NO933703L - Melaninbaserte midler for avbildingsforbedring - Google Patents
Melaninbaserte midler for avbildingsforbedringInfo
- Publication number
- NO933703L NO933703L NO933703A NO933703A NO933703L NO 933703 L NO933703 L NO 933703L NO 933703 A NO933703 A NO 933703A NO 933703 A NO933703 A NO 933703A NO 933703 L NO933703 L NO 933703L
- Authority
- NO
- Norway
- Prior art keywords
- melanin
- metal
- metals
- paramagnetic
- preferred
- Prior art date
Links
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 title abstract 12
- 239000003623 enhancer Substances 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 229910052751 metal Inorganic materials 0.000 abstract 10
- 239000002184 metal Substances 0.000 abstract 10
- 150000002739 metals Chemical class 0.000 abstract 4
- 230000005298 paramagnetic effect Effects 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052692 Dysprosium Inorganic materials 0.000 abstract 1
- 229910052691 Erbium Inorganic materials 0.000 abstract 1
- 229910052693 Europium Inorganic materials 0.000 abstract 1
- 229910052689 Holmium Inorganic materials 0.000 abstract 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052777 Praseodymium Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 abstract 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 abstract 1
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- PUDIUYLPXJFUGB-UHFFFAOYSA-N praseodymium atom Chemical compound [Pr] PUDIUYLPXJFUGB-UHFFFAOYSA-N 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/685,937 US5310539A (en) | 1991-04-15 | 1991-04-15 | Melanin-based agents for image enhancement |
PCT/US1992/003177 WO1992018166A1 (en) | 1991-04-15 | 1992-04-15 | Melanin-based agents for image enhancement |
Publications (2)
Publication Number | Publication Date |
---|---|
NO933703D0 NO933703D0 (no) | 1993-10-14 |
NO933703L true NO933703L (no) | 1993-12-14 |
Family
ID=24754272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO933703A NO933703L (no) | 1991-04-15 | 1993-10-14 | Melaninbaserte midler for avbildingsforbedring |
Country Status (11)
Country | Link |
---|---|
US (1) | US5310539A (de) |
EP (1) | EP0580734A1 (de) |
JP (1) | JPH06506468A (de) |
AU (1) | AU652829B2 (de) |
CA (1) | CA2108362A1 (de) |
CZ (1) | CZ218193A3 (de) |
FI (1) | FI934542A (de) |
HU (1) | HUT74435A (de) |
NO (1) | NO933703L (de) |
SK (1) | SK112693A3 (de) |
WO (1) | WO1992018166A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744125A (en) * | 1993-08-19 | 1998-04-28 | Yale University | Cosmetic melanins |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US6346387B1 (en) * | 1995-06-27 | 2002-02-12 | Xanthon, Inc. | Detection of binding reactions using labels detected by mediated catalytic electrochemistry |
US5900228A (en) * | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
US6022526A (en) * | 1997-07-30 | 2000-02-08 | Pharmacyclics, Inc. | Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma |
US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
EP1032430A2 (de) | 1997-11-17 | 2000-09-06 | Research Corporation Technologies, Inc. | Mri-mittel zum nachweis von physiologischen mitteln |
FR2800243B1 (fr) * | 1999-11-02 | 2002-01-18 | Royal Canin Sa | Composition alimentaire ou veterinaire pour carnivore domestique contenant de la tyrosine libre pour prevenir les anomalies de pigmentation du pelage |
US20010014442A1 (en) * | 2000-02-09 | 2001-08-16 | Morris James G. | Essential constituent and method of use for maintaining hair coloration or reversing hair discoloration |
US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
WO2002006287A2 (en) | 2000-07-17 | 2002-01-24 | California Institute Of Technology | Macrocyclic mri contrast agents |
JP2002089253A (ja) * | 2000-09-11 | 2002-03-27 | Ibiden Co Ltd | 排ガス浄化用触媒コンバーターの保持シール材 |
WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
WO2002087632A1 (en) * | 2001-05-02 | 2002-11-07 | Metaprobe, Inc. | High throughput screening methods using magnetic resonance imaging agents |
US20030135108A1 (en) * | 2001-05-02 | 2003-07-17 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
AU2003282765A1 (en) * | 2002-10-07 | 2004-05-04 | Trellis Bioscience, Inc. | Multihued labels |
FR2849830B1 (fr) | 2003-01-10 | 2005-12-16 | Messier Dowty Sa | Amortisseur de jambe de train d'atterrissage, et train d'atterrissage a jambes independantes equipees d'un tel amortisseur |
US20040225214A1 (en) * | 2003-05-07 | 2004-11-11 | General Electric Company | Method of high-throughput quantitative pet for small animal imaging using a large-bore pet scanner for the assessment of pet tracer performance |
US6987270B2 (en) * | 2003-05-07 | 2006-01-17 | General Electric Company | Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes |
WO2005070473A1 (en) | 2004-01-15 | 2005-08-04 | Koninklijke Philips Electronics N.V. | Ultrasound contrast agents for molecular imaging |
KR20080099279A (ko) * | 2006-02-24 | 2008-11-12 | 말린크로트, 인코포레이티드 | 이관능성 레조르시놀, 티오레조르시놀, 및 디티오레조르시놀 유도체 금속 킬레이팅 컨쥬게이트 |
FR2906253A1 (fr) * | 2006-09-22 | 2008-03-28 | Biosphere Medical Sa | Nouveaux materiaux polymeres bio-compatibles, leur procede d'obtention et leurs utilisations, notamment en imagerie medicale par resonnance magnetique |
WO2009140408A2 (en) | 2008-05-13 | 2009-11-19 | University Of Kansas | Metal abstraction peptide (map) tag and associated methods |
US8696759B2 (en) | 2009-04-15 | 2014-04-15 | DePuy Synthes Products, LLC | Methods and devices for implants with calcium phosphate |
US20100268227A1 (en) * | 2009-04-15 | 2010-10-21 | Depuy Products, Inc. | Methods and Devices for Bone Attachment |
US8475536B2 (en) * | 2010-01-29 | 2013-07-02 | DePuy Synthes Products, LLC | Methods and devices for implants with improved cement adhesion |
KR101309789B1 (ko) * | 2011-01-26 | 2013-09-23 | (주)프로테옴텍 | 티로신 산화물이 결합된 바이오 물질을 포함하는 단백질 검출용 조성물 |
US20130183263A1 (en) | 2012-01-17 | 2013-07-18 | Steven Hoffman | Pharmaceutical compositions and methods |
US10272068B2 (en) | 2012-01-17 | 2019-04-30 | Tyme, Inc. | Pharmaceutical compositions and methods |
US10646552B2 (en) | 2012-01-17 | 2020-05-12 | Tyme, Inc. | Pharmaceutical compositions and methods |
KR101729710B1 (ko) | 2012-04-09 | 2017-04-24 | 서울대학교산학협력단 | 물에 안정하게 분산되는 멜라닌 나노입자를 포함하는 핵자기 공명 영상 조영제 |
WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
US20140356283A1 (en) * | 2013-06-04 | 2014-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Probes, Methods of Making Probes, and Methods of Use |
US9585841B2 (en) * | 2013-10-22 | 2017-03-07 | Tyme, Inc. | Tyrosine derivatives and compositions comprising them |
KR101729711B1 (ko) | 2017-02-07 | 2017-04-24 | 서울대학교산학협력단 | 물에 안정하게 분산되는 멜라닌 나노입자를 포함하는 핵자기 공명 영상 조영제 |
CN110082382A (zh) * | 2019-05-08 | 2019-08-02 | 中国科学院武汉物理与数学研究所 | 一种利用动态核极化进行油水两相nmr信号分离的方法 |
MX2021013901A (es) | 2019-05-14 | 2022-04-12 | Tyme Inc | Composiciones y métodos para el tratamiento del cáncer. |
Family Cites Families (29)
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---|---|---|---|---|
GB1605337A (en) * | 1962-02-03 | 1991-12-18 | Telefunken Patents Verwertungs | An electronic proximity fuze |
GB1529150A (en) * | 1977-05-17 | 1978-10-18 | Tabushi I | Alkyl substituted cyclic alkyltetramines |
US4247406A (en) * | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
US4432907A (en) * | 1979-09-10 | 1984-02-21 | Analytical Radiation Corporation | Diamine acid fluorescent chelates |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4421671A (en) * | 1982-06-18 | 1983-12-20 | General Electric Company | Rare-earth-doped yttria-gadolinia ceramic scintillators |
US4731239A (en) * | 1983-01-10 | 1988-03-15 | Gordon Robert T | Method for enhancing NMR imaging; and diagnostic use |
NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
US4735796A (en) * | 1983-12-08 | 1988-04-05 | Gordon Robert T | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
GB8413849D0 (en) * | 1984-05-31 | 1984-07-04 | Amersham Int Plc | Nmr contrast agents |
US4698374A (en) * | 1984-06-08 | 1987-10-06 | Gallas James M | Optical lens system incorporating melanin as an absorbing pigment for protection against electromagnetic radiation |
US5187207A (en) * | 1984-06-08 | 1993-02-16 | Photoprotective Technologies, Inc. | Melanin hydrophilic contact lenses |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
EP0184899B1 (de) * | 1984-11-01 | 1990-04-18 | Nycomed As | Paramagnetische Kontrastmittel für die Anwendung in "in vivo" NMR-diagnostischen Methoden und die Herstellung davon |
US4735210A (en) * | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
US4770183A (en) * | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
MX12394A (es) * | 1987-07-23 | 1993-12-01 | Ciba Geigy Ag | Procedimiento par la obtencion de carbamatos de polietilenglicol. |
US5137711A (en) * | 1988-07-19 | 1992-08-11 | Mallickrodt Medical, Inc. | Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents |
JPH07114812B2 (ja) * | 1990-08-11 | 1995-12-13 | 株式会社日本健康増進研究会 | 光を利用した睡眠等の誘導補助具 |
-
1991
- 1991-04-15 US US07/685,937 patent/US5310539A/en not_active Expired - Fee Related
-
1992
- 1992-04-15 CA CA002108362A patent/CA2108362A1/en not_active Abandoned
- 1992-04-15 CZ CS932181A patent/CZ218193A3/cs unknown
- 1992-04-15 HU HU9302889A patent/HUT74435A/hu unknown
- 1992-04-15 EP EP92910282A patent/EP0580734A1/de not_active Withdrawn
- 1992-04-15 JP JP4509464A patent/JPH06506468A/ja active Pending
- 1992-04-15 SK SK1126-93A patent/SK112693A3/sk unknown
- 1992-04-15 WO PCT/US1992/003177 patent/WO1992018166A1/en not_active Application Discontinuation
- 1992-04-15 AU AU17549/92A patent/AU652829B2/en not_active Ceased
-
1993
- 1993-10-14 FI FI934542A patent/FI934542A/fi unknown
- 1993-10-14 NO NO933703A patent/NO933703L/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO1992018166A1 (en) | 1992-10-29 |
NO933703D0 (no) | 1993-10-14 |
CZ218193A3 (en) | 1994-03-16 |
FI934542A (fi) | 1993-12-13 |
SK112693A3 (en) | 1994-10-05 |
HUT74435A (en) | 1996-12-30 |
US5310539A (en) | 1994-05-10 |
EP0580734A1 (de) | 1994-02-02 |
JPH06506468A (ja) | 1994-07-21 |
AU652829B2 (en) | 1994-09-08 |
CA2108362A1 (en) | 1992-10-16 |
HU9302889D0 (en) | 1993-12-28 |
AU1754992A (en) | 1992-11-17 |
FI934542A0 (fi) | 1993-10-14 |
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