NO940305L - Kinazolin-derivater som acetylcholinesteraseinhibitorer - Google Patents
Kinazolin-derivater som acetylcholinesteraseinhibitorerInfo
- Publication number
- NO940305L NO940305L NO940305A NO940305A NO940305L NO 940305 L NO940305 L NO 940305L NO 940305 A NO940305 A NO 940305A NO 940305 A NO940305 A NO 940305A NO 940305 L NO940305 L NO 940305L
- Authority
- NO
- Norway
- Prior art keywords
- kinazoline
- derivatives
- acetylcholinesterase inhibitors
- crr
- iia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73688891A | 1991-07-29 | 1991-07-29 | |
US91166292A | 1992-07-16 | 1992-07-16 | |
PCT/US1992/005864 WO1993003034A1 (en) | 1991-07-29 | 1992-07-22 | Quinazoline derivatives as acetylcholinesterase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO940305D0 NO940305D0 (no) | 1994-01-28 |
NO940305L true NO940305L (no) | 1994-03-28 |
Family
ID=27113138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940305A NO940305L (no) | 1991-07-29 | 1994-01-28 | Kinazolin-derivater som acetylcholinesteraseinhibitorer |
Country Status (13)
Country | Link |
---|---|
US (1) | US5486512A (es) |
EP (1) | EP0597956A1 (es) |
JP (1) | JPH06509576A (es) |
AU (1) | AU665207B2 (es) |
CA (1) | CA2113115A1 (es) |
CZ (1) | CZ281628B6 (es) |
FI (1) | FI940393A (es) |
HU (1) | HUT66324A (es) |
IE (1) | IE922434A1 (es) |
MX (1) | MX9204425A (es) |
NO (1) | NO940305L (es) |
PT (1) | PT100742A (es) |
WO (1) | WO1993003034A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030153598A1 (en) * | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
ATE345803T1 (de) * | 2000-03-03 | 2006-12-15 | Eisai Co Ltd | Neue methoden unter verwendung von cholinesteraseinhibitoren |
US20030229072A1 (en) * | 2000-09-07 | 2003-12-11 | Bullock William H | Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binning agents |
US7022844B2 (en) | 2002-09-21 | 2006-04-04 | Honeywell International Inc. | Amide-based compounds, production, recovery, purification and uses thereof |
AU2005239878B9 (en) * | 2004-05-06 | 2010-01-07 | Warner-Lambert Company Llc | 4-phenylamino-quinazolin-6-yl-amides |
CA2590997A1 (en) * | 2004-12-23 | 2006-07-06 | Voyager Pharmaceutical Corporation | Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer`s disease |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
KR20080087070A (ko) * | 2005-05-20 | 2008-09-30 | 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 | 피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제 |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
CN101220043A (zh) * | 2008-01-24 | 2008-07-16 | 沈阳药科大学 | 噻唑并[3,2-a]嘧啶类衍生物及其应用 |
US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
JP2016510000A (ja) | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
US11160785B2 (en) | 2013-03-15 | 2021-11-02 | Agenebio Inc. | Methods and compositions for improving cognitive function |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CA2928658A1 (en) | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
BR112017025031B1 (pt) | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
CA2988572A1 (en) | 2015-06-26 | 2016-12-29 | Takeda Pharmaceutical Company Limited | 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor |
JP6787913B2 (ja) * | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
AU2017324251A1 (en) | 2016-09-08 | 2019-03-21 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2992221A (en) * | 1958-07-03 | 1961-07-11 | Petersen Siegfried | Polymethylene-oxoquinazolines and their production |
US3271396A (en) * | 1964-08-17 | 1966-09-06 | Squibb & Sons Inc | Pyrido-quinazoline derivatives |
US3745216A (en) * | 1969-12-18 | 1973-07-10 | Smith Kline French Lab | Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds |
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
BE794964A (fr) * | 1972-02-04 | 1973-08-02 | Bristol Myers Co | Nouveaux agents hypotenseurs et procede pour les preparer |
JPS5752352B2 (es) * | 1974-02-28 | 1982-11-06 | ||
NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
HU182009B (en) * | 1977-08-19 | 1983-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines |
DE2845766A1 (de) * | 1978-10-18 | 1980-04-30 | Schering Ag | Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung |
AT377586B (de) * | 1981-06-30 | 1985-04-10 | Erba Farmitalia | Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen |
FR2512674B1 (fr) * | 1981-09-16 | 1986-01-10 | Sandoz Sa | Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives |
US4395554A (en) * | 1981-12-01 | 1983-07-26 | Mobil Oil Corporation | Process for producing alpha-picoline |
IL74349A (en) * | 1984-02-15 | 1988-07-31 | Syntex Inc | (2-oxo-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolinyl)-oxyalkylamides,their preparation and pharmaceutical compositions containing them |
US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
US4837239A (en) * | 1985-08-23 | 1989-06-06 | Syntex (U.S.A.) Inc. | Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins |
US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
US4766126A (en) * | 1986-01-10 | 1988-08-23 | Daiichi Seiyaku Co., Ltd. | Process for treatment of nephritis with imidazoquinazolines |
US4760065A (en) * | 1986-02-13 | 1988-07-26 | Hardtmann Goetz E | Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity |
-
1992
- 1992-07-22 CZ CZ94135A patent/CZ281628B6/cs unknown
- 1992-07-22 AU AU23978/92A patent/AU665207B2/en not_active Ceased
- 1992-07-22 EP EP92916726A patent/EP0597956A1/en not_active Withdrawn
- 1992-07-22 JP JP5503581A patent/JPH06509576A/ja active Pending
- 1992-07-22 WO PCT/US1992/005864 patent/WO1993003034A1/en not_active Application Discontinuation
- 1992-07-22 HU HU9400258A patent/HUT66324A/hu unknown
- 1992-07-22 CA CA002113115A patent/CA2113115A1/en not_active Abandoned
- 1992-07-24 IE IE243492A patent/IE922434A1/en not_active Application Discontinuation
- 1992-07-29 PT PT100742A patent/PT100742A/pt not_active Application Discontinuation
- 1992-07-29 MX MX9204425A patent/MX9204425A/es unknown
-
1994
- 1994-01-26 FI FI940393A patent/FI940393A/fi not_active Application Discontinuation
- 1994-01-28 NO NO940305A patent/NO940305L/no unknown
- 1994-03-17 US US08/214,911 patent/US5486512A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1993003034A1 (en) | 1993-02-18 |
CZ281628B6 (cs) | 1996-11-13 |
HUT66324A (en) | 1994-11-28 |
NO940305D0 (no) | 1994-01-28 |
CZ13594A3 (en) | 1994-05-18 |
FI940393A0 (fi) | 1994-01-26 |
FI940393A (fi) | 1994-03-11 |
AU2397892A (en) | 1993-03-02 |
US5486512A (en) | 1996-01-23 |
HU9400258D0 (en) | 1994-06-28 |
EP0597956A1 (en) | 1994-05-25 |
PT100742A (pt) | 1993-10-29 |
MX9204425A (es) | 1993-01-01 |
IE922434A1 (en) | 1993-02-10 |
CA2113115A1 (en) | 1993-02-18 |
AU665207B2 (en) | 1995-12-21 |
JPH06509576A (ja) | 1994-10-27 |
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