ATE188697T1 AT93908861T AT93908861T ATE188697T1 AT E188697 T1 ATE188697 T1 AT E188697T1 AT 93908861 T AT93908861 T AT 93908861T AT 93908861 T AT93908861 T AT 93908861T AT E188697 T1 ATE188697 T1 AT E188697T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- substituted
- antagonists
- ureas
- phenylcarbamates
- Prior art date
Links
- -1 PHENYL UREAS Chemical class 0.000 title 1
- 239000003523 serotonin 4 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 235000013877 carbamide Nutrition 0.000 abstract 2
- 150000003672 ureas Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical group C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- PWXJULSLLONQHY-UHFFFAOYSA-N phenylcarbamic acid Chemical class OC(=O)NC1=CC=CC=C1 PWXJULSLLONQHY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929206989A GB9206989D0 (en) | 1992-03-31 | 1992-03-31 | Chemical compounds |
| GB929217827A GB9217827D0 (en) | 1992-08-21 | 1992-08-21 | Chemical compounds |
| GB929221718A GB9221718D0 (en) | 1992-10-16 | 1992-10-16 | Chemical compounds |
| PCT/EP1993/000779 WO1993020071A1 (en) | 1992-03-31 | 1993-03-26 | Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-ht antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE188697T1 true ATE188697T1 (de) | 2000-01-15 |
Family
ID=27266122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93908861T ATE188697T1 (de) | 1992-03-31 | 1993-03-26 | Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonisten |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0640081B1 (de) |
| JP (1) | JP3236298B2 (de) |
| AT (1) | ATE188697T1 (de) |
| AU (1) | AU663780B2 (de) |
| CA (1) | CA2133083A1 (de) |
| CZ (1) | CZ236894A3 (de) |
| DE (1) | DE69327583T2 (de) |
| DK (1) | DK0640081T3 (de) |
| ES (1) | ES2141763T3 (de) |
| FI (1) | FI944513A7 (de) |
| GR (1) | GR3032877T3 (de) |
| HU (1) | HUT72321A (de) |
| NO (1) | NO943631L (de) |
| NZ (1) | NZ251687A (de) |
| PT (1) | PT640081E (de) |
| SK (1) | SK116394A3 (de) |
| WO (1) | WO1993020071A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995021820A1 (en) * | 1994-02-10 | 1995-08-17 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
| FR2750991A1 (fr) * | 1996-07-12 | 1998-01-16 | Pf Medicament | Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament |
| FR2752732B1 (fr) | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| UA73543C2 (uk) * | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| MXPA02005596A (es) * | 1999-12-07 | 2004-09-10 | Theravance Inc | Derivados de carbamato con actividad antagonista para el rerceptor muscarinico. |
| BR0113073A (pt) * | 2000-08-07 | 2004-06-22 | Glaxosmithkline Lab Sas | Uso de antagonistas receptores 5ht4 na fabricação de um medicamento para a profilaxia ou tratamento de fibrilação atrial |
| AU2001280187A1 (en) * | 2000-08-28 | 2002-03-13 | Toray Industries, Inc. | Cyclic amine derivatives |
| FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
| FR2843750B1 (fr) * | 2002-08-23 | 2004-10-22 | Cerep | Composes derives d'arylcarbamates, preparation et utilisations |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| ES2329586T3 (es) | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| WO2006023460A2 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| WO2006023457A1 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA76475B (en) * | 1975-03-10 | 1977-08-31 | Ciba Geigy Ag | Indolyalkylpiperidines |
| JPH0140026B2 (de) * | 1978-07-03 | 1989-08-24 | Amerikan Hoomu Purodakutsu Corp | |
| IE62231B1 (en) * | 1987-12-24 | 1995-01-11 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| DK443489D0 (da) * | 1989-09-08 | 1989-09-08 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| FR2677019B1 (fr) * | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
| FR2679555B1 (fr) * | 1991-07-25 | 1993-11-19 | Fabre Medicament Pierre | Nouveaux derives de l'uree, leur preparation et leur application en therapeutique. |
-
1993
- 1993-03-26 PT PT93908861T patent/PT640081E/pt unknown
- 1993-03-26 ES ES93908861T patent/ES2141763T3/es not_active Expired - Lifetime
- 1993-03-26 NZ NZ251687A patent/NZ251687A/en unknown
- 1993-03-26 DK DK93908861T patent/DK0640081T3/da active
- 1993-03-26 AU AU39497/93A patent/AU663780B2/en not_active Ceased
- 1993-03-26 AT AT93908861T patent/ATE188697T1/de not_active IP Right Cessation
- 1993-03-26 HU HU9402825A patent/HUT72321A/hu unknown
- 1993-03-26 SK SK1163-94A patent/SK116394A3/sk unknown
- 1993-03-26 WO PCT/EP1993/000779 patent/WO1993020071A1/en not_active Ceased
- 1993-03-26 JP JP51708893A patent/JP3236298B2/ja not_active Expired - Fee Related
- 1993-03-26 CZ CZ942368A patent/CZ236894A3/cs unknown
- 1993-03-26 EP EP93908861A patent/EP0640081B1/de not_active Expired - Lifetime
- 1993-03-26 CA CA002133083A patent/CA2133083A1/en not_active Abandoned
- 1993-03-26 DE DE69327583T patent/DE69327583T2/de not_active Expired - Fee Related
- 1993-03-26 EP EP99201608A patent/EP0972773A1/de not_active Withdrawn
-
1994
- 1994-09-29 NO NO943631A patent/NO943631L/no unknown
- 1994-09-29 FI FI944513A patent/FI944513A7/fi unknown
-
2000
- 2000-03-07 GR GR20000400570T patent/GR3032877T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3032877T3 (en) | 2000-07-31 |
| AU3949793A (en) | 1993-11-08 |
| JP3236298B2 (ja) | 2001-12-10 |
| PT640081E (pt) | 2000-05-31 |
| CZ236894A3 (en) | 1995-09-13 |
| DE69327583T2 (de) | 2000-05-31 |
| DK0640081T3 (da) | 2000-06-19 |
| JPH07505868A (ja) | 1995-06-29 |
| NO943631D0 (no) | 1994-09-29 |
| FI944513A0 (fi) | 1994-09-29 |
| EP0640081B1 (de) | 2000-01-12 |
| HUT72321A (en) | 1996-04-29 |
| NZ251687A (en) | 1995-12-21 |
| ES2141763T3 (es) | 2000-04-01 |
| WO1993020071A1 (en) | 1993-10-14 |
| NO943631L (no) | 1994-11-29 |
| SK116394A3 (en) | 1995-04-12 |
| EP0972773A1 (de) | 2000-01-19 |
| FI944513A7 (fi) | 1994-11-29 |
| DE69327583D1 (de) | 2000-02-17 |
| AU663780B2 (en) | 1995-10-19 |
| EP0640081A1 (de) | 1995-03-01 |
| HU9402825D0 (en) | 1994-12-28 |
| CA2133083A1 (en) | 1993-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69327583D1 (de) | Substituierte phenylcarbamate und phenylharnstoffe, ihre herstellung und ihre verwendung als 5-ht4-antagonisten | |
| FI931888A0 (fi) | Kramploesande cykliska fruktopyranossulfiter -och sulfater | |
| NO953305D0 (no) | Antranilsyrederivat | |
| ATE176912T1 (de) | 2-piperazinon-verbindungen und deren verwendung | |
| DK0486948T3 (da) | Forbindelser, der hæmmer retrovirale proteaser | |
| FI924454A0 (fi) | Nya 7-substituerad-9-(substituerad amino)-6-demetyl-6-deoxitetracykliner | |
| ATE206709T1 (de) | Heterocyclische substituierte benzofuran- harnstoffe | |
| ATE110382T1 (de) | Oxetanocin. | |
| ES8105274A1 (es) | Un procedimiento para la preparacion de derivados de acido benceno -1,2,-disulfonico. | |
| PH18858A (en) | Herbicidally active novel substituted phenyl-sulfonylurea derivatives and intermediates therefor | |
| DE69202120D1 (de) | Harnstoffderivate, ihre Herstellung und ihre Verwendung bei der Therapie. | |
| DE69028610D1 (de) | Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte | |
| ES8402566A1 (es) | Procedimiento para preparar fenilsulfonilisocianatos sustituidos. | |
| IL71361A0 (en) | Urea derivatives,their preparation and their use as pesticides | |
| ES2158290T3 (es) | Derivados de tiazolidinona opticamente activos. | |
| SE8501988L (sv) | Iminotiazolidinderivat | |
| ATE92480T1 (de) | Oxadiazolverbindungen, ihre herstellung und ihre verwendung als pestizide. | |
| IT1241988B (it) | 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono | |
| ATE183502T1 (de) | Octahydro-2-naphthalincarbonsäure-derivate, ihre herstellung und verwendung | |
| ATE142201T1 (de) | 2- und 3-amino und azidoderivate von 1,5- iminozuckern als antivirale arzneimittel | |
| DE69303352D1 (de) | Verfahren zur Herstellung 5-Pyrazolomerkaptan-Derivate und dessen zwischenprodukte | |
| ATE125790T1 (de) | N-fumaramidsäurederivate und diese enthaltende fungizide. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |